Review
Cell Biology
Falko Lange, Julia Hoernschemeyer, Timo Kirschstein
Summary: The progression of glioblastomas and tumor-associated epilepsy is closely linked through various pathophysiological mechanisms involving the neurotransmitter glutamate. Current research focuses on the role of glutamate receptors in these diseases and discusses future interventions to interfere with the glutamatergic network.
Article
Cell Biology
M. Crespo, D. A. Leon-Navarro, M. Martin
Summary: Febrile seizures in children can lead to epilepsy in adults, with glutamate playing a key role in the development of neurological disorders. In the short term after seizures, GLT-1 levels increase and glutamate concentration decreases, while mGlu(5)R levels remain unchanged. However, in the long term, an increase in mGlu(5)R levels and decreases in GLT-1 and glutamate levels are observed, associated with the development of an anxious phenotype and potentially increased vulnerability to epileptic events in adults.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2022)
Article
Neurosciences
Zexu Chen, Han Long, Jianhua Guo, Yiran Wang, Kezhe He, Chenchen Tao, Xiong Li, Keji Jiang, Su Guo, Yan Pi
Summary: De novo deletion of the NECAB2 locus is associated with autism spectrum disorders. NECAB2 regulates psychomotor and social behavior through modulating the mGluR1 signaling pathway.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Article
Psychiatry
Li Wang, Xingming Tang, Peng Liang, Chuan Zhou, Yingjie Sun, Yundan Liang
Summary: This study investigated the association between genetic polymorphisms in CREB1 and GRM7 and the risk of depression. The frequencies of rs2253206, rs10932201, and rs162209 were analyzed in 479 depressed patients and 329 normal controls. The results revealed a significant association between rs2253206 and rs10932201 polymorphisms and an increased risk of depression, while no association was found for rs162209. Stratification analysis showed no correlation between these polymorphisms and disease onset, severity, family history, or suicidal tendency. These findings suggest a potential involvement of CREB1 polymorphisms rs2253206 and rs10932201 in the onset of depression.
Article
Neurosciences
Benjamin D. Auerbach, Senthilvelan Manohar, Kelly Radziwon, Richard Salvi
Summary: The study characterized auditory hypersensitivity in a Fmr1 knockout transgenic rat model of FX, revealing perceptual evidence of excessive loudness growth and altered integration of sound duration and bandwidth in Fmr1 KO rats. Antagonism of mGlu5 selectively and dose-dependently restored normal loudness growth in Fmr1 KO rats, suggesting a pharmacologic approach for alleviating sensory hypersensitivity associated with FX. Leveraging the tractable nature of the auditory system and unique behavioral advantages of rats, this study provides important insights into an understudied aspect of FX and ASD.
NEUROBIOLOGY OF DISEASE
(2021)
Review
Oncology
Kevinn Eddy, Suzie Chen
Summary: Melanoma is the most aggressive and dangerous form of skin cancer, with poor prognosis for late-stage patients. Abnormal glutamatergic signaling contributes to melanoma and is a potential target for therapeutic strategies.
Article
Neurosciences
Xiaona Wang, Chao Gao, Yaodong Zhang, Shunan Hu, Yidan Qiao, Zhengqin Zhao, Lingshan Gou, Jijun Song, Qi Wang
Summary: The etiology of autism spectrum disorder (ASD) is still not fully understood due to its complexity, but research suggests that the decreased levels of mGluR7 protein in the prefrontal cortex may be related to the development of ASD. Overexpression of mGluR7 in the prefrontal cortex of mice has been found to reduce the severity of ASD-like behaviors, offering a potential therapeutic target for ASD and related neurodevelopmental disorders.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Endocrinology & Metabolism
Manabu Kubota, Yasuyuki Kimura, Masafumi Shimojo, Yuhei Takado, Joao M. N. Duarte, Hiroyuki Takuwa, Chie Seki, Hitoshi Shimada, Hitoshi Shinotoh, Keisuke Takahata, Soichiro Kitamura, Sho Moriguchi, Kenji Tagai, Takayuki Obata, Jin Nakahara, Yutaka Tomita, Masaki Tokunaga, Jun Maeda, Kazunori Kawamura, Ming-Rong Zhang, Masanori Ichise, Tetsuya Suhara, Makoto Higuchi
Summary: The study demonstrates that food intake and changes in plasma glucose levels dynamically alter metabotropic glutamate receptor subtype 5 (mGluR5) ligand binding and glutamate levels in the human brain. These findings suggest a mechanistic link between food-associated glucose intake and glutamatergic tones in the brain, which can be accessed in vivo by bimodal PET and MRS techniques in both clinical and non-clinical settings.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2021)
Article
Biochemistry & Molecular Biology
Alexandre Maisterrena, Emmanuel Matas, Helene Mirfendereski, Anais Balbous, Sandrine Marchand, Mohamed Jaber
Summary: This study investigated the state of key players in the dopamine and glutamate neurotransmission systems in an animal model of Autism Spectrum Disorder (ASD). The results showed slight decrease in dopamine levels and increased gene expression of D1 and D2 dopamine receptors in the valproic acid (VPA) exposed mice, along with decreased protein levels of parvalbumin and increased levels of p-mTOR. These findings are important for potential clinical trials targeting the dopamine and glutamate systems.
Article
Psychiatry
Leonardo Nardi, Stuti Chhabra, Petra Leukel, Dilja Krueger-Burg, Clemens J. Sommer, Michael J. Schmeisser
Summary: Autism spectrum disorder (ASD) is a range of neurodevelopmental conditions characterized by impaired social interaction and repetitive behavior. Synaptic dysfunction, particularly in the excitatory/inhibitory (E/I) balance, is believed to be one of the key mechanisms underlying ASD. This study investigated three mouse lines that mimic both idiopathic and genetic forms of ASD and found specific alterations in excitatory ionotropic receptor density in different brain regions. Interestingly, there was an increase in GABA(A) receptor binding density in the dorsal hippocampus but a reduction in the cerebellum.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Neurosciences
Ferdinando Nicoletti, Luisa Di Menna, Luisa Iacovelli, Rosamaria Orlando, Anna Rita Zuena, P. Jeffrey Conn, Shalini Dogra, Max E. Joffe
Summary: Cellular responses to metabotropic glutamate (mGlu) receptor activation are influenced by mechanisms of receptor-receptor interaction, including receptor dimerization and complex formation with other GPCRs. The interactions between different mGlu receptor subtypes and other receptors have been studied in various brain regions and have been implicated in the pathophysiology of several neurological and psychiatric disorders. Understanding these interactions could lead to the development of new therapeutic targets for these conditions.
Article
Clinical Neurology
Maria Bove, Stefania Schiavone, Paolo Tucci, Vladyslav Sikora, Stefania Dimonte, Anna Laura Colia, Maria Grazia Morgese, Luigia Trabace
Summary: This study investigated whether early ketamine administration in mice could induce behavioral features that mimic typical symptoms of autism spectrum disorder (ASD). The results showed that adult mice receiving early ketamine administration exhibited increased stereotyped behaviors, social impairments, and anxiety-like behavior. Additionally, neurochemical and biomolecular analyses revealed alterations in neurotransmitters and immune activation biomarkers related to ASD in specific brain regions. These findings suggest that early ketamine administration may represent a suitable animal model for studying ASD-related symptoms.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2022)
Article
Multidisciplinary Sciences
Sharmistha Saha, Mahasweta Chatterjee, Swagata Sinha, Kanchan Mukhopadhyay
Summary: The study for the first time identified a potential association between a missense variant in the GABRQ gene and the severity of specific symptoms in female ASD patients, warranting further investigation.
SCIENTIFIC REPORTS
(2021)
Article
Psychiatry
Jifeng Wang, Yuan Cao, Weiliang Hou, Dexi Bi, Fang Yin, Yaohui Gao, Dengfeng Huang, Yingying Li, Zhan Cao, Yinmei Yan, Jianhua Zhao, Dewu Kong, Xiaoqiong Lv, Linsheng Huang, Hui Zhong, Chunyan Wu, Qiyi Chen, Rong Yang, Qing Wei, Huanlong Qin
Summary: Autism spectrum disorder (ASD) is a complex behavioral disorder characterized by difficulties in social interaction, restricted verbal communication, and repetitive behaviors. Fecal microbiota transplantation (FMT) is a safe and efficient strategy to adjust gut microbiota dysbiosis and improve ASD-related behavioral symptoms, but its mechanism is still unknown. Understanding the impact of microbiota on ASD development is crucial for developing new therapeutic strategies.
TRANSLATIONAL PSYCHIATRY
(2023)
Article
Biochemistry & Molecular Biology
Wajeha Hamoudi, Manish Kumar Tripathi, Shashank Kumar Ojha, Haitham Amal
Summary: This study identifies novel SNO of key glutamatergic proteins in Shank3 mutant mice and reveals a cross-talk between nitric oxide and the glutamatergic system.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Hossein Sadeghi, Veys Hashemnia, Ehsan Nazemalhosseini-Mojarad, Mohammad Reza Ghasemi, Reza Mirfakhraie
Summary: Experimental studies suggest that vitamin D has tumor-suppressive effects by controlling differentiation, proliferation, and apoptosis in cancer cells. This study investigated the expression level of vitamin D metabolic pathway genes in colorectal cancer (CRC) samples and found that CYP3A4 and VDR genes were significantly downregulated in CRC tissues compared to adjacent tissues. Additionally, a positive correlation was observed between the expression of CYP3A4 and VDR genes. ROC curve analysis revealed the potential diagnostic power of these genes in CRC samples.
MOLECULAR BIOLOGY REPORTS
(2023)
Article
Endocrinology & Metabolism
Jalal Gharesouran, Hassan Hosseinzadeh, Ali Naghiloo, Soudeh Ghafouri-Fard, Bashdar Mahmud Hussen, Mohammad Taheri, Maryam Rezazadeh, Mohammad Samadian
Summary: This study reports a case of CMT, a hereditary neuropathy, in which the patient developed symptoms late in life. A novel 4074 bp homozygote deletion in the MPZ gene was identified through exome sequencing. The study suggests the presence of another protein in peripheral nervous system myelin biogenesis to compensate for the lack of MPZ protein.
METABOLIC BRAIN DISEASE
(2023)
Review
Neurosciences
Soudeh Ghafouri-Fard, Ashkan Pourtavakoli, Bashdar Mahmud Hussen, Mohammad Taheri, Seyed Abdulmajid Ayatollahi
Summary: Autism spectrum disorder (ASD) is a common neurodevelopmental disease, affecting approximately 1 in 59 individuals. The disorder is genetically heterogeneous, with both inheritable and de novo mutations in several genes playing a role. The review discusses the different types of mutations, including missense and nonsense mutations, as well as copy number variations, found in individuals affected by ASD.
MOLECULAR NEUROBIOLOGY
(2023)
Review
Pathology
Mohammad Taheri, Bashdar Mahmud Hussen, Snur Rasool Abdullah, Soudeh Ghafouri-Fard, Elena Jamali, Seyedpouzhia Shojaei
Summary: Wilms tumor, the most common pediatric kidney tumor, is associated with dysregulation of non-coding RNAs. Dysregulated miRNAs such as miR-200c, miR-155-5p, miR-1180, miR-22-3p, miR-483-5p, miR-140-5p, miR-92a-3p, miR-483-3p, miR-572, miR-539, and miR-613, as well as dysregulated long non-coding RNAs including CRNDE, XIST, SNHG6, MEG3, LINC00667, MEG8, DLGAP1-AS2, and SOX21-AS1, have been identified in this tumor. Additionally, circCDYL is down-regulated, while circ0093740 and circSLC7A6 are up-regulated in Wilms tumor. These dysregulated transcripts offer new insights into understanding the pathogenesis and developing targeted therapies for this pediatric tumor.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Article
Pathology
Soudeh Ghafouri-Fard, Yadollah Poornajaf, Bashdar Mahmud Hussen, Shiva Tavakkoli Avval, Mohammad Taheri, Majid Mokhtari
Summary: The Hippo pathway plays a crucial role in regulating organ size, homeostasis, and tumorigenesis. It is involved in lung carcinogenesis through various mechanisms, including the interaction between miRNAs and the Hippo pathway. Non-coding RNAs such as PVT1, SFTA1P, NSCLCAT1, and circ_0067741 are also implicated in this process. Furthermore, several anti-cancer agents can modulate the Hippo pathway to exert their anti-cancer effects in lung cancer. This article summarizes recent studies on the role of Hippo signaling in lung cancer progression, the impact of non-coding RNAs on this pathway, and the effects of anti-cancer agents.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Article
Endocrinology & Metabolism
Hani Sabaie, Parham Tamimi, Jalal Gharesouran, Zoha Salkhordeh, Mohammad Reza Asadi, Mirmohsen Sharifi-Bonab, Zeinab Shirvani-Farsani, Mohammad Taheri, Arezou Sayad, Maryam Rezazadeh
Summary: Alzheimer's disease (AD) is a complex global health problem, and new methodologies are needed to investigate its pathophysiology and develop treatments. The interaction of immune modulation and neurodegeneration offers potential for discovering biomarkers and therapies. In this study, we compared the expression levels of inhibitory B7 family members in the blood of AD patients and healthy individuals, and found that certain members were significantly higher in patients. These findings suggest the potential of these molecules as diagnostic biomarkers for AD.
METABOLIC BRAIN DISEASE
(2023)
Article
Endocrinology & Metabolism
Soudeh Ghafouri-Fard, Sara Ahmadi Teshnizi, Shahryar Azizi, Solat Eslami, Mohammad Taheri, Fariborz Rashnoo
Summary: Obesity is a global problem influenced by genetic factors. The study found an association between the GRM7 gene and obesity.
METABOLIC BRAIN DISEASE
(2023)
Article
Pathology
Soudeh Ghafouri-Fard, Maryam Khaledabadi, Ghazal Najafi, Arash Safarzadeh, Bashdar Mahmud Hussen, Solat Eslami, Guive Sharifi, Mohammad Taheri, Nader Akbari Dilmaghani
Summary: This study evaluated the expression of 5 long non-coding RNAs (lncRNAs) in non-functioning pituitary adenomas (NFPAs) and found that the expression of ATP6V0E2-AS1, EPB41L4A-AS1, FGD5-AS1, and WWC2-AS2 was significantly increased in NFPAs. However, the expression of ARHGAP5-AS1 did not differ. Additionally, there were significant positive associations between age of NFPA patients and invasiveness of NFPA, diseases duration and CSF leak, as well as tumor size and Knosp classification and invasiveness of NFPA. This study provides valuable information on lncRNA dysregulation in NFPAs and calls for further research in this field.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Article
Pathology
Soudeh Ghafouri-Fard, Farzaneh Abbasi, Amir Nicknam, Bashdar Mahmud Hussen, Solat Eslami, Nader Akbari Dilmaghani, Mohammad Taheri, Guive Sharifi
Summary: Pituitary adenomas are slow-growing tumors with dysregulation of lncRNAs, including PVT1 and NEAT1, which play important roles in regulating cell functions. In this study, higher expression levels of NEAT1 were found in pituitary adenoma tissues, especially non-functioning pituitary adenoma samples. However, the sensitivity values and AUC values of PVT1 and NEAT1 were not adequate for distinguishing non-functioning pituitary adenomas from non-cancerous tissues.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Review
Pathology
Soudeh Ghafouri-Fard, Arash Safarzadeh, Bashdar Mahmud Hussen, Mohammad Taheri, Ahmad Eghbali
Summary: LINC00174 is a long intergenic non-coding RNA that plays important roles in human cancer development. It has been shown to have oncogenic effects in various cancers, including colorectal carcinoma, thymic carcinoma, glioma, glioblastoma, hepatocellular carcinoma, kidney renal clear cell carcinoma, breast cancer, and non-functioning pituitary adenoma. However, the role of LINC00174 in lung cancer remains uncertain. This lincRNA is also involved in determining the prognosis of different cancers, particularly colorectal cancer. In this review, we discuss the role of LINC00174 in human carcinogenesis based on available literature and bioinformatics tools.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Review
Pathology
Soudeh Ghafouri-Fard, Hamed Shoorei, Toofan Sabernia, Bashdar Mahmud Hussen, Mohammad Taheri, Hasan Pourmoshtagh
Summary: CircRNAs play an important role in immune-related disorders by regulating immune system function and contributing to pathophysiology.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Article
Pathology
Soudeh Ghafouri-Fard, Hamed Shoorei, Leili Noferesti, Bashdar Mahmud Hussen, Mohammad Hossein Behzad Moghadam, Mohammad Taheri, Fariborz Rashnoo
Summary: miRNA-loaded nanoparticles have been used for the treatment of various disorders, particularly cancers, ischemic stroke, and pulmonary fibrosis. The wide range application of this type of therapy is based on the important roles of miRNAs in regulating cell behavior. The ability of miRNAs to inhibit or increase gene expression gives them an advantage over other therapies.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Article
Pathology
Lina Moallemi Rad, Arash Safarzadeh, Mohammad Taheri, Soudeh Ghafouri-Fard, Ahmad Eghbali
Summary: In this study, an in-silico approach was developed to identify the RNA network in breast cancer, which revealed differentially expressed mRNAs, lncRNAs, and miRNAs. Pathway analysis indicated the involvement of various pathways in breast cancer. Furthermore, a ceRNA network consisting of lncRNAs, mRNAs, and miRNAs was constructed, suggesting its potential as a target for anti-cancer therapy and identification of novel markers for breast cancer.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Review
Biochemistry & Molecular Biology
Soudeh Ghafouri-Fard, Hamed Shoorei, Shahram Dabiri Oskuei, Bashdar Mahmud Hussen, Snur Rasool Abdullah, Mohammad Taheri, Elena Jamali
Summary: Toxic agents exist widely in the environment, households, and workplaces. Their contamination in food and drinking water leads to their entry into the body, where they interact with microRNAs (miRNAs), influencing the etiology of various disorders. These agents can alter redox status, release inflammatory cytokines, and affect mitochondrial function. Dysregulation of miRNA expression is implicated in the development of pathological conditions and signaling pathways, while also playing a role in environmental adaptation. Therefore, the interactions between miRNAs and toxic materials contribute to the detrimental effects on human health.
NON-CODING RNA RESEARCH
(2023)
Review
Oncology
Soudeh Ghafouri-Fard, Arian Askari, Bashdar Mahmud Hussen, Mohammad Taheri, Nader Akbari Dilmaghani
Summary: miR-424 is a miRNA involved in the carcinogenic process, with its expression being found to be up-regulated or down-regulated in various cancers. Its expression is regulated by the methylation status of its promoter, and it is also regulated by several long non-coding RNAs. Additionally, miR-424 is involved in the regulation of E2F transcription factors. This review aims to summarize the role of miR-424 in cancer evolution and its impact on clinical outcomes, in order to identify potential markers for malignancies.
CLINICAL & TRANSLATIONAL ONCOLOGY
(2023)
