期刊
LIFE SCIENCES
卷 233, 期 -, 页码 -出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.lfs.2019.116695
关键词
Alzheimer's disease; Amyloid beta-peptides; Apoptosis; Dementia; Inflammation; Oxidative stress; Scopolamine; Tau proteins
资金
- Ministry of Education, Malaysia [FRGS/1/2012/SKK01/MUSM/03/1]
Alzheimer's disease (AD) is neurodegenerative disorder that is associated with memory and cognitive decline in the older adults. Scopolamine is commonly used as a behavioral model in studying cognitive disorders including AD. Many studies have also concurrently examined the neurochemical mechanisms underlying the behavioral modifications by scopolamine treatment. Nonetheless, the scopolamine model has not become a standard tool in the early assessment of drugs. Furthermore, the use of scopolamine as a pharmacological model to study AD remains debatable. This report reviews the scopolamine-induced cellular and molecular changes and discusses how these changes relate to AD pathogenesis.
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