期刊
JOURNAL OF VETERINARY DIAGNOSTIC INVESTIGATION
卷 31, 期 5, 页码 761-765出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/1040638719868274
关键词
antigen distribution; chickens; coinfection; Marek's disease virus; reticuloendotheliosis virus; subgroup J avian leukosis virus
资金
- Academic Backbone Training Project of Anhui Agricultural University [2014XKPY-25]
- Natural Science Foundation of China [31872445, 31772707]
We investigated the histologic findings and viral antigen distribution in 3 cases of natural coinfection of layer hens with subgroup J avian leukosis virus (ALV-J), Marek's disease virus (MDV), and reticuloendotheliosis virus (REV) in hens. At autopsy, diseased hens were found to have hepatosplenomegaly and thickened proventriculi, with white tumor nodules in the liver, spleen, lung, kidney, and ovary. Microscopically, most tissues had been infiltrated by neoplastic lymphocytes; the spleen, lung, proventriculus, heart, and liver had been infiltrated by both neoplastic lymphocytes and myeloblastic cells and/or primitive reticular cells. Fluorescence multiplex immunohistochemistry staining revealed ALV-J, MDV, and REV antigens co-expressed in the same tissue, even the same cell.
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