期刊
JOURNAL OF TRAVEL MEDICINE
卷 26, 期 7, 页码 -出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/jtm/taz064
关键词
Japanese encephalitis; JE; JE virus; JE vaccine; Japanese encephalitis vaccine; Travel medicine; Traveller
资金
- National Institute for Health Research [RP-PG-0108-10,048]
- European Union Zika Pan Latin American Network consortium (ZikaPLAN)
- European Union [734584]
- Wellcome clinical career development fellow [205228/Z/16/Z]
- MRC [MC_PC_15096, G116/194] Funding Source: UKRI
Background: Japanese encephalitis (JE), caused by the mosquito-borne JE virus, is a vaccine-preventable disease endemic to much of Asia. Travellers from non-endemic areas are susceptible if they travel to a JE endemic area. Although the risk to travellers of JE is low, the consequences may be severe. Methods: Here, we describe three cases of JE in British travellers occurring in 2014-15. In addition, we report, through interviews with survivors and their families, personal experiences of life after JE. Results: Three cases of JE were diagnosed in British travellers in 2014/15. One was acquired in Thailand, one in China and one in either Thailand, Laos or Cambodia. All three patients suffered severe, life-threatening illnesses, all were admitted to intensive care units and required medical evacuation back to the UK. One patient suffered a cardiac arrest during the acute stage but made a good recovery. The other two patients remain significantly paralysed and ventilator dependent. All three cases had clear indications for vaccination, and all have been left with life-changing neurological sequelae. Conclusions:Travel health providers should be aware of the severity of JE, as well as the risk, allowing travellers to make fully informed decisions on JE vaccination.
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