Article
Biochemistry & Molecular Biology
Eiji Munetsuna, Hiroya Yamada, Mirai Yamazaki, Yoshitaka Ando, Genki Mizuno, Yuji Hattori, Itsuki Kageyama, Atsushi Teshigawara, Yuki Nouchi, Hiroaki Ishikawa, Ryosuke Fujii, Yoshiji Ohta, Koji Suzuki, Yohei Shimono, Koji Ohashi, Shuji Hashimoto
Summary: Excessive maternal fructose intake may lead to abnormal liver function in offspring, increasing the risk of developing metabolic disorders. This abnormal hepatic programming induced by an imbalanced maternal nutritional environment is likely to be maintained throughout life and contribute to metabolic disorders.
Article
Biochemistry & Molecular Biology
Yunfeng Zhang, Lingyu Xie, Xiaoqing Ding, Yuanyuan Wang, Yibin Xu, Danlei Li, Shuang Liang, Yongxia Wang, Ling Zhang, Aikun Fu, Xiuan Zhan
Summary: This study found that maternal zinc can alleviate oxidative stress injury caused by heat stress in chicken embryos. It enhances antioxidant capacity, reduces apoptosis, and activates the Nrf2 signaling pathway.
Article
Agriculture, Dairy & Animal Science
Yanqiang Geng, Xiaoming Sun, Lin Lu, Xi Lin, Xiudong Liao, Liyang Zhang, Runlian Wang, Xugang Luo
Summary: This study aimed to investigate the effects of in ovo manganese injection on embryonic development, antioxidant capacity, and performance of offspring broilers. The results showed that in ovo manganese injection can enhance the antioxidant capacity in the chick embryonic heart, but high temperature can negatively affect the growth performance of the offspring broilers.
Article
Biology
Shizhen Qin, Liang Huang, Lin Lu, Liyang Zhang, Yanli Guo, Lin Xi, Xiudong Liao, Xugang Luo
Summary: Manganese is a necessary trace element that can alleviate the negative effects of heat stress on the heart of broiler breeders and embryos, but the mechanisms behind this protection are still unclear. Two experiments were conducted to investigate the protective effects of manganese on primary cultured chick embryonic myocardial cells exposed to heat challenge. The results showed that supplementation of manganese could enhance the expression of manganese superoxide dismutase and attenuate heat shock response, protecting the myocardial cells from heat-induced damage.
JOURNAL OF THERMAL BIOLOGY
(2023)
Article
Pediatrics
Chung-Ming Chen, Jaulang Hwang, Hsiu-Chu Chou
Summary: Neonatal hyperoxia results in oxidative stress and kidney injuries, but maternal Tn immunization can reduce kidney injury and collagen deposition in neonatal rats by attenuating oxidative stress and NF-kappa B activity. Maternal Tn immunization may be a promising treatment for hyperoxia-induced kidney injury in neonates.
PEDIATRIC RESEARCH
(2021)
Article
Obstetrics & Gynecology
Bingqian Zhang, Zijing Wang, Kexin Dai, Linlin Cui, Zi-Jiang Chen
Summary: This retrospective cohort study evaluated the long-term cardiometabolic health of offspring conceived by frozen embryo transfer and born to mothers with overweight/obesity. The study found that offspring conceived by frozen embryo transfer from overweight/obese mothers were associated with higher systolic blood pressure and adverse metabolic changes compared to those conceived by fresh embryo transfer. However, in offspring of mothers with normal weight, frozen embryo transfer was associated with lower low-density lipoprotein-cholesterol levels.
FERTILITY AND STERILITY
(2022)
Article
Pharmacology & Pharmacy
C. C. Paccola, G. S. Souza, I. M. M. Freitas, J. C. Souza, L. L. Martins, V. Vendramini, S. M. Miraglia
Summary: Nicotine exposure during pregnancy and breastfeeding can potentially harm female gametes, affecting reproductive capacity. However, it does not significantly impact the number of oocytes and fertility in adult rats. Nevertheless, morphological alterations in oocytes, mitochondrial changes, embryonic fragmentation, and disruption of fetal development can still occur as a result of nicotine exposure.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2021)
Review
Endocrinology & Metabolism
Phoebe D. Edwards, Sophia G. Lavergne, Laura K. McCaw, Sanoji Wijenayake, Rudy Boonstra, Patrick O. McGowan, Melissa M. Holmes
Summary: This review discusses the impact of five major maternal cues on offspring phenotype during the perinatal period: maternal androgen levels, photoperiod, microbiome, immune regulation, and milk composition. The mechanisms of action for each of these cues in mammals are explored, along with their interactions with each other and with maternal diet and stress. The review also highlights the importance of considering these effects in non-model species and natural ecological systems.
FRONTIERS IN NEUROENDOCRINOLOGY
(2021)
Article
Developmental Biology
Oana Kubinyecz, Fatima Santos, Deborah Drage, Wolf Reik, Melanie A. Eckersley-Maslin
Summary: The study reveals the importance of Dppa2/4 proteins in early mouse embryonic development, especially the impact of maternal Dppa2/4 on offspring survival.
Article
Agriculture, Dairy & Animal Science
Vanessa das Gracas Pereira de Souza, Gustavo Torres de Souza, Diana Rangel de Lemos, Judith Maria de Oliveira Guimaraes, Carolina Capobiango Romano Quintao, Michele Munk, Naiara Zoccal Saraiva, Luiz Sergio de Almeida Camargo
Summary: Heat shock during in vitro maturation affects the abundance of bta-miR-19b and DROSHA in pre-implantation embryos, leading to compromised oocyte nuclear maturation, cleavage, and embryonic development with higher apoptotic indices.
REPRODUCTION IN DOMESTIC ANIMALS
(2021)
Article
Immunology
Matthew Lacorcia, Reka Kugyelka, Lorenz Spechtenhauser, Ulrich Fabien Prodjinotho, Youssef Hamway, Thomas Spangenberg, Clarissa Prazeres da Costa
Summary: Maternal treatment with Praziquantel prior to mating enhances maternal immune responses against schistosomiasis, improves immune system development of exposed offspring, and reduces morbidity during infection. Additionally, offspring exposed to prenatal anthelminthic treatment show improved responsiveness to infection and restored protective IgE antibody responses. Maternal treatment can restore a more normalized immune profile to offspring exposed in utero to parasite infection.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Maria M. Guzewska, Kamil Myszczynski, Yael Heifetz, Monika M. Kaczmarek
Summary: In this study, EVs were observed at the embryo-maternal interface through transmission electron microscopy, and different secretion pathways were identified. It was found that embryonic signals can regulate the biogenesis and secretion of EVs, as well as the gene expression in endometrial cells. These findings highlight the important role of embryonic signals in modulating endometrial secretory activity during early pregnancy.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Biochemistry & Molecular Biology
Shizhen Qin, Rui Wang, Jinlu Li, Defu Tang, Zhaoguo Shi
Summary: Heat stress threatens cardiac function in poultry, but manganese has a beneficial effect on heat-stress resistance in broilers. This study aimed to confirm the alleviation mechanism of manganese by proteomic analysis in primary broiler myocardial cells exposed to heat stress. The results showed that manganese pretreatment affected a variety of biological regulatory pathways and significantly influenced protein processing and repair, apoptosis, and DNA replication and repair. These findings contribute to a better understanding of the effects of manganese on heat-stress and the possible mechanisms to protect heart function in high temperature.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2023)
Article
Nutrition & Dietetics
Dana E. Lowry, Heather A. Paul, Raylene A. Reimer
Summary: The composition of breast milk in rats can be influenced by maternal consumption of a high-fat/sucrose diet and prebiotic supplementation, leading to changes in protein and miRNA levels. These components in milk may partially explain the impact of maternal diets on offspring body composition. Furthermore, the correlations between milk components, offspring body composition, and gut microbiota can vary by sex, indicating a complex interplay of factors.
BRITISH JOURNAL OF NUTRITION
(2022)
Article
Psychiatry
Hiba Zaidan, Dalia Galiani, Inna Gaisler-Salomon
Summary: Pre-reproductive stress alters behavior and gene expression in offspring, with post-stress drug treatment reversing some effects. Changes in Crhr1 and Crhr1-targeting microRNA were observed in stressed female rats and their offspring, while paternal F2 offspring showed different effects compared to maternal F2 offspring.
TRANSLATIONAL PSYCHIATRY
(2021)
Article
Biochemistry & Molecular Biology
Xi Lin, Brandon Pike, Jinan Zhao, Yu Fan, Yongwen Zhu, Yong Zhang, Feng Wang, Jack Odle
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Environmental Sciences
Tharushi Prabha Keerthisinghe, Feng Wang, Mengjing Wang, Qin Yang, Jiawei Li, Jingfeng Yang, Lin Xi, Wu Dong, Mingliang Fang
ENVIRONMENT INTERNATIONAL
(2020)
Article
Agriculture, Dairy & Animal Science
Y. L. Huang, Q. H. Luo, F. Xiao, X. Lin, J. W. Spears
Article
Multidisciplinary Sciences
Hao-Wei Chang, Nathan P. McNulty, Matthew C. Hibberd, David O'Donnell, Jiye Cheng, Vincent Lombard, Bernard Henrissat, Olga Ilkayeva, Michael J. Muehlbauer, Christopher B. Newgard, Michael J. Barratt, Xi Lin, Jack Odle, Jeffrey Gordon
Summary: The study found that microbiomes associated with diet restriction have specific features in amino acid metabolism, which affect ponderal growth and health. Experimental colonization of gnotobiotic mice further confirmed the impact of microbiomes on host energy metabolism and the selection of energy substrates.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Nutrition & Dietetics
Dan Wang, Pei Li, Jack Odle, Xi Lin, Jiangchao Zhao, Kan Xiao, Yulan Liu
Summary: Intestinal stem cells play a crucial role in maintaining intestinal epithelial homeostasis and disease development. Diet and nutrient-sensing pathways impact intestinal health by regulating the self-renewal and differentiation of intestinal stem cells.
NUTRITION RESEARCH REVIEWS
(2022)
Article
Agriculture, Dairy & Animal Science
Yanqiang Geng, Xiaoming Sun, Lin Lu, Xi Lin, Xiudong Liao, Liyang Zhang, Runlian Wang, Xugang Luo
Summary: This study aimed to investigate the effects of in ovo manganese injection on embryonic development, antioxidant capacity, and performance of offspring broilers. The results showed that in ovo manganese injection can enhance the antioxidant capacity in the chick embryonic heart, but high temperature can negatively affect the growth performance of the offspring broilers.
Article
Agriculture, Dairy & Animal Science
Timothy E. Boston, Feng Wang, Xi Lin, Suzanne Leonard, Sung Woo Kim, Denny McKilligan, Vivek Fellner, Jack Odle
Summary: The study examined the effects of supplementing piglets with a gruel feed before weaning. The results showed that piglets fed gruel had higher feed intake and body weight, and these effects were sustained after weaning. Additionally, the gruel feed had an impact on the intestinal health of the piglets.
Article
Biology
Shizhen Qin, Liang Huang, Lin Lu, Liyang Zhang, Yanli Guo, Lin Xi, Xiudong Liao, Xugang Luo
Summary: Manganese is a necessary trace element that can alleviate the negative effects of heat stress on the heart of broiler breeders and embryos, but the mechanisms behind this protection are still unclear. Two experiments were conducted to investigate the protective effects of manganese on primary cultured chick embryonic myocardial cells exposed to heat challenge. The results showed that supplementation of manganese could enhance the expression of manganese superoxide dismutase and attenuate heat shock response, protecting the myocardial cells from heat-induced damage.
JOURNAL OF THERMAL BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Brandon Pike, Jinan Zhao, Julie A. Hicks, Feng Wang, Rachel Hagen, Hsiao-Ching Liu, Jack Odle, Xi Lin
Summary: This study investigated the effects of peroxisome proliferator-activated receptor alpha (PPARα) on carnitine status and intestinal fatty acid oxidation in neonates. Suckled newborn piglets were fed different diets with or without clofibrate, succinate+glycerol, tri-valerate, tri-hexanoate, or tri-2-methylpentanoate. Clofibrate increased carnitine concentrations in the liver and plasma, but had no effect in the intestine. TC5 and TMPA stimulated fatty acid oxidation, while TC6 had no effect. These results suggest that clofibrate improves carnitine status and increases fatty acid oxidation in neonates.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Feng Wang, Chaolai Man, Xiaoqiu Wang, Jack Odle, Christian Maltecca, Xi Lin
Summary: Maternal undernutrition during pregnancy can lead to severe fetal impairments, but the exact mechanisms are not fully understood. This study investigated the potential impacts of restricted nutrition on metabolic pathways in fetal pigs. The results revealed differential expression of mRNA and miRNA, as well as alterations in metabolic and signaling pathways. These findings provide valuable insights into the negative effects of maternal malnutrition on hepatic metabolism in full-term fetal pigs via miRNA-mRNA interactions.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2023)
Meeting Abstract
Agriculture, Dairy & Animal Science
Timothy E. Boston, Feng Wang, Lin Xi, Sung Woo Kim, Vivek Fellner, Mark F. Scott, Amanda L. Ziegler, Laurianne Van Landeghem, Anthony T. Blikslager, Jack Odle
JOURNAL OF ANIMAL SCIENCE
(2023)
Article
Agriculture, Dairy & Animal Science
Jeongeun Lee, Shah Ahmed Belal, Xi Lin, Jinryong Park, Kwanseob Shim
Summary: The efficacy of incorporating insect peptide CopA3 to stabilize cell proliferation and heat shock protein expression was assessed in this study. The results showed that CopA3 treatment mitigated the deleterious impact of heat stress on cell viability and reduced cell apoptosis. It also maintained stable expression of Bcl-2-associated X (BAX), HSP70, and HSP40.
Article
Agriculture, Dairy & Animal Science
Jinan Zhao, Brandon Pike, Jin Huang, Zhihua Feng, Jack Odle, Xi Lin
Summary: Supporting the anaplerotic and ketogenic fatty acids (FA) could potentially impact FA oxidation and modify the metabolism of acetyl-CoA via alteration of tricarboxylic acid (TCA) cycle activity. However, it has no significant effect on the hepatic FA oxidative capacity induced by peroxisome proliferator-activated receptor-alpha (PPARa). The availability of carnitine is crucial for maintaining FA oxidation during the neonatal period.
Meeting Abstract
Agriculture, Dairy & Animal Science
Lin Xi, Feng Wang, Daisy Cagle, Yue Zhu, Jack Odle, Deyu Xie
JOURNAL OF ANIMAL SCIENCE
(2023)
Article
Agriculture, Dairy & Animal Science
Tingting Li, Wengang He, Xiudong Liao, Xi Lin, Liyang Zhang, Lin Lu, Yanli Guo, Zongping Liu, Xugang Luo
Summary: The study found that zinc can alleviate heat stress on broiler hepatocytes by enhancing their antioxidant ability and attenuating heat shock responses.
Article
Biology
Aref Maddahi, Adel Saberivand, Hossein Hamali, Farnoosh Jafarpour, Maryam Saberivand
Summary: Heat stress affects the fertility of dairy cattle, but supplementing vitamins E and coenzyme Q10 can alleviate its adverse effects on oocyte maturation and embryo development. Vitamin E was found to be more effective than vitamin C and coenzyme Q10 in improving maturation and cleavage rates, as well as increasing the count of blastocyst cells.
JOURNAL OF THERMAL BIOLOGY
(2024)
