Article
Engineering, Environmental
Ruixue Li, Yang Sun, Zhengwei Cai, Yang Li, Jian Sun, Wei Bi, Fei Yang, Qianrong Zhou, Tingjun Ye, Youcheng Yu
Summary: A novel peptide hydrogel (HA-c-CGRP) was constructed in this study, which sustained release highly bioactive CGRP and promoted BMSCs proliferation and osteoblast differentiation. The cocrosslinking HA-c-CGRP hydrogel accelerated new bone formation process with the highly bioactive peptide, showing promising prospect for healing defected bone tissue.
CHEMICAL ENGINEERING JOURNAL
(2021)
Review
Engineering, Biomedical
Quanjing Mei, Jingdong Rao, Ho Pan Bei, Yaxiong Liu, Xin Zhao
Summary: Three-dimensional (3D) bioprinting is a promising strategy for bone manufacturing, with control over geometry and microarchitectures of the scaffolds. Photo-crosslinkable hydrogel is a promising material in tissue engineering, with biocompatibility, easy fabrication, and controllable properties for bone and cartilage scaffolds. This review discusses the applications of 3D bioprinted photo-crosslinkable hydrogel scaffolds for bone and cartilage engineering and future perspectives in the field.
INTERNATIONAL JOURNAL OF BIOPRINTING
(2021)
Article
Engineering, Biomedical
Sarah A. Schoonraad, Alan A. Jaimes, Arjun J. X. Singh, Kiera J. Croland, Stephanie J. Bryant
Summary: This study investigates the osteogenic effects of tethered BMP-2 and BMP-9 on human MSCs encapsulated in a hydrogel. The results show that tethered BMP-2 and BMP-9 both effectively enhance osteogenesis of MSCs, leading to a mature osteoblast phenotype.
ACTA BIOMATERIALIA
(2023)
Article
Cell & Tissue Engineering
Wai Long Tam, Luis Freitas Mendes, Xike Chen, Raphaelle Lesage, Inge Van Hoven, Elke Leysen, Greet Kerckhofs, Kathleen Bosmans, Yoke Chin Chai, Akihiro Yamashita, Noriyuki Tsumaki, Liesbet Geris, Scott J. Roberts, Frank P. Luyten
Summary: This study investigated the potential of human pluripotent stem cells to form cartilage and bone tissues in vitro and in vivo. The induced pluripotent stem cells were differentiated into chondrocytes and self-assembled into cartilaginous organoids, which showed promising results in bone defect models. The findings highlight the use of induced pluripotent stem cell technology for creating functional cartilage tissue intermediates in bone healing strategies.
STEM CELL RESEARCH & THERAPY
(2021)
Review
Biochemistry & Molecular Biology
Favour Felix-Ilemhenbhio, George A. E. Pickering, Endre Kiss-Toth, Jeremy Mark Wilkinson
Summary: Heterotopic ossification refers to the formation of bone in tissues where it is not normally present. The disease can be caused by rare genetic forms or as a response to trauma. Research has identified various cell types and biological pathways involved in the pathogenesis of HO. Recent advances in molecular therapies have shown promise in treating and preventing this condition.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Engineering, Multidisciplinary
Fan Yu, Atta Ur Rehman Khan, Yaqiang Li, Binan Zhao, Xianrui Xie, Mohamed EL-Newehy, Hany EL-Hamshary, Yosry Morsi, Jun Li, Jianfeng Pan, Xiumei Mo
Summary: In this study, a multifunctional nanofiber reinforced photo-crosslinking hydrogel wound dressing based on natural biomaterials was developed. The wound dressing mimics the structure and components of the native extracellular matrix (ECM). It exhibited excellent antibacterial effect, antioxidant property, and printability through 3D printing. Furthermore, it promoted angiogenesis, re-epithelialization, and wound healing when applied to full-thickness skin defects.
COMPOSITES PART B-ENGINEERING
(2022)
Article
Biochemistry & Molecular Biology
Seunghun S. Lee, Matthias Santschi, Stephen J. Ferguson
Summary: Bone regeneration is a complex physiological process regulated by factors such as bone-mimicking extracellular matrix and osteogenic growth factors like BMP-2. The development of a biomimetic hybrid scaffold with sustained release of BMP-2 showed enhanced bone formation in this study. Analysis of the scaffold's characteristics revealed improved cell proliferation rate and apatite formation, as well as sustained BMP-2 release, leading to enhanced osteogenic differentiation.
Article
Engineering, Biomedical
Oju Jeon, Tae-Hee Kim, Eben Alsberg
Summary: This study developed a hydrogel system with reversible dynamic mechanics, demonstrating the tunability of mechanical signals on encapsulated stem cells and providing a promising platform to investigate the effect of dynamic mechanical changes on cell behaviors.
ACTA BIOMATERIALIA
(2021)
Article
Engineering, Biomedical
Se-Hwan Lee, Kang-Gon Lee, Jaeyeon Lee, Yong Sang Cho, Min-Soo Ghim, Soojin Kim, Su-Jin Heo, Yongdoo Park, Young-Sam Cho, Bu-Kyu Lee
Summary: An effective bone graft with both osteoconductivity and osteoinductivity is required for clinical therapy. In this study, a 3D-printed PCL kagome-structure scaffold containing HA-based hydrogel was fabricated and evaluated for its retention capacity. The osteoinductivity of the scaffold was further reinforced by incorporating BMP-2 in the HA hydrogel. The results showed that the scaffold exhibited favorable bone regeneration characteristics.
BIO-DESIGN AND MANUFACTURING
(2023)
Review
Cell Biology
Xianchun Ruan, Zhaowei Zhang, Munire Aili, Xiang Luo, Qiang Wei, Demao Zhang, Mingru Bai
Summary: Mineralized tissues, such as teeth and bones, are difficult to repair due to their hardness, low permeability, and limited blood flow. Bone morphogenetic proteins (BMPs) play a crucial role in mineralized tissue formation and repair. Activin receptor-like kinase 3 (ALK3), a key transmembrane receptor, is important for transmitting BMP signals and influencing cellular responses. Recent research has shown that ALK3 is involved in the regulation of mineralized tissues and affects tooth and bone development.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Pallavi Srivastava, Sara Romanazzo, Chantal Kopecky, Stephanie Nemec, Jake Ireland, Thomas G. Molley, Kang Lin, Pavithra B. Jayathilaka, Elvis Pandzic, Avani Yeola, Vashe Chandrakanthan, John Pimanda, Kristopher Kilian
Summary: This article describes a method to initiate gastrulation using hydrogel islands to constrain pluripotent stem cells, mimicking the early stages of in vivo embryonic development. The authors show that within hours of seeding, the cells display a contractile phenotype, leading to enhanced proliferation and differentiation. Molecular analysis reveals a role for mechanotransduction-coupled WNT signaling in orchestrating differentiation. After two days, multilayered aggregates are formed, which can be removed for further growth and differentiation.
Article
Multidisciplinary Sciences
Gusty R. T. Ryanto, Koji Ikeda, Kazuya Miyagawa, Ly Tu, Christophe Guignabert, Marc Humbert, Tomoyuki Fujiyama, Masashi Yanagisawa, Ken-ichi Hirata, Noriaki Emoto
Summary: The dysregulation of the activin A-bone morphogenetic protein receptor type 2 link in endothelium plays a critical role in the progression of pulmonary arterial hypertension. Inhibin-beta -A/activin-A in endothelial cells could be a potential pharmacotherapeutic target for the treatment of pulmonary arterial hypertension.
NATURE COMMUNICATIONS
(2021)
Article
Engineering, Biomedical
Xu Xue, Yan Hu, Sicheng Wang, Xiao Chen, Yingying Jiang, Jiacan Su
Summary: Bone tissue engineering provides promising tools for the treatment of bone-related diseases using biomimetic hydrogels. This article discusses the fabrication of biomimetic hydrogels using thermal sensitive polymers, mineral ions, chemically triggered agents, photo crosslinking initiators, and enzyme triggers. These hydrogels accelerate bone regeneration and the article also highlights key factors influencing therapeutic effects.
BIOACTIVE MATERIALS
(2022)
Article
Nanoscience & Nanotechnology
Feng Li, Jian Li, Xujun Song, Tong Sun, Lian Mi, Jian Liu, Xiaomin Xia, Na Bai, Xue Li
Summary: This study developed and evaluated an appropriate GA-nCeO2 hydrogel scaffold for bone tissue engineering. The results showed that the scaffold had a favorable structure, biocompatibility, and strong osteogenic potential. This research provides a potential new material for the treatment of bone defects.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Article
Multidisciplinary Sciences
Jian Zhang, Yongjun Zheng, Jimmy Lee, Jieyu Hua, Shilong Li, Ananth Panchamukhi, Jiping Yue, Xuewen Gou, Zhaofan Xia, Linyong Zhu, Xiaoyang Wu
Summary: Effective healing of skin wounds is crucial for survival, but scar formation is a complex process. Inhibiting TGF beta signaling can reduce scar formation, yet systemic inhibition of TGF beta may have significant side effects.
NATURE COMMUNICATIONS
(2021)
Article
Engineering, Chemical
Xu Yang, Jieshi Xiao, Jian Huang, Kaixiang Peng
Summary: This study introduces an online convolutional adversarial autoencoder (AAE) model to learn representative industrial process information. By extracting features that reflect diverse information and follow a Gaussian distribution, the model improves the accuracy of fault detection and removes redundant information through a feature selection strategy.
JOURNAL OF THE TAIWAN INSTITUTE OF CHEMICAL ENGINEERS
(2024)
Article
Engineering, Chemical
Shao-Yang Wu, Meng-Tsun Lai, Chung-Hui Hsu, Kevin C. W. Wu, Yesong Gu
Summary: This study investigated the effectiveness of using Fe-based MOF or MIL-100(Fe) in conjunction with a PEDOT-modified Pt electrode for detecting the synthetic azo dye tartrazine. By modifying the electrode with two different methods, favorable lower reductive potentials, competitive sensitivities, and good repeatability and stability were achieved in all MIL-100(Fe)/PEDOT/Pt electrodes.
JOURNAL OF THE TAIWAN INSTITUTE OF CHEMICAL ENGINEERS
(2024)
