期刊
JOURNAL OF RARE EARTHS
卷 37, 期 9, 页码 943-948出版社
ELSEVIER
DOI: 10.1016/j.jre.2019.03.018
关键词
NaYF4:Yb,Tm; CA-125 molecules; Silver NPs; Energy transfer; Good stability; High sensitivity and selectivity
资金
- National Key Research and Development Program [2016YFC0207101]
- National Natural Science Foundation of China [61775080, 81602659, 11704056]
- Natural Science Foundation of Jilin Province, China [20170101170JC]
Sensitive and specific bioassays of tumor markers are critical for early cancer detection and treatment. In recent years, lanthanide (Ln(3+)) doped upconversion nanoparticles (UCNPs) have attracted wide attentions in tumor markers detection. Herein, we combined NaYF4:Yb,Tm and silver nanoparticles, serving as energy donor and receptor, respectively, to form an up-conversion fluorescence based inhibitory tumor marker biosensor system. The tumor marker CA-125 molecules are labeled with silver NPs, and the energy transfer fluorescent signal can be detected between the UCNPs and the silver NP receptors. The biosensor shows good stability, high sensitivity and selectivity in the tumor marker concentration range from 5 to 100 ng/mL, as well as a detection limit of 120 pg/mL. Due to the advantage of ease of fabrication and operation, low cost and high information capacity, this technology holds great potential for the clinical applications. (C) 2019 Chinese Society of Rare Earths. Published by Elsevier B.V. All rights reserved.
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