Article
Chemistry, Analytical
Puneet Jain, Takuya Aida, Masahiro Motosuke
Summary: Fluorescence anisotropy is utilized as a temperature sensor to measure temperature fields in microfluidics in this study. The relationship between molecule size and viscosity is crucial in obtaining a large temperature coefficient in anisotropy. Additionally, the potential of temperature imaging is confirmed through the measurement of temperature distribution under focused laser heating.
Article
Spectroscopy
Zhipeng Li, Saiqing Li, Hanxiao Lv, Jianliang Shen, Xiaojun He, Bo Peng
Summary: In this study, a new fluorescent probe was developed for monitoring O-2(center dot) with excellent selectivity and high brightness. Successful detection of endogenous O-2(center dot) changes in living cells was achieved through fluorescence imaging. The probe has potential applications in the diagnosis and study of related diseases.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Article
Chemistry, Multidisciplinary
Xuanying Chen, Shideng Yuan, Mengyuan Qiao, Xin Jin, Jiacheng Chen, Lifang Guo, Jianhua Su, Da-Hui Qu, Zhiyun Zhang
Summary: In this study, a series of fluorophore-substituted surfactants were developed by functionalizing different alkyl-trimethylammonium bromides with a viscosity sensor. The immersion depth of the sensor units in micelles depends on the alkyl chain lengths, and the distribution of viscosity inside the micelles was quantified. This research provides a tailored approach to explore the microviscosity of micellar interiors.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Multidisciplinary
Kyong T. Fam, Lazare Saladin, Andrey S. Klymchenko, Mayeul Collot
Summary: Probing cell surface receptors using fluorogenic dyes can help monitor their expression levels, with biotin receptors (BRs) being of particular interest due to their overexpression in cancer cells. In this study, two fluorogenic systems based on BODIPYs were adapted and compared, with the fluorogenic dimer proving more efficient than the rotor in imaging BRs in cancer cells and effectively discriminating them from non-cancer cells.
CHEMICAL COMMUNICATIONS
(2021)
Article
Chemistry, Medicinal
Yong-Feng Wei, Xuan Wang, Wen-Jing Shi, Ru Chen, Liyao Zheng, Zi-Zhou Wang, Kun Chen, Liqian Gao
Summary: Hydrogen peroxide plays vital roles in living organisms, and there is a need to develop better probes for its detection. A novel fluorescent probe has been designed with high selectivity and sensitivity, suitable for detecting the presence of H2O2 in aqueous solutions and living cells.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Nanoscience & Nanotechnology
Baoxing Shen, Chenggong Ma, Yuan Ji, Jianan Dai, Bingzhi Li, Xing Zhang, He Huang
Summary: A red emission fluorescent probe CBZ-BOD@ZIF-8 was fabricated based on metal-organic frameworks for detecting CES1, exhibiting ultra-sensitive quantification detection and good biocompatibility. Molecular docking study revealed that CES1 can bind with the probe before and after hydrolysis.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Medicinal
Tianxin Xie, Yuying Li, Chuan Tian, Chang Yuan, Bin Dai, Shubo Wang, Kaixiang Zhou, Jiaqi Liu, Hongwei Tan, Yi Liang, Jiapei Dai, Baian Chen, Mengchao Cui
Summary: This study developed a novel probe TNIR7-1A that can selectively detect NFTs and clearly distinguish tauopathy from the control group in vivo.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Ying-Jie Tang, Shan He, Xiao-Feng Guo, Hong Wang
Summary: The endoplasmic reticulum (ER) is a critical organelle in cells involved in protein synthesis, folding, and transport, with redox balance being essential for its normal function. A newly designed fluorescent probe N-Se showed selective and rapid response to ClO- with reversible detection capability, allowing real-time monitoring of redox status in the ER through changes in fluorescence intensity.
Article
Chemistry, Physical
Rua B. Alnoman, Shazia Parveen, Arif Khan, Julian G. Knight, Mohamad Hagar
Summary: This study introduces quinoline-based BODIPYs as potential inhibitors of EGFR/VEGFR-2 with promising physicochemical properties for oral bioavailability. Molecular docking analysis showed a stronger binding affinity of the compounds to VEGFR-2 compared to EGFR, and in vitro experiments demonstrated significant inhibitory effects of compounds 1 and 3 on HeLa cells.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Chemistry, Organic
Mingguang Zhu, Guoyang Zhang, Ziwei Hu, Chaofeng Zhu, Yixiang Chen, Tony D. James, Lijun Ma, Zhuo Wang
Summary: Alzheimer's disease (AD) is a neurodegenerative disease, and detecting amyloid-beta (Aβ) plaques can improve diagnosis and therapy. A new Aβ recognition unit, BocBDP, was developed using the [4-(Boc-amino) benzene] unit. BocBDP can recognize and image Aβ plaques both in vitro and in vivo through hydrogen bonding with amino acid residues Lys16 (K16), Val18 (V18), and Glu22 (E22). BocBDP has a strong binding affinity to Aβ and can cross the blood-brain barrier for at least 2 hours.
ORGANIC CHEMISTRY FRONTIERS
(2023)
Article
Chemistry, Analytical
Xiao Fang, Siqi Wang, Qingqing Wang, Jun Gong, Li Li, Helin Lu, Ping Xue, Zhanhong Ren, Xiaobo Wang
Summary: In this study, a new fluorescent probe, BA-Cyclen-Cu, was designed and synthesized for sensitive and rapid detection of aqueous hydrogen sulfide (H2S). The probe exhibited good membrane permeability, low toxicity, and lysosome-targeting ability in living cells. The results demonstrated the potential applications of the probe in detecting both exogenous and endogenous H2S in various cell types and serum samples.
Article
Chemistry, Analytical
Xiang-Yu Wang, You-Mei Lin, Xiao-Yan Sun, Ya-Qian Wu, Hui Miao, Jun Chu, Tian-Wen Bai, Ying-Long Fu
Summary: In this study, a fluorescent probe BML was synthesized for the detection of nitric oxide (NO) in lysosomes. The BML probe showed fast detection time, low detection limit, and resistance to interference and acidity, making it suitable for NO detection in lysosomes. The probe was successfully used to detect endogenous and exogenous NO in living cells and zebrafish.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Engineering, Environmental
Bo Situ, Bairong He, Xu Chen, Xiaojing He, Weiwei Feng, Xinyi Ye, Yifang Huang, Xiaolei Xue, Shan Liu, Qiong Xia, Jianjun Zou, Ben Zhong Tang, Lei Zheng
Summary: MASPB is a density-responsive bioprobe for fluorescent sensing of cell nucleus density, capable of distinguishing between tumor cells and normal cells based on nuclear condensation and cellular distribution, providing a rapid tool for nucleus density mapping with potential applications in cancer diagnosis.
CHEMICAL ENGINEERING JOURNAL
(2021)
Article
Spectroscopy
Galina B. Guseva, Elena Antina, Mikhail B. Berezin, Alexander A. Ksenofontov, Pavel S. Bocharov, Anastassia S. Smirnova, Roman S. Pavelyev, Ilmir R. Gilfanov, Svetlana Pestova, Evgeny S. Izmest'ev, Svetlana A. Rubtsova, Airat R. Kayumov, Sergei Kiselev, Zulfiya R. Azizova, Olga Ostolopovskaya, Sergey Efimov, Vladimir V. Klochkov, Ilya A. Khodov, Liliya E. Nikitina
Summary: This study designed a fluorescent probe based on a thioterpene fragment of meso-carboxysubstituted-BODIPY, increasing its affinity to platelet receptor PY12. The probe showed high fluorescence quantum yield and is significant for studying the mechanisms of thioterpenoids and their contributions to platelets and anticoagulation.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Article
Chemistry, Multidisciplinary
Yuan Mei, Ziyun Li, Kuanrong Rong, Zijuan Hai, Wenjian Tang, Qin-Hua Song
Summary: A dual functional BODIPY fluorescent probe has been developed for simultaneous detection of H2O2 and viscosity. Bioimaging results show that H2O2 accumulates and cytoplasmic viscosity increases during PA-induced pyroptosis.
CHEMICAL COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Ashleigh D. Smith McWilliams, Selin Ergillen, Meredith M. Ogle, Carlos A. de los Reyes, Matteo Pasquali, Angel A. Marti
PURE AND APPLIED CHEMISTRY
(2020)
Article
Chemistry, Physical
Ashleigh D. Smith McWilliams, Zhao Tang, Selin Ergulen, Carlos A. de los Reyes, Angel A. Marti, Matteo Pasquali
JOURNAL OF PHYSICAL CHEMISTRY B
(2020)
Article
Chemistry, Inorganic & Nuclear
Erick Flores, Michelle Munoz-Osses, Claudia Torrent, Yesseny Vasquez-Martinez, Alejandra Gomez, Marcelo Cortez-San Martin, Andres Vega, Angel A. Marti, Fernando Godoy, Carolina Mascayano
Review
Chemistry, Inorganic & Nuclear
Bo Jiang, Angel A. Marti
Summary: Metal complexes in photoluminescence spectroscopy have been utilized for the detection of amyloid aggregates, exhibiting specific responses in the presence of these aggregates such as intensity changes, emission wavelength shifts, variations in lifetime, and anisotropy changes.
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
(2021)
Article
Chemistry, Applied
Fabiana Liendo, Amaya Paz de la Vega, Maria Jesus Aguirre, Fernando Godoy, Angel A. Marti, Erick Flores, Jaime Pizarro, Rodrigo Segura
Summary: A glassy carbon modified electrode with electroreduced graphene oxide was developed for the determination of Antimony (III) in commercial lettuce, celery, and beverages. The electrode surface was heterogeneous and rough, with a real area larger than a regular glassy carbon electrode. By using optimal chemical and electrochemical parameters, satisfactory results in terms of accuracy and reproducibility were obtained.
Article
Chemistry, Inorganic & Nuclear
Marcia V. S. Lima, Rafael C. Marchi, Carolina R. Cardoso, Nathan P. Cook, Wallance M. Pazin, Flavio V. C. Kock, Tiago Venancio, Angel A. Marti, Rose M. Carlos
Summary: This study reports the synthesis and characterization of a photoluminescent and water-soluble complex Ru2Apy, and investigates its spectroscopic and physicochemical properties as well as its interactions with biomolecules. The complex shows promising potential for biological applications, particularly in assessing the formation of aggregates in real time.
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
(2022)
Review
Biochemistry & Molecular Biology
Meredith M. Ogle, Rolando Trevino, Joseph Schell, Mahboubeh Varmazyad, Nobuo Horikoshi, David Gius
Summary: The dysregulation of cellular and mitochondrial antioxidants can lead to oxidative damage and tumor development. Disruption of mitochondrial networks is a characteristic of cancer and therapy resistance. Loss or disruption of manganese superoxide dismutase may be an early event or a promoter of tumor development.
Article
Multidisciplinary Sciences
Cedric J. Simonsen Ginestra, Cecilia Martinez-Jimenez, Asia Matatyaho Ya'akobi, Oliver S. Dewey, Ashleigh D. Smith McWilliams, Robert J. Headrick, Jesus A. Acapulco, Lyndsey R. Scammell, Michael W. Smith, Dmitry Kosynkin, Daniel M. Marincel, Cheol Park, Sang-Hyon Chu, Yeshayahu Talmon, Angel A. Marti, Matteo Pasquali
Summary: This study demonstrates the formation of BNNT liquid crystals in chlorosulfonic acid (CSA) that can be used to produce macroscopically aligned fibers of BNNTs, with potential high-performance applications.
NATURE COMMUNICATIONS
(2022)
Article
Chemistry, Analytical
Freddy Navarro, Rodrigo Segura, Fernando Godoy, Angel A. Marti, Carolina Mascayano, Maria J. Aguirre, Erick Flores, Jaime Pizarro
Summary: The interactions between zopiclone and electrochemically reduced graphene oxide (rGO) modified electrode were investigated. The results showed that the modified surface had lower conductivity compared to the glassy carbon electrode. The role of rGO was to provide specific adsorption sites for the analyte. The analytical methodology demonstrated good linearity and low detection limit under alkaline conditions.
Review
Materials Science, Multidisciplinary
Ashleigh D. Smith McWilliams, Cecilia Martinez-Jimenez, Kevin R. Shumard, Matteo Pasquali, Angel A. Marti
Summary: This review summarizes the work on dispersing boron nitride nanotubes (BNNTs) in various solvents, highlighting different dispersion methods and related topics. The properties of the dispersions and materials made are discussed, culminating with an outlook on future directions and challenges in the field.
JOURNAL OF MATERIALS RESEARCH
(2022)
Article
Materials Science, Multidisciplinary
Michael B. Jakubinek, Keun Su Kim, Myung Jong Kim, Angel A. Marti, Matteo Pasquali
Summary: Boron nitride nanotubes (BNNTs) have similar mechanical properties to carbon nanotubes (CNTs), but possess unique chemistry and multifunctional properties. Advances in synthesis have made BNNTs more accessible for research, and the field is expected to see rapid growth and applications in various fields. The development of manufacturing processes for pure BNNT materials remains a key challenge, but holds great potential for the future.
JOURNAL OF MATERIALS RESEARCH
(2022)
Article
Chemistry, Organic
Alexis van Venrooy, Aaron M. Wyderka, Victor Garcia-Lopez, Lawrence B. Alemany, Angel A. Marti, James M. Tour
Summary: Understanding the rotary cycle of molecular motors is crucial for advancing cell opening research. In-situ analysis of illuminated light-active molecular motors using nuclear magnetic resonance spectroscopy revealed that the presence of N,N-dimethylethylenediamine at a conjugated position to the central olefin affects the rotation and decreases the photostability of a second-generation Feringa-type molecular motor. Various techniques like modulating light dose, dilution, and stirring were found to mitigate degradation, while the presence of moisture affects the motor's rotation rate.
JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Bo Jiang, Utana Umezaki, Andrea Augustine, Vindi M. Jayasinghe-Arachchige, Leonardo F. Serafim, Zhi Mei Sonia He, Kevin M. Wyss, Rajeev Prabhakar, Angel A. Marti
Summary: In this study, time-resolved spectroscopy was used to investigate the binding interactions between amyloid-beta fibrillar structures and photoluminescent ligands, revealing a novel binding site. Additionally, it was found that common polypyridine complexes can also bind to amyloid-beta at two distinct binding sites. These findings are crucial for understanding the toxicity of proteins and designing potential drugs to mitigate their deleterious effects.
Article
Chemistry, Multidisciplinary
Ram Manohar Yadav, Rajesh Kumar, Amir Aliyan, Pramod S. S. Dobal, Santoshkumar Biradar, Robert Vajtai, Dinesh Pratap Singh, Angel A. A. Marti, Pulickel M. M. Ajayan
NEW JOURNAL OF CHEMISTRY
(2020)
Review
Chemistry, Physical
Meredith M. Ogle, Ashleigh D. Smith McWilliams, Bo Jiang, Angel A. Marti