Article
Medicine, General & Internal
Keita Hasegawa, Satoru Ikenoue, Yuya Tanaka, Maki Oishi, Toyohide Endo, Yu Sato, Ryota Ishii, Yoshifumi Kasuga, Daigo Ochiai, Mamoru Tanaka
Summary: This study aimed to investigate the accuracy of the placenta accreta index (PAI) for predicting placenta accreta spectrum (PAS) in women with placenta previa. The results showed that a PAI > 2 was the most effective cut-off point for predicting PAS and was more sensitive than traditional evaluation methods. Women with PAS had higher incidences of previous cesarean delivery, severe placental lacunae, thin myometrial thickness, anterior placenta, and presence of bridging vessels compared to those without PAS. PAI could be used to predict outcomes in women with placenta previa and reduce perinatal complications caused by PAS.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Obstetrics & Gynecology
Albaro Jose Nieto-Calvache, Maria Camila Lopez-Giron, Adriana Messa-Bryon, M. Lili Ceballos-Posada, Manuel Duque-Galan, Juan Gabriel De Rios-Posada, Luis Alberto Plazas-Cordoba, Margarita Maria Chancy-Castano
Summary: Urinary tract injuries (UTI) are a common complication of morbidly adherent placenta (MAP) management. This study found that UTI occurred in 27.7% of patients, associated with increased blood loss, transfusion requirement, hospital stay, and need for additional surgeries. Rigid ureteral catheters and retrovesical dissection before hysterotomy were associated with lower incidence of ureteral injuries.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2021)
Article
Obstetrics & Gynecology
Mohamed Amr H. ElNoury, Sophia NE. Webster, Diaa A. Abdelhalim
Summary: The ElNoury-Webster Bundle is a stepwise surgical technique for the conservative management of morbidly low or adherent placenta particularly in low and middle-income healthcare settings. The technique was piloted on 16 patients with positive outcomes, showing a reduced risk for cesarean hysterectomy and postpartum hemorrhage. No patients in the series required hysterectomy, return to theater after initial surgery, or experienced secondary postpartum hemorrhage.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Article
Acoustics
Sarah K. Happe, Casey S. Yule, Catherine Y. Spong, C. Edward Wells, Jodi S. Dashe, Elysia Moschos, Martha W. F. Rac, Donald D. McIntire, Diane M. Twickler
Summary: The study validated the PAI for predicting PAS in pregnancies with previous CD, demonstrating high sensitivity and specificity. Contemporaneous application of the PAI is useful in prenatal prediction of PAS.
JOURNAL OF ULTRASOUND IN MEDICINE
(2021)
Article
Obstetrics & Gynecology
Amarnath Bhide
Summary: Screening for clinically significant placenta accreta spectrum (PAS) can accurately identify the condition with high sensitivity and specificity (>90-95%). The focus should be on women with placenta previa and previous Cesarean deliveries, as screening for PAS without placenta previa is less productive and may result in false negatives. Screening results can indicate a low or high probability of PAS, and women who test positive or have uncertain ultrasound features should be referred to specialized centers. Those confirmed with a high probability of PAS should plan for delivery at such centers.
BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY
(2023)
Article
Obstetrics & Gynecology
Ahmed Abd-Elmoneim Abo-Elroose, Magdy Refaat Ahmed, Mohamed Mokhtar Shaaban, Hanan Mohamed Ghoneim, Tamer Yahia Mohamed
Summary: The Triple-P procedure is an effective conservative treatment for women with morbidly adherent placenta (MAP), particularly in young patients with low parity. The procedure significantly reduces operative time and blood loss, with only a small number of cases requiring hysterectomy.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2021)
Article
Obstetrics & Gynecology
Florrie N. Y. Yu, K. Y. Leung
Summary: Antenatal diagnosis of placenta accreta spectrum (PAS) disorders allows for planned management, reducing hemorrhagic morbidity. Cesarean section and placenta previa are common risk factors, and ultrasound is a promising diagnostic tool for PAS, even in the first trimester.
BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Charis Bourgioti, Konstantina Zafeiropoulou, Chara Tzavara, George Daskalakis, Stavros Fotopoulos, Marianna Theodora, Maria Evangelia Nikolaidou, Marianna Konidari, Sofia Gourtsoyianni, Evangelia Panourgias, Vassilis Koutoulidis, Epameinondas Anastasios Martzoukos, Anastasia Evangelia Konstantinidou, Lia Angela Moulopoulos
Summary: This study compared the diagnostic capabilities of 1.5-T and 3.0-T MRI in placenta accreta spectrum (PAS) and found that both imaging techniques have equivalent effectiveness. MRI showed high sensitivity and specificity for PAS diagnosis and accurately predicted extrauterine placental spread.
DIAGNOSTIC AND INTERVENTIONAL IMAGING
(2022)
Article
Cell Biology
Jingmei Ma, Yawei Liu, Zhirong Guo, Run Sun, Xinrui Yang, Weiran Zheng, Yongdan Ma, Yin Rong, Hongmei Wang, Huixia Yang, Zhenyu Xiao
Summary: This study used single-cell RNA-sequencing analysis to investigate the pathological landscape of invasive placenta accreta spectrum disorders (PAS) placenta and revealed the interaction between invasive trophoblasts and maternal stromal cells during the invasion process. The study also presented the immune microenvironmental landscape of invasive PAS. These findings provide a foundation for future research on PAS.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Editorial Material
Obstetrics & Gynecology
Frederic Chantraine, Vedran Stefanovic, Thorsten Braun, Pavel Calda, Pasquale Martinelli, Sally L. Collins
Summary: Placenta accreta spectrum (PAS) is a rare but potentially lethal condition, and international collaboration can improve understanding and treatment of this disease, promote high-quality research, and enhance medical education for both healthcare professionals and patients.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2021)
Article
Endocrinology & Metabolism
Jose M. Murrieta-Coxca, Emanuel Barth, Paulina Fuentes-Zacarias, Ruby N. Gutierrez-Samudio, Tanja Groten, Alexandra Gellhaus, Angela Koeninger, Manja Marz, Udo R. Markert, Diana M. Morales-Prieto
Summary: Placenta accreta spectrum (PAS) is a group of pathological conditions characterized by abnormal attachment of the placenta to the uterus wall, and it is a major cause of maternal morbidity and mortality worldwide. In this study, altered miRNA expression, particularly in placenta-specific miRNA clusters, was identified in placenta accreta tissue compared to normal placental tissues. Dysregulated pathways associated with cell cycle regulation, inflammation, and invasion were also observed. The study provides miRNA:mRNA associations that could contribute to our understanding of PAS development.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Obstetrics & Gynecology
Flore-Anne Pain, Anthony Dohan, Gilles Grange, Louis Marcellin, Joelle Uzan-Augui, Francois Goffinet, Philippe Soyer, Vassilis Tsatsaris
Summary: The study aimed to assess the performance of ultrasound and MRI features in distinguishing different types of placenta accreta spectrum and developed a predictive score for predicting the risk of placenta percreta. The results showed that the predictive score had good accuracy in identifying placenta percreta.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2022)
Article
Obstetrics & Gynecology
Humaira Ali, Edwin Chandraharan
Summary: PAS disorders, including placenta accreta, increta, and percreta, are associated with serious maternal morbidity and mortality. Risk factors such as previous cesarean sections and uterine surgeries contribute to the increased incidence. Early diagnosis and planning of delivery are crucial for improving maternal and fetal outcomes.
BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY
(2021)
Article
Obstetrics & Gynecology
Vivek Madhusudan Joshi, Suhas Raghuvir Otiv, Yogesh Bhairav Sovani, Prasad Kisanrao Kulat
Summary: Temporary aortic clamping proved to be safe and effective in limiting blood loss during cesarean hysterectomy for placenta percreta in a retrospective case series of 15 women. The procedure significantly reduced transfusion requirements without any intra-operative or post-operative complications, showing favorable outcomes compared to other management strategies for placenta percreta.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2022)
Review
Obstetrics & Gynecology
J. M. Nielsen, P. Humaidan, M. B. Jensen, B. Alsbjerg
Summary: Bleeding before the eighth week of gestation is common in HRT-FET patients, but does not affect reproductive outcomes. Spontaneously conceived pregnancies have a 20% incidence of bleeding, most of which have normal outcomes.
HUMAN REPRODUCTION
(2023)
Article
Medical Laboratory Technology
Yoshihiko Araki, Yoshiki Miura, Hiroshi Fujiwara
Summary: This article discusses the use of peptide fragments as potential disease biomarkers for hypertensive disorders of pregnancy (HDP). It also provides an overview of the basic techniques of peptidomics, particularly quantitative proteomics, and outlines the current status and challenges of measuring peptides in blood as disease biomarkers for HDP.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2022)
Article
Obstetrics & Gynecology
Rena Yamazaki, Masanori Ono, Tomoharu Sugie, Masafumi Inokuchi, Satoko Ishikawa, Yuki Horage, Yasuyuki Kojima, Takeshi Iwasa, Tetsuaki Hara, Yumi Nagata, Keiichi Kato, Yasuhito Michikura, Takeshi Kuramoto, Soko Uchida, Akihito Horie, Hiroshi Fujiwara, Toshiya Matsuzaki
Summary: This study assessed the impact of breast cancer treatment on fertility and found that women under 35 had a higher chance of spontaneous pregnancy, with rates decreasing as age increased. Women who became pregnant after breast cancer treatment generally achieved conception within 1 to 3 years of trying for pregnancy. It is recommended that women 35 and older consider assisted reproductive technology promptly after breast cancer treatment.
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Junya Kojima, Masanori Ono, Naoaki Kuji, Hirotaka Nishi
Summary: The placenta is crucial for establishing pregnancy and fetal well-being in humans, allowing for maternal physiological adaptation and embryonic immunological acceptance. Placental tissue varies widely among species, making it challenging to directly apply findings from animal studies to human research. Artificial induction of early villous differentiation can potentially elucidate the causes of perinatal diseases and aid in the development of novel therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Masanori Ono, Natsumi Toyoda, Kyosuke Kagami, Takashi Hosono, Takeo Matsumoto, Shin-ichi Horike, Rena Yamazaki, Mitsuhiro Nakamura, Yasunari Mizumoto, Tomoko Fujiwara, Hitoshi Ando, Hiroshi Fujiwara, Takiko Daikoku
Summary: Recent research has shown that the expression of the uterine gene BMAL1 is reduced in the endometrium of women with recurrent spontaneous abortion. By studying mice, it was found that conditional deletion of the uterine clock gene Bmal1 resulted in mice being able to undergo embryo implantation but unable to sustain pregnancy. Gene ontology analysis revealed suppressed function of uterine NK cells in these mice. Histological examination also showed poor formation of maternal vascular spaces in the placenta. However, progesterone supplementation prolonged pregnancy in some mice and recruited specific NK cells in the spongiotrophoblast layer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Masanori Ono, Hitoshi Ando, Takiko Daikoku, Tomoko Fujiwara, Michihiro Mieda, Yasunari Mizumoto, Takashi Iizuka, Kyosuke Kagami, Takashi Hosono, Satoshi Nomura, Natsumi Toyoda, Naomi Sekizuka-Kagami, Yoshiko Maida, Naoaki Kuji, Hirotaka Nishi, Hiroshi Fujiwara
Summary: The circadian rhythm, controlled by clock genes, is crucial for reproduction. In the mouse uterus, the oscillation of circadian clock gene has been observed. CLOCK-BMAL1 heterodimer promotes the transcription of Per1/2 and Cry1/2 genes by binding to their promoters' E-box sequences. The endometrial clock plays an important role in pregnancy, and disruptions in the uterine clock can lead to complications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Tomoo Suzuki, Yidan Dai, Masanori Ono, Junya Kojima, Toru Sasaki, Hiroshi Fujiwara, Naoaki Kuji, Hirotaka Nishi
Summary: Uterine leiomyomas, the most common pelvic tumors in women of reproductive age, can cause various symptoms and reproductive issues. This study found that UCHL1 expression is significantly higher in leiomyomas than in the myometrium. Inhibition of UCHL1 resulted in downregulation of COL1A1 and COL3A1 expression and decreased migration and contractility of leiomyoma cells. Targeting UCHL1 activity may be a potential therapeutic strategy for uterine leiomyoma.
Article
Obstetrics & Gynecology
Hirotaka Nishi, Masanori Ono, Shinichiro Ohno, Zenta Yamanaka, Toru Sasaki, Kazuma Ohyashiki, Junko H. Ohyashiki, Masahiko Kuroda
Summary: This study found that expression of miR-100 is significantly upregulated in cervical cancer cell lines SiHa and HeLa under hypoxic conditions. It also discovered that miR-100 affects the sensitivity to paclitaxel by regulating the expression of USP15. In other words, the high expression of miR-100 under hypoxic conditions leads to the downregulation of USP15 and increased resistance to paclitaxel.
GYNECOLOGIC ONCOLOGY REPORTS
(2023)
Article
Oncology
Masanori Ono, Miyuki Harada, Akihito Horie, Yidan Dai, Itsuko Horiguchi, Eiji Kikuchi, Fuminori Kimura, Tomoe Koizumi, Mitsuru Komeya, Naoki Mizunuma, Kumiko Oseto, Kuniaki Ota, Chikako Shimizu, Kohei Sugimoto, Seido Takae, Emi Takeuchi, Hirotaka Nishi, Yasushi Yumura, Tatsuro Furui, Yasushi Takai, Ken-Ichirou Morishige, Chie Watanabe, Yutaka Osuga, Nao Suzuki
Summary: Our web-based training program aimed to improve healthcare professionals' knowledge and self-confidence regarding reproductive health issues in adolescent and young adult cancer patients and survivors. The study showed significant improvements in participants' knowledge and self-confidence, leading to changes in their behavior towards patients.
INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Multidisciplinary Sciences
Stanislav M. Cherepanov, Teruko Yuhi, Takashi Iizuka, Takashi Hosono, Masanori Ono, Hiroshi Fujiwara, Shigeru Yokoyama, Satoshi Shuto, Haruhiro Higashida
Summary: Uterine contraction is crucial for parturient processes and insufficient uterine tone can lead to postpartum hemorrhage, a major cause of maternity-related deaths globally. This study found that the synthetic oxytocin analogs HPOT and FBOT exhibited highly potent uterotonic effects in human uterus, surpassing the effects of OT and may have potential in preventing postpartum hemorrhage.
Article
Obstetrics & Gynecology
Junya Kojima, Yidan Dai, Tomoo Suzuki, Masanori Ono, Hirotaka Nishi
Summary: SIRT1 and INSL4 genes play an important role in placental development, and the dysfunction of placental development leads to fetal growth restriction. This study shows that the SIRT1-INSL4 axis may be a potential treatment for fetal growth restriction caused by insufficient placental development.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2023)
Review
Obstetrics & Gynecology
Masanori Ono, Naoaki Kuji, Keiko Ueno, Junya Kojima, Hirotaka Nishi
Summary: ART led to the birth of 60,381 infants in Japan in 2020, and this number is expected to rise. Couples using ART are interested in the long-term outcomes of their children, comparing those conceived naturally with those conceived through ART. This study collected data from various observational studies to investigate the relationship between ART and physical and psychomotor developments in children.
REPRODUCTIVE SCIENCES
(2023)
Article
Multidisciplinary Sciences
Takuma Suzuki, Takashi Iizuka, Kyosuke Kagami, Takeo Matsumoto, Rena Yamazaki, Takiko Daikoku, Akihito Horie, Masanori Ono, Akira Hattori, Hiroshi Fujiwara
Summary: Human extravillous trophoblast (EVT) interacts with monocytes through a specific cell surface enzyme to produce immune suppressive factors, creating an immunosuppressive environment in the uterus during pregnancy.