期刊
JOURNAL OF NEUROSCIENCE
卷 39, 期 45, 页码 8916-8928出版社
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.1436-19.2019
关键词
cortex; inferior colliculus; motor; prefrontal; somatosensory; visual
资金
- Biotechnology and Biological Sciences Research Council [BB/P003249/1]
- Biotechnology and Biological Sciences Research Council [BB/P003249/1] Funding Source: researchfish
- BBSRC [BB/P003249/1] Funding Source: UKRI
Our perceptual experience of sound depends on the integration of multiple sensory and cognitive domains, however the networks subserving this integration are unclear. Connections linking different cortical domains have been described, but we do not know the extent to which connections also exist between multiple cortical domains and subcortical structures. Retrograde tracing in adult male rats (Rattus norvegicus) revealed that the inferior colliculus, the auditory midbrain, receives dense descending projections not only, as previously established, from the auditory cortex, but also from the visual, somatosensory, motor, and prefrontal cortices. While all these descending connections are bilateral, those from sensory areas show a more pronounced ipsilateral dominance than those from motor and prefrontal cortices. Injections of anterograde tracers into the cortical areas identified by retrograde tracing confirmed those findings and revealed cortical fibers terminating in all three subdivisions of the inferior colliculus. Immunolabeling showed that cortical terminals target both GABAergic inhibitory, and putative glutamatergic excitatory neurons. These findings demonstrate that auditory perception and behavior are served by a network that includes extensive descending connections to the midbrain from sensory, behavioral, and executive cortices.
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