期刊
JOURNAL OF NATURAL PRODUCTS
卷 82, 期 10, 页码 2907-2915出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jnatprod.9b00749
关键词
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资金
- Ministry of Education, Culture, Sports, Science and Technology, Japan [15K01803, 18K05337, 18K14346, 16H03285]
- Grants-in-Aid for Scientific Research [18K05337, 16H03285, 18K14346, 15K01803] Funding Source: KAKEN
The bioassay-guided fractionation of an Okeania sp. marine cyanobacterium collected in Okinawa led to the isolation of the lipopeptide mabuniamide (1). The gross structure of 1 was determined by spectroscopic analyses, and its absolute configuration was determined using Marfey's analysis of the acid hydrolysate of 1. The absolute configuration of 1 was confirmed by total synthesis. Mabuniamide (1) stimulated glucose uptake in cultured rat L6 myotubes. In addition, mabuniamide (1) and its stereoisomer (2) exhibited moderate antimalarial activity.
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