Article
Environmental Sciences
Yueqi Hao, Fubo Yu, Xiangang Hu
Summary: Soil microbial assemblages play a crucial role in biogeochemical cycling, and predicting ecological safety concerns requires consideration of multiple factors. The FEML approach can visualize the relationships among factors and predict changes in bacterial and fungal hotspots in the future. The imbalance between bacteria and fungi in soil ecosystems is significant, and mitigating climate change is essential to address this imbalance.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Medicine, Research & Experimental
Zhongke Wang, Ruxin Xie, Xiaolin Yang, Huachun Yin, Xin Li, Tianyao Liu, Yuanyuan Ma, Junwei Gao, Zhenle Zang, Ruotong Ruan, Yang Li, Kaixuan Huang, Qingbo Chen, Kaifeng Shen, Shengqing Lv, Chunqing Zhang, Hui Yang, Maragret Warner, Jan-Ake Gustafsson, Shiyong Liu, Xiaotang Fan
Summary: The study found that the expression of estrogen receptor beta is decreased in female temporal lobe epilepsy, and its deletion exacerbates seizure susceptibility and imbalance in synaptic excitation/inhibition. ER beta may regulate synaptic E/I through the GLUL gene, providing a potential therapeutic target for female temporal lobe epilepsy patients.
Article
Hematology
Gauri Arolkar, Sneha K. Kumar, Hanjay Wang, Karen M. Gonzalez, Suraj Kumar, Bhavnesh Bishnoi, Pamela Rios E. Coronado, Y. Joseph Woo, Kristy Red-Horse, Soumyashree Das
Summary: In this study, researchers found that neonatal artery endothelial cells have the ability to regenerate and develop into functional collateral arteries in ischemic regions of the heart. However, adult artery endothelial cells lack this regenerative ability due to their limited capacity for dedifferentiation and proliferation. These findings are significant for understanding the mechanisms of cardiac regeneration and could lead to the development of related therapeutic strategies.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Article
Agriculture, Multidisciplinary
Shiying Yang, Yuying Zhang, Wu Li, Bangyan You, Jiawen Yu, Xiaoxia Huang, Ruili Yang
Summary: PCA2 administration was found to attenuate HFD-induced AS in ApoE(-/-) mice by improving gut microbiota imbalance and regulating pathological abnormalities, lipid accumulation, oxidative stress, and inflammation. However, antibiotic intervention offset the benefits of PCA2 and prevented gut microbiota-mediated biotransformation, resulting in a significant decrease in microbial metabolites. The study highlights the significant influence of gut microbiota on the bioavailability of microbial metabolites and the potential of PCA2 in preventing AS.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Multidisciplinary Sciences
Gang Chi, Jinhong Pei, Xueqing Li
Summary: By eliminating liver resident macrophages, it was found that M2 macrophages played a dominant role in the early immune response stage of autoimmune hepatitis (AIH), and hepatic inflammation gradually worsened after their depletion. M2 macrophages could effectively delay the development of AIH and polarize into M1 macrophages as the disease progresses. TLR2 and TLR4 ligands mediated the polarization of liver resident macrophages, favoring the development of chronic AIH.
Article
Oncology
Yiqi Fan, Qing Su, Junxiao Chen, Yong Wang, Shuai He
Summary: This study evaluated the relationship between gut microbiome (GM) and glioma and found that an imbalance in GM promotes glioma growth, while a balanced GM can delay glioma development. In particular, an increased abundance of Bacteroidia is associated with accelerated glioma progression.
FRONTIERS IN ONCOLOGY
(2022)
Article
Engineering, Environmental
Yunyun Li, Shu-Shen Dai, Jiating Zhao, Zhi-Cheng Hu, Qin Liu, Jiao Feng, Qiaoyun Huang, Yuxi Gao, Yu-Rong Liu
Summary: This study explored the effects of carbon (C), nitrogen (N), and sulfur (S) on microbial production of methylmercury (MeHg) in two different paddy soils. Results showed that the addition of C alone significantly increased MeHg production, but this effect was mitigated when N and C were added together. S had a buffering effect on C-facilitated MeHg production in one soil type but not the other. MeHg production was correlated with the abundance of specific bacteria in both soils, and changes in the Hg methylating community influenced MeHg production. The study provides important insights into microbe-driven Hg conversion in paddy and wetland ecosystems.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Article
Multidisciplinary Sciences
Yichao Wu, Chengxia Fu, Caroline L. Peacock, Soren J. Sorensen, Marc A. Redmile-Gordon, Ke-Qing Xiao, Chunhui Gao, Jun Liu, Qiaoyun Huang, Zixue Li, Peiyi Song, Yongguan Zhu, Jizhong Zhou, Peng Cai
Summary: Cooperative interactions between free-living and biofilm-forming bacteria are found to drive spatial segregation and enable species coexistence in a microfluidic chip environment, promoting their respective dominance in segregated microhabitats. This active spatial segregation is induced by cooperative interactions, improving the fitness of both biofilm and planktonic populations. The study also shows that free-living Arthrobacter induces surface colonization and receives benefits from public goods secreted by biofilm-forming strains.
NATURE COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Katarina Lopusna, Pawel Nowialis, Jana Opavska, Ajay Abraham, Alberto Riva, Staci L. Haney, Rene Opavsky
Summary: DNA methylation regulates gene transcription and is involved in various physiological processes in mammals, including development and hematopoiesis. Dnmt3b catalytic activity is critical in preventing B-cell transformation in vivo, while accessory and methylation-independent repressive functions are important in preventing T-cell transformation.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Multidisciplinary Sciences
Gabriele Micali, Alyson M. Hockenberry, Alma Dal Co, Martin Ackermann, Dianne Newman
Summary: Microbial communities are essential for life on Earth, but their metabolic dependencies can be detrimental when external conditions change rapidly. We found that the spatial arrangement of a microbial community plays a crucial role in maintaining metabolic interactions and growth after an environmental shift.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Multidisciplinary Sciences
S. Emil Ruff, Pauline Humez, Isabella Hrabe De Angelis, Muhe Diao, Michael Nightingale, Sara Cho, Liam Connors, Olukayode O. Kuloyo, Alan Seltzer, Samuel Bowman, Scott D. Wankel, Cynthia N. McClain, Bernhard Mayer, Marc Strous
Summary: This study investigated the age, geochemistry, and microbiology of groundwater samples from 95 monitoring wells in 14 aquifers in Canada. The results showed the presence of diverse microbial communities and large-scale aerobic and anaerobic cycling in the groundwater. Older groundwater contained more cells and higher concentrations of oxygen, highlighting their importance in sustaining productive subsurface ecosystems.
NATURE COMMUNICATIONS
(2023)
Article
Engineering, Environmental
Filip Gamon, Anna Banach-Wisniewska, Jaspreet Jandoo Kaur, Grzegorz Cema, Aleksandra Ziembinska-Buczynska
Summary: This study investigated the impact of three common antibiotics (oxytetracycline, ciprofloxacin, and clarithromycin) on the anammox process in wastewater. The results showed that these antibiotics did not significantly affect the nitrogen removal rate and specific anammox activity, but had an impact on the abundance of functional genes and antibiotic resistance genes.
JOURNAL OF WATER PROCESS ENGINEERING
(2022)
Article
Ecology
Jennifer L. Kane, James B. Kotcon, Zachary B. Freedman, Ember M. Morrissey
Summary: Soil bacteria and fungi play a crucial role in terrestrial biogeochemical cycling, but their community composition, diversity, and function are influenced by trophic interactions. This study investigated the impact of a fungal-feeding nematode on soil microbial community and found that fungivory decreased fungal and bacterial diversity while stimulating carbon and nitrogen cycling. These results highlight the intimate connection between soil trophic dynamics, microbial diversity, and biogeochemical cycling patterns.
Article
Multidisciplinary Sciences
Renata R. Braga, Barbara M. Crisol, Rafael S. Bricola, Marcella R. Sant'ana, Susana C. B. R. Nakandakari, Suleyma O. Costa, Patricia O. Prada, Adelino S. R. da Silva, Leandro P. Moura, Jose R. Pauli, Dennys E. Cintra, Eduardo R. Ropelle
Summary: The study demonstrates that physical training alters mitochondrial proteostasis in hypothalamus, inducing mitonuclear protein imbalance and UPRmt, which leads to an increase in maximum mitochondrial respiratory capacity in the brain.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Adam D. Lietzan, Joshua B. Simpson, William G. Walton, Parth B. Jariwala, Yongmei Xu, Marcella H. Boynton, Jian Liu, Matthew R. Redinbo
Summary: Periodontitis is a chronic inflammatory disease associated with oral microbial dysbiosis. The human beta-glucuronidase (GUS) can be used as a biomarker for its severity. This study examines the role of GUS enzymes encoded by the human microbiome in periodontal disease and identifies oral GUS activity as a biomarker for clinical monitoring and treatment of periodontitis.
Review
Immunology
Zhussipbek Mukhatayev, Yekaterina O. Ostapchuk, Deyu Fang, I. Caroline Le Poole
Summary: Regulatory T cells (Tregs) play a crucial role in autoimmune skin diseases, and alterations in their numbers and functions can lead to various conditions. The use of antigen-specific Tregs engineered cells shows promise in improving treatment efficacy, though challenges in clinical applications need to be addressed.
AUTOIMMUNITY REVIEWS
(2021)
Review
Oncology
I. Caroline Le Poole
Summary: Melanocytes play opposite roles in vitiligo and melanoma. UV exposure may support malignant transformation in melanocytes at a young age, but it can also induce mutations that lead to vitiligo. Various microbes may influence the development of these diseases before they take hold.
PIGMENT CELL & MELANOMA RESEARCH
(2021)
Review
Oncology
Prathyaya Ramesh, Rohan Shivde, Dinesh Jaishankar, Diana Saleiro, I. Caroline Le Poole
Summary: Cytokines play crucial roles in immune cell communication and tumor clearance, and measuring a single cytokine is insufficient to reflect anti-tumor immune activity, highlighting the importance of combining multiple cytokines for accuracy.
Article
Immunology
Olga Kalinina, Sarah Talley, Jesus Zamora-Pineda, Wonbeom Paik, Edward M. Campbell, Katherine L. Knight
Summary: Research showed that treatment with exopolysaccharide (EPS) from Bacillus subtilis significantly increased the survival rate of mice in acute graft-versus-host disease (aGvHD), by inducing dendritic cells with inhibitory characteristics to inhibit T cell activation.
JOURNAL OF IMMUNOLOGY
(2021)
Article
Cell Biology
Dinesh Jaishankar, Cormac Cosgrove, Prathyaya Ramesh, James Mahon, Rohan Shivde, Emilia R. Dellacecca, Shiayin F. Yang, Jeffrey Mosenson, Jose A. Guevara-Patino, I. Caroline Le Poole
Summary: Biolistic delivery of HSP70i(Q435A) shows potential in promoting anti-tumor responses in melanoma, in addition to limiting autoimmunity and inflammation. This therapy elicits humoral responses that facilitate tumor growth inhibition and could be used in combination with immune checkpoint inhibitors to control tumor growth while reducing adverse events.
CELL STRESS & CHAPERONES
(2021)
Article
Oncology
Amanda M. Lulu, Kara L. Cummings, Erin D. Jeffery, Paisley T. Myers, Dennis Underwood, Rachel M. Lacy, Kimberly A. Chianese-Bullock, Craig L. Slingluff, Susan C. Modesitt, Victor H. Engelhard
Summary: A study found preexisting immune memory to cancer-expressed phosphopeptides in most healthy donors, indicating exposure to common microbial agents, but with significant variability. The research suggests that the immunogens generating phosphopeptide-specific immune memory are rare infectious agents or early cancer cells with distinct phosphoproteome dysregulations, and repetitive immunogenic exposures occur in individual donors. Overall, enhancing phosphopeptide-specific T-cell responses could be a useful approach to improve tumor immunotherapy.
CANCER IMMUNOLOGY RESEARCH
(2021)
Article
Oncology
Kevin T. Lynch, Samuel J. Young, Max O. Meneveau, Nolan A. Wages, Victor H. Engelhard, Craig L. Slingluff, Ileana S. Mauldin
Summary: The presence of TLS in cutaneous melanoma metastases is associated with increased intratumoral lymphocyte infiltration and improved overall survival in patients. Different types of TLS have varying effects on patient survival, indicating potential regulatory or antigen-driven immune responses.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Immunology
Burkitkan Akbay, Syed Hani Abidi, Mahmoud A. A. Ibrahim, Zhussipbek Mukhatayev, Syed Ali
Summary: This study identifies T and B cell epitopes conserved among human coronaviruses (HCoVs) which may serve as attractive candidates for a vaccine against SARS-CoV-2 and its variants. The designed vaccine is predicted to be soluble, stable, and exhibit low allergenicity and toxicity, while also potentially eliciting strong immune responses. These findings suggest that the multi-subunit vaccine may provide strong immune protection against SARS-CoV-2 and its emerging variants with minimal risk of adverse effects.
Article
Medicine, Research & Experimental
Ancy Thomas, Saurav Sumughan, Emilia R. Dellacecca, Rohan S. Shivde, Nicola Lancki, Zhussipbek Mukhatayev, Cristina C. Vaca, Fei Han, Levi Barse, Steven W. Henning, Jesus Zamora-Pineda, Suhail Akhtar, Nikhilesh Gupta, Jasmine O. Zahid, Stephanie R. Zack, Prathyaya Ramesh, Dinesh Jaishankar, Agnes S. Y. Lo, Joel Moss, Maria M. Picken, Thomas N. Darling, Denise M. Scholtens, Daniel F. Dilling, Richard P. Junghans, I. Caroline Le Poole
Summary: Mutations in TSC lead to tumors with biallelic mutations in TSC7 or TSC2 and hyperactive mTORC1. Overexpression of GD3 was observed in affected tissues from TSC patients and aging Tsc2(+/-) mice. Treatment with GD3 CAR-T cells significantly reduced tumor burden in mice and resulted in tumor-free outcome for the majority of treated animals.
Article
Education & Educational Research
Moldir Yelibay, Laura Karabassova, Zhussipbek Mukhatayev, Assiya Yermukhambetova
Summary: Higher and doctoral education in Kazakhstan underwent a systemic reform since independence in 1990, driven by the country's entry into the global market and the need to increase competitiveness. However, the transition to a three-cycle education system, particularly in doctoral education, has faced challenges, with a low graduation rate of doctoral students. This qualitative study aims to explore the perceptions of doctoral students regarding doctoral training and their experiences in Kazakhstani universities, providing insights into the recent reforms.
EUROPEAN JOURNAL OF EDUCATION
(2022)
Article
Multidisciplinary Sciences
Ainur Mukhatayeva, Aidana Mustafa, Natalya Dzissyuk, Alpamys Issanov, Zhussipbek Mukhatayev, Bauyrzhan Bayserkin, Sten H. Vermund, Syed Ali
Summary: In Kazakhstan, the prevalence of HIV subtype CRF02_AG is associated with the development of ARTRM L10V and S162A, and a lower risk of Q174K. The use of darunavir and nevirapine may be less effective in PLHIV infected with CRF02_AG, and should be replaced with emtricitabine. Zidovudine and nevirapine use is associated with the development of ARTRM E138A.
SCIENTIFIC REPORTS
(2022)
Article
Medicine, Research & Experimental
Katia Corano Scheri, Xiaoyan Liang, Vidhi Dalal, I. Caroline Le Poole, John Varga, Tomoko Hayashida
Article
Biochemistry & Molecular Biology
Ameera Bukhari, Amer Khojah, Wilfredo Marin, Andrey Khramtsov, Galina Khramtsova, Christopher Costin, Gabrielle Morgan, Prathyaya Ramesh, Marisa S. Klein-Gitelman, I. Caroline Le Poole, Lauren M. Pachman
Summary: The expression of otoferlin mRNA is increased in JDM patients' PBMCs and muscle compared to healthy controls. This study aims to evaluate the role of otoferlin in JDM disease pathophysiology and its association with disease activity in untreated children with JDM. The findings suggest that otoferlin expression is associated with muscle weakness, making it a possible biomarker of disease activity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Arslan Iftikhar, Rimsha Nausheen, Mohsin Khurshid, Rana Khalid Iqbal, Humaira Muzaffar, Abdul Malik, Azmat Ali Khan, Farwah Batool, Suhail Akhtar, Ayesha Yasin, Haseeb Anwar
Summary: Based on the experiment, researchers found that manuka honey has potential effects in pancreatic regeneration in alloxan-induced diabetic rats. Manuka honey can ameliorate hyperglycemia, hyperinsulinemia, oxidative stress, and necrotic changes in islets, along with significant upregulation of relevant transcription factors.