期刊
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
卷 76, 期 -, 页码 188-196出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jiec.2019.03.039
关键词
Bispecific antibody; Cancer immunotherapy; Gene transfection; Magnetic resonance imaging; Superparamagnetic iron oxide
资金
- National Natural Science Foundation of China (NSFC) [81471778, 51602338, 81702581, 51203177, 81700531]
- Science and Technology Program of Guangzhou, China [201804010101]
- Scientific and Technological Innovation Commission of Shenzhen [JCYJ20170306091400043]
- Creative Research Groups of China [81621003]
Due to the tumor immune escape mechanism, strategies like the utilization of bispecific antibodies were used to assist immunotherapy. Herein a visible polymer-inorganic hybrid gene vehicle had been prepared to deliver anti-EpCAM/anti-CD3 encoding minicircle DNA into normal cells thus these transfected cells effectively secreted bispecific antibody with bioactivity. In the experiments, this compound system exhibited excellent biocompatibility, high transfection efficiency and ultrasensitive imaging capacity. Furthermore, the transfected cells could be detected under the MR imaging system and the gene product showed an outstanding immune effect. In conclusion, this nanocomposite showed synergistic advantages in gene delivery and non-invasive MR imaging. (C) 2019 The Korean Society of Industrial and Engineering Chemistry. Published by Elsevier B.V. All rights reserved.
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