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Chemistry, Multidisciplinary
Girija Goyal, Pranav Prabhala, Gautam Mahajan, Bruce Bausk, Tal Gilboa, Liangxia Xie, Yunhao Zhai, Roey Lazarovits, Adam Mansour, Min Sun Kim, Aditya Patil, Danielle Curran, Jaclyn M. Long, Sanjay Sharma, Abidemi Junaid, Limor Cohen, Thomas C. Ferrante, Oren Levy, Rachelle Prantil-Baun, David R. Walt, Donald E. Ingber
Summary: In this study, researchers successfully cultured human ectopic lymphoid follicles with similar characteristics to lymphoid follicles in a microfluidic chip. These follicles showed improved immune responses to vaccines and can serve as an alternative to non-human primates for preclinical evaluation.
Article
Immunology
Le Kang, Angelika Schmalzl, Tamara Leupold, Miguel Gonzalez-Acera, Raja Atreya, Markus F. Neurath, Christoph Becker, Stefan Wirtz
Summary: The complex immune cell network in intestinal inflammation involves the chemokine receptor CCR8, which plays a protective role in the gut through its interaction with the chemotactic ligand CCL1. This pathway is linked to the function of intestinal innate lymphoid cells producing IFN-gamma. Modulating this regulatory circuit may present a new strategy for treating inflammatory bowel disease.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Agriculture, Dairy & Animal Science
Fuxuan Wang, Shihao Li, Fuhua Li
Summary: The lymphoid organ is a vital part of the shrimp immune system, exhibiting different functions in response to different pathogens, providing new insights into the immune functions of the lymphoid organ in shrimp.
Article
Immunology
Il-Young Hwang, Chung Park, Kathleen Harrison, John H. Kehrl
JOURNAL OF IMMUNOLOGY
(2017)
Article
Multidisciplinary Sciences
Il-Young Hwang, Kathleen Harrison, Chung Park, John H. Kehrl
SCIENTIFIC REPORTS
(2017)
Article
Immunology
Ali Vural, Neel R. Nabar, Il-Young Hwang, Silke Sohn, Chung Park, Mikael C. I. Karlsson, Joe B. Blumer, John H. Kehrl
JOURNAL OF IMMUNOLOGY
(2019)
Article
Immunology
Tejas Kadakia, Xuguang Tai, Michael Kruhlak, Jan Wisniewski, Il-Young Hwang, Sumedha Roy, Terry I. Guinter, Amala Alag, John H. Kehrl, Yuan Zhuang, Alfred Singer
JOURNAL OF EXPERIMENTAL MEDICINE
(2019)
Article
Biology
Chung Park, John H. Kehrl
Article
Immunology
Wei Zhao, Chong-Shan Shi, Kathleen Harrison, Il-Young Hwang, Neel R. Nabar, Min Wang, John H. Kehrl
JOURNAL OF IMMUNOLOGY
(2020)
Article
Cell Biology
Neel R. Nabar, Christopher N. Heijjer, Chong-Shan Shi, Il-Young Hwang, Sundar Ganesan, Mikael C. I. Karlsson, John H. Kehrl
Summary: CD38 and LRRK2 form a complex in immune cells and activate TFEB, involved in regulating autophagy and lysosome machinery. Furthermore, the pathogenic mutant LRRK2(G2019S) appears to promote hyperactivation of TFEB even in the absence of CD38.
Article
Biology
Jia C. Wang, Yang-In Yim, Xufeng Wu, Valentin Jaumouille, Andrew Cameron, Clare M. Waterman, John H. Kehrl, John A. Hammer
Summary: This study found that LFA-1:ICAM-1 interactions promote the formation of a contractile actomyosin arc network, which plays a dominant role in B-cell immune synapse (IS) formation. This network is created by mDia1, organized into concentric, contractile arcs by myosin 2A, and flows inward at the same rate as B-cell receptor (BCR):antigen clusters. The results demonstrate that integrin is crucial for synapse formation and inhibiting myosin impairs synapse formation and BCR signaling.
Article
Biochemistry & Molecular Biology
Kristoffer H. Johansen, Dominic P. Golec, Bonnie Huang, Chung Park, Julie H. Thomsen, Silvia Preite, Jennifer L. Cannons, Fabien Garcon, Edward C. Schrom, Christina J. F. Courreges, Tibor Z. Veres, James Harrison, Meritxell Nus, James D. Phelan, Wolfgang Bergmeier, John H. Kehrl, Klaus Okkenhaug, Pamela L. Schwartzberg
Summary: The study reveals the critical role of RASA3 in T cell migration, homeostasis, and function. RASA3 suppresses the activation of LFA-1 in T cells and its expression is rapidly reduced upon T cell activation. Loss of RASA3 leads to increased Rap1 activation, defective lymph node entry and egress, and impaired responses to T-dependent immunization in mice.
Meeting Abstract
Immunology
Jia C. Wang, Yang-in Yim, Xufeng Wu, John A. Hammer
JOURNAL OF IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Serena L. S. Yan, Il-Young Hwang, Olena Kamenyeva, John H. Kehrl
Article
Immunology
Christina Guzzo, David Ichikawa, Chung Park, Damilola Phillips, Qingbo Liu, Peng Zhang, Alice Kwon, Huiyi Miao, Jacky Lu, Catherine Rehm, James Arthos, Claudia Cicala, Myron S. Cohen, Anthony S. Fauci, John H. Kehrl, Paolo Lusso
SCIENCE IMMUNOLOGY
(2017)