Article
Biochemistry & Molecular Biology
Eduarda O. Z. Minin, Layde R. Paim, Elisangela C. P. Lopes, Larissa C. M. Bueno, Luis F. R. S. Carvalho-Romano, Edmilson R. Marques, Camila F. L. Vegian, Jose A. Pio-Magalhaes, Otavio R. Coelho-Filho, Andrei C. Sposito, Jose R. Matos-Souza, Wilson Nadruz, Roberto Schreiber
Summary: In this study, hypertensive patients with carotid plaques were found to have increased expression of miR-145-5p and miR-let7c, suggesting a potential role of these miRNAs as biomarkers for subclinical atherosclerosis in hypertensive individuals.
Article
Environmental Sciences
Yonglian Liu, Wenjuan Wang, Zhonglan Zou, Baofei Sun, Bing Liang, Aihua Zhang
Summary: This study explores the association between coal-induced arsenicosis and hyperglycemia, finding that arsenic exposure disrupts glucose homeostasis and that an elevated inflammatory response is implicated in the risk of arsenic-induced hyperglycemia.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Environmental Sciences
Prasenjit Mitra, Taru Goyal, Preeti Singh, Shailja Sharma, Praveen Sharma
Summary: The study found that miR-155 and miR-221 were significantly upregulated in occupationally lead-exposed workers, while miR-20b showed no significant difference. These miRNAs have the potential to trigger various genes and cellular pathways, highlighting the importance of miRNA dysregulation in the systemic effects of lead toxicity.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Miruna Nemecz, Diana Simona Stefan, Ioana Karla Comarita, Alina Constantin, Gabriela Tanko, Cristian Guja, Adriana Georgescu
Summary: In this study, miR-218, miR-132, and miR-143 were identified as significantly up-regulated miRNAs in both circulating MVs and plasma from diabetic patients with dyslipidemia. These miRNAs showed significant correlations with important plasma markers representative of this pathology.
CARDIOVASCULAR DIABETOLOGY
(2023)
Article
Cell Biology
Purvi Purohit, Dipayan Roy, Shailendra Dwivedi, Naresh Nebhinani, Praveen Sharma
Summary: The study found that individuals with chronic opioid use disorder had elevated levels of inflammatory cytokines TNF-alpha and IL-10, while IL-6 was reduced. There was a dose-dependent upregulation of miR-155-5p and miR-187-5p at opium doses greater than 1500 g/month, along with an increase in TNF-alpha and IL-10.
Article
Pediatrics
Per Sward, Bjorn E. Rosengren, Lars Jehpsson, Magnus K. Karlsson
Summary: This study found that higher circulating furin levels were associated with obesity and overweight in children, with positive correlations between furin and markers of adiposity and inflammation. These findings suggest a potential link between furin, adiposity, and inflammatory milieu in children, warranting further investigation into the role of furin in fat tissue inflammation and cardiometabolic diseases in children.
Review
Behavioral Sciences
Claudia Zuccarella-Hackl, Mary Princip, Bianca Auschra, Rebecca E. Meister-Langraf, Juergen Barth, Roland von Kanel
Summary: Accumulating evidence suggests that positive psychological well-being (PPWB) has a protective effect on health outcomes, possibly through enhanced immune functioning. This project conducted a systematic review and meta-analysis to explore the association between PPWB and circulating inflammatory biomarkers. The findings indicate that higher levels of PPWB are associated with lower levels of interleukin-6 (IL-6) and C-reactive protein (CRP) in the circulation, supporting the potential role of inflammation in mediating the health benefits of PPWB.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2023)
Article
Medicine, General & Internal
Noemi Gaytan-Pacheco, Alejandro Ibanez-Salazar, Ana Sofia Herrera-Van Oostdam, Juan Jose Oropeza-Valdez, Martin Magana-Aquino, Jesus Adrian Lopez, Joel Monarrez-Espino, Yamile Lopez-Hernandez
Summary: COVID-19 infection caused a global public health crisis from 2020 to 2022, and its impact is still ongoing. This study in Mexico analyzed the plasmatic expression of five miRNAs involved in immune response and inflammation in COVID-19 patients compared to healthy controls. The results showed significant upregulation of certain miRNAs and identified potential gene targets for therapeutic interventions. The dysregulation of circulating miRNAs could serve as biomarkers to distinguish severe COVID-19 cases.
Review
Cell Biology
Wang-Dong Xu, Si-Yu Feng, An-Fang Huang
Summary: MiR-155, a member of the microRNAs family, plays a critical role in the regulation of gene expression in both innate and adaptive immunity. It is aberrantly expressed in various inflammatory autoimmune diseases and is involved in their development. Inhibition of MiR-155 can alter disease progression or ameliorate symptoms, making it a potential therapeutic target for these diseases.
INFLAMMATION RESEARCH
(2022)
Article
Medicine, General & Internal
Fabio Moretti, Jvan Gianini, Rosaria Del Giorno, Luca Gabutti
Summary: This study investigated the impact of white-coat effect on the circadian rhythm of urinary water and salt excretion. It found a higher night/day ratio of urinary water excretion in the white-coat effect group, but no significant differences in the circadian pattern of urinary sodium excretion. This has potential implications for hypertension prevention, but further research is needed to understand the clinical significance of the impact on the night/day ratio of water excretion.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Immunology
Fiona Collier, Cerys Chau, Toby Mansell, Keshav Faye-Chauhan, Peter Vuillermin, Anne-Louise Ponsonby, Richard Saffery, Mimi L. K. Tang, Martin O'Hely, John Carlin, Lawrence E. K. Gray, Siroon Bekkering, David Burgner
Summary: Early childhood is characterized by repeated infectious exposures that elicit inflammatory responses from the innate immune system, which may contribute to the link between childhood infection and adult non-communicable diseases. Boys have a higher inflammatory response than girls, and adiposity and winter season are associated with increased circulating inflammatory markers.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Xavier Humbert, Sophie Fedrizzi, Agnes Hofferer, Mathieu Bansard, Anne-Laure Huet, Christiane Bedier, Andry Rabiaza, Jeanne Le Bas, Francois Le Bas, Joachim Alexandre, Paolo Emilio Puddu
Summary: The study found that the office white-coat effect tail (OWCET) increases the risk of cardiovascular disease, coronary heart disease, and stroke in women over a long-term follow-up, but does not significantly impact men.
CURRENT PHARMACEUTICAL DESIGN
(2021)
Article
Veterinary Sciences
Jie Wen, Yiru Wu, Yufei Tian, Janwei Han, Qiuyuan Wang, Yang Liu, Chaolai Man
Summary: This study investigated the expression, potential function, and mechanism of miR-155 in the immune responses of 12-day-old chickens to three vaccines. The results showed differential expression levels of serum circulating miR-155 during the immune responses, with some common key time points and associated tissues. Bioinformatics analysis suggested key target genes of miR-155 that possibly play a role in immune function regulation through specific signaling pathways.
RESEARCH IN VETERINARY SCIENCE
(2022)
Article
Medicine, General & Internal
Paolo Palatini, Lucio Mos, Francesca Saladini, Olga Vriz, Claudio Fania, Andrea Ermolao, Francesca Battista, Marcello Rattazzi
Summary: The aim of this study was to investigate the reproducibility of white-coat hypertension (WCH) and its predictive capacity for hypertension needing antihypertensive treatment (HT) in young to middle-age subjects. The results showed that WCH has limited reproducibility, and the risk of future hypertension increased when diagnosed with two sets of blood pressure measurements instead of one.
Article
Neurosciences
Macarena S. Aloi, Katherine E. Prater, Bryce Sopher, Stephanie Davidson, Suman Jayadev, Gwenn A. Garden
Summary: Microglia play a crucial role in neurodegenerative diseases by modulating inflammatory responses through miR-155, affecting the cellular ability to degrade Aβ.
Article
Medicine, General & Internal
Yu-Qing Huang, Jia-Yi Huang, Lin Liu, Chao-Lei Chen, Yu-Ling Yu, Song-tao Tang, Bin Zhang, Ying Qing Feng
POSTGRADUATE MEDICAL JOURNAL
(2020)
Article
Medicine, General & Internal
Jie LI, Jia-Yi Huang, Kenneth Lo, Bin Zhang, Yu-Qing Huang, Ying Qing Feng
POSTGRADUATE MEDICAL JOURNAL
(2020)
Article
Medicine, General & Internal
Jiayi Huang, Lin Liu, Yu-Qing Huang, Kenneth Lo, Yu-Ling Yu, Chao-Lei Chen, Song-tao Tang, Bin Zhang, Ying Qing Feng
Summary: According to the study, in the elderly hypertensive population in China, pulse pressure is significantly associated with the risk of first ischemic stroke and is an independent risk factor for stroke. Certain subgroups (such as those aged >= 70 years, males, smokers or drinkers, with diabetes, etc.) may have a higher risk of stroke.
POSTGRADUATE MEDICAL JOURNAL
(2021)
Article
Biochemistry & Molecular Biology
Yu-qing Huang, Xiao-cong Liu, Kenneth Lo, Ying-qing Feng, Bin Zhang
LIPIDS IN HEALTH AND DISEASE
(2020)
Article
Geriatrics & Gerontology
Yu-qing Huang, Xiao-cong Liu, Kenneth Lo, Lin Liu, Yu-ling Yu, Chao-lei Chen, Jia-yi Huang, Ying-qing Feng, Bin Zhang
CLINICAL INTERVENTIONS IN AGING
(2020)
Article
Health Care Sciences & Services
Jia-Yi Huang, Lin Liu, Yu-Ling Yu, Chao-Lei Chen, Kenneth Lo, Bin Zhang, Song-Tao Tang, Yu-Qing Huang, Ying-Qing Feng
ANNALS OF PALLIATIVE MEDICINE
(2020)
Article
Cardiac & Cardiovascular Systems
Yu-Qing Huang, Lin Liu, Xiao-Cong Liu, Kenneth Lo, Song-Tao Tang, Ying-Qing Feng, Bin Zhang
Summary: This study found that high variability of total cholesterol and low-density lipoprotein cholesterol in hypertensive patients was associated with an increased risk of ischemic stroke. The results suggest that reducing lipid variability may lead to better outcomes in hypertensive patients.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2021)
Article
Nutrition & Dietetics
Yu-Qing Huang, Lin Liu, Kenneth Ka Ho Lo, Yu-Ling Yu, Chao-Lei Chen, Jia-Yi Huang, Bin Zhang, Ying-qing Feng
Summary: This study aimed to examine the association between exposure to famine in early life and the risk of ascending aorta dilatation (AAD) in adulthood. The data of 2598 adults born between 1952 and 1964 in Guangdong, China were investigated. The study found that exposure to famine was associated with elevated risk of AAD, particularly for individuals who experienced famine during early life.
BRITISH JOURNAL OF NUTRITION
(2022)
Article
Cardiac & Cardiovascular Systems
Kaize Wu, Bingzheng Luo, Zehan Huang, Bin Zhang
Summary: The retrograde approach has significantly improved the success rates in complex coronary total occlusion (CTO) lesions, but unsuccessful crossing of collateral channels remains the strongest predictor of retrograde failure.
INTERNATIONAL HEART JOURNAL
(2021)
Article
Peripheral Vascular Disease
Min Gao, Ming-Ming Ma, Feng-Ting Lu, Cheng-Cui Huang, Lu Sun, Xiao-Fei Lv, Bin Zhang, Guan-Lei Wang, Yong-Yuan Guan
Summary: The study revealed that ClC-5 plays a key role in low extracellular Cl-induced Cl- currents, with upregulated expression in arterial tissues of hypertensive rats and patients. ClC-5 expression positively correlated with basilar artery remodeling during hypertension, and it promotes hypertension-induced cerebrovascular remodeling via the WNK1/AKT signaling pathway.
Article
Chemistry, Multidisciplinary
Hui Han, Chang Liu, Mei Li, Jin Wang, Yao-sheng Liu, Yi Zhou, Zi-cheng Li, Rui Hu, Zhi-hong Li, Ruo-mei Wang, Yong-yuan Guan, Bin Zhang, Guan-lei Wang
Summary: Elevated neutrophil [Cl-](i) during the development of atherosclerosis and ACS contributes to increased NET formation via Cl--sensitive SGK1 signaling, suggesting that defective CFTR function might be a novel therapeutic target for atherosclerotic cardiovascular diseases.
ACTA PHARMACOLOGICA SINICA
(2022)
Article
Chemistry, Multidisciplinary
Han-Yan Yang, Chao Zhang, Liang Hu, Chang Liu, Ni Pan, Mei Li, Hui Han, Yi Zhou, Jie Li, Li-Yan Zhao, Yao-Sheng Liu, Bing-Zheng Luo, Xiong-Qing Huang, Xiao-Fei Lv, Zi-Cheng Li, Jun Li, Zhi-Hong Li, Ruo-Mei Wang, Li Wang, Yong-Yuan Guan, Can-Zhao Liu, Bin Zhang, Guan-Lei Wang
Summary: Platelet hyperactivity in cystic fibrosis patients is influenced by increased intracellular Cl- levels. Cl- level elevation accelerates thrombus formation and platelet aggregation. Regulating Cl- levels and CFTR expression can modulate platelet activation signaling cascade.
ACTA PHARMACOLOGICA SINICA
(2022)
Article
Cardiac & Cardiovascular Systems
Jing Wang, Junlin Huang, Abdul-Subulr Yakubu, Kaize Wu, Zehan Huang, Zhian Zhong, Hongtao Liao, Bin Zhang
Summary: The study evaluated the safety and feasibility of rotational atherectomy (RA) in retrograde chronic total occlusion percutaneous coronary intervention (CTO-PCI). The results showed that there were no significant differences in technical and procedural success rates, major procedural complications, and long-term outcomes between the RA group and the non-RA group.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Liu-Yi Lu, Ni Pan, Ze-Han Huang, Jing-Song Wang, Yong-Bo Tang, Hong-Shuo Sun, Hui Han, Han-Yan Yang, Jun-Zhen Zhu, Yong-Yuan Guan, Bin Zhang, Dong-Zhi Li, Guan-Lei Wang
Summary: This study found that CFTR attenuates neointimal formation by suppressing the cell signaling pathway stimulated by PDGF-BB, indicating that CFTR plays an important negative regulatory role in vascular remodeling.
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
(2022)