Cytolytic activity correlates with the mutational burden and deregulated expression of immune checkpoints in colorectal cancer
出版年份 2019 全文链接
标题
Cytolytic activity correlates with the mutational burden and deregulated expression of immune checkpoints in colorectal cancer
作者
关键词
Colorectal cancer, Cytolytic activity, Classically defined neoepitopes, Alternatively defined neoepitopes, Mutation burden, Immune checkpoints, Cancer drivers
出版物
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
Volume 38, Issue 1, Pages -
出版商
Springer Science and Business Media LLC
发表日期
2019-08-20
DOI
10.1186/s13046-019-1372-z
参考文献
相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。- Cytolytic Activity Score to Assess Anticancer Immunity in Colorectal Cancer
- (2018) Sumana Narayanan et al. ANNALS OF SURGICAL ONCOLOGY
- Durable Clinical Benefit With Nivolumab Plus Ipilimumab in DNA Mismatch Repair–Deficient/Microsatellite Instability–High Metastatic Colorectal Cancer
- (2018) Michael J. Overman et al. JOURNAL OF CLINICAL ONCOLOGY
- Prognostic significance of nomograms integrating IL-37 expression, neutrophil level, and MMR status in patients with colorectal cancer
- (2018) Bing Zhu et al. Cancer Medicine
- The Expression and Prognostic Impact of Immune Cytolytic Activity-Related Markers in Human Malignancies: A Comprehensive Meta-analysis
- (2018) Constantinos Roufas et al. Frontiers in Oncology
- 1830OLiquid biopsy as tool to monitor and predict clinical benefit from chemotherapy (CT) and immunotherapy (IT) in advanced non-small cell lung cancer (aNSCLC): A prospective study
- (2018) L Bonanno et al. ANNALS OF ONCOLOGY
- Development of tumor mutation burden as an immunotherapy biomarker: utility for the oncology clinic
- (2018) T A Chan et al. ANNALS OF ONCOLOGY
- Targeting Immunotherapy to the Tumor Microenvironment
- (2017) Michael Dougan et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- Detection of Mismatch Repair Deficiency and Microsatellite Instability in Colorectal Adenocarcinoma by Targeted Next-Generation Sequencing
- (2017) Jonathan A. Nowak et al. JOURNAL OF MOLECULAR DIAGNOSTICS
- The immune contexture in cancer prognosis and treatment
- (2017) Wolf H. Fridman et al. Nature Reviews Clinical Oncology
- Mismatch repair deficiency predicts response of solid tumors to PD-1 blockade
- (2017) Dung T. Le et al. SCIENCE
- A pathology atlas of the human cancer transcriptome
- (2017) Mathias Uhlen et al. SCIENCE
- Clinical Impact of Tumor DNA Repair Expression and T-cell Infiltration in Breast Cancers
- (2017) Andrew R. Green et al. Cancer Immunology Research
- Distinctive features of tumor-infiltrating γδ T lymphocytes in human colorectal cancer
- (2017) S. Meraviglia et al. OncoImmunology
- Targeted Cell-to-Cell Delivery of Protein Payloads via the Granzyme-Perforin Pathway
- (2017) Daniel J. Woodsworth et al. Molecular Therapy-Methods & Clinical Development
- Number of Intratumoral T Lymphocytes Is Associated With Lymph Node Size, Lymph Node Harvest, and Outcome in Node-Negative Colon Cancer
- (2016) Bruno Märkl et al. AMERICAN JOURNAL OF CLINICAL PATHOLOGY
- Mismatch repair status in patients with primary operable colorectal cancer: associations with the local and systemic tumour environment
- (2016) James H Park et al. BRITISH JOURNAL OF CANCER
- SynTarget: an online tool to test the synergetic effect of genes on survival outcome in cancer
- (2016) I Amelio et al. CELL DEATH AND DIFFERENTIATION
- Immune Cytolytic Activity Stratifies Molecular Subsets of Human Pancreatic Cancer
- (2016) David Balli et al. CLINICAL CANCER RESEARCH
- PD-L1 expression in colorectal cancer is associated with microsatellite instability, BRAF mutation, medullary morphology and cytotoxic tumor-infiltrating lymphocytes
- (2016) Matthew W Rosenbaum et al. MODERN PATHOLOGY
- Clonal neoantigens elicit T cell immunoreactivity and sensitivity to immune checkpoint blockade
- (2016) N. McGranahan et al. SCIENCE
- Genomic Correlates of Immune-Cell Infiltrates in Colorectal Carcinoma
- (2016) Marios Giannakis et al. Cell Reports
- Molecular and Genetic Properties of Tumors Associated with Local Immune Cytolytic Activity
- (2015) Michael S. Rooney et al. CELL
- Intra-tumor genetic heterogeneity in rectal cancer
- (2015) Karin M Hardiman et al. LABORATORY INVESTIGATION
- The consensus molecular subtypes of colorectal cancer
- (2015) Justin Guinney et al. NATURE MEDICINE
- Robust enumeration of cell subsets from tissue expression profiles
- (2015) Aaron M Newman et al. NATURE METHODS
- Combination cancer immunotherapies tailored to the tumour microenvironment
- (2015) Mark J. Smyth et al. Nature Reviews Clinical Oncology
- PD-1 Blockade in Tumors with Mismatch-Repair Deficiency
- (2015) Dung T. Le et al. NEW ENGLAND JOURNAL OF MEDICINE
- Anti program death-1/anti program death-ligand 1 in digestive cancers
- (2015) Eléonore de Guillebon World Journal of Gastrointestinal Oncology
- Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients
- (2014) Roy S. Herbst et al. NATURE
- The Vigorous Immune Microenvironment of Microsatellite Instable Colon Cancer Is Balanced by Multiple Counter-Inhibitory Checkpoints
- (2014) Nicolas J. Llosa et al. Cancer Discovery
- voom: precision weights unlock linear model analysis tools for RNA-seq read counts
- (2014) Charity W Law et al. GENOME BIOLOGY
- OncodriveCLUST: exploiting the positional clustering of somatic mutations to identify cancer genes
- (2013) David Tamborero et al. BIOINFORMATICS
- Dendritic Cell Tumor Killing Activity and Its Potential Applications in Cancer Immunotherapy
- (2013) Neale Hanke et al. CRITICAL REVIEWS IN IMMUNOLOGY
- Clinical impact of programmed cell death ligand 1 expression in colorectal cancer
- (2013) Raoul A. Droeser et al. EUROPEAN JOURNAL OF CANCER
- Up-Regulation of PD-L1, IDO, and Tregs in the Melanoma Tumor Microenvironment Is Driven by CD8+ T Cells
- (2013) S. Spranger et al. Science Translational Medicine
- Predictive and prognostic biomarkers with therapeutic targets in breast, colorectal, and non-small cell lung cancers: A systemic review of current development, evidence, and recommendation
- (2013) Clement Chung et al. JOURNAL OF ONCOLOGY PHARMACY PRACTICE
- Safety and Activity of Anti–PD-L1 Antibody in Patients with Advanced Cancer
- (2012) Julie R. Brahmer et al. NEW ENGLAND JOURNAL OF MEDICINE
- MATH, a novel measure of intratumor genetic heterogeneity, is high in poor-outcome classes of head and neck squamous cell carcinoma
- (2012) Edmund A. Mroz et al. ORAL ONCOLOGY
- An immune-active tumor microenvironment favors clinical response to ipilimumab
- (2011) Rui-Ru Ji et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- Phenotype, Function, and Gene Expression Profiles of Programmed Death-1 hi CD8 T Cells in Healthy Human Adults
- (2011) Jaikumar Duraiswamy et al. JOURNAL OF IMMUNOLOGY
- PrimerBank: a PCR primer database for quantitative gene expression analysis, 2012 update
- (2011) X. Wang et al. NUCLEIC ACIDS RESEARCH
- GISTIC2.0 facilitates sensitive and confident localization of the targets of focal somatic copy-number alteration in human cancers
- (2011) Craig H Mermel et al. GENOME BIOLOGY
- Genomic instability — an evolving hallmark of cancer
- (2010) Simona Negrini et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- The molecular signature of CD8+T cells undergoing deletional tolerance
- (2009) Ian A. Parish et al. BLOOD
- In Situ Cytotoxic and Memory T Cells Predict Outcome in Patients With Early-Stage Colorectal Cancer
- (2009) Franck Pagès et al. JOURNAL OF CLINICAL ONCOLOGY
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started