Article
Critical Care Medicine
Anthony J. Fischer, Sachinkumar B. Singh, Mason M. LaMarche, Lucas J. Maakestad, Zoe E. Kienenberger, Tahuanty A. Pena, David A. Stoltz, Dominique H. Limoli
Summary: Staphylococcus aureus and Pseudomonas aeruginosa are both abundant in sputum cultures of cystic fibrosis patients. Contrary to common assumption, there is no rapid replacement of S. aureus by P. aeruginosa. Many CF patients have long-term coinfection with these organisms.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2021)
Review
Immunology
Lalitha Biswas, Friedrich Goetz
Summary: Cystic fibrosis is a genetic disorder characterized by recurrent lung infections caused by Staphylococcus aureus and Pseudomonas aeruginosa. The interactions between these pathogens play a significant role in their survival, antibiotic resistance, and disease progression. Understanding these interactions is crucial for the treatment and prevention of cystic fibrosis.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Microbiology
Eryn E. Bernardy, Vishnu Raghuram, Joanna B. Goldberg
Summary: The interaction between Staphylococcus aureus and Pseudomonas aeruginosa in the lungs of cystic fibrosis patients is key to understanding the severity of respiratory infections. The survival of S. aureus is significantly higher when coinfected with P. aeruginosa, suggesting that interactions between these two bacteria promote coexistence in the CF lung environment.
MICROBIOLOGY SPECTRUM
(2022)
Article
Microbiology
Marie K. Wieneke, Felix Dach, Claudia Neumann, Dennis Gorlich, Lena Kaese, Theo Thissen, Angelika Duebbers, Christina Kessler, Joerg Grosse-Onnebrink, Peter Kuester, Holger Schueltingkemper, Bianca Schwartbeck, Johannes Roth, Jerzy-Roch Nofer, Janina Treffon, Julia Posdorfer, Josefine Marie Boecken, Mariele Strake, Miriam Abdo, Sophia Westhues, Barbara C. Kahl
Summary: Through a 1-year observational prospective study with 14 CF patients with long-term S. aureus infection, we found that a highly diverse and dynamic S. aureus population was associated with P. aeruginosa coinfection and inflammation in CF patients.
Article
Microbiology
Samantha L. Durfey, Sudhakar Pipavath, Anna Li, Anh T. Vo, Anina Ratjen, Suzanne Carter, Sarah J. Morgan, Matthew C. Radey, Brenda Grogan, Stephen J. Salipante, Michael J. Welsh, David A. Stoltz, Christopher H. Goss, Edward F. McKone, Pradeep K. Singh
Summary: Studies show that chronic CF infections may persist despite improvements induced by CFTR modulators and aggressive antibiotic treatment. Combining CFTR modulators with intensive antibiotics may be most effective for patients with higher CFTR activity. Challenges remain in improving the health of people with CF.
Review
Biochemistry & Molecular Biology
Aubin Souche, Francois Vandenesch, Anne Doleans-Jordheim, Karen Moreau
Summary: Cystic fibrosis (CF) is a severe genetic disease causing impaired lung function and premature death. Chronic infections with Staphylococcus aureus (SA) and Pseudomonas aeruginosa (PA) are common in CF lungs. SA and PA are able to adapt to the host immune response through various strategies, including bypassing the airway epithelia, evading recognition, modulating host immune cell proliferation, and inhibiting the immune response. These mechanisms not only benefit the bacteria but also promote coinfections in CF lungs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Microbiology
Laura Camus, Paul Briaud, Francois Vandenesch, Karen Moreau
Summary: Pseudomonas aeruginosa and Staphylococcus aureus are the two most prevalent bacteria species in the lungs of cystic fibrosis (CF) patients. Co-infection by the two species is common, and recent studies have shown that they are able to coexist, with this change in relationship linked to bacterial strain evolution.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Respiratory System
Claudia Grehn, A-M Dittrich, J. Wosniok, F. Holz, S. Hafkemeyer, L. Naehrlich, C. Schwarz
Summary: The study revealed that cystic fibrosis arthropathy (CFA) is common in CF patients, especially in adults, and is significantly associated with factors such as age, gender, hospitalizations, chronic Pseudomonas aeruginosa infection, CF-related diabetes, pancreatic insufficiency, sinusitis/polyps, and antimycotic treatment.
JOURNAL OF CYSTIC FIBROSIS
(2021)
Article
Critical Care Medicine
Dustin R. Long, Daniel J. Wolter, Michael Lee, Mimi Precit, Kathryn McLean, Elizabeth Holmes, Kelsi Penewit, Adam Waalkes, Lucas R. Hoffman, Stephen J. Salipante
Summary: This study characterized the molecular epidemiology and genetic adaptation of Staphylococcus aureus in chronic CF airway infection, revealing that patients often carry multiple, genetically distinct S. aureus lineages with adaptations in persistence and antimicrobial resistance genes. Limited strain-sharing was identified among patients, and S. aureus genetic diversity was found to be unconstrained, suggesting the need for novel diagnostic and therapeutic approaches in the future.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2021)
Article
Biology
Min Lu, Yongli Li, Mei X. Wu
Summary: Multidrug-resistant bacteria pose a significant threat and are depleting treatment options. This study explores the combination of blue-laser and thymol to eradicate these bacteria, successfully preventing systematic dissemination in mice. The strategy leverages the unique properties of bacteria to transform harmless thymol into a powerful sterilizer when activated by blue-laser excitation.
COMMUNICATIONS BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Samuel L. Neff, Thomas H. Hampton, Charles Puerner, Liviu Cengher, Georgia Doing, Alexandra J. Lee, Katja Koeppen, Ambrose L. Cheung, Deborah A. Hogan, Robert A. Cramer, Bruce A. Stanton
Summary: Researchers have developed an application called CF-Seq, which allows users to filter studies and view differential gene expression analyses using a compendium of 128 studies and 1,322 samples.
Review
Infectious Diseases
Danni Li, Elena K. Schneider-Futschik
Summary: Impaired mucus transport and enhanced colonization of bacteria in cystic fibrosis patients lead to pulmonary infection, causing significant morbidity and mortality. Pseudomonas aeruginosa and Staphylococcus aureus are the most common bacteria found in CF lungs, and they undergo adaptational mechanisms such as biofilm formation, resulting in chronic infections. Inhaled antibiotics, such as tobramycin, aztreonam, levofloxacin, and colistin, are used to treat chronic pulmonary infections with advantages of higher airway concentration and lower systemic toxicity.
Article
Microbiology
Laura J. Dunphy, Kassandra L. Grimes, Nishikant Wase, Glynis L. Kolling, Jason A. Papin
Summary: In a synthetic cystic fibrosis media, distinct species-specific metabolic signatures were revealed for Pseudomonas aeruginosa and Staphylococcus aureus, indicating potential nutrient competition's impact on community dynamics. Both bacteria consumed similar nutrients, suggesting metabolic competition's role in coinfection dynamics. Furthermore, unique metabolites produced by each species may serve as species-specific biomarkers for cystic fibrosis lung infections.
Review
Microbiology
Christina S. Thornton, Michael G. Surette
Summary: Cystic fibrosis is the most common and lethal genetic disease among the Caucasian population, leading to chronic airway inflammation and declining pulmonary function. Studies have shown a diverse community of anaerobic bacteria in CF patients' airways, potentially impacting disease progression through synergistic interaction with principal pathogens. Despite the understanding of this complex bacterial milieu, the specific roles of anaerobes in disease progression remain unclear.
JOURNAL OF CLINICAL MICROBIOLOGY
(2021)
Article
Microbiology
Micaela Mossop, Luca Robinson, Jhih-Hang Jiang, Anton Y. Peleg, Luke Blakeway, Nenad Macesic, Audrey Perry, Stephen Bourke, Fatima R. Ulhuq, Tracy Palmer
Summary: One third of CF patients in the UK are co-infected with both Staphylococcus aureus and Pseudomonas aeruginosa, which contribute to lung tissue destruction and respiratory failure. This study aims to characterize twenty-five clinical S. aureus isolates from CF patients, including those with mono- and coinfection with P. aeruginosa, using molecular and phenotypic tools.
JOURNAL OF MEDICAL MICROBIOLOGY
(2023)
Article
Respiratory System
Meir Mei Zahav, Annalisa Orenti, Andreas Jung, Elpis Hatziagorou, Hanne Vebert Olesen, Eitan Kerem
Summary: Patients with residual function (RF) mutations in cystic fibrosis experience a decline in pulmonary function with age and shortened life spans. The study emphasizes the importance of standard of care therapies and CFTR function augmentation to improve the survival and quality of life for these patients.
JOURNAL OF CYSTIC FIBROSIS
(2023)
Article
Allergy
Pauline Peftoulidou, Maria Gioulvanidou, Elissavet-Anna Chrysochoou, Elpis Hatziagorou
Summary: This study aimed to assess the association between lung function, physical activity, and quality of life (QoL) in children with well-controlled asthma. The results showed a significant correlation between QoL and both lung function and physical activity levels. However, despite reasonable asthma control, the children exhibited low physical activity levels, which negatively impacted their QoL.
Article
Respiratory System
Annalisa Orenti, Meir Mei-Zahav, Patrizia Boracchi, Anders Lindblad, Michal Shteinberg
Summary: Many patients with cystic fibrosis without chronic Pseudomonas aeruginosa infection receive long-term treatment with inhaled antibiotics, despite a lack of support from clinical trials or practice guidelines. Factors such as PA infection, severe genotype, diabetes, and pancreatic insufficiency are associated with inhaled antibiotic treatment, but no improvement in outcomes was observed.
JOURNAL OF CYSTIC FIBROSIS
(2023)
Article
Respiratory System
Anne Munck, Daria Berger, Kevin W. Southern, Carla Carducci, Karin M. de Winter-de Groot, Silvia Gartner, Nataliya Kashirskaya, Barry Linnane, Marijke Proesmans, Dorota Sands, Olaf Sommerburg, Carlo Castellani, Juerg Barben
Summary: The study aimed to assess the current status and performance of newborn bloodspot screening (NBS) for CF in Europe. A survey was conducted among representatives of NBS programs across Europe, and performance was evaluated using a previously developed framework. The results showed that in 2022, there were 22 national and 34 regional NBS programs in Europe. The integration of DNA analysis into the NBS protocol improved the positive predictive value, but also led to increased carrier and CFSPID recognition.
JOURNAL OF CYSTIC FIBROSIS
(2023)
Article
Respiratory System
Eitan Kerem, Annalisa Orenti, Anna Zolin, Luigi Annicchiarico, Pavel Drevinek
Summary: This study analyzed data from European cystic fibrosis patients and found that Achromobacter infection has a similar impact on lung disease severity as Pseudomonas aeruginosa infection. The co-infection of both bacteria is associated with a more severe disease outcome.
JOURNAL OF CYSTIC FIBROSIS
(2023)
Article
Respiratory System
Galit Livnat, Adi Dagan, Moshe Heching, Einat Shmueli, Dario Prais, Karin Yaacoby-Bianu, Nili Stein, Meir Mei-Zahav, Michal Gur, Malena Cohen-Cymberknoh, Michal Shteinberg
Summary: This study demonstrates the clinical efficacy of ETI in patients with CF carrying non-F508del mutations, supporting its routine use in this patient group. ETI treatment resulted in reduced sweat chloride concentration, decreased pulmonary exacerbations, and improvements in nutritional status and lung function.
JOURNAL OF CYSTIC FIBROSIS
(2023)
Article
Health Care Sciences & Services
Angela Flavia Luppino, Gilberto Cincinelli, Annalisa Orenti, Patrizia Boracchi, Ennio Giulio Favalli, Roberto Caporali, Francesca Ingegnoli
Summary: This study analyzed the impact of different patterns of healthcare delivery on remission of RA patients treated with targeted therapies during the pandemic. The results showed that the different healthcare delivery strategies did not significantly affect the remission rate of RA patients, including difficult-to-treat patients.
JOURNAL OF TELEMEDICINE AND TELECARE
(2023)
Article
Pediatrics
Shay Ehrlich, Inbal Golan Tripto, Moran Lavie, Michal Cahal, Tommy Shonfeld, Dario Prais, Hagit Levine, Meir Mei-Zahav, Ophir Bar-On, Yulia Gendler, Jonatan Zalcman, Eahab Sarsur, Micha Aviram, Aviv Goldbart, Patrick Stafler
Summary: A retrospective study conducted in three pediatric centers in Israel showed that home high-flow nasal cannula (HFNC) therapy was well tolerated and safe for a variety of indications, leading to improved weight gain, reduced hospitalization days, and high parental satisfaction.
PEDIATRIC PULMONOLOGY
(2023)
Article
Health Care Sciences & Services
Simone Gambazza, Annalisa Orenti, Giovanna Pizzamiglio, Anna Zolin, Carla Colombo, Dario Laquintana, Federico Ambrogi, ECFSPR
Summary: This study aimed to understand the prognosis for people with cystic fibrosis (pwCF) on oxygen therapy (OT), evaluating the probability of lung transplantation (LTx) and death in pwCF with and without OT. The study found that OT is strongly associated with poor survival in pwCF, highlighting the importance of harmonizing CF care throughout European countries and minimizing the onset of pulmonary gas exchange abnormalities.
THERAPEUTICS AND CLINICAL RISK MANAGEMENT
(2023)
Article
Pediatrics
Nikolaos Karantaglis, Fotios Kirvassilis, Elpis Hatziagorou, Antonios Gkantaras, Kalliopi Kontouli, John Tsanakas, Maria Emporiadou
Summary: Bronchial provocation tests, such as the mannitol challenge, can help identify and measure the severity of bronchial hyperresponsiveness in asthmatic patients. This study aimed to compare the bronchial hyperresponsiveness to mannitol in treatment-naive asthmatic children before and after receiving asthma prophylaxis. The results showed that the provocative dose of mannitol increased significantly after treatment, suggesting that bronchial hyperresponsiveness to mannitol could be a potential monitoring tool in pediatric asthmatic patients.
Article
Respiratory System
Elpis Hatziagorou, Steffen Fieuws Annalisa Orenti, Lutz Naehrlich, Uros Krivec, Meir Mei-Zahav, Andreas Jung, Kris De Boeck
Summary: This study used data from the European Cystic Fibrosis Society patient registry to examine the trajectory of forced expiratory volume in 1 second (FEV1) from 2008 to 2016. Risk factors for FEV1 decline were evaluated, and it was found that age and age at diagnosis were significant factors. Males had a higher %FEV1 but experienced a higher yearly %FEV1 loss during adolescence. Patients from low-income countries had a faster decline in %FEV1 compared to those from middle- and high-income countries.
Article
Pediatrics
Sotirios Fouzas, Christos Kogias, Maria Gioulvanidou, Aris Bertzouanis, Elisavet-Anna Chrysochoou, Michael B. Anthracopoulos, John Tsanakas, Elpis Hatziagorou
Summary: The study investigates the utility of lower-frequency forced oscillations technique (FOT) in assessing ventilation inhomogeneity in cystic fibrosis (CF) patients. The specific respiratory conductance (sGrs) at 5 Hz was found to be strongly correlated with the lung clearance index (LCI) and unaffected by lung hyperinflation.
PEDIATRIC PULMONOLOGY
(2023)
Letter
Microbiology
Jan Tkadlec, Jana Prasilova, Pavel Drevinek
MICROBIOLOGY SPECTRUM
(2023)