Article
Instruments & Instrumentation
Cristina Pangua, Socorro Espuelas, Maria Cristina Martinez-Oharriz, Jose Luis Vizmanos, Juan M. Irache
Summary: The study aimed to develop a carrier for oral delivery of therapeutic protein bevacizumab by using mucus-permeating nanoparticles and permeation enhancers. The encapsulation of bevacizumab in PEG-coated albumin nanoparticles with sodium deoxycholate or sodium docusate significantly increased its oral bioavailability. This strategy could potentially allow the therapeutic use of orally administered proteins, including monoclonal antibodies.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Denisa Lizonova, Filip Hladek, Stanislav Chvila, Adam Balaz, Stepanka Stankova, Frantisek Stepanek
Summary: Pharmaceutical nanocrystals, particularly curcumin nanocrystals stabilized by phospholipids enriched with polyethylene glycol, show promise as a highly effective solution-like drug delivery system with improved bioactivity and anticancer potential.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Pharmacology & Pharmacy
Patrick Knoll, Giuseppe Francesco Racaniello, Valentino Laquintana, Florina Veider, Ahmad Saleh, Anna Seybold, Nunzio Denora, Andreas Bernkop-Schnuerch
Summary: The aim of this study was to evaluate the uptake mechanism of thiolated nanostructured lipid carriers (NLCs). NLCs with different modifications were evaluated for size, surface morphology, stability, cytotoxicity, adhesion to the cell surface, internalization, and their influence on paracellular permeability. The results showed that NLCs with shorter PEG chains and thiolation exhibited higher cellular uptake. The cellular uptake of all NLCs was mainly clathrin-mediated endocytosis, and thiolated NLCs also showed caveolae-dependent and clathrin-and caveolae-independent uptake.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Nanoscience & Nanotechnology
Yaru Zou, Wei Gao, Huizhen Jin, Chenmei Mao, Yi Zhang, Xiaoling Wang, Dong Mei, Libo Zhao
Summary: The present study investigates the uptake and trafficking mechanisms of 6-MP nanomedicines. The results demonstrate that 6-MP nanomedicines enhance oral bioavailability through multiple pathways, including active transport, paracellular transport, lymphatic delivery, and MRP4 transporter. These findings shed light on the cellular uptake and transcellular trafficking mechanisms of oral nanomedicines.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Chemistry, Multidisciplinary
Xue Li, Fan Xu, Donglei Yang, Pengfei Wang
Summary: A fusion protein was designed to enhance the cellular uptake efficiency and in vivo retention time of DNA nanostructures in cancer cells and mice, showing potential for facilitating the biological applications of DNA nanostructures.
Article
Biochemistry & Molecular Biology
Bartlomiej Dabrowski, Agnieszka Zuchowska, Artur Kasprzak, Grazyna Zofia Zukowska, Zbigniew Brzozka
Summary: Graphene oxide has potential applications in biomedicine, particularly as a drug carrier, due to its high surface area and functionalization capabilities. However, the internalization of graphene oxide inside mammalian cells is not well understood. Factors such as particle size and surface modifications can affect the cellular uptake of graphene oxide. Additionally, interaction with biological fluids can alter its biological properties. This study investigated the effect of graphene oxide particle size on internalization efficiency and the impact of serum components on its structure and interaction with cells.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Pharmacology & Pharmacy
Zonghua Tian, Yue Zhao, Yaping Mai, Fangxia Qiao, Jueshuo Guo, Luning Dong, Yang Niu, Guojing Gou, Jianhong Yang
Summary: This study demonstrates the potential of using nanocrystals for oral delivery of multicomponent anticancer drugs. The nanocrystals improved drug dissolution behavior and permeation through the mucus layer, enhanced cellular uptake, and improved intestinal absorption efficiency.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Biochemistry & Molecular Biology
Yue Hao, Shu Bai, Linling Yu, Yan Sun
Summary: In this study, a magnetically driven, mucus-inert Janus-type nanovehicle was fabricated, which effectively improved the diffusion and endocytosis of the nanovehicles in mucus.
Article
Engineering, Biomedical
Florina Veider, Patrick Knoll, Arne Matteo Joergensen, Daniel Stengel, Andreas Bernkop-Schnuerch
Summary: This study investigated the impact of the mucus gel barrier on the uptake of lipid-based nanocarriers by intestinal cells. Different surfactant-based nanoemulsions were developed and assessed. The results showed that zwitterionic and polyglycerol nanocarriers had similar mucus permeation properties as polyethylene glycol nanocarriers, but they exhibited higher cellular uptake. These findings suggest that zwitterionic and polyglycerol nanocarriers have the potential to overcome both the mucus and epithelial barriers of the mucosa.
ACTA BIOMATERIALIA
(2023)
Article
Chemistry, Multidisciplinary
J. S. Mortensen, S. S. -R Bohr, S. Harloff-Helleberg, N. S. Hatzakis, L. Saaby, H. M. Nielsen
Summary: This study investigated the interaction between the permeation enhancer SNAC and gastrointestinal mucus barrier. The results showed that SNAC altered the physical and barrier properties of intestinal mucus, but did not affect gastric mucus. The study highlights the importance of choosing the appropriate mucus model for such studies.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Chemistry, Multidisciplinary
Wufa Fan, Qiuyu Wei, Jiajia Xiang, Yisi Tang, Quan Zhou, Yu Geng, Yanpeng Liu, Rui Sun, Lei Xu, Guowei Wang, Ying Piao, Shiqun Shao, Zhuxian Zhou, Jianbin Tang, Tao Xie, Zichen Li, Youqing Shen
Summary: The study introduces a novel polymeric micelle that can penetrate mucus layer and be absorbed by villi, efficiently delivering anticancer drugs to tumors with improved therapeutic efficacy.
ADVANCED MATERIALS
(2022)
Article
Biochemistry & Molecular Biology
Eram Fathima, Ilaiyaraja Nallamuthu, T. Anand, Mahadeva Naika, Farhath Khanum
Summary: This study optimized the fabrication condition for folic acid-loaded chitosan nanoparticles and characterized their properties. The optimized formulation exhibited suitable particle size, zeta potential, and encapsulation efficiency, and demonstrated controlled release of folic acid. Both in vitro and in vivo experiments showed that these nanoparticles had good biocompatibility and absorption properties.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Engineering, Environmental
Yuping Xiang, Yingying Guo, Guangliang Liu, Yanwei Liu, Maoyong Song, Jianbo Shi, Ligang Hu, Yongguang Yin, Yong Cai, Guibin Jiang
Summary: A biosensor based on Escherichia coli was developed to assess the bioavailability of particle-bound mercury (HgP). The results showed that HgP uptake by microorganisms was ubiquitous in both oxic and anoxic environments, with enhanced bioavailability under anoxic conditions.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Zhenqi Liu, Alison B. Lansley, Tu Ngoc Duong, John D. Smart, Ananth S. Pannala
Summary: This study investigated the potential of novel polymer-surfactant-based formulations to improve the solubility and permeability of curcumin. The results showed that formulation A, containing Soluplus (R) and vitamin E TPGs, significantly increased the permeation and cellular uptake of curcumin compared to other samples.
Review
Anatomy & Morphology
Irina S. Sesorova, Ivan D. Dimov, Alexandre D. Kashin, Vitaly V. Sesorov, Natalia R. Karelina, Maria A. Zdorikova, Galina Beznoussenko, Alexander A. Mironov
Summary: The article provides an in-depth analysis of the process of lipid transcytosis through mammalian enterocytes and their absorption into lymph. It outlines the key steps involved in the process, including the role of cellular organelles and their interactions, leading to the functional outcomes of lipid transport.
Review
Chemistry, Multidisciplinary
Zhiyuan Shi, Yong Hu, Xin Li
Summary: Controlled drug delivery systems that can respond to mechanical force offer a unique solution for on-demand drug activation and release. Among various mechanical stimuli, ultrasound (US) has advantages in achieving spatiotemporally controlled drug release. Traditional US-triggered drug release relies on heat-induced phase transitions or chemical transformations, while the cutting-edge approach of Sonopharmacology leverages polymer mechanochemistry. The remaining challenges and potential future directions in this field are also discussed.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Lijie Zheng, Yuanzheng Chen, Xun Gu, Yingying Li, Hanqing Zhao, Wenjun Shao, Tao Ma, Chuanbin Wu, Qingqing Wang
Summary: In this study, a novel dosage form consisting of dissolving microneedles and an adhesive transdermal patch was developed for the treatment of rheumatoid arthritis. In vitro and in vivo experiments demonstrated that the combination of drugs delivered by this dosage form effectively reduced joint inflammation and damage.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Kyungjik Yang, Hwa Seung Han, Seung Hwan An, Kyung Hoon Park, Keonwook Nam, Shinha Hwang, Yuyeon Lee, Sung Yeon Cho, Taehyung Kim, Deokyeong Choe, Sang Won Kim, Wonkyu Yu, Hyunah Lee, Jiyong Park, Sangguan You, Dong- Gyu Jo, Ki Young Choi, Young Hoon Roh, Jae Hyung Park
Summary: This study developed CP-loaded CS microcapsules to enhance the oral bioavailability of CP through controlled gastrointestinal delivery. The optimized microcapsules exhibited desirable physicochemical properties, showed anti-photoaging effects via antioxidant activity, and achieved controlled release in the gastrointestinal tract. This research provides a simple and economical approach for enhancing the oral bioavailability of CP for customized bioactive compound administration.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Huiyang Li, Shuo Liu, Wenjin Dai, Bingmei Yao, Yong Zhou, Sujia Si, Hairong Yu, Riguang Zhao, Fang Jin, Liqun Jiang
Summary: Changes in bodily fluid pressures are crucial in diseases like high-altitude pulmonary edema (HAPE). Researchers have developed hydrostatic pressure-sensitive multivesicular liposomes (PSMVLs) that can release drugs in response to pressure changes, with potential applications in HAPE treatment. Animal experiments showed that this system provides better protection for lung tissues and respiratory function, reducing the occurrence of pulmonary edema.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Qian Hu, Hongbing Lan, Yinmei Tian, Xiaonan Li, Mengmeng Wang, Jiao Zhang, Yulin Yu, Wei Chen, Li Kong, Yuanyuan Guo, Zhiping Zhang
Summary: Coacervate droplets formed through liquid-liquid phase separation have potential as delivery vesicles for therapeutics. However, their lack of physiological stability and membranes are challenges. In this study, polylysine-polynucleotide complex coacervate droplets with favorable stability were formulated to concentrate molecules and nanoparticles. Phospholipid membranes were further coated on the droplets to create coacervate-based artificial protocells (ArtPC) with membrane-like structures. These biofunctional ArtPC effectively reduced blood uric acid levels and prevented renal injuries.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Xiaowei Wang, Hongwei Lu, Fang Luo, Dan Wang, Apeng Wang, Xuelei Wang, Wenkai Feng, Xiaobo Wang, Jiayi Su, Mingliang Liu, Guimin Xia
Summary: Four novel lipid-like GEM diesters were synthesized and encapsulated into liposomes to improve the antitumor efficacy of Gemcitabine. The liposomes loaded with dimyristoyl GEM (LipodmGEM) showed enhanced cellular uptake, improved inhibition of cell migration, and a greatly extended half-life compared to free Gemcitabine. LipodmGEM successfully enriched the drug in the tumor and exhibited excellent anticancer efficacy in vivo with negligible systemic toxicity.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Pengyu Li, Jieyi Pan, Yating Dong, Yingying Sun, Yalong Wang, Kang Liao, Yili Chen, Xin Deng, Shihui Yu, Haiyan Hu
Summary: Chronic pulmonary infection caused by Pseudomonas aeruginosa is a serious public health problem with high mortality rates. In this study, infection-microenvironment responsive nanoparticles were developed to eradicate biofilms and inhibit virulence. These nanoparticles showed promising results in treating chronic pulmonary infections.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Yajing Sun, Ze Lu, John A. Taylor, Jessie L. S. Au
Summary: A recent development in cancer chemotherapy is the use of cytotoxics to induce tumor-specific immune response through immunogenic cell death (ICD). This study describes a method that utilizes immunostaining and machine-learning to identify cells with ecto-CRT in intact 3-dimensional tissues. The method was successfully applied to study drug-induced ICD in human bladder cancer.
JOURNAL OF CONTROLLED RELEASE
(2024)
Review
Chemistry, Multidisciplinary
Rafat Ali, Shantanu Sen, Rohil Hameed, Aamir Nazir, Sandeep Verma
Summary: This review provides a focused overview of emerging strategies for delivering gasotransmitters in a controlled and sustained manner to reestablish neurophysiological homeostasis.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Jing Chen, Xinyi Zhang, Jinshen Zhang, Zhaoxia Wang, Guilan Zhu, Ming Geng, Jinmiao Zhu, Yajun Chen, Wei Wang, Youcui Xu
Summary: In this study, a multifunctional responsive hydrogel system was developed for synergistic reoxygenation and chemo/photothermal therapy. The hydrogel system showed both therapeutic effects against metastatic breast cancer and wound infection, making it a promising strategy for treating and preventing tumor recurrence and associated wound infection.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Baoshan Huang, Na Zhang, Xinying Qiu, Rui Zeng, Shuimiao Wang, Mengxia Hua, Qing Li, Kaihui Nan, Sen Lin
Summary: This study revealed that robust ROS can oxidize mitochondrial DNA (ox-mtDNA) and cause its release into the cytosol, resulting in the activation of NLRP3 inflammasome. By using the mitochondria-targeted antioxidant SkQ1 and a novel mitochondria-targeted nanoparticle (SkQ1 NP), it was found that mitochondrial ROS scavenging could in situ inhibit DED-induced mtDNA oxidation and suppress NLRP3-mediated inflammation.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Wenqi Liu, Cheng Hu, Linyu Long, Shuyi He, Wen Zhang, Zhicun Wang, Li Yang, Yunbing Wang
Summary: Myocardial infarction is the leading cause of cardiovascular mortality, and current treatment methods have limitations. This study developed a smart carrier that can release different therapeutic substances for different pathological processes, effectively improving cardiac function, promoting cardiac repair, and preventing ventricular remodeling.
JOURNAL OF CONTROLLED RELEASE
(2024)