期刊
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
卷 105, 期 1, 页码 85-95出版社
ENDOCRINE SOC
DOI: 10.1210/clinem/dgz031
关键词
type 1 diabetes; preeclampsia; carotid atherosclerosis; vascular ultrasonography; cardiovascular disease
资金
- Menarini
- Associacio Catalana de Diabetis (ACD), Ajut per a la recerca en diabetis modalitat clinica 2018
Purpose: Although preeclampsia (PE) is a well-established cardiovascular risk factor (CVRF) in the general population, its role in type 1 diabetes (T1D) has been scarcely studied. We assessed the association between PE and preclinical atherosclerosis in T1D. Methods: We recruited 112 women without cardiovascular disease and last pregnancy >= 5 years before: (1) T1D and previous PE (T1D(+)/PE+; n = 28); (2) T1D without preeclampsia (T1D(+)/PE-; n = 28); (3) previous PE without T1D (T1D-/PE+; n = 28); and (4) controls (without T1D or PE; T1D(-)/PE-; n = 28). Groups were matched by age, several CVRFs, and diabetes duration and retinopathy (in T1D participants). Carotid intima-media thickness (IMT) and the presence of plaque (IMT >= 1.5 mm) were assessed by standardized ultrasonography protocol. Results: Mean age of the participants was 44.9 +/- 7.8 years (14.3% hypertension and 21.4% active smokers). Groups including T1D (T1D(+)/PE+ and T1D(+)/PE-) more frequently presented hypertension and statin treatment (23.2% vs 5.4% and 37.5% vs 8.9%; respectively; P < 0.01), without differences in other CVRFs. Carotid plaques were observed in 20.5%. In multivariate models adjusted for age, CVRF, and statins, both T1D and PE showed a similar impact on the presence of plaque, with odds ratios (95% confidence interval), 5.45 (1.36-21.9) and 4.24 (1.04-17.3), respectively. Both entities showed an additive effect when combined, both in common carotid-IMT (T1D(+)/PE- or T1D(-)/PE+, beta = 0.198; T1D(+)/PE+, beta = 0.297) and in the presence of plaque (8.53 [1.07-68.2] and 28.1 [2.67-296.4], respectively). Conclusions: Previous PE was independently associated with preclinical atherosclerosis in T1D. Further studies are needed to ascertain its usefulness for stratifying risk in T1D women.
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