期刊
JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
卷 15, 期 10, 页码 2142-2148出版社
AMER SCIENTIFIC PUBLISHERS
DOI: 10.1166/jbn.2019.2829
关键词
Antimicrobial Photodynamic Inactivation; Gram-Positive Bacteria; Gram-Negative Bacteria; Copper-Cysteamine Nanoparticles; Reactive Oxygen Species
资金
- National Natural Science Foundation of China [81860369, 81472002, 81774374, 81373700]
- Guangxi Scientific and Technological Project [1355005-1-2]
- Guangxi Natural Science Foundation [2014GXNSFAA118162, 2016GXNSFAA380312]
- US NIH [R01AI050875, R21AI121700]
- U.S. Army Medical Research Acquisition Activity (USAMRAA) [W81XWH-10-1-0279, W81XWH-10-1-0234]
- NIH/NCI [1R15CA199020-01A1]
Copper-cysteamine (Cu-Cy) nanoparticles (NPs) are a new type of sensitizers that can be activated by UV light, X-rays, microwaves and ultrasound to produce reactive oxygen species for cancer treatment. Here, for the first time, we explored Cu-Cy NPs for bacteria inactivation by treating gram-positive bacteria (methicillin-resistant Staphylococcus aureus and Enterococcus faecalis) and gram-negative bacteria (Escherichia coli and Acinetobacter baumannii), respectively. The results show that Cu-Cy NPs are very effective in killing gram-positive bacteria but are quite limited in killing gram-negative bacteria yet. The major killing mechanism is cell damage by singlet oxygen and Cu-Cy NPs are potential agents for bacteria inactivation.
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