Radical SAM enzymes: surprises along the path to understanding mechanism

The Elusive 5′-Deoxyadenosyl Radical: Captured and Characterized by Electron Paramagnetic Resonance and Electron Nuclear Double Resonance Spectroscopies

(2019) Hao Yang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Paradigm Shift for Radical S-Adenosyl-l-methionine Reactions: The Organometallic Intermediate Ω Is Central to Catalysis

(2018) Amanda S. Byer et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Organometallic and radical intermediates reveal mechanism of diphthamide biosynthesis

(2018) Min Dong et al.   SCIENCE

Mechanism of Radical Initiation in the Radical S-Adenosyl-l-methionine Superfamily

(2018) William E. Broderick et al.   ACCOUNTS OF CHEMICAL RESEARCH

Monovalent Cation Activation of the Radical SAM Enzyme Pyruvate Formate-Lyase Activating Enzyme

(2017) Krista A. Shisler et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The photochemistry and photobiology of vitamin B12

(2017) Alex R. Jones   PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES

Radical SAM catalysis via an organometallic intermediate with an Fe-[5'-C]-deoxyadenosyl bond

(2016) M. Horitani et al.   SCIENCE

Energy Cascades, Excited State Dynamics, and Photochemistry in Cob(III)alamins and Ferric Porphyrins

(2015) Aaron S. Rury et al.   ACCOUNTS OF CHEMICAL RESEARCH

Why Nature Uses Radical SAM Enzymes so Widely: Electron Nuclear Double Resonance Studies of Lysine 2,3-Aminomutase Show the 5′-dAdo• “Free Radical” Is Never Free

(2015) Masaki Horitani et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Radical S-Adenosylmethionine Enzymes

(2014) Joan B. Broderick et al.   CHEMICAL REVIEWS

Flavodoxin cofactor binding induces structural changes that are required for protein–protein interactions with NADP+ oxidoreductase and pyruvate formate-lyase activating enzyme

(2013) Adam V. Crain et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

The Structure–Function Linkage Database

(2013) Eyal Akiva et al.   NUCLEIC ACIDS RESEARCH

Structural Insights into Radical Generation by the Radical SAM Superfamily

(2011) Jessica L. Vey et al.   CHEMICAL REVIEWS

S K-edge XAS and DFT Calculations on SAM Dependent Pyruvate Formate-Lyase Activating Enzyme: Nature of Interaction between the Fe4S4Cluster and SAM and its Role in Reactivity

(2011) Abhishek Dey et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Control of radical chemistry in the AdoMet radical enzymes

(2009) Kaitlin S Duschene et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

The Radical SAM Superfamily

(2008) Perry A. Frey et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

X-ray Structure of the [FeFe]-Hydrogenase Maturase HydE fromThermotoga maritima

(2008) Yvain Nicolet et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural basis for glycyl radical formation by pyruvate formate-lyase activating enzyme

(2008) J. L. Vey et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA