Article
Chemistry, Applied
Guo Huang, Guichen Liu, Zejian Xu, Lianzhou Jiang, Yan Zhang, Xiaonan Sui
Summary: Modifying proteins with pH shifting treatment and carboxymethyl chitosan can improve the stability of Pickering emulsions. The pH shifting treatment decreases the particle size of soy protein and enhances its affinity to carboxymethyl chitosan. The addition of carboxymethyl chitosan changes the particle size distribution of soy protein and improves the stability of Pickering emulsions.
FOOD HYDROCOLLOIDS
(2023)
Article
Chemistry, Physical
Shaochun Su, Li Hao, Huayao Chen, Xinhua Zhou, Hongjun Zhou
Summary: This study demonstrates the potential application of amphiphilic chitosan oligosaccharide nanoparticles as carriers for pesticides, improving their delivery and release properties for effective pest management and plant growth.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2023)
Article
Chemistry, Multidisciplinary
Zhenyao Wu, Jie Li, Xin Zhang, Yangjia Li, Dongwei Wei, Lichang Tang, Shiming Deng, Guijin Liu
Summary: The objective of this study was to design and fabricate a natural zein-based nanocomposite for the delivery of anticancer drugs. The core-shell nanoparticles were successfully produced with folate-conjugated zein as the core and a shell made of soy lecithin and carboxymethyl chitosan. Docetaxel was encapsulated into the nanoparticles, which increased drug dissolution and cytotoxicity.
Article
Pharmacology & Pharmacy
Ahmed M. Omer, Maha S. Ahmed, Gehan M. El-Subruiti, Randa E. Khalifa, Abdelazeem S. Eltaweil
Summary: Alg-CMCs@AmCs dual polyelectrolyte complexes were successfully employed as a pH-sensitive drug carrier for efficient encapsulation and release of diclofenac sodium. The developed microcapsules showed excellent stability and high encapsulation efficiency under colonic conditions, suggesting great potential for practical applications.
Article
Biochemistry & Molecular Biology
Kyeong-Jung Kim, Min-Jin Hwang, Wang-Geun Shim, Young -Nam Youn, Soon Do Yoon
Summary: The study synthesized CTP-incorporated biomaterials for antihypertensive therapy and found that these materials have excellent drug release capacity and significant inhibition effect on cardiovascular disease.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Xin Zhang, Yangjia Li, Zhenyao Wu, Jie Li, Junjian Li, Shiming Deng, Guijin Liu
Summary: The objective of this work is to develop zein-based nanoparticles for the delivery of natural polyphenols. Through the atomizing/antisolvent precipitation process, carboxymethyl chitosan-coated zein/soy lecithin nanoparticles were successfully fabricated. These nanoparticles showed desirable redispersibility and physicochemical stability. The encapsulation of resveratrol in the optimized zein-based nanoparticles resulted in improved dissolution rate, bioaccessibility, and scavenging activity compared to free resveratrol. The nanoparticles also exhibited a higher retention rate during storage. Therefore, zein-based nanoparticles have great potential as carriers for natural polyphenols.
Article
Chemistry, Applied
Ming Zhao, Hongjun Zhou, Li Hao, Huayao Chen, Xinhua Zhou
Summary: The CMC-g-PRSG carrier-based nanopesticide AVM@CMC-g-PRSG prepared in this study enhances the dispersibility and stability of AVM in water, allowing prolonged control of pests and reducing toxicity to aquatic animals.
CARBOHYDRATE POLYMERS
(2021)
Article
Chemistry, Applied
Chunli Xu, Lidong Cao, Muhammad Bilal, Chong Cao, Pengyue Zhao, Hongjun Zhang, Qiliang Huang
Summary: Carboxymethyl chitosan (CMCS) is a promising biopolymer carrier for controlled release formulations of pesticides. In this study, a manganese-based carboxymethyl chitosan hydrogel was prepared to encapsulate and release fungicide prothioconazole in a controllable manner, with faster release in neutral and slightly alkaline solutions.
CARBOHYDRATE POLYMERS
(2021)
Article
Biochemistry & Molecular Biology
Ruiquan Hou, Chao Li, Yuting Tan, Yongqing Wang, Suqing Huang, Chen Zhao, Zhixiang Zhang
Summary: In this study, a pH-controlled release carrier was used to encapsulate the insecticide chlorfenapyr (CF) and enhance its insecticidal activity while reducing toxicity to bees. The nanopesticide CF@O-CMCS was shown to have excellent pH release dependence and was more effective at controlling Spodoptera frugiperda larvae compared to CF SC. It also had lower toxicity to worker bees, making it a safer option for sustainable agriculture.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Nuo Wei, Ze Lv, Xiaohan Meng, Qianwei Liang, Tianzhen Jiang, Shaoyang Sun, Yan Li, Jianguo Feng
Summary: The development of controlled release formulations for agrochemicals has been driven by increasing concerns about environmental pollution. In this study, a convenient polysaccharide hydrogel was successfully prepared for the controlled release of a specific agrochemical. The hydrogel exhibited excellent agrochemical load capacity and encapsulation efficiency. It also showed promising protective properties for the encapsulated agrochemical, resulting in better control against a specific plant disease. Safety assessment studies further demonstrated the hydrogel's good biocompatibility with non-targeted organisms and the crop.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Yujia Dong, Yanhui He, Daidi Fan, Zhansheng Wu
Summary: In this study, ginsenoside loaded nanoparticles were prepared using an ionic cross-linking method, which provided a sustained slow release effect of ginsenoside Rb1 in the intestinal fluid through intelligent response. The nanoparticles exhibited good pH sensitivity and controlled release properties in buffer solutions of different pH's. The results showed that CDA3.6-NPs can effectively control release and intelligently deliver ginsenoside Rb1, which could be a promising alternative for oral delivery.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Applied
Meng Cheng, Yingjun Cui, Yanli Guo, Peixin Zhao, Juan Wang, Rongfei Zhang, Xiangyou Wang
Summary: pH-responsive CC/SA/CA hydrogels were prepared using CC and SA as wall materials, with the hydrogel formation attributed to electrostatic interactions and hydrogen bonding. The hydrogels exhibited improved thermostability with increasing CC content, as well as increased swelling degree with higher pH of the buffer solution. CA release from the hydrogels was mainly controlled by Fickian diffusion, and the release rate was positively correlated with temperature and environmental pH, allowing for on-demand release of CA. The hydrogels also showed good storage stability, antioxidant and antibacterial activities, and biocompatibility, making them a promising platform for environmentally-responsive preservatives with precise release and intelligent preservation capabilities.
Article
Biochemistry & Molecular Biology
Mengmeng Wang, Yipeng Zang, Kangjin Hong, Xiaofeng Zhao, Chenrui Yu, Dandan Liu, Zichao An, Liyuan Wang, Wenjin Yue, Guangjun Nie
Summary: A novel strategy was designed to construct a pH-sensitive hydrogel structure that is stable in simulated gastric fluid but breaks down in simulated intestinal fluid. The structure showed a high embedding rate of Bacillus subtilis natto and sustained release for over 10 hours, balancing the conflicting properties of pH sensitivity and sustained release.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Biochemistry & Molecular Biology
Ashiq Hussain Pandit, Safiya Nisar, Khalid Imtiyaz, Masood Nadeem, Nasreen Mazumdar, M. Moshahid Alam Rizvi, Sharif Ahmad
Summary: The synthesized N,O-CMCS/MAGG hydrogel showed promising applications in localized delivery of anticancer drugs. The hydrogel exhibited pH-responsive swelling behavior, good mechanical properties, excellent self-healing and thixotropic properties due to the reversible Schiff base linkages. The Dox-loaded hydrogel demonstrated significant killing effect against breast cancer cells, indicating its potential in anticancer drug delivery.
Article
Chemistry, Applied
Hekai Zhao, Shengnan Wang, Xiulin Liu, Guilan Zhao, Lina Yang, Hong Song, Guangchen Zhang, Yutang He, He Liu
Summary: The non-covalent complex of soy protein isolate fiber and soy soluble polysaccharide was used to create a pH-responsive emulsion system, demonstrating stability and drug release at different pH values.
Article
Multidisciplinary Sciences
Long Chen, Hongjun Zhou, Li Hao, Huayao Chen, Xinhua Zhou
ROYAL SOCIETY OPEN SCIENCE
(2019)
Article
Agricultural Engineering
Long Chen, Hongjun Zhou, Li Hao, Ziyong Li, Hua Xu, Huayao Chen, Xinhua Zhou
INDUSTRIAL CROPS AND PRODUCTS
(2020)
Article
Chemistry, Multidisciplinary
Mei Guan, Li Hao, Long Chen, Fan Gao, Songfa Qiu, Hongjun Zhou, Huayao Chen, Xinhua Zhou
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
(2020)
Article
Agronomy
Long Chen, Yuanxiong Lin, Hongjun Zhou, Li Hao, Huayao Chen, Xinhua Zhou
Summary: Polyamine-modified zein (AM-zein) was synthesized to improve stability as a nanocarrier, enhance electrostatic force, and prepare AVM-loaded nanoparticles with high positive charge. The nanoparticles showed better leaf affinity and UV barrier effect. Additionally, they demonstrated significantly lower toxicity against zebrafish.
PEST MANAGEMENT SCIENCE
(2021)
