Article
Multidisciplinary Sciences
Jaakko Silvola, Kirsi Grondahl-Yli-Hannuksela, Tiina Hirvioja, Kaisu Rantakokko-Jalava, Esa Rintala, Kari Auranen, Jenna Junnila, Harri Marttila, Laura Lindholm, Jaana Vuopio
Summary: The incidence of MRSA infections in Finland has been relatively low, but the t172 strain has been increasing in Southwest Finland. By studying the molecular epidemiology of t172-MRSA, the transmission of this strain was better understood. Whole genome sequencing revealed the presence of multiple t172-MRSA subclones in regional healthcare and the community, highlighting the importance of targeted surveillance.
SCIENTIFIC REPORTS
(2022)
Article
Environmental Sciences
Long-Jiang Mu, Xiao-Yu Wang
Summary: The Beaufort Gyre is a crucial reservoir of freshwater in the Arctic Ocean. Through modeling and numerical simulation, the study provides insights into the processes related to the change in freshwater content and identifies sea surface salinity restoring and weak vertical background diffusivity as important factors affecting the ocean structure and freshwater variations in the Beaufort Gyre.
ADVANCES IN CLIMATE CHANGE RESEARCH
(2022)
Article
Food Science & Technology
Zengfeng Zhang, Shoukui He, Xuebin Xu, Jiang Chang, Zeqiang Zhan, Yan Cui, Chunlei Shi, Xianming Shi
Summary: The study revealed an increase in antimicrobial resistance in Salmonella enterica serovar Indiana in China, particularly to ciprofloxacin and ceftriaxone. The detection of drug-resistant strains poses a significant threat to food safety and public health.
Article
Microbiology
Ye Jin, Wangxiao Zhou, Qing Zhan, Beiwen Zheng, Yunbo Chen, Qixia Luo, Ping Shen, Yonghong Xiao
Summary: Since 2010, MRSA ST59 has gradually replaced ST239 to become the dominant clone in most hospitals in China. ST59 clones demonstrate higher susceptibility to antibiotics, and the detection of virulence factors suggests that sak and chp genes may contribute to their successful spread.
Article
Infectious Diseases
Zheng Yin, Alison E. Brown, Brian D. Rice, Gaetano Marrone, Anders Sonnerborg, Barbara Suligoi, Andre Sasse, Dominique Van Beckhoven, Teymur Noori, Vincenza Regine, Valerie C. Delpech
Summary: Migrants in Europe are at risk of acquiring HIV post-migration, regardless of origin, sex and exposure to HIV. Factors such as younger age at arrival and longer time since migration are predictors of this risk. Prevention activities should be targeted towards migrant communities to address this issue.
Article
Microbiology
Aida Hamdan-Partida, Samuel Gonzalez-Garcia, Francisco Javier Martinez-Ruiz, Miguel Angel Zavala-Sanchez, Anaid Bustos-Hamdan, Jaime Bustos-Martinez
Summary: The aim of this study was to determine the source of contamination of mobile phones and characterize the corresponding genotypic and phenotypic properties of the isolated strains of Staphylococcus aureus. The study found that the strains of S. aureus present in the nose and/or pharynx of phone owners can contaminate mobile phones, and these strains can have different genotypes.
Article
Infectious Diseases
James A. Karlowsky, Melanie R. Baxter, Andrew J. Walkty, Philippe R. S. Lagace-Wiens, Denice Bay, Heather J. Adam, George G. Zhanel
Summary: This study found that fosfomycin has in vitro activity against common Gram-positive and Gram-negative urinary pathogens. However, further study is needed before applying the existing breakpoints to pathogens not specified by standard methods.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2022)
Article
Orthopedics
Robert A. Burnett, Joseph Serino, JaeWon Yang, Craig J. Della Valle, P. Maxwell Courtney
Summary: The study found a substantial decline in post-acute care costs and resource utilization following TKA, with the most significant decrease occurring after the introduction of Medicare bundled payment models in 2013. This downward trend in costs and resource utilization highlights the impact of advancements in perioperative care on improving efficiency and reducing healthcare expenditure.
JOURNAL OF ARTHROPLASTY
(2021)
Article
Oceanography
C. DeFrancesco, C. Gueguen, W. J. Williams, S. Zimmermann
Summary: The interannual variability of fluorescent dissolved organic matter (FDOM) in the Pacific- and Atlantic-derived halocline and Atlantic waters of the Canada Basin was studied. A seven-component model was validated using fluorescence spectroscopy excitation-emission matrices and parallel factor analysis. Over the 11-year period, humic-like intensities increased, particularly in shallower waters, while no significant trends were observed for protein-like intensities. The changes in humic-like fluorescence intensities may be attributed to alterations in Bering Strait inflow and freshwater accumulation in the Beaufort gyre.
JOURNAL OF GEOPHYSICAL RESEARCH-OCEANS
(2023)
Article
Microbiology
Henrike Krueger-Haker, Xing Ji, Dennis Hanke, Stefan Fiedler, Andrea T. Fessler, Nansong Jiang, Heike Kaspar, Yang Wang, Congming Wu, Stefan Schwarz
Summary: This study investigated the genomic diversity and antimicrobial resistance traits of Livestock-associated methicillin-resistant Staphylococcus aureus (LA-MRSA) clonal complex 398 isolates collected from diseased swine in Germany. The isolates displayed close phylogenetic relationships but a wide molecular variety, and harbored a wide range of antimicrobial resistance properties. The study highlights the importance of monitoring and preventing the spread of LA-MRSA in swine husbandry facilities and the human community.
MICROBIOLOGY SPECTRUM
(2023)
Article
Infectious Diseases
Puthiya Purayil Preeja, Sanath H. Kumar, Veena Shetty
Summary: The study revealed the prevalence, molecular characteristics, and antibiotic resistance profiles of CA-MRSA in a tertiary care hospital in Mangalore, India. It found that CA-MRSA showed higher resistance to certain antibiotics compared to HA-MRSA, indicating the urgent need to address the emergence of multidrug-resistant CA-MRSA in healthcare settings.
Article
Medicine, General & Internal
Kathleen M. Decker, Pascal Lambert, Jen Bravo, Alain Demers, Harminder Singh
Summary: This study analyzed colorectal cancer (CRC) incidence rates in Canada from 1992 to 2016 and found variations by age group and income quintile. The results indicate a noticeable increase in CRC incidence rates among younger individuals, particularly in the lower income quintiles. Targeted interventions and further research are needed to address this issue.
Article
Infectious Diseases
Jiahui Huang, Feng Zhang, Jumei Zhang, Jingsha Dai, Dongli Rong, Miao Zhao, Juan Wang, Yu Ding, Moutong Chen, Liang Xue, Qihui Gu, Shi Wu, Qingping Wu
Summary: The study revealed the molecular characteristics of rifampin-resistant Staphylococcus aureus in retail food samples in China from 2011 to 2016. The majority of isolates were resistant to multiple antibiotics, with mutations in the rpoB gene contributing to rifampin resistance. Different genetic backgrounds were observed among the strains, highlighting the concerning presence of MRSA in retail food.
Article
Parasitology
Rebecca A. Guy, Christine A. Yanta, Pia K. Muchaal, Marisa A. Rankin, Karine Thivierge, Rachel Lau, Andrea K. Boggild
Summary: This study identified species and subtypes of Cryptosporidium in clinical cases from Ontario, Canada, revealing that zoonotic transmission is the main route of cryptosporidiosis transmission in the region. However, the presence of C. hominis in about a quarter of cases suggests that anthroponotic transmission is also an important contributor to cryptosporidiosis pathogenesis in Ontario.
PARASITES & VECTORS
(2021)
Article
Green & Sustainable Science & Technology
Shurui Jiang, Xue Tan, Peiqi Hu, Yue Wang, Lei Shi, Zhong Ma, Genfa Lu
Summary: This study examines the interrelationship between economic growth and air pollution in China's 2 + 26 cities from 2007 to 2016. The results reveal an unbalanced spatial agglomeration effect and a U-shaped relationship between economic growth and air pollution.
JOURNAL OF CLEANER PRODUCTION
(2022)
Article
Infectious Diseases
Andrew J. Denisuik, Lauren A. Garbutt, Alyssa R. Golden, Heather J. Adam, Melanie Baxter, Kimberly A. Nichol, Philippe Lagace-Wiens, Andrew J. Walkty, James A. Karlowsky, Daryl J. Hoban, Michael R. Mulvey, George G. Zhanel
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2019)
Article
Microbiology
J. J. LeBlanc, M. ElSherif, S. Mulpuru, M. Warhuus, A. Ambrose, M. Andrew, G. Boivin, W. Bowie, A. Chit, G. Dos Santos, K. Green, S. A. Halperin, T. F. Hatchette, B. Ibarguchi, J. Johnstone, K. Katz, J. M. Langley, P. Lagace-Wiens, M. Loeb, A. Lund, D. MacKinnon-Cameron, A. McCarthy, J. E. McElhaney, A. McGeer, A. Poirier, J. Powis, D. Richardson, M. Semret, V Shinde, D. Smyth, S. Trottier, L. Valiquette, D. Webster, L. Ye, S. A. McNeil
JOURNAL OF MEDICAL MICROBIOLOGY
(2020)
Article
Infectious Diseases
Christiaan H. Righolt, Philippe Lagace-Wiens, Salaheddin M. Mahmud
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
(2020)
Article
Infectious Diseases
Alyssa R. Golden, Heather J. Adam, Melanie Baxter, Andrew Walkty, Philippe Lagace-Wiens, James A. Karlowsky, George G. Zhanel
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
(2020)
Review
Pharmacology & Pharmacy
George G. Zhanel, Jenine Esquivel, Sheryl Zelenitsky, Courtney K. Lawrence, Heather J. Adam, Alyssa Golden, Rachel Hink, Liam Berry, Frank Schweizer, Michael A. Zhanel, Denice Bay, Philippe R. S. Lagace-Wiens, Andrew J. Walkty, Joseph P. Lynch, James A. Karlowsky
Editorial Material
Medicine, General & Internal
Carl Boodman, Philippe Lagace-Wiens, Jared Bullard
CANADIAN MEDICAL ASSOCIATION JOURNAL
(2020)
Article
Public, Environmental & Occupational Health
Christiaan H. Righolt, Geng Zhang, Gregory W. Hammond, Philippe Lagace-Wiens, Salaheddin M. Mahmud
INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY
(2020)
Article
Microbiology
James A. Karlowsky, Philippe R. S. Lagace-Wiens, Nancy M. Laing, Melanie R. Baxter, Heather J. Adam, George G. Zhanel
JOURNAL OF CLINICAL MICROBIOLOGY
(2020)
Editorial Material
Medicine, General & Internal
Carl Boodman, Terence Wuerz, Philippe Lagace-Wiens
CANADIAN MEDICAL ASSOCIATION JOURNAL
(2020)
Review
Pharmacology & Pharmacy
George G. Zhanel, Christina Deng, Sheryl Zelenitsky, Courtney K. Lawrence, Heather J. Adam, Alyssa Golden, Liam Berry, Frank Schweizer, Michael A. Zhanel, Neal Irfan, Denice Bay, Philippe Lagace-Wiens, Andrew Walkty, Lionel Mandell, Joseph P. Lynch, James A. Karlowsky
Summary: Lefamulin is a novel oral and intravenous pleuromutilin developed for community-acquired bacterial pneumonia, with a unique mechanism of action and broad-spectrum antibacterial activity. It has been approved by FDA, EMA, and Health Canada for the treatment of CABP.
Article
Immunology
Carl Boodman, Catherine Smith, Ken von Kuster, Philippe Lagace-Wiens, Terence Wuerz
Summary: The ongoing epidemic of intravenous opioid and methamphetamine use in North America is associated with an increased risk of bacteremia from environmental organisms. This study reports a case of Mycobacterium mucogenicum bacteremia and soft tissue infection in a person who uses tap water to inject drugs.
OPEN FORUM INFECTIOUS DISEASES
(2021)
Editorial Material
Medicine, General & Internal
Carl Boodman, Terence Wuerz, Philippe Lagace-Wiens
CANADIAN MEDICAL ASSOCIATION JOURNAL
(2021)
Article
Infectious Diseases
George G. Zhanel, Justin Kosar, Melanie Baxter, Rita Dhami, Sergio Borgia, Neal Irfan, Kelly S. MacDonald, Gordon Dow, Philippe Lagace-Wiens, Maxime Dube, Marco Bergevin, Carlo Tascini, Yoav Keynan, Andrew Walkty, James Karlowsky
Summary: Ceftobiprole is used in Canada as a directed therapy for treating severe infections caused by MRSA, often in combination with daptomycin or vancomycin. Treatment duration is typically over 10 days, with high rates of microbiological and clinical success and a good safety profile.
JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE
(2021)
Article
Microbiology
David C. Alexander, Robert M. Taylor, Irene Martin, Heather Adam, Philippe Lagace-Wiens, Peter Pieroni, James A. Karlowsky, Paul Van Caeseele
Summary: This study compared the performance of microscopy, culture, and the Hologic Aptima Combo 2 (AC2) assay for detecting Neisseria gonorrhoeae in joint fluid specimens. The results showed that AC2 was more sensitive than culture for diagnosing gonococcal arthritis.
JOURNAL OF CLINICAL MICROBIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Courtney K. Lawrence, Chris Sathianathan, Mauro Verrelli, Philippe Lagace-Wiens, Robert Ariano, Grace Badejo, Michelle L. Boyce, J. Christine Davis, Sheryl A. Zelenitsky
CANADIAN JOURNAL OF HOSPITAL PHARMACY
(2020)