Article
Pharmacology & Pharmacy
Elsaied H. Barakat, Mohamed A. Akl, Mohamed F. Ibrahim, Hamdy Mohamed Dawaba, Mohsen I. Afouna
Summary: The goal of this study was to develop, optimize, and evaluate an effective colon target delivery system for the treatment of ulcerative colitis. The results showed that the optimized formulation significantly improved theophylline distribution to the colon and reduced inflammation compared to a pure theophylline solution.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Engineering, Biomedical
Hao Wang, Dandan Su, Rufan Huang, Fan Shu, Fang Cheng, Gang Zheng
Summary: The study introduces a new therapy for treating psoriasis by functionalizing cell membranes with metabolic glycoengineering method, achieving targeted treatment effect to effectively reduce overproliferating keratinocytes and modulate immunity.
ACTA BIOMATERIALIA
(2021)
Article
Biochemistry & Molecular Biology
Sherif Ashraf Fahmy, Asmaa Ramzy, Amany M. Sawy, Mohamed Nabil, Mohamed Z. Gad, Mohamed El-Shazly, Mourad A. M. Aboul-Soud, Hassan Mohamed El-Said Azzazy
Summary: This study designed and optimized a niosomal vesicular nanoplatform loaded with ozonated olive oil (OL) to improve its solubility, skin permeation, and anticancer activity. The encapsulated OL showed enhanced water solubility, skin permeation, and double the anticancer activity compared to free OL.
Article
Biophysics
Supriya Mehta, Shweta Dumoga, Sahil Malhotra, Neetu Singh
Summary: Liposomes and red blood cell-derived nanovesicles are two ideal drug delivery vehicles. Liposomes, conjugated with PEG, have been used in several nano-medicines on the market, while nanovesicles derived from red blood cells may not stimulate the immune system due to the presence of self-recognition markers. However, a direct comparison between the two is still lacking.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Biotechnology & Applied Microbiology
Kashif Iqbal, Sidra Khalid, Craig A. McElroy, Muhammad Adnan, Gul Majid Khan, M. Junaid Dar
Summary: This study developed and evaluated detergent-free nanovesicles, H-ENVs, for the topical treatment of cutaneous leishmaniasis. The results showed that H-ENVs improved the efficacy of the drugs and could be a safe choice for the treatment of cutaneous leishmaniasis.
Article
Instruments & Instrumentation
Mohd Danish Ansari, Sadat Shafi, Jayamanti Pandit, Ayesha Waheed, Rao Nargis Jahan, Iram Khan, Divya Vohora, Shreshta Jain, Mohd Aqil, Yasmin Sultana
Summary: This research evaluates the use of spanlastic nanogel for transdermal delivery of raloxifene to improve its bioavailability and manage osteoporosis. The nanogel exhibited suitable viscosity and spreadability for transdermal application, and it did not cause skin irritation. The transdermal administration of the nanogel showed significantly higher bioavailability compared to oral administration, without any toxic effects. Therefore, spanlastic nanogel could be a better approach for delivering raloxifene via transdermal route to treat osteoporosis.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2023)
Article
Dermatology
M. G. Lebwohl, L. Stein Gold, K. Papp, G. Han, D. M. Pariser, T. Lin, S. Harris, A. Jacobson
Summary: The study evaluated the long-term safety and efficacy of HP/TAZ lotion in the treatment of plaque psoriasis, with a majority of participants achieving treatment success and maintaining efficacy over the 52-week study period.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Natalia Andryskova, Paul Sourivong, Melania Babincova, Maria Simaljakova
Summary: An intelligent hyperthermia nanofiber system was developed by embedding magnetic nanoparticles in electrospun polycaprolactone nanofibers, enabling controlled delivery of tazarotene through the skin using external magnetic fields, with minimal skin irritation. This novel system could potentially provide a new approach for the topical therapy of psoriasis.
APPLIED SCIENCES-BASEL
(2021)
Article
Immunology
You-Wang Lu, Yong-Jun Chen, Nian Shi, Lu-Hui Yang, Hong-Mei Wang, Rong-Jing Dong, Yi-Qun Kuang, Yu-Ye Li
Summary: In this study, genes and cytokines related to the pathogenesis of psoriasis were identified through gene expression analysis. These findings may contribute to the diagnosis and treatment of psoriasis.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Shuo Zhang, Jiao Wang, Liu Liu, Xiaoying Sun, Yaqiong Zhou, Siting Chen, Yi Lu, Xiaoce Cai, Manqi Hu, Ge Yan, Xiao Miao, Xin Li
Summary: Curcumin (CUR) demonstrates excellent efficacy and broad potential in the treatment of psoriasis, improving the disease phenotype and reducing inflammatory responses through multiple mechanisms.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Pharmacology & Pharmacy
Vito Di Lernia, Laura Macca, Lucia Peterle, Ylenia Ingrasciotta, Gianluca Trifiro, Claudio Guarneri
Summary: The study found that biological therapies may provide short-term efficacy for moderate-to-severe psoriasis in children. The probability of achieving PASI 75 and PASI 90 was higher for IL-12/23 and IL-17 inhibitors, with a more favorable NNT. Therefore, these systemic drugs may be beneficial for treating plaque psoriasis in children and adolescents.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Geetha Maniam, Chun-Wai Mai, Mohd Zulkefeli, Ju-Yen Fu
Summary: This study successfully synthesized niosomes co-encapsulating GEM and tocotrienols, and demonstrated their enhanced antiproliferative effects in Panc 10.05 cells. Niosomes significantly improved the cytotoxicity of the drug combination and showed higher cellular uptake of GEM, providing a new approach for the treatment of pancreatic cancer cells.
Article
Dermatology
Nagwa Essa Abd Elazim, Ayat Mahmoud Abdelsalam, Sara Mohamed Awad
Summary: The study showed that combined fractional CO2 laser with topical tazarotene was more effective in treating nail psoriasis compared to tazarotene monotherapy, especially in improving nail bed lesions. Both treatments significantly improved the severity of nail lesions, with the combined therapy showing greater efficacy for nail bed signs and faster improvement of nail matrix signs. Patient global assessment scores were significantly higher after the combined therapy, and both treatments were well tolerated.
JOURNAL OF COSMETIC DERMATOLOGY
(2022)
Article
Pharmacology & Pharmacy
Sunita Thakur, Md Meraj Anjum, Shweta Jaiswal, Anurag Kumar Gautam, Paruvathanahalli Siddalingam Rajinikanth
Summary: This study proposes the preparation of Nanostructured Lipid Carriers (NLCs) for the treatment of psoriasis and evaluates their effectiveness in vitro and in vivo. Results indicate that the TZT-CPT-NLC gel formulation exhibits good drug release and suitable chemical characteristics, suggesting that combination therapy may be a promising approach for the treatment of psoriasis.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Review
Dermatology
Jason E. Hawkes, Kyoungah See, Russel Burge, Stephanie Strakbein, Missy McKean-Matthews, Daniel Saure, Melinda Gooderham, Craig Leonardi
Summary: Animated visualizations were used to simplify complex data from ixekizumab clinical trials, demonstrating rapid and sustained efficacy of the treatment, providing comparisons with other biologics, and presenting individual patient progression over time.
DERMATOLOGY AND THERAPY
(2021)
Article
Dermatology
Hossam M. Abdel-Wahab, Maha H. Ragaie
Summary: The study demonstrated significant improvement in pityriasis alba with all three treatments, with tacrolimus 0.03% ointment showing the best repigmentation effect. However, topical corticosteroid received the highest level of patient satisfaction among the treatments.
JOURNAL OF DERMATOLOGICAL TREATMENT
(2022)
Article
Pharmacology & Pharmacy
Sandra Sherif Amer, Wael Mamdouh, Maha Nasr, Amr ElShaer, Elena Polycarpou, Rasha T. A. Abdel-Aziz, Omaima A. Sammour
Summary: This study successfully developed composite nanofibers of polyvinyl alcohol/quercetin/essential oils with significant antibacterial efficacy against Propionibacterium acne, showing promising results in reducing acne lesions in patients.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Biochemistry & Molecular Biology
Dalia O. Saleh, Maha Nasr, Azza Hassan, Sally A. El-Awdan, Gehad A. Abdel Jaleel
Summary: The aim of this study was to investigate the therapeutic effects of curcumin nanoemulsion (NC) on cerebral damage in diabetic rats. The results showed that NC treatment reduced neurological deficit and redox imbalance, decreased inflammation and apoptosis, and restored glucose transporter 1 expression in the brain.
JOURNAL OF FOOD BIOCHEMISTRY
(2022)
Article
Pharmacology & Pharmacy
Maha Nasr, Hend Abd-Allah, Omar A. H. Ahmed-Farid, Rofanda M. Bakeer, Nabila S. Hassan, Rania F. Ahmed
Summary: Curcumin nanoemulsion can effectively mitigate the adverse effects of a high-fat high-fructose diet on spermatogenesis, improving sperm production and regulating blood, oxidative, and nitrosative parameters.
JOURNAL OF PHARMACY AND PHARMACOLOGY
(2022)
Editorial Material
Biotechnology & Applied Microbiology
Robert M. Frederickson, Thomas Ritter, Kevin Morris, Marcin Kortylewski, Maha Nasr, Roland W. Herzog
Article
Chemistry, Medicinal
Omar Abu-Azzam, Saed Aldalaen, Maha Nasr
Summary: This study aimed to investigate the cytotoxic effect of phloretin on cervical cancer, as well as its nanoparticulated form. The results showed that phloretin microemulsion exhibited suitable particle size, homogenous dispersion, and stability. Both phloretin and its microemulsion exhibited cytotoxic activity against cervical cancer cells, with the microemulsion showing more potent effect. This study highlights the potential of phloretin microemulsion as a stable product for enhanced cytotoxic activity.
PHARMACEUTICAL CHEMISTRY JOURNAL
(2022)
Article
Pharmacology & Pharmacy
Shymaa Hatem, Seham A. Elkheshen, Amany O. Kamel, Maha Nasr, Noha H. Moftah, Maha H. Ragai, Reham S. Elezaby, Nada M. El Hoffy
Summary: This study developed functionalized chitosan nanoparticles (CSNPs) in gel form for enhanced topical delivery of alpha-arbutin to treat melasma. The CSNPs demonstrated positive zeta potential, high entrapment efficiency, good stability, and sustained release of alpha-arbutin. In vitro and clinical evaluations showed that the CSNPs hydrogel had better therapeutic efficacy compared to the free drug hydrogel, making it a promising modality for melasma treatment.
Article
Pharmacology & Pharmacy
Mohamed Fawzi Kabil, Maha Nasr, Ismail T. Ibrahim, Yasser A. Hassan, Ibrahim M. El-Sherbiny
Summary: In this study, lipid nanovesicles were used to encapsulate the drug rolapitant for the treatment of lung cancer. The results showed promising potential for the developed lipid nanovesicles as a treatment modality for lung cancer.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Ramy Said-Elbahr, Maha Nasr, Mohamed A. Alhnan, Ismail Taha, Omaima Sammour
Summary: This study demonstrates that nanoemulsion is a promising nebulizable system, which can be used for the treatment of lung diseases other than lung cancer.
EXPERT OPINION ON DRUG DELIVERY
(2022)
Article
Pharmacology & Pharmacy
Rania F. Ahmed, Maha Nasr, Marawan Abd Elbaset, Alyaa Farouk Hessin, Omar A. H. Ahmed-Farid, Nermeen M. Shaffie, Marwa E. Shabana
Summary: The study indicated that branched chain amino acids loaded nanoliposomes could be a new strategy in preventing the adverse effects of cisplatin.
PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Abdullah El-Kholy, Maha Fadel, Maha Nasr, Ibrahim El-Sherbiny, Abeer Tawfik, Yasser O. Mosaad, Doaa Abdel Fadeel
Summary: This study introduces a new protocol for managing Hidradenitis Suppurativa using the synergistic photodynamic and photothermal effect of Eosin Yellow-Gold-Polypyrrole hybrid nanoparticles. The study shows promising results in improving the lesions and demonstrates good tolerance and safety.
Article
Pharmacology & Pharmacy
Mai Mansour, Maha Nasr, Omar A. H. Ahmed-Farid, Rania F. Ahmed
Summary: This study demonstrated that ondansetron microemulsion, administered via the nasal or oral route, can alleviate the adverse effects of cisplatin chemotherapy. The nasal administration of ondansetron microemulsion showed superior effects compared to oral administration.
PHARMACOLOGICAL REPORTS
(2023)
Article
Psychology, Clinical
Ryan Ahmed, Brian D. Boyd, Damian Elson, Kimberly Albert, Patrick Begnoche, Hakmook Kang, Bennett A. Landman, Sarah M. Szymkowicz, Patricia Andrews, Jennifer Vega, Warren D. Taylor
Summary: This study found that clinical improvement in late-life depression is associated with functional connectivity in intrinsic brain networks, particularly in the default mode, cognitive control, and limbic networks. Future research should focus on clinical markers of network connectivity informing prognosis.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Dina Mahmoud Abd-Alaziz, Mai Mansour, Maha Nasr, Omaima A. Sammour
Summary: A novel vesicular system, spanethosomes, was developed by introducing ethanol into spanlastics, showing improved drug encapsulation efficiency, drug release, and cellular uptake compared to spanlastics.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Eman M. E. Dokla, Riham I. El-Gogary, Nada M. Abd-Elsaid, Mariam Gad, Reem K. Abd-Elhalim, Hana H. Habib, Wesam Eldeeb, Esraa R. Eldahshan, Salma H. Nassar, Aya N. Issa, Neveen Rabeh, Samar Abd-Elkhalik, Maha Nasr
Summary: In this study, a benzimidazole derivative was synthesized and loaded into a hyaluronic acid-based nanoemulgel, which showed superior wound healing activity by increasing the skin deposition of the drug and promoting collagen fiber deposition and VEGF expression.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Greta Camilla Magnano, Marika Quadri, Elisabetta Palazzo, Roberta Lotti, Francesca Loschi, Stefano Dall'Acqua, Michela Abrami, Francesca Larese Filon, Alessandra Marconi, Dritan Hasa
Summary: This study aimed to investigate the loading of sildenafil citrate in three commercial transdermal vehicles using 3D full-thickness skin equivalent and compare the results with permeability experiments using porcine skin. The results showed that the results obtained using the 3D skin equivalent were comparable to those obtained using porcine skin, suggesting that the 3D skin model can be a valid alternative for ex-vivo skin absorption experiments.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2024)
Article
Pharmacology & Pharmacy
James W. Mckeage, Andrew Z. H. Tan, Andrew J. Taberner
Summary: Needle-free jet injection is a promising alternative drug delivery technique that offers rapid, non-invasive, and large-volume injections. The study presents a prototype multi-orifice nozzle and a computational fluid dynamic model to demonstrate the feasibility and effectiveness of this technology.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2024)
