Article
Biochemistry & Molecular Biology
Ailec Ho-Plagaro, Cristina Rodriguez-Diaz, Concepcion Santiago-Fernandez, Carlos Lopez-Gomez, Sara Garcia-Serrano, Flores Martin-Reyes, Francisca Rodriguez-Pacheco, Alberto Rodriguez-Canete, Guillermo Alcain-Martinez, Luis Vazquez-Pedreno, Sergio Valdes, Lourdes Garrido-Sanchez, Eduardo Garcia-Fuentes
Summary: This study found that regardless of the degree of insulin resistance, morbid obesity is associated with altered expression of genes related to intestinal defenses, antimicrobial and immune responses, and gastrointestinal cancer.
Article
Nutrition & Dietetics
Minna F. Schleu, Beatriz Barreto-Duarte, Maria B. Arriaga, Mariana Araujo-Pereira, Ana Marice Ladeia, Bruno B. Andrade, Maria L. Lima
Summary: The study found that lower levels of VITD are strongly associated with increased insulin resistance in obese women. Different expression profiles of laboratory markers were observed according to 25(OH)D levels.
Article
Multidisciplinary Sciences
Aarti Darra, Vandana Singh, Anuraag Jena, Priyanka Popli, Ritambhra Nada, Pankaj Gupta, Sanjay Kumar Bhadada, Anupam Kumar Singh, Vishal Sharma, Anish Bhattacharya, Anurag Agrawal, Usha Dutta
Summary: The gut microbiome plays a role in the development and progression of metabolic disorders, such as diabetes. This study explores the gut microbiota in the duodenal mucosa, which is less studied compared to stool, in individuals with hyperglycemia. The findings suggest that duodenal dysbiosis and altered local metabolism may be early events in hyperglycemia.
SCIENTIFIC REPORTS
(2023)
Review
Biochemistry & Molecular Biology
Dariusz Szukiewicz
Summary: Insulin has comprehensive anabolic effects on the body, including lipid homeostasis and anti-inflammatory modulation, especially in adipose tissue. Obesity, with its accompanying health problems such as glucose intolerance, insulin resistance, and diabetes, has been increasing worldwide. Despite hyperinsulinemia, impaired tissue sensitivity to insulin paradoxically leads to diseases with an inflammatory component. Visceral fat accumulation in obesity disrupts epigenetic regulatory mechanisms in the immune system, resulting in autoimmunity and inflammation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Surgery
Alice Wang, Abdelrahman Nimeri, Michael Genz, James Feimster, Kyle Thompson, Alexander Abdurakhmanov, Vilok Vijayanagar, Iain McKillop, Selwan Barbat, Timothy Kuwada, Keith S. Gersin, Roc Bauman
Summary: This study aimed to assess the safety and efficacy of BPD-DS in patients with a BMI < 50 kg/m(2). The results showed that BPD-DS can be considered in these patients and can achieve sustained weight loss and improvements in comorbidities. However, vitamin D and zinc deficiency remain a challenge.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Endocrinology & Metabolism
Francesca Battista, Andrea Ermolao, Marleen A. van Baak, Kristine Beaulieu, John E. Blundell, Luca Busetto, Eliana V. Carraca, Jorge Encantado, Dror Dicker, Nathalie Farpour-Lambert, Adriyan Pramono, Alice Bellicha, Jean-Michel Oppert
Summary: This systematic review found that exercise intervention programs can effectively improve cardiometabolic health indicators in adults with overweight or obesity, including reducing blood pressure, insulin resistance, and intrahepatic fat.
Article
Endocrinology & Metabolism
Marta Borges-Canha, Joao Sergio Neves, Fernando Mendonca, Maria Manuel Silva, Claudia Costa, Pedro M. Cabral, Vanessa Guerreiro, Rita Lourenco, Patricia Meira, Daniela Salazar, Maria Joao Ferreira, Jorge Pedro, Ebrahim Barkoudah, Ana Sande, Eva Lau, Selma B. Souto, John Preto, Paula Freitas, Davide Carvalho
Summary: This study aimed to evaluate the association between beta cell function and total body weight loss (TBWL%) 1 to 4 years after bariatric surgery in patients with morbid obesity. The results showed that baseline beta cell function was associated with long-term weight loss, especially after the first year post-surgery. This may be a helpful predictor of weight loss in clinical practice.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Nutrition & Dietetics
Yongbo She, Rabban Mangat, Sue Tsai, Spencer D. Proctor, Caroline Richard
Summary: Obesity is strongly linked to inflammation, impaired insulin signaling, lipid metabolism, and immune function. Recent research has provided insights into the mechanisms of immune dysfunction in obesity, using various animal and clinical models. Nutritional strategies, particularly those involving choline-rich foods, are emerging as potential ways to improve immune function in the context of obesity.
FRONTIERS IN NUTRITION
(2022)
Article
Critical Care Medicine
Michael C. Peters, Mark L. Schiebler, Juan Carlos Cardet, Mats W. Johansson, Ronald Sorkness, Mark D. DeBoer, Eugene R. Bleecker, Deborah A. Meyers, Mario Castro, Kaharu Sumino, Serpil C. Erzurum, Matthew C. Tattersall, Joe G. Zein, Annette T. Hastie, Wendy Moore, Bruce D. Levy, Elliot Israel, Brenda R. Phillips, David T. Mauger, Sally E. Wenzel, Merritt L. Fajt, Suneil K. Koliwad, Loren C. Denlinger, Prescott G. Woodruff, Nizar N. Jarjour, John Fahy
Summary: This study demonstrates that insulin resistance (IR) is common in asthma and is associated with lower lung function, accelerated decline of lung function, and suboptimal responses to bronchodilator and corticosteroid treatments.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Malgorzata Mirr, Anna Braszak-Cymerman, Aleksandra Ludziejewska, Matylda Kregielska-Narozna, Pawel Bogdanski, Wieslaw Bryl, Maciej Owecki
Summary: This study aimed to investigate the correlation between serum asprosin levels and insulin resistance indices, as well as the correlation between asprosin and obesity indices. The results showed that asprosin concentrations were significantly higher in obese patients, and there was a positive correlation between asprosin concentrations and body mass index, waist circumference, and all tested indices of insulin resistance. Therefore, asprosin can be considered a marker of obesity and insulin resistance.
Article
Biochemistry & Molecular Biology
Concepcion Santiago-Fernandez, Flores Martin-Reyes, Monica Tome, Carolina Gutierrez-Repiso, Diego Fernandez-Garcia, Luis Ocana-Wilhelmi, Jose Rivas-Becerra, Franz Tatzber, Edith Pursch, Francisco J. Tinahones, Eduardo Garcia-Fuentes, Lourdes Garrido-Sanchez
Summary: Morbid obesity and hypoxia lead to increased levels of scavenger receptors (SRs) and inflammatory markers in visceral adipocytes. In a hypoxic state, ox-LDL enhances the proinflammatory response of visceral adipocytes to hypoxia.
Article
Food Science & Technology
Sara Garcia-Serrano, Ailec Ho-Plagaro, Concepcion Santiago-Fernandez, Cristina Rodriguez-Diaz, Flores Martin-Reyes, Sergio Valdes, Francisco J. Moreno-Ruiz, Carlos Lopez-Gomez, Eduardo Garcia-Fuentes, Francisca Rodriguez-Pacheco
Summary: The study shows that EVOO has more beneficial effects on satiety markers, metabolic status, and inflammation compared to OO and SO. RYGB surgery leads to improvement in the metabolic response to all three types of oils in patients with morbid obesity.
MOLECULAR NUTRITION & FOOD RESEARCH
(2021)
Article
Nutrition & Dietetics
Youngyoon Lee, Yelim Kim, Minam Lee, Dayong Wu, Munkyong Pae
Summary: Studies suggest that time-restricted feeding (TRF) may prevent obesity and its related diseases by improving immune cell composition in obese mice, resulting in reduced weight gain and fat deposition, as well as enhanced insulin sensitivity.
Article
Multidisciplinary Sciences
Jee Hoon Sim, Jinhee Kwon, Hyeonwook Chae, Su-Bon Kim, Hyunsu Cho, Woochan Lee, So Hee Kim, Chun-Won Byun, Sangin Hahn, Do Hyun Park, Seunghyup Yoo
Summary: This study proposes an organic light-emitting diode (OLED) catheter as an effective platform for photobiomodulation (PBM) in tubular organs. The fully encapsulated and flexible OLED catheter can operate in aqueous environments for extended periods. In a diabetic rat model, the red OLED catheter showed promising results in reducing hyperglycemia and insulin resistance, indicating its potential for the treatment of type 2 diabetes and other diseases.
Article
Pharmacology & Pharmacy
R. Mourelatou, E. Kostopoulou, A. P. Rojas-Gil, X. Sinopidis, I Kehagias, D. Linos, F. E. Kalfarentzos, B. E. Spiliotis
Summary: This study investigated the molecular mechanisms of glucose transport regulators in adipose tissue of obese patients, and found that in the Glut of MODM patients, the expression of p85PI3K, Rab5, and Gapex5 did not differ significantly from lean individuals.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2022)
Review
Food Science & Technology
C. Rodriguez, B. Taminiau, E. Garcia-Fuentes, G. Daube, N. Korsak
Summary: Listeria monocytogenes is a pathogenic bacterium that causes listeriosis in humans and animals, mainly transmitted through contaminated foods and affecting vulnerable populations such as pregnant women, newborns, and the elderly. The bacterium is commonly found in various environments including farm settings, with strict hygiene measures and control measures necessary to reduce the risk of milk contamination.
Article
Biochemistry & Molecular Biology
Jose Luis Guerrero Orriach, Juan Jose Escalona Belmonte, Marta Ramirez Aliaga, Alicia Ramirez Fernandez, Maria Jose Rodriguez Capitan, Guillermo Quesada Munoz, Aida Raigon Ponferrada, Juan Alcaide Torres, Concepcion Santiago-Fernandez, Emilio Matute Gonzalez, Manuel Rubio Navarro, Rocio Bautista, Josefa Gomez Maldonado, Lourdes Garrido-Sanchez, Jose Cruz Manas
Summary: Numerous studies have shown the myocardial conditioning effects of halogenated agents in cardiac surgery. This study investigated whether the benefits of maintaining exposure to these agents postoperatively are mediated by the activation or suppression of miRNAs. The study found variations in miRNA expression associated with different concentrations of cardioprotective enzymes in patients who received different anesthetics.
CURRENT MEDICINAL CHEMISTRY
(2021)
Article
Nutrition & Dietetics
Ana Lago-Sampedro, Ailec Ho-Plagaro, Sara Garcia-Serrano, Concepcion Santiago-Fernandez, Cristina Rodriguez-Diaz, Carlos Lopez-Gomez, Flores Martin-Reyes, Gonzalo Ruiz-Aldea, Guillermo Alcain-Martinez, Montserrat Gonzalo, Custodia Montiel-Casado, Jose R. Fernandez, Eduardo Garcia-Fuentes, Francisca Rodriguez-Pacheco
Summary: The study revealed that oleic acid plays a role in restoring the circadian rhythm of clock genes in intestinal tissues of obese patients, influencing their behavior.
CLINICAL NUTRITION
(2021)
Article
Pharmacology & Pharmacy
Isabel Gonzalez-Mariscal, Beatriz Carmona-Hidalgo, Matthias Winkler, Juan D. Unciti-Broceta, Alejandro Escamilla, Maria Gomez-Canas, Javier Fernandez-Ruiz, Bernd L. Fiebich, Silvana-Yanina Romero-Zerbo, Francisco J. Bermudez-Silva, Juan A. Collado, Eduardo Munoz
Summary: Natural cannabidiol and its derivatives, particularly the enantiomer (+)-CBD-HPE, showed enhanced binding and functional activities on cannabinoid receptors CB1R and CB2R. The compound demonstrated potential in preventing hyperglycemia and its complications in a mouse model, with promising pharmacological profile for metabolic and immune-related disorders.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Food Science & Technology
Sara Garcia-Serrano, Ailec Ho-Plagaro, Concepcion Santiago-Fernandez, Cristina Rodriguez-Diaz, Flores Martin-Reyes, Sergio Valdes, Francisco J. Moreno-Ruiz, Carlos Lopez-Gomez, Eduardo Garcia-Fuentes, Francisca Rodriguez-Pacheco
Summary: The study shows that EVOO has more beneficial effects on satiety markers, metabolic status, and inflammation compared to OO and SO. RYGB surgery leads to improvement in the metabolic response to all three types of oils in patients with morbid obesity.
MOLECULAR NUTRITION & FOOD RESEARCH
(2021)
Article
Medicine, Research & Experimental
Isabel Gonzalez-Mariscal, Macarena Pozo-Morales, Silvana Y. Romero-Zerbo, Vanesa Espinosa-Jimenez, Alejandro Escamilla-Sanchez, Lourdes Sanchez-Salido, Nadia Cobo-Vuilleumier, Benoit R. Gauthier, Francisco J. Bermudez-Silva
Summary: Abn-CBD significantly reduces inflammation in NOD mice and STZ-injected mice, improving glucose tolerance and reducing cell apoptosis to delay the progression of insulitis in T1D.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Agriculture, Dairy & Animal Science
Veronica Molina-Hernandez, Maria T. Ruiz-Campillo, Francisco J. Martinez-Moreno, Leandro Buffoni, Alvaro Martinez-Moreno, Rafael Zafra, Maria J. Bautista, Alejandro Escamilla, Raul Perez-Caballero, Jose Perez
Summary: The study evaluated hepatic lesions in sheep vaccinated with a partly protective vaccine, a non-protective vaccine, and an infected control group. The partially protective vaccine group showed less severe hepatic lesions compared to the infected control group, with dead flukes surrounded by severe granulomatous inflammation observed in the protective vaccine group. This finding suggests that the host response induced by the vaccine may have contributed to the death of adult flukes.
Article
Microbiology
Carolina Gutierrez-Repiso, Isabel Moreno-Indias, Gracia M. Martin-Nunez, Ailec Ho-Plagaro, Luis Ocana-Wilhelmi, Diego Fernandez Garcia, Montserrat Gonzalo Marin, Francisco J. Moreno-Ruiz, Eduardo Garcia-Fuentes, Francisco J. Tinahones
Summary: Little is known about the influence of gastric microbiota on host metabolism, even though factors like proton pump inhibitor treatment and Helicobacter pylori have been suggested to alter gut microbiota. This study found that H. pylori and PPI treatment are two important factors for gastric mucosa-associated microbiota, with H. pylori reducing diversity and PPIs altering beta-diversity. These factors may have a role in the metabolic evolution of patients undergoing bariatric surgery.
MICROBIOLOGY SPECTRUM
(2021)
Article
Biochemistry & Molecular Biology
Concepcion Santiago-Fernandez, Flores Martin-Reyes, Monica Tome, Carolina Gutierrez-Repiso, Diego Fernandez-Garcia, Luis Ocana-Wilhelmi, Jose Rivas-Becerra, Franz Tatzber, Edith Pursch, Francisco J. Tinahones, Eduardo Garcia-Fuentes, Lourdes Garrido-Sanchez
Summary: Morbid obesity and hypoxia lead to increased levels of scavenger receptors (SRs) and inflammatory markers in visceral adipocytes. In a hypoxic state, ox-LDL enhances the proinflammatory response of visceral adipocytes to hypoxia.
Article
Biochemistry & Molecular Biology
Ailec Ho-Plagaro, Cristina Rodriguez-Diaz, Concepcion Santiago-Fernandez, Carlos Lopez-Gomez, Sara Garcia-Serrano, Flores Martin-Reyes, Francisca Rodriguez-Pacheco, Alberto Rodriguez-Canete, Guillermo Alcain-Martinez, Luis Vazquez-Pedreno, Sergio Valdes, Lourdes Garrido-Sanchez, Eduardo Garcia-Fuentes
Summary: This study found that regardless of the degree of insulin resistance, morbid obesity is associated with altered expression of genes related to intestinal defenses, antimicrobial and immune responses, and gastrointestinal cancer.
Article
Nutrition & Dietetics
Concepcion Santiago-Fernandez, Cristina Rodriguez-Diaz, Ailec Ho-Plagaro, Carolina Gutierrez-Repiso, Wilfredo Oliva-Olivera, Flores Martin-Reyes, Virginia Mela, Rocio Bautista, Monicas Tome, Josefa Gomez-Maldonado, Francisco J. Tinahones, Eduardo Garcia-Fuentes, Lourdes Garrido-Sanchez
Summary: This study found that extra virgin olive oil (EVOO) and sunflower oil (SO) have different effects on the miRNA composition of endothelial cell-derived extracellular vesicles (EVs). These EVs can regulate the transcriptomic profile of smooth muscle cells (SMCs), which plays a role in the development of atherosclerosis.
FRONTIERS IN NUTRITION
(2022)
Article
Pharmacology & Pharmacy
Flores Martin-Reyes, Ailec Ho-Plagaro, Cristina Rodriguez-Diaz, Carlos Lopez-Gomez, Sara Garcia-Serrano, Damaris Rodriguez de los Reyes, Montserrat Gonzalo, Jose C. Fernandez-Garcia, Custodia Montiel-Casado, Jose L. Fernandez-Aguilar, Jose R. Fernandez, Eduardo Garcia-Fuentes, Francisca Rodriguez-Pacheco
Summary: The effect of oleic acid on the regulation of circadian rhythm in visceral and subcutaneous adipose tissue of morbidly obese patients has not been studied yet. This study found that body weight, BMI, and waist circumference were correlated with different clock genes in both VAT and SAT. After bariatric surgery, the improvement in body weight, BMI, and waist circumference was associated with specific clock genes in SAT.
PHARMACOLOGICAL RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Juan Antonio Lopez-Villodres, Alejandro Escamilla, Silvia Mercado-Saenz, Carmen Alba-Tercedor, Luis Manuel Rodriguez-Perez, Isabel Arranz-Salas, Raquel Sanchez-Varo, Diego Bermudez
Summary: In the last decade, the microbiota-gut-brain axis has become increasingly important in the study of neurodegenerative and metabolic disorders such as Alzheimer's disease and diabetes. A balanced gut microbiota plays a crucial role in maintaining the intestinal barrier and immune system, while dysbiosis can lead to immune dysregulation and neuroinflammation. In addition, harmful microbial products can cross the blood-brain barrier and contribute to the progression of Alzheimer's disease.