期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 20, 期 16, 页码 -出版社
MDPI
DOI: 10.3390/ijms20163967
关键词
atopic dermatitis; lysosomotropic compounds; apoptosis; lysosome; ceramide metabolism; amitriptyline; ceramide de novo synthesis; antioxidants; linoleic acid; sphingolipid profile
资金
- Institute of Precision Medicine, Furtwangen University, VS-Schwenningen, Germany
- Institute for Applied Research (IAF), Furtwangen University, VS-Schwenningen, Germany
Active rebuilding, stabilizing, and maintaining the lipid barrier of the skin is an encouraging disease management and care concept for dry skin, atopic dermatitis (eczema, neurodermatitis), and psoriasis. For decades, corticosteroids have been the mainstay of topical therapy for atopic dermatitis; however, innovations within the scope of basic therapy are rare. In (extremely) dry, irritated, or inflammatory skin, as well as in lesions, an altered (sphingo)lipid profile is present. Recovery of a balanced (sphingo)lipid profile is a promising target for topical and personalized treatment and prophylaxis. New approaches for adults and small children are still lacking. With an ingenious combination of commonly used active ingredients, it is possible to restore and reinforce the dermal lipid barrier and maintain refractivity. Lysosomes and ceramide de novo synthesis play a key role in attenuation of the dermal lipid barrier. Linoleic acid in combination with amitriptyline in topical medication offers the possibility to relieve patients affected by dry and itchy skin, mild to moderate atopic dermatitis lesions, and eczemas without the commonly occurring serious adverse effects of topical corticosteroids or systemic antibody administration.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据