Article
Chemistry, Applied
Guozhu Chang, Qifeng Dang, Chengsheng Liu, Xiaoyu Wang, Hao Song, Hong Gao, Hantian Sun, Bonian Zhang, Dongsu Cha
Summary: A new dual drug delivery system CMCSH was designed to promote diabetic wound healing effectively. This system improved drug availability, promoted cell proliferation, and reduced inflammation.
CARBOHYDRATE POLYMERS
(2022)
Article
Nanoscience & Nanotechnology
Jinfeng Cao, Ping Wu, Qianqian Cheng, Chen He, Yun Chen, Jinping Zhou
Summary: A new type of injectable CMCh hydrogel wound dressing with self-healing properties is constructed using coordination bonds and alkali/urea aqueous solutions. The hydrogel exhibits self-healing, self-adaption, and thermoresponsive ability, significantly accelerating skin tissue regeneration and wound closure. It has great potential in tissue engineering applications.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Pharmacology & Pharmacy
Cheng Yang, Yuhui Chen, Hai Huang, Shicai Fan, Chengliang Yang, Liping Wang, Wenqiang Li, Wenxin Niu, Jianwen Liao
Summary: The ROS-sensitive hydrogel prepared in this study showed strong free radical scavenging ability, accelerated wound healing, and promoted tissue regeneration in experiments.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Materials Science, Multidisciplinary
Kai Chen, Changci Tong, Jinge Yang, Peifang Cong, Ying Liu, Xiuyun Shi, Xu Liu, Jun Zhang, Rufei Zou, Keshen Xiao, Yuyang Ni, Lei Xu, Mingxiao Hou, Hongxu Jin, Yunen Liu
Summary: The melatonin-loaded hydrogel promotes granulation tissue formation, accelerates wound healing, and reduces inflammation levels.
JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yuhang Liu, Anwei Zhou, Yiping Zhang, Zihan Tian, Xiao Cheng, Ya Gao, Xinyuan Zhou, Xiaotong Wu, Kerong Chen, Xinghai Ning
Summary: A photoactive self-healing hydrogel called Macropatch has been developed to promote wound healing by protecting the wound from further injury, sealing organ bleeding, and preventing bacterial infections under visible light irradiation. The hydrogel exhibits good self-healing capability, mechanical strength, tissue adhesiveness, and visible light-induced antibacterial activity, leading to a fast recovery of bacteria-infected wounds.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Applied
Kepeng Hu, Erna Jia, Qimeng Zhang, Wei Zheng, Rongjiao Sun, Mengao Qian, Ying Tan, Wanle Hu
Summary: Tea tree oil (TTO) is encapsulated into the hydrogel network via a previous emulsification process, and a tough and antibacterial injectable hydrogel is synthesized by the Schiff base reaction between carboxymethyl chitosan (CMCS) and genipin (GP). The obtained hydrogels exhibit high adhesive strength (about 162.75 kPa), excellent antibacterial properties (over 90%), and great biocompatibility. The heterogeneous hydrogel shows good slow-release properties of TTO for accelerated healing of complex anal fistula wounds according to an anal fistula-like wound healing experiment.
CARBOHYDRATE POLYMERS
(2023)
Article
Biochemistry & Molecular Biology
M. C. Linju, M. R. Rekha
Summary: The present study developed a L-proline conjugated chitosan scaffold for wound healing. The scaffold was characterized by various tests and showed no cytotoxicity. In vitro experiments demonstrated that the modified scaffold promoted wound closure and collagen deposition. These findings suggest that the L-proline conjugated scaffold has potential as a wound dressing to improve wound healing.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Applied
Yuanping Hao, Wenwen Zhao, Hao Zhang, Weiping Zheng, Qihui Zhou
Summary: The BP/CS-bFGF hydrogel dressing prepared in this study shows great potential for diabetic chronic wound management. It has strong wet-tissue adhesion, self-mending, and antibacterial properties, and displays fast hemostasis capacity. The hydrogel dressing significantly accelerates full-thickness diabetic wound repair by increasing the production of Ki67, promoting the generation of epithelialization and collagen, inducing the formation of hair follicles, and enhancing neovascularization.
CARBOHYDRATE POLYMERS
(2022)
Article
Biochemistry & Molecular Biology
Lin Zhao, Zhipan Feng, Yang Lyu, Jueying Yang, Lizhi Lin, Haochen Bai, Yujing Li, Yongqiang Feng, Yu Chen
Summary: An electroactive hydrogel was constructed by rapidly forming dynamic imine bonds between oxidized sodium alginate (OSA) and carboxymethyl chitosan (CMCS), and in situ forming silver nanoparticles (AgNPs) by UV irradiation. The hydrogel exhibited injectability, self-healing ability, biocompatibility, and antibacterial activities. It promoted cell proliferation and accelerated wound healing in a skin defect model.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Weiwei Zhang, Yixing Wei, Qingcong Wei, Yanfei Zhao, Ziming Jin, Yaxing Wang, Guanglei Ma, Xing He, Zhiguo Hu, Yuqin Jiang
Summary: A series of multifunctional carboxymethyl chitosan (CMCS)-based hydrogels were fabricated using a facile urate oxidase (UOX)-horseradish peroxidase (HRP) cascade enzymatic crosslinking system, which can accelerate wound healing due to the retained enzymatic activity. These hydrogels exhibit excellent antioxidant performance and enhanced antibacterial capacity, effectively promoting skin wound repair by reducing oxidative stress, relieving inflammation, promoting collagen deposition and upregulating the expression level of CD31.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Yalei Liu, Jie Mao, Zhiyong Guo, Yufang Hu, Sui Wang
Summary: The authors prepared a bifunctional hydrogel with antibacterial and self-healing properties by cross-linking polyvinyl alcohol and carboxymethyl chitosan through hydrogen bonds and borate ester bonds. The hydrogel showed improved mechanical properties and the addition of silver nanoparticles effectively inhibited bacterial growth, providing potential applications in biological wound healing.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Chemistry, Applied
Yuchen Huan, Qing Kong, Qingjuan Tang, Yuming Wang, Haijin Mou, Rui Ying, Chunjun Li
Summary: This study developed a hydrogel by grafting self-assembling peptides onto O-carboxymethyl chitosan, which exhibited sustained drug release effect and promoted wound closure and skin tissue regeneration.
CARBOHYDRATE POLYMERS
(2022)
Article
Engineering, Biomedical
Karol Kamil Klosinski, Radoslaw Aleksander Wach, Weronika Kruczkowska, Lukasz Duda, Damian Kolat, Zaneta Kaluzinska-Kolat, Piotr Tomasz Arkuszewski, Zbigniew Wlodzimierz Pasieka
Summary: Hydrogels formed from CMCS biopolymer via electron beam irradiation were evaluated for their potential in wound healing therapy. The hydrogel supported healing and showed positive effects on inflammatory infiltration, collagen formation, and epidermalization. The use of competitive radiation technology for synthesis allowed for the product to be sterilized during synthesis.
JOURNAL OF FUNCTIONAL BIOMATERIALS
(2023)
Article
Polymer Science
Maila Castellano, Andrea Dodero, Sonia Scarfi, Serena Mirata, Marina Pozzolini, Eleonora Tassara, Alina Sionkowska, Katarzyna Adamiak, Marina Alloisio, Silvia Vicini
Summary: Composite chitosan-collagen nanofibrous mats embedded with curcumin were prepared by electrospinning and showed superior biological activity as wound-healing patches. A mild crosslinking protocol was developed to ensure stability without affecting biocompatibility. The composite patches had a porous nanostructure, thermal stability, mechanical features, and water-related properties suitable for wound healing. Curcumin release was sustained for 72 hours, providing prolonged bioactivity and antioxidant properties. The combination of chitosan, collagen, and curcumin promoted cell adhesion, proliferation, and antibacterial capabilities.
Article
Biotechnology & Applied Microbiology
Lin Hou, Wei Wang, Mei-Kun Wang, Xue-Song Song
Summary: This study reports a multifunctional composite wound dressing loaded with chitosan-binding bFGF and antimicrobial peptides. The dressing exhibited excellent antibacterial activity, effectively inhibiting the growth of bacteria, and accelerated wound healing. Cell experiments and animal experiments demonstrated the positive effects of the composite dressing on cell growth and tissue repair.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
