Review
Biochemistry & Molecular Biology
Chien-Ning Hsu, You-Lin Tain
Summary: The developmental origins of health and disease theory suggests that many adult-onset diseases can originate in early life. Oxidative stress plays a crucial role in renal programming, and perinatal use of antioxidants can reverse programming processes and prevent adult-onset diseases.
Article
Biochemistry & Molecular Biology
You-Lin Tain, Chien-Ning Hsu
Summary: Oxidative stress plays a crucial role in the developmental origins of hypertension, as early-life oxidative stress leads to developmental programming in key blood pressure-controlled organs and subsequently results in hypertension in adulthood. Antioxidant therapy has the potential to lower blood pressure and serves as a novel preventive strategy for hypertension with developmental origins.
Article
Pharmacology & Pharmacy
Josiane Fernandes da Silva, Juliana A. Bolsoni, Rafael M. da Costa, Juliano Alves, Alecsander F. M. Bressan, Luiz Eduardo Silva, Tiago J. Costa, Antonio E. R. Oliveira, Carla P. Manzato, Carlos A. Aguiar, Rubens Fazan, Fernando Q. Cunha, Helder Nakaya, Fernando S. Carneiro, Rita C. Tostes
Summary: The study suggests that AhR activation contributes to vascular dysfunction in obesity, but AhR deletion can alleviate dyslipidaemia and vascular dysfunction induced by a high-fat diet. Targeting AhRs may prevent obesity-associated vascular dysfunction.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Hisanori Fukunaga
Summary: Mitochondrial dysfunction is closely related to disease, and environmental factors during fetal life may influence health risks in offspring.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Sora Kang, Aden Geonhee Lee, Suyeol Im, Seung Jun Oh, Hye Ji Yoon, Jeong Ho Park, Youngmi Kim Pak
Summary: Obesity is a chronic peripheral inflammation condition that is strongly correlated with neurodegenerative diseases and associated with exposure to environmental chemicals. This study found that HBU651, a novel AhR antagonist, exhibited anti-obesity and anti-inflammatory activity. It may serve as a potential candidate for the treatment of obesity-related metabolic diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Chien-Ning Hsu, You-Lin Tain
Summary: The cardiovascular system can be programmed by early-life insults, potentially leading to cardiovascular disease in adulthood. Hydrogen sulfide plays a crucial role in the pathogenesis of cardiovascular disease of developmental origins, with early interventions based on H2S showing benefits in preventing adult-onset CVD. Understanding cardiovascular programming and recent advances in H2S-based interventions may help lower the global burden of CVD.
Review
Biochemistry & Molecular Biology
Chien-Ning Hsu, You-Lin Tain
Summary: Animal models are essential for investigating the causal relationship between early-life exposure and the developmental programming of hypertension, providing insights into how early interventions can reprogram disease processes and prevent hypertension.
Review
Biochemistry & Molecular Biology
You-Lin Tain, Chien-Ning Hsu
Summary: Hypertension is a significant global disease burden and can originate in early life. Melatonin, a hormone with multifaceted biological functions, plays important roles in pregnancy, fetal development, and blood pressure regulation. Early melatonin therapy as a reprogramming strategy can protect against the early life origins of hypertension.
Review
Genetics & Heredity
Salvo Danilo Lombardo, Ivan Fernando Wangsaputra, Jorg Menche, Adam Stevens
Summary: This article highlights the importance of the early developmental phase for human health and disease, focusing on the integration and analysis methods for studying transcriptomic and epigenetic processes relevant to the periconceptional period.
Article
Biochemistry & Molecular Biology
Raimo Pohjanvirta, Ira Karppinen, Suylen Galban-Velazquez, Javier Esteban, Helen Hakansson, Satu Sankari, Jere Linden
Summary: Studies have shown that AHR is essential for the development of obesity and steatohepatitis, and AHRKO rats display different weight development and biochemical/genetic profiles compared to wildtype rats.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2021)
Review
Endocrinology & Metabolism
Hiroaki Itoh, Megumi Ueda, Misako Suzuki, Yukiko Kohmura-Kobayashi
Summary: Metabolic syndrome, associated with obesity, increases the risk of type 2 diabetes, coronary diseases, stroke, and other disabilities. The Developmental Origins of Health and Disease (DOHaD) theory suggests that early developmental environmental imbalance affects health and predisposes individuals to non-communicable diseases, including metabolic syndrome. The 'Thrifty Phenotype' hypothesis proposes that undernourished fetuses develop evolutionary advantageous traits for survival in a hangry environment after birth, but this phenotype increases the risk of metabolic syndrome under an obesogenic diet. Chronic inflammation, referred to as 'Metaflammation', is believed to mediate the connection between obesity and metabolic disorders in metabolic syndrome. However, the contribution of evolutionary maladaptation to the pathophysiology of 'Metaflammation' remains understudied. Investigating 'Metaflammation' from the perspective of selective advantages and mismatches to contemporary lifestyles can provide valuable insights, considering the concept of evolutionarily conserved nutrient sensing and immune signaling systems.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Biochemistry & Molecular Biology
You-Lin Tain, Chien-Ning Hsu
Summary: This review discusses the innovative use of animal models in studying the mechanisms behind developmental origins of hypertension. Research has found that early maternal stress can alter the gut microbiota, leading to adverse outcomes in offspring. Dysbiosis of the gut microbiota is involved in the developmental origins of hypertension, while targeted therapy for the gut microbiota can prevent hypertension in later life.
Article
Nutrition & Dietetics
Wenji Wang, Yu Huo, Jialing Zhang, Da Xu, Fan Bai, Yonghao Gui
Summary: Maternal nutrition and health status in the peri-pregnancy period significantly influence offspring myocardial remodeling. This study established mouse models to investigate the effects of maternal obesity, high-fat diet, and fetal weight on offspring heart development. The results showed that fetal weight played a mediating role in the relationship between perinatal high-fat diet and offspring myocardial remodeling. Sensible and healthy perinatal nutrition, especially during pregnancy, positively impacted offspring health.
Article
Pediatrics
Erika Hagemann, Desiree T. Silva, Jacqueline A. Davis, Lisa Y. Gibson, Susan L. Prescott
Summary: Interventional birth cohorts are focusing on optimizing health potential of individuals and communities, beyond disease prevention, by examining factors such as nature relatedness, interpersonal relationships, mindfulness, and positive emotions. They aim to influence core behaviors through better relationships with self, community, and the environment, with the goal of achieving positive change in every community.
PAEDIATRIC RESPIRATORY REVIEWS
(2021)
Review
Endocrinology & Metabolism
Chien-Ning Hsu, You-Lin Tain
Summary: To reduce the global burden of kidney disease and hypertension, urgent action is needed to identify toxic chemicals in the environment, avoid harmful chemical exposure during pregnancy and lactation, and translate effective reprogramming interventions from animal studies into clinical practice.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Pediatrics
You-Lin Tain, Pei-Chen Lu, Hsiao-Ching Kuo, Chien-Ning Hsu
Summary: The study found that there is some disagreement between children and parents in the assessment of HRQOL in Taiwanese children with chronic kidney disease. Children reported higher scores in the physical and psychosocial domains compared to parent proxies. Factors such as the development of mineral bone disorder/anemia and proteinuria were associated with increased discordance in school functioning during follow-up, while fathers with chronic disease were associated with increased discordance in social functioning.
PEDIATRIC NEPHROLOGY
(2023)
Article
Medicine, General & Internal
Wei-Chia Lee, Kay L. H. Wu, You -Lin Tain, Steve Leu, Yuan-Tso Cheng, Julie Y. H. Chan
Summary: This study investigated the common mechanisms between metabolic syndrome and overactive bladder caused by fructose exposure in rats. Dysregulated insulin signaling was found at the bladder mucosa, leading to bladder overactivity in rats with fructose-induced metabolic syndrome. These findings highlight the importance of understanding the role of insulin signaling in bladder function.
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
(2023)
Article
Health Care Sciences & Services
Meixia Liao, Kim Rand, Zhihao Yang, Chien-Ning Hsu, Hsiang-Wen Lin, Nan Luo
Summary: This study aimed to investigate whether a time-based willingness-to-accept (tWTA) question can be used to elicit values lower than -1 and improve the estimation of EQ-5D-5L values. The results showed that using a tWTA question to address the censoring issue of values in cTTO tasks is not an effective solution.
QUALITY OF LIFE RESEARCH
(2023)
Article
Nutrition & Dietetics
You-Lin Tain, Chi- Chang, Chih-Yao Hou, Guo-Ping Chang-Chien, Sufan Lin, Chien-Ning Hsu
Summary: In this study, the protective effects of resveratrol butyrate monoester (RBM) on kidney dysfunction and hypertension in a CKD model were examined. RBM supplementation improved NO bioavailability, balanced the renin-angiotensin system, reduced oxidative stress, and altered gut microbiota composition. These findings suggest that RBM supplementation holds promise for improving CKD outcomes and hypertension treatment.
Review
Biochemistry & Molecular Biology
You-Lin Tain, Chien-Ning Hsu
Summary: Oxidative stress occurs when the production of reactive oxygen or nitrogen species exceeds the capacity of antioxidant systems. It has a significant impact on kidney development and can lead to kidney disease in adulthood. Evaluating biomarkers allows us to assess oxidative stress in fetuses and neonates. Animal models have provided valuable insights into the mechanisms of renal programming related to oxidative stress and interventions to prevent kidney disease. This comprehensive review examines the effects of perinatal oxidative stress on renal programming, the role of antioxidant strategies in kidney disease prevention, and the challenges in translating findings from animal models to clinical practice.
Article
Pediatrics
You-Lin Tain, Chien-Ning Hsu
Summary: The disruption of gut microbiota composition and structure, known as dysbiosis, plays a crucial role in the development of kidney diseases. Understanding the connection between dysbiotic gut microbiota and pediatric renal diseases is important for the prevention and treatment of these conditions. This review explores the link between dysbiotic gut microbiota and various pediatric renal diseases and discusses potential gut microbiota-targeted therapies.
Review
Biochemistry & Molecular Biology
Kuo-Shu Tang, Chun-Yi Ho, Chien-Ning Hsu, You-Lin Tain
Summary: Melatonin, a hormone released by the pineal gland at night, has various functions and plays a crucial role in kidney health and disease. As the prevalence of chronic kidney disease continues to rise, it is important to find a strategy to not only treat but also prevent it. This review examines the effect of melatonin on kidney development, its clinical uses in early life, preventive applications in animal models, and considerations for melatonin supplementation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Correction
Biochemistry & Molecular Biology
I. Chun Lin, Chih-Wei Wu, You-Lin Tain, I-Chun Chen, Chun-Ying Hung, Kay L. H. Wu
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2023)
Review
Nutrition & Dietetics
Hsi-Yun Liu, Chen-Hao Lee, Chien-Ning Hsu, You-Lin Tain
Summary: A balanced diet during gestation is crucial for fetal development, and excessive intake of saturated fats during this period is linked to increased risk of offspring kidney disease. Maternal high-fat diet influences kidney health and disease in offspring through renal programming. This review summarizes preclinical research on the connection between maternal high-fat diet during gestation and lactation and offspring kidney disease, the molecular mechanisms behind renal programming, and early-life interventions to mitigate adverse programming effects. Animal models suggest that perinatal supplementation with polyunsaturated fatty acids, changes in gut microbiota, and modulation of nutrient-sensing signals can improve offspring kidney health. These findings emphasize the importance of a balanced maternal diet for offspring kidney health.
Article
Biochemistry & Molecular Biology
You-Lin Tain, Hung-Wei Yang, Chih-Yao Hou, Guo-Ping Chang-Chien, Sufan Lin, Chien-Ning Hsu
Summary: This study investigated the use of Cu/ZIF-8 nanoparticles to deliver GSNO and effectively reduce hypertension and improve kidney function in a pediatric CKD model. The nanoparticles enhanced endogenous NO generation, reduced renal oxidative stress, and downregulated the renin-angiotensin system. This research has the potential to improve the treatment of pediatric CKD.
Review
Biochemistry & Molecular Biology
You-Lin Tain, Chien-Ning Hsu
Summary: Hypertension can be influenced by metabolic disturbances during pregnancy, leading to programmed hypertension later in life. Maternal dietary nutrients and disrupted nutrient-sensing signals play a role in fetal programming of hypertension. Metabolism-modulated metabolites and nutrient-sensing signals are potential targets for new drug discovery to prevent and treat hypertension.
Review
Biochemistry & Molecular Biology
Chih-Jen Chen, Ming-Chou Cheng, Chien-Ning Hsu, You-Lin Tain
Summary: Hydrogen sulfide (H2S) plays a crucial role in kidney health and disease through dysregulated signaling and interactions with various mechanisms. Interventions such as sulfur-containing amino acids, N-acetylcysteine, H2S donors, and organosulfur compounds during gestation and lactation have shown promising results in improving renal outcomes. However, more research is needed to translate these findings into clinical practice.
Article
Public, Environmental & Occupational Health
Lung-Chih Li, You-Lin Tain, Hsiao-Ching Kuo, Chien-Ning Hsu
Summary: A cohort study in Taiwan found that pediatric and young adult patients on dialysis had a higher risk of cardiovascular disease and mortality compared to adult patients. Non-atherosclerotic cardiovascular disease was more prevalent in younger patients within the first 6 months of dialysis initiation, while atherosclerotic cardiovascular disease risk was higher in adults after 6 months.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Medicine, General & Internal
Wei-Ling Chen, Wei-Ting Liao, Chien-Ning Hsu, You-Lin Tain
Summary: Cardiovascular disease is a major cause of mortality and morbidity in children with chronic kidney disease (CKD). The causes of pediatric CKD differ from adults, with congenital anomalies in the kidney and urinary tract being the leading causes in childhood. This study identified pregnancy zone protein (PZP) as a potential marker for cardiovascular risk in CKD children and found associations between PZP and arterial stiffness, blood pressure abnormalities, and nitric oxide levels.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Environmental Sciences
Yan-Duan Lin, Ping-Hsiu Huang, Yu-Wei Chen, Chang-Wei Hsieh, You-Lin Tain, Bao-Hong Lee, Chih-Yao Hou, Ming-Kuei Shih
Summary: This review explores the origins, absorption, and harmful effects of microplastics on the environment and humans. The production and presence of microplastics pose a significant threat to the environment and human health and require attention. Various methods exist for degrading plastics, but microplastics continue to be produced during degradation. Microplastics enter the human body through inhalation, ingestion, or skin contact and may have negative impacts on multiple aspects of human health. Most countries have taken measures to regulate plastic particles and reduce plastic usage.