MeCP2: A Critical Regulator of Chromatin in Neurodevelopment and Adult Brain Function

Sensory experience remodels genome architecture in neural circuit to drive motor learning

(2019) Tomoko Yamada et al.   NATURE

Genomic insights into MeCP2 function: A role for the maintenance of chromatin architecture

(2019) Daniel R Connolly et al.   CURRENT OPINION IN NEUROBIOLOGY

Lack of Methyl-CpG Binding Protein 2 (MeCP2) Affects Cell Fate Refinement During Embryonic Cortical Development

(2018) Clementina Cobolli Gigli et al.   CEREBRAL CORTEX

Dendritic structural plasticity and neuropsychiatric disease

(2018) Marc P. Forrest et al.   NATURE REVIEWS NEUROSCIENCE

Rett syndrome: insights into genetic, molecular and circuit mechanisms

(2018) Jacque P. K. Ip et al.   NATURE REVIEWS NEUROSCIENCE

Adult hippocampal MeCP2 preserves the genomic responsiveness to learning required for long-term memory formation

(2018) Kubra Gulmez Karaca et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Affinity for DNA Contributes to NLS Independent Nuclear Localization of MeCP2

(2018) Matthew J. Lyst et al.   Cell Reports

MeCP2-regulated miRNAs control early human neurogenesis through differential effects on ERK and AKT signaling

(2017) N Mellios et al.   MOLECULAR PSYCHIATRY

Biotin tagging of MeCP2 in mice reveals contextual insights into the Rett syndrome transcriptome

(2017) Brian S Johnson et al.   NATURE MEDICINE

Neuronal activity modifies the chromatin accessibility landscape in the adult brain

(2017) Yijing Su et al.   NATURE NEUROSCIENCE

MeCP2 recognizes cytosine methylated tri-nucleotide and di-nucleotide sequences to tune transcription in the mammalian brain

(2017) Sabine Lagger et al.   PLoS Genetics

MECP2, a multi-talented modulator of chromatin architecture

(2016) Floriana Della Ragione et al.   Briefings in Functional Genomics

Acute and crucial requirement for MeCP2 function upon transition from early to late adult stages of brain maturation

(2016) Fang Du et al.   HUMAN MOLECULAR GENETICS

DNA methylation in the gene body influences MeCP2-mediated gene repression

(2016) Benyam Kinde et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nuclear organization and 3D chromatin architecture in cognition and neuropsychiatric disorders

(2016) Alejandro Medrano-Fernández et al.   Molecular Brain

Defects DuringMecp2Null Embryonic Cortex Development Precede the Onset of Overt Neurological Symptoms

(2015) Francesco Bedogni et al.   CEREBRAL CORTEX

MECP2 disorders: from the clinic to mice and back

(2015) Laura Marie Lombardi et al.   JOURNAL OF CLINICAL INVESTIGATION

Disruption of DNA-methylation-dependent long gene repression in Rett syndrome

(2015) Harrison W. Gabel et al.   NATURE

Stimulus-specific combinatorial functionality of neuronal c-fos enhancers

(2015) Jae-Yeol Joo et al.   NATURE NEUROSCIENCE

MeCP2 binds to non-CG methylated DNA as neurons mature, influencing transcription and the timing of onset for Rett syndrome

(2015) Lin Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Differentiation of multipotent neural stem cells derived from Rett syndrome patients is biased toward the astrocytic lineage

(2015) Tomoko Andoh-Noda et al.   Molecular Brain

Excitation/inhibition imbalance and impaired synaptic inhibition in hippocampal area CA3 ofMecp2knockout mice

(2014) Gaston Calfa et al.   HIPPOCAMPUS

In vivo interrogation of gene function in the mammalian brain using CRISPR-Cas9

(2014) Lukasz Swiech et al.   NATURE BIOTECHNOLOGY

Decoding transcriptional repressor complexes in the adult central nervous system

(2014) Megumi Adachi et al.   NEUROPHARMACOLOGY

Analysis of neonatal brain lacking ATRX or MeCP2 reveals changes in nucleosome density, CTCF binding and chromatin looping

(2014) Kristin D. Kernohan et al.   NUCLEIC ACIDS RESEARCH

MeCP2 post-translational modifications: a mechanism to control its involvement in synaptic plasticity and homeostasis?

(2014) Elisa Bellini et al.   Frontiers in Cellular Neuroscience

An AT-Hook Domain in MeCP2 Determines the Clinical Course of Rett Syndrome and Related Disorders

(2013) Steven Andrew Baker et al.   CELL

Dynamic DNA methylation across diverse human cell lines and tissues

(2013) K. E. Varley et al.   GENOME RESEARCH

SUMOylation of MeCP2 is essential for transcriptional repression and hippocampal synapse development

(2013) Ju Cheng et al.   JOURNAL OF NEUROCHEMISTRY

Novel Higher-Order Epigenetic Regulation of the Bdnf Gene upon Seizures

(2013) A. Walczak et al.   JOURNAL OF NEUROSCIENCE

Activity-dependent phosphorylation of MeCP2 threonine 308 regulates interaction with NCoR

(2013) Daniel H. Ebert et al.   NATURE

Distribution, recognition and regulation of non-CpG methylation in the adult mammalian brain

(2013) Junjie U Guo et al.   NATURE NEUROSCIENCE

Rett syndrome mutations abolish the interaction of MeCP2 with the NCoR/SMRT co-repressor

(2013) Matthew J Lyst et al.   NATURE NEUROSCIENCE

Neuronal morphology in MeCP2 mouse models is intrinsically variable and depends on age, cell type, and Mecp2 mutation

(2013) I-Ting J. Wang et al.   NEUROBIOLOGY OF DISEASE

Global Epigenomic Reconfiguration During Mammalian Brain Development

(2013) R. Lister et al.   SCIENCE

Binding of TFIIIC to SINE Elements Controls the Relocation of Activity-Dependent Neuronal Genes to Transcription Factories

(2013) Luca Crepaldi et al.   PLoS Genetics

Base-Resolution Analyses of Sequence and Parent-of-Origin Dependent DNA Methylation in the Mouse Genome

(2012) Wei Xie et al.   CELL

SIRT1-mediated deacetylation of MeCP2 contributes to BDNF expression

(2012) Loredana Zocchi et al.   Epigenetics

Postnatal inactivation reveals enhanced requirement for MeCP2 at distinct age windows

(2012) Hélène Cheval et al.   HUMAN MOLECULAR GENETICS

MeCP2 Is Critical for Maintaining Mature Neuronal Networks and Global Brain Anatomy during Late Stages of Postnatal Brain Development and in the Mature Adult Brain

(2012) M. V. C. Nguyen et al.   JOURNAL OF NEUROSCIENCE

Phosphorylation of Distinct Sites in MeCP2 Modifies Cofactor Associations and the Dynamics of Transcriptional Regulation

(2012) M. L. Gonzales et al.   MOLECULAR AND CELLULAR BIOLOGY

Reduced expression of MECP2 affects cell commitment and maintenance in neurons by triggering senescence: new perspective for Rett syndrome

(2012) Tiziana Squillaro et al.   MOLECULAR BIOLOGY OF THE CELL

Neurotrophin regulation of neural circuit development and function

(2012) Hyungju Park et al.   NATURE REVIEWS NEUROSCIENCE

MeCP2 Dependent Heterochromatin Reorganization during Neural Differentiation of a Novel Mecp2-Deficient Embryonic Stem Cell Reporter Line

(2012) Bianca Bertulat et al.   PLoS One

The Role of MeCP2 in the Brain

(2011) Jacky Guy et al.   Annual Review of Cell and Developmental Biology

MeCP2 Rett mutations affect large scale chromatin organization

(2011) Noopur Agarwal et al.   HUMAN MOLECULAR GENETICS

MeCP2 is required for global heterochromatic and nucleolar changes during activity-dependent neuronal maturation

(2011) Malaika K. Singleton et al.   NEUROBIOLOGY OF DISEASE

Genome-Wide Activity-Dependent MeCP2 Phosphorylation Regulates Nervous System Development and Function

(2011) Sonia Cohen et al.   NEURON

Neuronal maturation defect in induced pluripotent stem cells from patients with Rett syndrome

(2011) K.-Y. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Adult Neural Function Requires MeCP2

(2011) C. M. McGraw et al.   SCIENCE

Unique Physical Properties and Interactions of the Domains of Methylated DNA Binding Protein 2

(2010) Rajarshi P. Ghosh et al.   BIOCHEMISTRY

MeCP2 Binds Cooperatively to Its Substrate and Competes with Histone H1 for Chromatin Binding Sites

(2010) R. P. Ghosh et al.   MOLECULAR AND CELLULAR BIOLOGY

Neuronal MeCP2 Is Expressed at Near Histone-Octamer Levels and Globally Alters the Chromatin State

(2010) Peter J. Skene et al.   MOLECULAR CELL

Quantification of O-glycosylation stoichiometry and dynamics using resolvable mass tags

(2010) Jessica E Rexach et al.   Nature Chemical Biology

MeCP2 in the nucleus accumbens contributes to neural and behavioral responses to psychostimulants

(2010) Jie V Deng et al.   NATURE NEUROSCIENCE

Neuronal differentiation of neural precursor cells is promoted by the methyl-CpG-binding protein MeCP2

(2009) Keita Tsujimura et al.   EXPERIMENTAL NEUROLOGY

Mouse models of MeCP2 disorders share gene expression changes in the cerebellum and hypothalamus

(2009) Shay Ben-Shachar et al.   HUMAN MOLECULAR GENETICS

Widespread changes in dendritic and axonal morphology inMecp2-mutant mouse models of rett syndrome: Evidence for disruption of neuronal networks

(2009) Pavel V. Belichenko et al.   JOURNAL OF COMPARATIVE NEUROLOGY

MeCP2-Mediated Transcription Repression in the Basolateral Amygdala May Underlie Heightened Anxiety in a Mouse Model of Rett Syndrome

(2009) M. Adachi et al.   JOURNAL OF NEUROSCIENCE

Comparative study of brain morphology inMecp2mutant mouse models of Rett syndrome

(2008) Nadia P. Belichenko et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Mecp2-Null Mice Provide New Neuronal Targets for Rett Syndrome

(2008) Rocio G. Urdinguio et al.   PLoS One