期刊
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
卷 44, 期 5, 页码 1801-1810出版社
SPANDIDOS PUBL LTD
DOI: 10.3892/ijmm.2019.4353
关键词
transient global cerebral ischemia; hyperpolarization- activated cyclic nucleotide-gated channel; astrocyte; pericyte; hippocampus; delayed neuronal death
资金
- 'Cooperative Research Program for Agriculture Science and Technology Development' Rural Development Administration, Republic of Korea [PJ01321101]
- National Research Foundation of Korea (NRF) - Ministry of Science, ICT & Future Planning [NRF-2017R1A2B4009079]
- NRF - Ministry of Education [NRF-2017R1D1A1B03029311]
Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels have been known to participate in the regulation of neuronal excitability, synaptic transmission and long-term potentiation in the hippocampus. The present study investigated transient ischemia-induced changes of HCN1 and HCN2 expressions in the Cornu Ammonis 1 (CA1) subfield of the hippocampus in gerbils subjected to 5 min transient global cerebral ischemia (tgCI). Neuronal death was exhibited in pyramidal neurons of the striatum pyramidale in the CA1 subfield 4 days after tgCI. HCN1 and HCN2 immunoreactivities were demonstrated in intact CA1 pyramidal neurons, and were transiently and markedly increased in the CA pyramidal neurons at 6 h after ischemia. Thereafter, they gradually decreased in a time-dependent manner. A total of 4 days after ischemia, HCN1 and HCN2 immunoreactivities were barely detected in the CA1 pyramidal neurons; however, HCN1 and HCN2 were began to be expressed in pericytes and astrocytes at 4 days after ischemia. The results indicated that HCN1 and HCN2 expression levels were apparently changed in the gerbil hippocampal CA1 subfield following tgCI and suggested that ischemia-induced alterations in HCN1 and HCN2 expression levels may be closely associated with the death of CA1 pyramidal neurons following 5 min of tgCI.
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