Article
Medicine, Research & Experimental
Moe Ijiri, Kazuhiro Yoshinaga, Hiroaki Kawaguchi, Naoto Miyazaki, Maiko Kawaguchi, Yoshikazu Fujimoto, Tomohide Matsuo, Ikuro Maruyama
Summary: Through studies on pigs and humans, it was found that 1,5-anhydro-D-fructose (1,5-AF) can be rapidly metabolized to 1,5-anhydro-D-glucitol (1,5-AG) in the body.
Article
Endocrinology & Metabolism
Feng Xu, Li-Hua Zhao, Xiao-Hua Wang, Chun-Hua Wang, Chao Yu, Xiu-Lin Zhang, Li-Yan Ning, Hai-Yan Huang, Jian-Bin Su, Xue-Qin Wang
Summary: This study found a close association between low plasma 1,5-anhydro-d-glucitol (1,5-AG) levels and impaired peripheral nerve function and diabetic peripheral neuropathy (DPN) in patients with type 2 diabetes (T2D) under mild-to-moderate hyperglycemia.
DIABETOLOGY & METABOLIC SYNDROME
(2022)
Article
Cardiac & Cardiovascular Systems
Hsin- Teng, Hsiang-Yao Chen, Chuan-Tsai Tsai, Wei-Chieh Huang, Ying-Ying Chen, Chien-Hung Hsueh, William K. K. Hau, Tse-Min Lu
Summary: This study demonstrated that low serum 1,5-AG levels were associated with an increased risk of CAC as assessed by OCT, especially in diabetic patients. Low serum 1,5-AG levels may predict future major adverse cardiovascular events in diabetic patients undergoing OCT-guided PCI.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Motoshi Ouchi, Asuka Morita, Keitaro Satoh, Shunsuke Kobayashi, Misao Terada, Hiroe Kon, Keitaro Hayashi, Tatsuya Suzuki, Kenzo Oba, Hitoshi Sugihara, Masahiro Yasutake, Naohiko Anzai, Tomoe Fujita
Summary: This study aimed to assess the effects of short-term stimulation with 1,5-AG on insulin secretion. The results indicated that 1,5-AG had no significant effect on insulin secretion, while stimulation with glimepiride significantly increased insulin secretion.
JOURNAL OF PHARMACOLOGICAL SCIENCES
(2022)
Article
Cardiac & Cardiovascular Systems
Tetsuji Morishita, Hiroyasu Uzui, Yasuhiko Mitsuke, Hiroshi Tada
Summary: The study investigates the added benefit of including 1,5-anhydro-d-glucitol (1,5-AG) information in an existing scoring system for acute coronary syndrome (ACS) patients. The results show that combining 1,5-AG with the syntax score does not provide any incremental value. However, 1,5-AG levels are useful for detecting major adverse cardiac and cerebral events (MACCE) in ACS patients.
Article
Multidisciplinary Sciences
Takashi Ito, Takaaki Totoki, Seiya Takada, Shotaro Otsuka, Ikuro Maruyama
Summary: 1,5-Anhydro-d-fructose (1,5-AF) shows potential benefits for the gut microbiota by altering its composition and metabolomic profile, enriching beneficial bacteria and associated genes. Further studies are needed to clarify the impact of 1,5-AF on health and disease.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Thi Thanh Le, Manh Tuan Ha, Thao Quyen Cao, Jeong Ah Kim, Jae Sue Choi, Byung Sun Min
Summary: Four undescribed compounds and fourteen known compounds were isolated and identified from leaves of Acer ginnala Maxim. The extracted compounds showed inhibitory effects on both protein tyrosine phosphatase-1B (PTP1B) and alpha-glucosidase, suggesting their potential as anti-diabetic medications. Enzyme kinetic analysis and molecular docking provided additional evidence supporting their inhibitory activities and mechanism.
Article
Biochemistry & Molecular Biology
Yuki Kasamo, Kiyoshi Kikuchi, Munekazu Yamakuchi, Shotaro Otsuka, Seiya Takada, Yuki Kambe, Takashi Ito, Ko-ichi Kawahara, Kazunori Arita, Koji Yoshimoto, Ikuro Maruyama
Summary: Mitochondrial functional abnormalities or quantitative decreases are considered key pathogenic mechanisms of Parkinson's disease. This study found that 1,5-anhydro-D-fructose (1,5-AF) had protective effects against rotenone-induced cytotoxicity by upregulating PGC-1 alpha through AMPK activation, leading to mitochondrial biogenic and cytoprotective effects. These results suggest that 1,5-AF has therapeutic potential for Parkinson's disease treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Masanori Nakata, Yuto Yamaguchi, Hikaru Monnkawa, Midori Takahashi, Boyang Zhang, Putra Santoso, Toshihiko Yada, Ikuro Maruyama
Summary: This study found that 1,5-Anhydro-D-fructose (1,5-AF) has a satiety effect and can suppress feeding behavior. The study also found that 1,5-AF can activate oxytocin neurons in the paraventricular nucleus, thereby suppressing feeding. These findings reveal the regulatory role of 1,5-AF as an energy storage monitoring messenger to the hypothalamus.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Food Science & Technology
Kenichi Tanabe, Sadako Nakamura, Toshiyuki Nakayama, Kazuhiro Yoshinaga, Chihiro Ushiroda, Tsuneyuki Oku
Summary: 1,5-AG may prevent the onset of diabetes-related symptoms by delaying the onset of diabetes through its antioxidant effect.
FOOD SCIENCE AND TECHNOLOGY RESEARCH
(2023)
Article
Endocrinology & Metabolism
Mana Ohigashi, Keiko Osugi, Yoshiki Kusunoki, Kahori Washio, Satoshi Matsutani, Taku Tsunoda, Toshihiro Matsuo, Kosuke Konishi, Tomoyuki Katsuno, Mitsuyoshi Namba, Hidenori Koyama
Summary: This study found that HbA1c and GA were negatively correlated with TIR, whereas 1,5-AG was positively correlated with TIR in both type 1 and type 2 diabetes patients. The estimated HbA1c corresponding to a TIR of 70% was approximately 7.0% for both type 1 and type 2 diabetes patients, suggesting potential differences in 1,5-AG levels based on TIR values between these two types of diabetes.
JOURNAL OF DIABETES INVESTIGATION
(2021)
Article
Chemistry, Multidisciplinary
Shiro Komba, Rika Iwaura
Summary: We developed low-molecular-weight organogelators by introducing various fatty acids into cyclic polyol derived from starch. The gelators are composed of ester bonds between naturally occurring materials. By heating powdered 1,5-anhydro-d-glucitol and powdered fatty acids, the compounds can be liquefied at 230 degrees C without using solvents or activated fatty acids, allowing for the synthesis of these gelling agents at a low cost.
Article
Pharmacology & Pharmacy
Raffaele Marfella, Lucia Scisciola, Nunzia D'Onofrio, Ciro Maiello, Maria Consiglia Trotta, Celestino Sardu, Iacopo Panarese, Franca Ferraraccio, Annalisa Capuano, Michelangela Barbieri, Maria Luisa Balestrieri, Claudio Napoli, Giuseppe Paolisso
Summary: The study focused on investigating SGLT2 expression in human cardiomyocytes, revealing higher levels in diabetic patients compared to non-diabetic patients.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Nutrition & Dietetics
Pollyanna Patriota, Idris Guessous, Serge Rezzi, Pedro Marques-Vidal
Summary: This prospective population-based study found that vitamin D levels were inversely associated with cardiovascular disease (CVD) events, but not with CVD or overall mortality.
Article
Cardiac & Cardiovascular Systems
Pil-Sung Yang, Eunsun Jang, Hee Tae Yu, Tae-Hoon Kim, Hui-Nam Pak, Moon-Hyoung Lee, Boyoung Joung
Summary: This study shows that in elderly and very elderly Asian populations, improvements in cardiovascular health status are associated with a reduced risk of cardiovascular disease, but body mass index and total cholesterol are not sufficiently predictive of all-cause mortality.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)