期刊
ATHEROSCLEROSIS
卷 255, 期 -, 页码 140-144出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.atherosclerosis.2016.10.043
关键词
Erythrocyte-derived microvesicles; Atherosclerosis; Coagulation; Inflammation; Adhesion
资金
- National Natural Sciences Foundation of China [81472009, 81500387]
- Natural Science Fund of Guangdong [2014A030313287, 2014A030310135, 2015A030313245]
- Medical Scientific Research Foundation of Guangdong Province [B2014245]
- President Foundation of Nanfang Hospital, Southern Medical University [2012B002, 2013B004, 2014Z003]
Microvesicles are formed under many circumstances, especially in atheromatous plaques. Erythrocyte-derived microvesicles (ErMVs) have been proved to promote atherosclerosis by promoting hyper-coagulation, mediating inflammation and inducing cell adhesion. Several clinical studies have reported potential roles of ErMVs in cardiovascular disease diagnosis, but the current understanding of ErMVs remains insufficient. In this paper, we will review current research on the formation and degradation of ErMVs and the possible effects of ErMVs in atherosclerosis, discuss potential clinical applications in cardiovascular disease, and hope to raise awareness of the relation with atherosclerosis. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
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