期刊
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
卷 134, 期 -, 页码 156-164出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijbiomac.2019.04.074
关键词
Chitosan; Multi-functional carboxylic acids; Scaffold; Dental tissue engineering
资金
- Petroleum and Petrochemical College, Chulalongkorn University
- Center of Excellence on Petrochemical and Materials Technology, Chulalongkorn University
- Ratchadaphiseksomphot Endowment Fund (2014), Chulalongkorn University [CU-57-091-IC]
In general, CS scaffold is prepared by lyophilizing CS hydrogel which traditionally can be prepared by dissolving CS in acetic acid and crosslinking with dialdehyde. However, this method expresses unpleasant odor and toxicity leading to obstruct the practical applications. Here, the aqueous solution of multi-functional carboxylic acids is considered as the alternative and ordorless solvents to provide dual functions, i.e. (i) protonation of CS for the dissolution, and (ii) providing the preferable structure to give crosslink networks under amide bond through the conjugation reaction. The present work demonstrates the potential use of multi-functional carboxylic acids for preparation of CS scaffold and shows the tunable physicochemical and mechanical properties. The work also extends to the basic studies on biological properties to propose as the potential material for dental tissue engineering. (C) 2019 Elsevier B.V. All rights reserved.
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