Article
Biochemistry & Molecular Biology
Hajar Zarei, Mostean Bahreinipour, Yahya Sefidbakht, Shokouh Rezaei, Rouhollah Gheisari, Susan Kabudanian Ardestani, Vuk Uskokovic, Hiroshi Watabe
Summary: The study found that vitamin C and vitamin E have radioprotective effects against gamma radiation-induced protein structural changes, preventing alterations in the secondary and tertiary structure of the protein.
Article
Medicine, General & Internal
Puja Bhattacharyya, Kathrin Schemann, San San Min, David R. Sullivan, Stephen J. Fuller
Summary: This study examined the relationship between vitamin C status and demographic factors in New South Wales. The results showed that vitamin C deficiency was more prevalent among older people and those living in areas of socio-economic disadvantage. It suggests that population assessment of vitamin C levels would be appropriate.
MEDICAL JOURNAL OF AUSTRALIA
(2023)
Article
Food Science & Technology
Filippo Rossi, Giorgia Spigno, Gloria Luzzani, Maria Elisabetta Bozzoni, Gianluca Donadini, Jessica Rolla, Terenzio Bertuzzi
Summary: The study revealed that consuming industrial beer can reduce HCY levels and increase folic acid levels, while craft beer can increase GGT levels and decrease vitamin B-6 levels.
INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION
(2021)
Article
Medicine, Research & Experimental
Yan Zou, Ronghua Zhang, Lichun Huang, Dong Zhao, Danting Su, Jia Meng, Yueqiang Fang
Summary: Gender, living area, age, CRP concentration, and vitamin A status were associated with overweight and obesity in children and adolescents. Boys living in urban areas should be given more attention in weight management interventions, and high serum CRP concentration is also a concern.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2022)
Article
Nutrition & Dietetics
Xin Xing, Min Xu, Lijun Yang, Wenqian Zhang, Xiaolin Niu, Dengfeng Gao
Summary: Intravenous vitamin C administration may reduce ICU and hospital length of stay for critically ill patients, but has no significant effect on mortality or organ failure. The results of trial sequential analysis were inconclusive, indicating a need for more high-quality RCTs to confirm the value of vitamin C for critically ill patients.
CLINICAL NUTRITION
(2021)
Article
Nutrition & Dietetics
Sarah E. Twardowski, Jean Wactawski-Wende, Kathleen M. Hovey, Christopher A. Andrews, Hailey R. Banack, Michael J. LaMonte, Amy E. Millen
Summary: The study found a negative association between plasma 25-hydroxyvitamin D (25[OH]D) concentrations and salivary CRP concentrations in postmenopausal women, which attenuated after adjusting for other factors. However, there was no significant association between 25[OH]D and serum CRP concentrations.
Article
Nutrition & Dietetics
Lara S. Boerenkamp, Birgit L. M. G. Gijsbers, Erik-Jan Ververs, Eva M. S. Pijpers, Bart Spaetgens, Aniek de Coninck, Wilfred T. V. Germeraad, Will K. W. H. Wodzig, Lotte Wieten, Gwendolyn N. Y. van Gorkom, Catharina H. M. J. van Elssen
Summary: This study investigated the levels of serum and intracellular vitamin C in hospitalized COVID-19 patients and found lower serum vitamin C levels in severe and critical cases. The study suggests that intracellular vitamin C levels decrease during COVID-19 infection, while serum levels remain relatively stable. These findings highlight the importance of further research on the role and mechanisms of intracellular vitamin C in COVID-19 infection.
Article
Medical Laboratory Technology
Jun-Il Yoo, Hye Jin Chung, Bo Gyu Kim, Youn-Kwan Jung, Kyung-Wan Baek, Myung-Geun Song, Min-Chul Cho
Summary: The levels of bioavailable 25(OH)D were found to be significantly decreased in sarcopenic patients. Using serum bioavailable 25(OH)D levels to diagnose sarcopenia, a cutoff point of 1.70 ng/ml was identified. The incidence of sarcopenia increased by 3.3 times in individuals with bioavailable 25(OH)D levels below 1.70 ng/ml.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2021)
Article
Biochemistry & Molecular Biology
Arik Sheinenzon, Mona Shehadeh, Regina Michelis, Ety Shaoul, Ohad Ronen
Summary: This study examined the correlation between albumin levels and inflammatory indices in hospitalized patients, showing negative correlations between albumin and CRP/white blood cell levels and positive correlations with platelets/hemoglobin levels. The strongest negative correlation between albumin and CRP was found in the Internal Medicine departments. Linear regression analysis revealed a minor effect of CRP on albumin levels, particularly at very high CRP levels. Further exploration of the mechanisms underlying this negative correlation is needed.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Review
Pharmacology & Pharmacy
Zahra Namkhah, Damoon Ashtary-Larky, Fatemeh Naeini, Cain C. T. Clark, Omid Asbaghi
Summary: The meta-analysis found that vitamin C supplementation significantly decreased TG and TC levels in T2DM patients, but did not affect LDL and HDL. Duration of treatment and dose of vitamin C were found to influence the improvement of lipid profile in T2DM patients. Results suggest that long-term vitamin C supplementation may be more beneficial for improving lipid profile in diabetic populations.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Chemistry, Analytical
Xianxin Meng, Guanjun Nan, Yan Du, Hongwen Zhao, Hongxia Zheng, Rong Lin, Guangde Yang
Summary: The interaction between nitrendipine and lysozyme/human serum albumin was investigated in this study, showing the formation of stable complexes between the drug and proteins. The addition of vitamin C or naringin decreased the binding constant between nitrendipine and the proteins. This disruption of interactions could potentially lead to an increased concentration of free nitrendipine in the bloodstream.
Review
Nutrition & Dietetics
N. Travica, K. Ried, I Hudson, A. Scholey, A. Pipingas, A. Sali
Summary: This review assessed the changes in plasma vitamin C concentrations post-surgery and found that there was a significant depletion of plasma vitamin C during the first postoperative week and 2-3 months postoperatively. Subgroup analyses revealed that these depletions occurred following different types of surgery, but high heterogeneity was observed during the first postoperative week. Larger, long-term investigations are needed to explore the changes in postoperative plasma vitamin C concentrations and their potential effects on clinical symptomology.
BRITISH JOURNAL OF NUTRITION
(2022)
Article
Food Science & Technology
Yan Wang, Mingyang Wu, Lu Xiang, Si Liu, Gang Luo, Qian Lin, Lin Xiao
Summary: This study found a strong and positive correlation between dietary vitamin C consumption and serum Klotho concentrations among the general adult population in the United States, especially in older, normal-weight, and male participants.
Article
Integrative & Complementary Medicine
Xin-xin Liu, Xiao-xue Wang, Ling-ling Cui
Summary: This meta-analysis included 16 eligible randomized controlled trials with a total of 1,013 participants. The results showed that vitamin C supplementation significantly lowered serum uric acid levels. Subgroup analyses indicated that the effect of vitamin C supplementation on serum uric acid was positively associated with participant age <65 years, use of placebo or blank control, trial duration <1 month, and high-quality studies.
COMPLEMENTARY THERAPIES IN MEDICINE
(2021)
Article
Orthopedics
Xiang Li, Xun Liu
Summary: The study found that elevated serum folate, vitamins A, and C levels were associated with higher bone mineral density (BMD), with sex and race/ethnicity modifying these associations.
BMC MUSCULOSKELETAL DISORDERS
(2021)
Article
Biochemistry & Molecular Biology
Wei-Han Hui, Yen-Lin Chen, Shu-Wei Chang
Summary: Crosslinking affects the mechanical behavior and tissue metabolism of collagen-based tissues. Aging and diabetes alter the crosslinking type and density, thus changing tissue properties. High-connectivity enzymatic crosslinking and advanced-glycation end-products result in uniform deformation under daily activity, while low-connectivity enzymatic crosslinking does not. High-connectivity model displays more sliding, while AGEs induce instability in structures near the binding sites.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yao-Bin Ma, Xiao-Qiu Zhou, Wei-Dan Jiang, Pei Wu, Yang Liu, Shu-Wei Li, Ling Tang, Lu Zhang, Hai-Feng Mi, Lin Feng
Summary: Tea polyphenols (TPs) are an inexpensive feed additive that can protect the gill function of fish against Flavobacterium columnare (F. columnare) through various mechanisms, including suppression of oxidative stress, apoptosis, and inflammation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yan-Jia Guo, Jing-Ru Pang, Yu Zhang, Zhong-Rui Li, Xiao-Lin Zi, Hong-Min Liu, Ning Wang, Li-Juan Zhao, Ya Gao, Bo Wang, Piet Herdewijn, Cheng-Yun Jin, Ying Liu, Yi-Chao Zheng
Summary: This study identifies the conjugation of NEDD8 to LSD1 and its impact on GC cells, revealing the significance of LSD1 neddylation in GC.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Geum-Jae Jeong, Fazlurrahman Khan, Nazia Tabassum, Young-Mog Kim
Summary: Vibrio species are motile gram-negative bacteria commonly found in aquatic environments. They can adapt to environmental fluctuations and develop protective mechanisms against host immune systems. Different types of sigma and anti-sigma factors play important roles in regulating gene expression and virulence in Vibrio species.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Zahra Mohammadbagheri, Behrooz Movahedi, Shaghayegh Saeedi, Abbas Rahmati
Summary: In this study, a reusable biobased composite hydrogel was successfully synthesized and used for the removal of Tl(I) from aqueous solutions. The hydrogel exhibited high adsorption capacity and thermal stability, and the adsorption process was found to be thermodynamically spontaneous. The results demonstrated that the hydrogel can be reused multiple times without significant loss of its adsorption capacity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Iqra Batool, Muhammad Imran, Ayesha Anwar, Farhan Ahmed Khan, Afrah E. Mohammed, Ashwag Shami, Hafiz Iqbal
Summary: Enzyme immobilization on ZnO/SnO2 and ZnO/SnO2/SA nanocomposites was studied, and the catalytic and biochemical characteristics of the immobilized enzyme were investigated. The results showed that ZnO/SnO2 and ZnO/SnO2/SA nanostructures are suitable carriers for enzyme immobilization.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Elias Mosaffa, Dhruvi Patel, Nasim Amiri Ramsheh, Rishikumar Indravadan Patel, Atanu Banerjee, Hossein Ghafuri
Summary: In this study, a unique 3D bead structure of adsorbent, composed of bacterial cellulose microfilaments reinforced chitosan adorned with melamine 2D plates, was synthesized for anionic dye removal. The adsorbent showed high specific surface area and abundant functional groups, resulting in exceptional adsorption capacity. The characteristics and optimal conditions of the adsorbent were assessed and analyzed.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Carolina Gismene, Jorge Enrique Hernandez Gonzalez, Marilia de Freitas Calmon, Andrey Fabricio Ziem Nascimento, Angela Rocio Nino Santisteban, Felipe Antunes Calil, Alana Della Torre da Silva, Paula Rahal, Rejane Maira Goes, Raghuvir Krishnaswamy Arni, Ricardo Barros Mariutti
Summary: Mammaliicoccus sciuri, a bacterium of clinical and veterinary relevance, expresses the virulence factor Exfoliative Toxin C (ExhC), which binds specifically to desmoglein-1 (Dsg1) and plays a role in tissue integrity. This study investigates the necrotic activity of ExhC and identifies a variant lacking necrotic potential but retaining enzymatic activity through mutagenesis experiments and crystal structure determination.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Bibhas K. Bhunia, Ashutosh Bandyopadhyay, Souradeep Dey, Biman B. Mandal
Summary: Intervertebral disc degeneration is a major cause of chronic low back pain and disability. Researchers have developed a bioactive silk-based hybrid hydrogel system functionalized with decellularized human Wharton's jelly extracellular matrix as bioactive cues. The hydrogels mimic the rheological and mechanical properties of the native nucleus pulposus tissue and support cell viability, proliferation, and tissue maturation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Qun Zhang, Yonggan Yan, Zhao Li, Jing Du, Kai Zhang, Liguo Zhang, Ting Wang, Alberto Bianco, Shaohua Ge, Baojin Ma
Summary: A new crosslinking strategy has been devised to construct injectable sodium alginate hydrogels, which can be regulated for injectability and have great potential in biomedical applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Seong Eun Hong, Ji-Soo Lee, Hyeon Gyu Lee
Summary: The potential of multi-layer nanoemulsions for improving the cellular uptake, antioxidant activity, and in vitro bioaccessibility of alpha-tocopherol was examined. The results showed that the multi-layer nanoemulsions significantly enhanced the cellular uptake and antioxidant activity of alpha-tocopherol compared to free coumarin 6. Furthermore, the use of chitosan and dextran sulfate as wall materials in the multi-layer nanoemulsions led to even higher cellular uptake, in vitro bioaccessibility, and antioxidant activity of alpha-tocopherol.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jingjing Yu, Yanhui Zhang, Ruoning Zhang, Yanxiang Gao, Like Mao
Summary: High internal phase emulsions (HIPEs) based on beeswax (BW) oleogels and octenyl succinic acid starch (OSA starch) were prepared by a simple one-step method. The results showed that oleogelation improved the stability and encapsulation capability of the HIPEs, which is significant for the development of novel healthy food.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Bi-Feng Yao, Xiu-Ju Luo, Jun Peng
Summary: The balanced and continuous fission and fusion of mitochondria, regulated by OPA1, are important for maintaining mitochondrial dynamics in cardiovascular disorders. Understanding the role of OPA1 in mitochondrial fusion can provide insights into the pathogenesis of cardiovascular diseases.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Gokul Paramasivam, Anandhavelu Sanmugam, Vishnu Vardhan Palem, Murugan Sevanan, Ananda Babu Sairam, Nachiappan Nachiappan, Buhyun Youn, Jung Sub Lee, Muthuchamy Nallal, Kang Hyun Park
Summary: Nanomaterials are being used to deliver therapeutic agents in living systems. Different nanotechnological applications such as immunosensors, immune assays, and drug delivery are being implemented using nanotechnology. Genomics plays a crucial role in selecting appropriate drugs for personalized cancer therapy. It helps in analyzing gene and protein expression, disease classification, and designing disease models. Delivering drugs to specific areas using nanoparticles is a challenging issue.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jing Li, Wei Wang, Han Wu, Feng Peng, Hui Gao, Ying Guan
Summary: In this study, CMH-based CPF films were prepared and their thermal and barrier properties were successfully regulated. The tensile strength and water vapor barrier property of CPF films were significantly improved, making them promising for food packaging applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)