Article
Immunology
Erin K. McCreary, Melissa D. Johnson, Travis M. Jones, S. Shaefer Spires, Angelina E. Davis, April P. Dyer, Elizabeth Dodds Ashley, Jason C. Gallagher
Summary: Antimicrobials are frequently prescribed and frequently misunderstood. This article will discuss common myths regarding the consultation from infectious diseases specialists, particularly focusing on specific considerations for various antibiotics.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Infectious Diseases
Takumi Sato, Ryota Ito, Masato Kawamura, Shigeru Fujimura
Summary: The study revealed that SXT-resistant strains of S. aureus began to emerge after 14 days of exposure, accounting for 45% of the clinical isolates. Half of these resistant strains showed a mutation in DfrB, allowing them to retain SXT resistance without selective pressure.
INFECTION AND DRUG RESISTANCE
(2022)
Article
Public, Environmental & Occupational Health
D. Cal Ham, Lucy Fike, Hannah Wolford, Lindsey Lastinger, Minn Soe, James Baggs, Maroya Spalding Walters
Summary: This study reviewed antibiotic susceptibility testing data of Staphylococcus aureus to trimethoprim-sulfamethoxazole in three national inpatient databases. The results showed an increasing percentage of methicillin-resistant Staphylococcus aureus that were not susceptible to trimethoprim-sulfamethoxazole. It is recommended that healthcare providers choose antibiotic regimens based on local resistance patterns and promptly report any changes to the public health department.
INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY
(2023)
Article
Microbiology
Dennis Nurjadi, Quan Chanthalangsy, Elfi Zizmann, Vanessa Stuermer, Maximilian Moll, Sabrina Klein, Sebastien Boutin, Klaus Heeg, Philipp Zanger
Summary: This study identified a novel hemin-inducible heteroresistance phenotype in Staphylococcus aureus, which may be missed by standard AST methods but can be detected using Mueller-Hinton agar supplemented with horse blood. This phenomenon may partly explain the discrepancies of AST methods in determining SXT resistance in S. aureus, highlighting the importance of accurately detecting antimicrobial resistance in clinical settings.
MICROBIOLOGY SPECTRUM
(2021)
Article
Medicine, General & Internal
Zhun-Yong Gu, Wen-Jun Liu, Dan-Lei Huang, Yu-Jing Liu, Hong-Yu He, Cheng Yang, Yi-Mei Liu, Ming Xu, Rui-Ming Rong, Du-Ming Zhu, Zhe Luo, Min-Jie Ju
Summary: This study evaluated the effect of combining clindamycin with low-dose trimethoprim-sulfamethoxazole (TMP/SMX) regimen on severe Pneumocystis pneumonia (PCP) after renal transplantation. The results showed that the combination therapy significantly improved the PaO2/FiO2 ratio, reduced the incidence of pneumomediastinum, and shortened the length of hospital and ICU stay compared to the standard dose of TMP/SMX treatment. Moreover, the combination therapy had a lower adverse reaction rate and reduced the dosage of TMP/SMX in patients.
FRONTIERS IN MEDICINE
(2022)
Article
Infectious Diseases
Louise Kime, Tina Waring, Merianne Mohamad, Benjamin F. Mann, Alex J. O'Neill
Summary: Resistance to antifolate drugs is prevalent in multidrug-resistant Staphylococcus aureus. Mutation in the drug targets and acquisition of genes encoding drug-insensitive proteins are the main mechanisms of resistance. A novel gene, dfrL, encoding a high-level resistant dihydrofolate reductase, was identified. This study provides important insights into the genotypes underlying staphylococcal resistance to antifolate drugs.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2023)
Article
Multidisciplinary Sciences
Pablo Catalan, Emily Wood, Jessica M. A. Blair, Ivana Gudelj, Jonathan R. Iredell, Robert E. Beardmore
Summary: This study explores the trends in antibiotic resistance using the global database ATLAS and compares the results with other surveillance data.
NATURE COMMUNICATIONS
(2022)
Article
Microbiology
Yi Shuan S. Wu, Michael Cohen-Wolkowiez, Christoph P. Hornik, Jacqueline G. Gerhart, Julie Autmizguine, Marjan Cobbaert, Daniel Gonzalez
Summary: The study investigated the pharmacokinetic characteristics of oral TMP-SMX in infants and children, resulting in new population PK models. The external data model had similar structures to the POPS model but differed in exposure prediction, both supporting dose increases for target bacteria with TMP-SMX.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Article
Infectious Diseases
Dennis Nurjadi, Sabrina Klein, Julius Hannesen, Klaus Heeg, Sebastien Boutin, Philipp Zanger
Summary: The prevalence of trimethoprim/sulfamethoxazole resistance in Staphylococcus aureus, particularly MRSA, has been increasing over the past years, with outpatients and younger patients being more likely to exhibit resistance. Whole genome sequencing revealed that most trimethoprim/sulfamethoxazole-resistant MRSA strains belonged to major pandemic CA-MRSA clones, suggesting independent introductions as the source of resistance.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2022)
Article
Pharmacology & Pharmacy
Seyed Ebrahim Alavi, Urooj Bakht, Maedeh Koohi Moftakhari Esfahani, Hossein Adelnia, Seyed Hossein Abdollahi, Hasan Ebrahimi Shahmabadi, Aun Raza
Summary: This study demonstrates the use of PEGylated nanostructured lipid carrier nanoparticles as a promising approach for improving the oral delivery and efficacy of trimethoprim/sulfamethoxazole (TMP/SMZ) for the treatment of MRSA skin infection. The nanoformulation was found to have a controlled release of drugs at intestinal pH, decreased drug toxicity, enhanced drug permeability, and improved antibacterial effects. The stability of the nanoparticles was also shown. Overall, this study highlights the potential of PEGylated NLC nanoparticles in improving the treatment of MRSA skin infection.
Article
Fisheries
Yongtao Liu, Gang Han, Jing Dong, Yibin Yang, Qiuhong Yang, Ning Xu, Shun Zhou, Xiaohui Ai
Summary: The study revealed significant sex-related differences in the disposition regularities of SMZ, N-ac-SMZ, and TMP in male and female yellow catfish. N-ac-SMZ showed a longer residue time compared to SMZ, and the findings could serve as reference data for establishing different use regimens and drug withdrawal times.
Editorial Material
Critical Care Medicine
Jonah Rubin, Michelle L. Chiu, Mari Mino-Kenudson, Amita Sharma, Alison S. Witkin, Peter P. Moschovis, Yehuda Vogel, Kenneth Shelton, Jerome Crowley, Yuval Raz
Summary: This is a case of a 19-year-old male patient presenting with acute cough, high fever, and dyspnea. Other than a resolved seizure episode, he had no previous medical history. He had been taking montelukast and trimethoprim-sulfamethoxazole before admission. Animal exposures to a new puppy and a friend's bird were noted. His paternal grandmother had rheumatoid arthritis.
Article
Microbiology
Dennis Nurjadi, Elfi Zizmann, Quan Chanthalangsy, Klaus Heeg, Sebastien Boutin
Summary: As whole genome sequencing becomes more accessible for clinical microbiological diagnostics, the reliability of genotypic antimicrobial resistance (AMR) predictions from sequencing data is crucial. Different computational approaches have varying levels of accuracy, with issues surrounding database quality and missed gene mutations.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Julia Grapsa, Christopher Blauth, Y. S. Chandrashekhar, Bernard Prendergast, Blair Erb, Michael Mack, Valentin Fuster
Summary: This paper presents a clinical case of Staphylococcus aureus infective endocarditis in a 19-year-old female patient and discusses the current evidence on the management and treatment of the disease.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Article
Infectious Diseases
Itziar Diego-Yague, Alberto Mora-Vargas, Jose Manuel Vazquez-Comendador, Beatriz Santamarina-Alcantud, Ana Fernandez-Cruz, Elena Munez-Rubio, Andrea Gutierrez-Villanueva, Isabel Sanchez-Romero, Victor Moreno-Torres, Antonio Ramos-Martinez, Jorge Calderon-Parra
Summary: Oral sequential therapy (OST) in uncomplicated Staphylococcus aureus bacteraemia (SAB) is found to be safe and effective, reducing mortality and microbiological failure.
CLINICAL MICROBIOLOGY AND INFECTION
(2023)
Article
Oncology
Clara Vigneron, Julien Charpentier, Florence Coussy, Jerome Alexandre, Frederic Pene, Matthieu Jamme
Summary: This retrospective study analyzed 177 breast cancer patients requiring ICU admission. The results showed a low ICU admission rate but a high one-year mortality rate. The patients' performance status was found to be an important predictor for short-term and long-term outcomes.
Article
Microbiology
Reham Magdy Wasfy, Malak Zoaiter, Melhem Bilen, Maryam Tidjani Alou, Cheikh Ibrahima Lo, Sara Bellali, Aurelia Caputo, Stephane Alibar, Claudia Andrieu, Didier Raoult, Pierre Edouard Fournier, Matthieu Million
Summary: This article reports a novel bacterial strain Marseille-P4005(T) isolated from a stool sample of a healthy donor. It is a Gram-stain negative, non-motile, non-spore-forming rod that grows optimally at 37 degrees C and at pH 7.0. Genomic analysis revealed it as a new species within the genus Agathobaculum, named Agathobaculum massiliense sp. nov. The strain showed resistance to several antibiotics and exhibited specific metabolic capabilities.
ANTONIE VAN LEEUWENHOEK INTERNATIONAL JOURNAL OF GENERAL AND MOLECULAR MICROBIOLOGY
(2023)
Review
Infectious Diseases
Myrto Koutantou, Konstantinos Kambas, Sofia Makka, Pierre-Edouard Fournier, Didier Raoult, Emmanouil Angelakis
Summary: Cat scratch disease (CSD) is difficult to diagnose, and serological assays have limitations in terms of sensitivity and specificity. Molecular assays should be considered as the gold standard for confirming CSD, and lymph node biopsy may be necessary in suspicious cases.
CANADIAN JOURNAL OF INFECTIOUS DISEASES & MEDICAL MICROBIOLOGY
(2023)
Article
Microbiology
Sory Ibrahima Traore, Cheikh Ibrahima Lo, Maaloum Mossaab, Guillaume Durand, Jean Christophe Lagier, Didier Raoult, Pierre-Edouard Fournier, Florence Fenollar
Summary: Bacterial strain Marseille-P3954 was isolated from a stool sample of a 35-year-old male patient living in France. It belongs to a new bacterial genus, classified in a new family, based on its genomic, phenotypic, and phylogenetic evidences. The proposed classification is Maliibacterium massiliense gen. nov., sp. nov. with the type strain Marseille-P3954 (CSUR P3954 = CECT 9568).
CURRENT MICROBIOLOGY
(2023)
Correction
Genetics & Heredity
Sahare Kokcha, Ajay Kumar Mishra, Jean-Christophe Lagier, Matthieu Million, Quentin Leroy, Didier Raoult, Pierre-Edouard Fournier
ENVIRONMENTAL MICROBIOME
(2023)
Article
Infectious Diseases
Anna Barbiero, Tommaso Manciulli, Michele Spinicci, Iacopo Vellere, Maria Grazia Colao, Gian Maria Rossolini, Alessandro Bartoloni, Didier Raoult, Lorenzo Zammarchi
Summary: This study reports ten cases of SENLAT in Tuscany, Italy, with symptoms including scalp eschar and cervical lymphadenopathy. The difficulty of microbiological diagnosis and previous antibiotic treatment administration hindered the identification of the causative agent.
Expression of Concern
Immunology
S. Meconi, C. Capo, M. Remacle-Bonnet, G. Pommier, D. Raoult, J. L. Mege
INFECTION AND IMMUNITY
(2023)
Correction
Infectious Diseases
Thi Loi Dao, Naomie Canard, Van Thuan Hoang, Tran Duc Anh Ly, Tassadit Drali, Laetitia Ninove, Florence Fenollar, Didier Raoult, Philippe Parola, Pierre Marty, Philippe Gautret
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2023)
Expression of Concern
Microbiology
T. Adekambi, M. Reynaud-Gaubert, G. Greub, M-J Gevaudan, B. La Scola, D. Raoult, D. Drancourt
JOURNAL OF CLINICAL MICROBIOLOGY
(2023)
Expression of Concern
Microbiology
W. Xu, D. Raoult
JOURNAL OF CLINICAL MICROBIOLOGY
(2023)
Article
Immunology
Babacar Mbaye, Reham Magdy Wasfy, Maryam Tidjani Alou, Patrick Borentain, Claudia Andrieu, Aurelia Caputo, Didier Raoult, Rene Gerolami, Matthieu Million
Summary: This study analyzed the microbial composition of NASH patients and controls using 16S rRNA sequencing and qPCR. The results showed an association between Lactobacillus and Lactoccocus with NASH, and an association between Methanobrevibacter, Faecalibacterium, and Romboutsia with controls. At the species level, ethanol-producing species of Lactobacillus and an already associated species of dysbiosis were associated with NASH. This study highlights the potential role of ethanol-producing gut microbes in NASH.
MICROBIAL PATHOGENESIS
(2023)
Correction
Public, Environmental & Occupational Health
Thi Loi Dao, Van Thuan Hoang, Amal Magmoun, Tran Duc Anh Ly, Sophie Alexandra Baron, Linda Hadjadj, Naomie Canard, Tassadit Drali, Frederique Gouriet, Didier Raoult, Philippe Parola, Pierre Marty, Jean-Marc Rolain, Philippe Gautret
TRAVEL MEDICINE AND INFECTIOUS DISEASE
(2023)
Article
Immunology
Sabrina Naud, Camille Valles, Abdourahim Abdillah, Linda Abou Chacra, Fatima Zouina Mekhalif, Ahmad Ibrahim, Aurelia Caputo, Jean-Pierre Baudoin, Frederique Gouriet, Fadi Bittar, Jean-Christophe Lagier, Stephane Ranque, Florence Fenollar, Maryam Tidjani Alou, Didier Raoult
Summary: In this study, TM7 were found to be ubiquitous members of the human oral microbiota and were also detected in other human samples, including fecal, breast milk, vaginal, and urine samples. TM7 were also detected in infectious samples, such as blood cultures and cardiac valves, at a low prevalence. The findings suggest that TM7 are human commensals and may have a role in a pathological setting, warranting further investigation.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Review
Cell Biology
Seydina M. Diene, Pierre Pontarotti, Said Azza, Nicholas Armstrong, Lucile Pinault, Eric Chabriere, Philippe Colson, Jean-Marc Rolain, Didier Raoult
Summary: Beta-lactamase enzymes are capable of conferring resistance to widely used antibiotics in human medicine, making them a topic of significant interest. Among these enzymes, the class B beta-lactamases are a type of metallo-beta-lactamase fold protein found not only in bacteria but also in other organisms. Previously unexplored in other organisms due to various barriers, modern search approaches have now uncovered their presence in different organisms including Bacteria, Archaea, Nanoarchaeota, Asgard, Humans, Giant viruses, and Candidate Phyla Radiation (CPR). These multifunctional enzymes exhibit diverse enzymatic or non-enzymatic activities, with at least thirteen reported activities such as beta-lactamase, ribonuclease, nuclease, glyoxalase, lactonase, phytase, ascorbic acid degradation, anti-cancer drug degradation, or membrane transport. This review discusses the existence of M beta L fold enzymes in different domains of life, presents suitable approaches for studying their homologous sequences in unexpected sources, and presents described M beta L fold enzymes with demonstrated enzymatic or non-enzymatic activities.
Article
Microbiology
Fatou Samba Diouf, Mamadou Beye, Mapenda Gaye, Babacar Mbaye, Stephane Alibar, Mariema Sarr, Gregory Dubourg, Jean-Christophe Lagier, Cheikh Sokhna, Florence Fenollar, Pierre-Edouard Fournier, Cheikh Ibrahima Lo
Summary: Blood is normally sterile, but bacteria in the bloodstream indicate an anomaly. By performing a blood culture on a patient with thalassemia major, a new strain of Streptococcus was isolated and identified through phenotypic, phylogenetic, and genomic characteristics analysis. Named Streptococcus thalassemiae sp. nov., this strain showed similarity to Streptococcus mitis but had significant differences based on DNA-DNA hybridization and average nucleotide identity analysis. This research demonstrates the importance of studying bacterial strains in blood cultures for accurate diagnosis.
INTERNATIONAL JOURNAL OF MICROBIOLOGY
(2023)
Review
Infectious Diseases
Allison M. Hitchcock, Wesley D. Kufel, Keri A. Mastro Dwyer, Eric F. Sidman
Summary: Lenacapavir is a novel HIV-1 treatment option for patients with multidrug-resistant (MDR) HIV-1 infection. It has a favorable pharmacokinetic profile and has shown good tolerability and efficacy in clinical trials.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2024)
Article
Infectious Diseases
Roberta Gagliardini, Alessandro Tavelli, Stefano Rusconi, Sergio Lo Caputo, Vincenzo Spagnuolo, Maria Mercedes Santoro, Andrea Costantini, Alessandra Vergori, Franco Maggiolo, Andrea Giacomelli, Giulia Burastero, Giordano Madeddu, Eugenia Quiros Roldan, Antonella d'Arminio Monforte, Andrea Antinori, Alessandro Cozzi-Lepri
Summary: This study evaluated multiple treatment failures to modern antiretroviral therapy in HIV-infected individuals and found that approximately 4% of them were difficult to treat. The difficult to treat group, compared to the non-difficult to treat group, was characterized by older age, higher prevalence of AIDS, lower CD4+ cell count, and higher risk of treatment failure.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2024)