Article
Food Science & Technology
Yan-Cui Liang, Qian Zhong, Run-Hui Ma, Zhi-Jing Ni, Kiran Thakur, Mohammad Rizwan Khan, Rosa Busquets, Jian-Guo Zhang, Zhao-Jun Wei
Summary: Apigenin (API) inhibits proliferation, induces apoptosis, and prevents migration and invasion of Ishikawa cells. The study suggests that API could be a promising dietary supplement and adjuvant chemotherapeutic agent.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Oncology
Lone A. A. Nazir, Naikoo H. H. Shahid, Kumar Amit, Sheikh A. A. Umar, Sharma Rajni, Sandip Bharate, Pyare L. L. Sangwan, Sheikh Abdullah Tasduq
Summary: NPC-402, a derivative of glycyrrhtinic acid, has shown anti-melanoma effects by inducing oxidative stress and apoptosis in melanoma cells. In vivo studies have demonstrated that NPC-402 significantly inhibited angiogenesis and reduced tumor growth without causing toxicity, suggesting its potential as a chemotherapeutic agent for melanoma.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Sunje Kim, Seong Eun Lee, Shinae Yi, Sangmi Jun, Yoon-Sun Yi, Harsha Nagar, Cuk-Seong Kim, Chungmin Shin, Min-Kyung Yeo, Yea Eun Kang, Sang-Ha Oh
Summary: The study identified that mitochondrial dysfunction and dysregulated endoplasmic reticulum stress signaling play a role in human keloid formation, and that treatment with tauroursodeoxycholic acid (TUDCA) shows potential in reducing scar formation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Wenjuan Chen, Yanjie Chen, Yun Qian, Jun Zhang, Xiaoshan Hu, Xiangyun Yan, Chengyao Jiang, Shuwen Yao, Qinlei Yu, Xiaohui Chen, Shuping Han
Summary: This study investigated the protective effects of casein-derived peptide YFYPEL on necrotizing enterocolitis (NEC). YFYPEL integration in the intestine increased survival and clinical conditions, lowered the incidence of NEC, alleviated bowel inflammation, and enhanced intestinal cell migration.
Article
Cell Biology
Hyojin Kang, Sunsik Yang, Jun Lee
Summary: Mesenchymal stem cells (MSCs) are pluripotent stromal cells that have potential applications in regenerative medicine. Tauroursodeoxycholic acid (TUDCA) is a drug that has been used in various cell types. However, the mechanism of osteogenic differentiation by TUDCA in human MSCs is still unknown.
Article
Environmental Sciences
Cao Zhaohui, Tang Cifei, Huang Di, Zeng Weijia, Han Cairui, Li Zecong, Hu Xiaobo
Summary: In this study, it was found that cadmium exposure induced cell death in HepG2 cells via a ROS-mediated PERK-CHOP-related apoptotic signaling pathway, providing a novel insight into the mechanisms of cadmium-induced hepatotoxicity. Inhibitors targeting oxidative stress and ER stress might be potential strategies for preventing or treating this disorder.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Pharmacology & Pharmacy
Wenbin Luo, Yu Tao, Shengnan Chen, Hao Luo, Xiaoping Li, Shuang Qu, Ken Chen, Chunyu Zeng
Summary: This study found that rosmarinic acid (RA) can effectively protect against pulmonary ischemia/reperfusion (IR) injury by activating the PI3K/Akt signaling pathway for antioxidation and anti-apoptosis, suggesting its potential therapeutic value.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Zhaolin Gao, Min Li, Fei Yao, Xiaobo Xia, Tianqi Duan, Jingzhuo Meng, Yanxia Huang, Ye He, Adonira Saro, Jufang Huang
Summary: The study investigated the effects and underlying mechanisms of valdecoxib on retinal ischemia-reperfusion injury and oxygen-glucose deprivation/recovery injury. The results showed that valdecoxib protected R28 cells by reducing cell apoptosis and exerted a protective effect on retinas by inhibiting retinal ganglion cell apoptosis. In addition, valdecoxib reversed the expression of certain proteins induced by glaucomatous model and the reversal was mediated by the PERK-ATF4-CHOP pathway. These findings suggest that valdecoxib protects against glaucomatous injury by inhibiting ER stress-induced apoptosis via the PERK-ATF4-CHOP pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Anatomy & Morphology
Lin Tian, Shuang Tao, Chunzhi He, Shanwu Dong, Yongli Chen, Ling Chen, Shu Jiang
Summary: The aim of this study was to investigate the potential impact of Astragaloside IV (AS-IV) on neonatal rat models with necrotizing enterocolitis (NEC) and to confirm the potential involvement of TNF-like ligand 1 A (TL1A) and the NF-KB signaling pathway. NEC neonatal rat models were induced through formula feeding, cold/asphyxia stress, and Lipo-polysaccharide (LPS) administration. The appearance, behavior, skin condition, and pathological status were evaluated in the NEC-modelled rats. Intestinal tissues were examined using H&E staining. The expression of oxidative stress biomarkers (SOD, MDA, GSH-Px) and inflammatory cytokines (TNF-α, IL-13, IL-6) were measured using ELISA and qRT-PCR. TL1A and NF-KB signaling pathway-related proteins were detected using Western blotting and immunohistochemistry. Cell apoptosis was assessed using TUNEL. The results showed that successful NEC neonatal rat models were established, with high expression of TL1A and activation of the NF-KB signaling pathway. AS-IV treatment suppressed TL1A and the NF-KB signaling pathway in NEC rats. Moreover, AS-IV attenuated the inflammatory response in the intestinal tissues of NEC rats by inhibiting TL1A and the NF-Kb signaling pathway.
Article
Biochemistry & Molecular Biology
Yu-Ming Wang, Xin Xu, Jian Tang, Zhi-Yong Sun, Yu-Jie Fu, Xiao-Jing Zhao, Xiu-Mei Ma, Qing Ye
Summary: Apatinib was shown to induce ER stress, autophagy, and apoptosis in ESCC cells, with inhibiting autophagy enhancing apatinib-induced apoptosis. The combination of apatinib and CQ sensitized ESCC cells to paclitaxel through the IRE-1 alpha-AKT-mTOR signaling pathway, suggesting its potential use in innovative anticancer therapeutic strategies.
CELL AND BIOSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Gaixia Zhang, Yuxin Zhang, Lingyang Jing, Hongfeng Zhao
Summary: Birds, especially Japanese quails, exposed to lead (Pb) contamination in drinking water showed an increase in kidney weight and a decrease in body weight and length. Pb exposure induced renal dysfunction, including abnormal uric acid metabolism, oxidative stress, apoptotic increment, and aggravated inflammation. The study revealed the nephrotoxic effects of Pb on birds through structural damages, disruption of purine metabolism, oxidation imbalance, apoptosis, and activation of the inflammatory pathway.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2023)
Review
Cell Biology
Jiahui Yang, Yongyan Shi
Summary: This review summarizes the features of Paneth cells, including their immune function, association with gut microbiota and intestinal stem cells, and their mechanism of regulating intestinal epithelial cell death, in order to explore the possible mechanisms by which Paneth cells affect necrotizing enterocolitis (NEC).
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Cell Biology
Juan Wang, Tongde Du, Ya Lu, Yan Lv, Yuxin Du, Jianzhong Wu, Rong Ma, Chenxin Xu, Jifeng Feng
Summary: The study identified VLX1570 as a potent inhibitor for lung cancer, capable of inhibiting cell proliferation by regulating the cell cycle and inducing apoptosis. Furthermore, VLX1570 activates the PERK/IRE1/ATF6 pathway, inducing ER stress and ultimately leading to apoptosis in lung cancer cells.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2022)
Article
Plant Sciences
Qun Zhao, Xinran Cheng, Wei Yu, Yun Bi, Jian Guo, Qingzhao Ma, Yingxia Gong, Li He, Xianjun Yu
Summary: Pristimerin exhibits potent antitumor activity against various cancers and can inhibit the proliferation of human OSCC cell lines by inducing apoptosis through endoplasmic reticulum stress activation and JNK signaling. Pri also suppresses tumor growth in OSCC xenografts, suggesting its potential therapeutic use for OSCC.
Article
Cell Biology
Yun Cao, Zhaowei Chen, Jijia Hu, Jun Feng, Zijing Zhu, Yanqin Fan, Qiaoxuan Lin, Guohua Ding
Summary: In this study, it was confirmed that Mfn2 regulates the morphology and functions of MAMs and mitochondria, and exerts anti-apoptotic effects on podocytes by inhibiting the PERK pathway. The Mfn2-PERK signaling pathway may be a new therapeutic target for preventing podocyte injury in DKD.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Dong Fu, Wei Sun, Jiakang Shen, Xiaojun Ma, Zhengdong Cai, Yingqi Hua
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2015)
Article
Multidisciplinary Sciences
Dong Fu, Yiqiong Zhao, Jiakang Shen, Zhengdong Cai, Yingqi Hua
Review
Orthopedics
Dong Fu, Guodong Li, Kai Chen, Hui Zeng, Xiaolong Zhang, Zhengdong Cai
JOURNAL OF ARTHROPLASTY
(2013)
Article
Orthopedics
Dong Fu, Guodong Li, Kai Chen, Yiqiong Zhao, Yingqi Hua, Zhengdong Cai
JOURNAL OF ARTHROPLASTY
(2013)
Article
Clinical Neurology
Guodong Li, Dong Fu, Kai Chen, Xiaojun Ma, Mengxiong Sun, Wei Sun, Jian Li, Zhendong Cai
Article
Cell Biology
Dong Fu, Chunwen Lu, Xingzhou Qu, Peng Li, Kai Chen, Liancheng Shan, Xiaodong Zhu
Article
Cell Biology
Dong Fu, Peng Li, Qingfeng Sheng, Zhibao Lv
Article
Chemistry, Analytical
Ping Xu, Chunwen Lu, Dahui Wang, Dong Fu
Summary: In this study, an ultrathin micro-patterned MXene/PEDOT:PSS-based organic electrochemical transistor biosensor was developed to amplify the amperometric signal and improve transistor's performance for the reliable determination of survivin. The novel interdigitated OECTs biosensor exhibited enhanced detectability, selectivity, reproducibility, and reliability compared to previous literatures, with favorable linearity and correlation coefficient when compared against a commercial ELISA kit. These advantages are expected to pave the way for the design of robust, non-invasive, and miniaturized OECTs biosensors for point-of-care applications.
Article
Medicine, Research & Experimental
Xuelian Wang, Gaojian Huang, Jiaxin Mu, Zhilei Cong, Shuyan Chen, Dong Fu, Jia Qi, Zhen Li
Article
Immunology
Jun Cui, Cheng Chen, Xiao Zhou, Wenju Shan, Yuhong Jian, Panpan Li, Yang Sun, Wei Yi
Summary: Bone marrow mesenchymal stem cells (BMSCs) are a promising therapy for sepsis, but metabolic syndromes threaten their effectiveness. This study investigated the potential of small extracellular vesicles from high-fat diet BMSCs in sepsis-induced liver-heart axis injury.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Binbin Zhu, Angyang Cao, Chunqu Chen, Weijian Zhou, Wenjun Luo, Yu Gui, Qinwen Wang, Zhipeng Xu, Jianhua Wang
Summary: GM6001 alleviates postoperative cognitive deficits and neuroinflammation, preserves blood-brain barrier integrity, and rescues aquaporin-4 mislocalization. MMP-9 inhibition plays a dual role in cognitive protection through direct anti-neuroinflammatory effects and regulation of aquaporin-4 membrane distribution.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Anika Sood, Valencia Fernandes, Kumari Preeti, Shruti Rajan, Dharmendra Kumar Khatri, Shashi Bala Singh
Summary: S1PR2 inhibitor improves cognitive function and skews microglia toward anti-inflammatory phenotype in type 2 diabetic mice, promising to be a potential therapy for neuroinflammation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Haochun Guo, Ran Yu, Haijun Zhang, Wanpeng Wang
Summary: Radiation therapy is an effective treatment for thoracic malignancies, but it can cause radiation-induced lung injury (RILI), including radiation pneumonitis (RP) and radiation pulmonary fibrosis (RPF). The damage to normal lung cells during radiation treatment leads to a pulmonary inflammatory response, resulting in RP and RPF.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Guanghui Wang, Haotian Zheng, Yunzhi Xiang, Yadong Wang, Kai Wang, Xiaoyang Ren, Jiajun Du
Summary: This study identified a T-cell synthetic driver-associated prognostic model that accurately predicted prognosis and effectiveness of immunotherapy in LUAD patients. It also highlighted the role of LDHA in promoting tumor cell proliferation, invasion, and resistance to treatment, as well as its involvement in immune escape within the tumor microenvironment. These findings provide a promising new therapeutic strategy for LUAD.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Bowen Wei, Aihua Wang, Wei Liu, Qingyun Yue, Yihua Fan, Bin Xue, Siwei Wang
Summary: This study systematically analyzed the association between pSS and cuproptosis, established a predictive model based on 5 genes, explored the pathogenic mechanisms and novel therapeutic strategies for pSS, and identified EED, CBL, and NFU1 as potential targets for treatment.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Nusrit Iqbal Andrabi, Aminur R. Sarkar, Syed Assim Haq, Diljeet Kumar, Dilpreet Kour, Diksha Saroch, Sanket Kumar Shukla, Ajay Kumar, Asha Bhagat, Asif Ali, Gurleen Kour, Zabeer Ahmed
Summary: Koenimbine and its novel semi-synthetic derivative 1G demonstrate significant anti-inflammatory effects by downregulating the nuclear factor kappa-B (NF-kappa B) signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Jing-Mei Lu, Xiang Xu, Fumie Aosai, Ming-Yue Zhang, Lian-Xun Piao
Summary: This study found that arctiin can improve allergic acute liver injury caused by T.g.HSP70 by inhibiting TLR4 signaling and reducing the production of inflammatory mediators.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Minxuan Xu, Fang Shi, Yongshen Gao, Shumei Han, Chensuo Huang, Qinsheng Hou, Xiaoweng Wen, Bengshi Wang, Zhenyu Zhu, Lei Zou, Mingxin Xiong, Wei Dong, Jun Tan
Summary: There is a growing body of research highlighting the involvement of metabolic imbalance and the inflammatory response in the advancement of colitis. This study recognizes arabinose as a significant protector of the intestinal mucosal barrier, reducing damage to the intestines. In addition, lower levels of arabinose in the bloodstream are associated with a higher severity of inflammatory bowel disease and colorectal cancer.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yueqing Han, Haoxin Song, Yanshan Li, Rongxin Li, Ling Chen, Bo Gao, Yijun Chen, Shuzhen Wang
Summary: The combination of tetracycline antibiotics, demeclocycline (D), chlortetracycline (C), and minocycline (M), showed therapeutic potential against liver fibrosis by inhibiting the activation of hepatic stellate cells and the MAPK signaling. This study suggests that tetracyclines may be repurposed for the treatment of liver fibrosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yu Li, Hailing Liu, Danwen Zhao, Danjie Zhang
Summary: Chronic stress can lead to lung injury, with the spleen playing a crucial role. This study found that the spleen contributes to chronic restraint stress-induced lung injury, and splenic CD11b+ cells may be an important factor in this process.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yingqian Mi, Mengyan Tang, Qiong Wu, Yinan Wang, Qihui Liu, Pei Zhu, Xiaoyang Xue, Yuntong Liu, Xinyu Chai, Yuyang Hou, Dongmei Yan
Summary: BCG therapy can induce macrophage polarization to the M1 type, and NMAAP1 plays a crucial role in this process by regulating glycolysis and HIF-1α expression. This promotes the antitumor effect of macrophages.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Xiaosheng Liu, Tingxia Lv, Xiuxia Li, Jing Xue, Ling Lin, Lianfeng Lu, Xiaodi Li, Yang Yang, Yuanni Wu, Qiang Wei, Wei Cao, Taisheng Li
Summary: LLDT-8 exhibits notable efficacy in alleviating immune activation in both an in vivo animal model and in vitro human cell experiments, suggesting its potential as a drug for managing systemic immune activation associated with SIV/HIV infection.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Honghong Yu, Qi Li, Huimin Zhu, Chang Liu, Weiwei Chen, Lingyun Sun
Summary: The activation of the inflammasome plays a critical role in the pathogenesis of systemic lupus erythematosus (SLE), and mesenchymal stem cells (MSC) have been shown to alleviate SLE by suppressing inflammasome activation. This study found that the NLRP3 inflammasome was activated in macrophages from SLE patients and mice, and its activation correlated with disease activity. After MSC transplantation, the severity of SLE was reduced, and NLRP3 inflammasome activation was inhibited. These findings suggest that MSC suppress inflammasome activation and provide a potential therapeutic target for SLE.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Wei Zhou, Dan Zeng, Shunan Liu, Yunxia Huang, Fenglin Lv, Weikang Zhou
Summary: This study found that inhibiting HDAC3 can protect the skin from atopic dermatitis by activating the Nrf2 transcription to upregulate Nrf2/HO-1 signaling pathway activity.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)