Review
Biochemistry & Molecular Biology
Eun Jin Sun, Miriam Wankell, Pranavan Palamuthusingam, Craig McFarlane, Lionel Hebbard
Summary: This review article discusses the pivotal role of the PI3K/Akt/mTOR pathway in HCC, focusing on its impact on cellular processes and providing an update on the ongoing clinical development of therapies targeting this pathway for HCC treatments.
Review
Pharmacology & Pharmacy
Jieun Bang, Mihyeon Jun, Soyun Lee, Hyuk Moon, Simon Weonsang Ro
Summary: Hepatocellular carcinoma (HCC) is a significant global health concern, with its incidence steadily increasing. Recent progress has been made in understanding the molecular signaling pathways, particularly the EGFR/PI3K/AKT/mTOR pathway, which plays a central role in HCC. Preclinical studies have shown the effectiveness of targeting this signaling pathway for HCC therapy, offering potential therapeutic options for patients.
Article
Medicine, Research & Experimental
Yanqing Ye, Maosheng Liu, Fengfei Wu, Shiyu Ou, Weidong Wang, Jieying Fei, Fang Xie, Lan Bai
Summary: TRMT6 is overexpressed in HCC tissues and associated with TNM stage, T classification, and N classification. Overexpression of TRMT6 promotes HCC cell proliferation through the PI3K/AKT/mTOR axis in vivo and in vitro. Inhibition of TRMT6 reduces tumor growth and is related to the PI3K/AKT pathway.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2023)
Article
Medicine, Research & Experimental
Zhangya Pu, Dan G. Duda, Yuanyuan Zhu, Siya Pei, Xiaofang Wang, Yan Huang, Panpan Yi, Zebing Huang, Fang Peng, Xingwang Hu, Xuegong Fan
Summary: This study found that VCP is significantly increased in HCC tissues and is associated with advanced TNM stages and poorer prognosis. VCP overexpression promotes HCC cell proliferation, migration, and invasion via PI3K/AKT/mTOR pathway activation. Additionally, VCP interacts with HMGB1 and enhances its protein stability, contributing to HCC progression.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Oncology
Yao Zhang, Xiaopei Hao, Guoyong Han, Yiwei Lu, Zhiqiang Chen, Long Zhang, Jindao Wu, Xuehao Wang
Summary: This study systematically investigated the expression and clinical significance of GINS2 in HCC, and revealed its important role in the progression of HCC through functional enrichment analysis and experimental validation. The results suggest that GINS2 may serve as a crucial diagnostic and therapeutic target for HCC.
AMERICAN JOURNAL OF CANCER RESEARCH
(2022)
Article
Chemistry, Medicinal
Linlin Wang, Li Cheng, Li Ma, Ammad Ahmad Farooqi, Gan Qiao, Yuxi Zhang, Hanlin Ye, Minghua Liu, Jianlin Huang, Xiaohui Yang, Xiukun Lin, Shousong Cao
Summary: Alnustone exhibits potent growth inhibition against hepatocellular carcinoma (HCC) by inducing apoptosis and inhibiting the PI3K/Akt/mTOR/p70S6K pathway.
PHYTOTHERAPY RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Jing Man, Wanbiao Zhou, Shi Zuo, Xueke Zhao, Qiang Wang, Huaxing Ma, Hai-Yang Li
Summary: TANGO1 promotes hepatocellular carcinoma by activating the PI3K/AKT/mTOR signaling pathway through interaction with NRTN, leading to increased proliferation and EMT. The TANGO1/NRTN axis may serve as a potential therapeutic target for HCC.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Shumin Bi, Yidan Zhang, Jia Zhou, Yuanyuan Yao, Jiadong Wang, Miaomiao Fang, Baozhu Li, Changhao Wu, Chunxia Ren
Summary: This study found that miR-210 can promote autophagy of M2 macrophages via the PI3K/AKT/mTOR signaling pathway, and M2 macrophage-derived miR-210 promotes the malignant progression of primary hepatocellular carcinoma (HCC) through autophagy. This suggests that macrophage autophagy may serve as a new therapeutic target for HCC, and targeting miR-210 may reset the effect of M2 macrophages on HCC.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Shuangda Li, Yu Qi, Yiran Huang, Yanru Guo, Tong Huang, Li Jia
Summary: The study revealed that SNHG16, through exosomes, enhances the proliferative, migratory, and angiogenic effects of HCC cells on endothelial cells, further activating the PI3K/Akt/mTOR pathway to promote tumor growth. Exosomal SNHG16 may serve as a therapeutic target for anti-angiogenesis in HCC progression.
JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY
(2021)
Article
Pharmacology & Pharmacy
Libing Wang, Mingxin Cui, Fengzhi Qu, Daming Cheng, Jingkun Yu, Zhaoyuan Tang, Ling Cheng, Yanbing Wei, Xiaotang Wu, Xiaogang Liu
Summary: miR-92a-3p plays a tumor-promoting role in HCC and may be a potential biomarker for the diagnosis and prognosis of HCC.
CURRENT PHARMACEUTICAL DESIGN
(2021)
Article
Pharmacology & Pharmacy
Yuting Wu, Xiangbo Xu, Mingyue Liu, Xiaochun Qin, Qiong Wu, Huaiwei Ding, Qingchun Zhao
Summary: This study identified a novel PI3Ki (DZW-310) with strong anti-HCC activity. DZW-310 significantly inhibited HCC cell growth by promoting intrinsic apoptosis and G0/G1 phase cell arrest, and reduced angiogenesis by regulating the HIF-1 alpha/VEGFA axis. Mechanistically, DZW-310 acted as a PI3Ki by targeting PI3K alpha and deactivating the PI3K/AKT/mTOR pathway, demonstrating its potential as a promising therapeutic agent for HCC.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Pathology
Yongfeng Hui, Dong Jin, Junzhi Leng, Di Liu, Peng Yuan, Chaofeng Tang, Qi Wang
Summary: The study showed that circ_0007059 was downregulated in HCC, and it may inhibit oncogenic processes in HCC cells by regulating the PTEN/AKT/mTOR pathway.
PATHOLOGY RESEARCH AND PRACTICE
(2022)
Article
Oncology
Qiong Wu, Tian-yi Liu, Bai-chun Hu, Xiang Li, Yu-ting Wu, Xiao-tong Sun, Xiao-wen Jiang, Shu Wang, Xiao-chun Qin, Huai-wei Ding, Qing-chun Zhao
Summary: CK-3, a dual blocker of the PI3K/AKT/mTOR and MAPK/ERK pathways, demonstrated anti-tumor activity against HCC cell lines in vitro by inhibiting cell proliferation, wound healing, and cell invasion. By simultaneously targeting both pathways, CK-3 may represent a superior treatment option for HCC compared to single pathway monotherapies.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Bo Lv, Xianzhuo Liu, Xinfeng Zhu, Min Huang
Summary: This study found that miR-382-5p is upregulated in hepatocellular carcinoma and can activate the PI3K/Akt signaling pathway by targeting PTEN, promoting HCC cell invasion.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2022)
Article
Cell Biology
He Wang, Qiao Zhang, Wenyu Cui, Wenlan Li, Jimei Zhang
Summary: The circRNA hsa_circ_0004018 inhibits the proliferation and migration of HCC cells by sequestering miR-1197 and modulating the PTEN/PI3K/AKT signaling pathway.
Article
Genetics & Heredity
Huamei Wei, Jianchu Wang, Zuoming Xu, Yuan Lu, Xianjian Wu, Chenyi Zhuo, Chuan Tan, Qianli Tang, Jian Pu
MOLECULAR GENETICS & GENOMIC MEDICINE
(2019)
Article
Biochemistry & Molecular Biology
Jianchu Wang, Ying Zhang, Libai Lu, Yuan Lu, Qianli Tang, Jian Pu
JOURNAL OF CELLULAR BIOCHEMISTRY
(2019)
Article
Medicine, Research & Experimental
Jianchu Wang, Libai Lu, Zongjiang Luo, Wenchuan Li, Yuan Lu, Qianli Tang, Jian Pu
BIOMEDICINE & PHARMACOTHERAPY
(2019)
Article
Immunology
Jun Cui, Cheng Chen, Xiao Zhou, Wenju Shan, Yuhong Jian, Panpan Li, Yang Sun, Wei Yi
Summary: Bone marrow mesenchymal stem cells (BMSCs) are a promising therapy for sepsis, but metabolic syndromes threaten their effectiveness. This study investigated the potential of small extracellular vesicles from high-fat diet BMSCs in sepsis-induced liver-heart axis injury.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Binbin Zhu, Angyang Cao, Chunqu Chen, Weijian Zhou, Wenjun Luo, Yu Gui, Qinwen Wang, Zhipeng Xu, Jianhua Wang
Summary: GM6001 alleviates postoperative cognitive deficits and neuroinflammation, preserves blood-brain barrier integrity, and rescues aquaporin-4 mislocalization. MMP-9 inhibition plays a dual role in cognitive protection through direct anti-neuroinflammatory effects and regulation of aquaporin-4 membrane distribution.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Anika Sood, Valencia Fernandes, Kumari Preeti, Shruti Rajan, Dharmendra Kumar Khatri, Shashi Bala Singh
Summary: S1PR2 inhibitor improves cognitive function and skews microglia toward anti-inflammatory phenotype in type 2 diabetic mice, promising to be a potential therapy for neuroinflammation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Haochun Guo, Ran Yu, Haijun Zhang, Wanpeng Wang
Summary: Radiation therapy is an effective treatment for thoracic malignancies, but it can cause radiation-induced lung injury (RILI), including radiation pneumonitis (RP) and radiation pulmonary fibrosis (RPF). The damage to normal lung cells during radiation treatment leads to a pulmonary inflammatory response, resulting in RP and RPF.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Guanghui Wang, Haotian Zheng, Yunzhi Xiang, Yadong Wang, Kai Wang, Xiaoyang Ren, Jiajun Du
Summary: This study identified a T-cell synthetic driver-associated prognostic model that accurately predicted prognosis and effectiveness of immunotherapy in LUAD patients. It also highlighted the role of LDHA in promoting tumor cell proliferation, invasion, and resistance to treatment, as well as its involvement in immune escape within the tumor microenvironment. These findings provide a promising new therapeutic strategy for LUAD.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Bowen Wei, Aihua Wang, Wei Liu, Qingyun Yue, Yihua Fan, Bin Xue, Siwei Wang
Summary: This study systematically analyzed the association between pSS and cuproptosis, established a predictive model based on 5 genes, explored the pathogenic mechanisms and novel therapeutic strategies for pSS, and identified EED, CBL, and NFU1 as potential targets for treatment.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Nusrit Iqbal Andrabi, Aminur R. Sarkar, Syed Assim Haq, Diljeet Kumar, Dilpreet Kour, Diksha Saroch, Sanket Kumar Shukla, Ajay Kumar, Asha Bhagat, Asif Ali, Gurleen Kour, Zabeer Ahmed
Summary: Koenimbine and its novel semi-synthetic derivative 1G demonstrate significant anti-inflammatory effects by downregulating the nuclear factor kappa-B (NF-kappa B) signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Jing-Mei Lu, Xiang Xu, Fumie Aosai, Ming-Yue Zhang, Lian-Xun Piao
Summary: This study found that arctiin can improve allergic acute liver injury caused by T.g.HSP70 by inhibiting TLR4 signaling and reducing the production of inflammatory mediators.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Minxuan Xu, Fang Shi, Yongshen Gao, Shumei Han, Chensuo Huang, Qinsheng Hou, Xiaoweng Wen, Bengshi Wang, Zhenyu Zhu, Lei Zou, Mingxin Xiong, Wei Dong, Jun Tan
Summary: There is a growing body of research highlighting the involvement of metabolic imbalance and the inflammatory response in the advancement of colitis. This study recognizes arabinose as a significant protector of the intestinal mucosal barrier, reducing damage to the intestines. In addition, lower levels of arabinose in the bloodstream are associated with a higher severity of inflammatory bowel disease and colorectal cancer.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yueqing Han, Haoxin Song, Yanshan Li, Rongxin Li, Ling Chen, Bo Gao, Yijun Chen, Shuzhen Wang
Summary: The combination of tetracycline antibiotics, demeclocycline (D), chlortetracycline (C), and minocycline (M), showed therapeutic potential against liver fibrosis by inhibiting the activation of hepatic stellate cells and the MAPK signaling. This study suggests that tetracyclines may be repurposed for the treatment of liver fibrosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yu Li, Hailing Liu, Danwen Zhao, Danjie Zhang
Summary: Chronic stress can lead to lung injury, with the spleen playing a crucial role. This study found that the spleen contributes to chronic restraint stress-induced lung injury, and splenic CD11b+ cells may be an important factor in this process.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yingqian Mi, Mengyan Tang, Qiong Wu, Yinan Wang, Qihui Liu, Pei Zhu, Xiaoyang Xue, Yuntong Liu, Xinyu Chai, Yuyang Hou, Dongmei Yan
Summary: BCG therapy can induce macrophage polarization to the M1 type, and NMAAP1 plays a crucial role in this process by regulating glycolysis and HIF-1α expression. This promotes the antitumor effect of macrophages.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Xiaosheng Liu, Tingxia Lv, Xiuxia Li, Jing Xue, Ling Lin, Lianfeng Lu, Xiaodi Li, Yang Yang, Yuanni Wu, Qiang Wei, Wei Cao, Taisheng Li
Summary: LLDT-8 exhibits notable efficacy in alleviating immune activation in both an in vivo animal model and in vitro human cell experiments, suggesting its potential as a drug for managing systemic immune activation associated with SIV/HIV infection.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Honghong Yu, Qi Li, Huimin Zhu, Chang Liu, Weiwei Chen, Lingyun Sun
Summary: The activation of the inflammasome plays a critical role in the pathogenesis of systemic lupus erythematosus (SLE), and mesenchymal stem cells (MSC) have been shown to alleviate SLE by suppressing inflammasome activation. This study found that the NLRP3 inflammasome was activated in macrophages from SLE patients and mice, and its activation correlated with disease activity. After MSC transplantation, the severity of SLE was reduced, and NLRP3 inflammasome activation was inhibited. These findings suggest that MSC suppress inflammasome activation and provide a potential therapeutic target for SLE.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Wei Zhou, Dan Zeng, Shunan Liu, Yunxia Huang, Fenglin Lv, Weikang Zhou
Summary: This study found that inhibiting HDAC3 can protect the skin from atopic dermatitis by activating the Nrf2 transcription to upregulate Nrf2/HO-1 signaling pathway activity.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)