Article
Medicine, General & Internal
Razvan Anghel, Cristina Andreea Adam, Ovidiu Mitu, Dragos Traian Marius Marcu, Viviana Onofrei, Mihai Roca, Alexandru Dan Costache, Radu Stefan Miftode, Grigore Tinica, Florin Mitu
Summary: The management of patients with peripheral artery disease (PAD) is integrative and multidisciplinary, in which cardiac rehabilitation (CR) plays a prognostic role in terms of functional status, quality of life, and long-term impact on morbidity and mortality. This study found that comorbidities such as obesity, renal dysfunction, dyslipidemia, tobacco use, and diabetes mellitus have long-term prognostic value for PAD patients. Additionally, factors such as low-density lipoprotein cholesterol, triglycerides, fasting glucose, peak oxygen uptake, pain-free walking distance, maximum walking time, and maximum walking distance are associated with clinical improvement at the 6-month follow-up for PAD patients.
Article
Cardiac & Cardiovascular Systems
Marc P. Bonaca, Naomi M. Hamburg, Mark A. Creager
Summary: Peripheral artery disease (PAD) is a manifestation of systemic atherosclerosis with modifiable risk factors including smoking, dyslipidemia, and diabetes. Medical therapies can reduce the risk of major adverse cardiovascular events and major adverse limb events, and improve function. Diagnosis and treatment should consider the individual risk profile of the patient.
CIRCULATION RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Olivier Stivalet, Anita Paisant, Dihia Belabbas, Alexis Le Faucheur, Philippe Landreau, Estelle Le Pabic, Loukman Omarjee, Guillaume Mahe
Summary: The combination of post-exercise ABI with Exercise-TcPO2 criteria shows better sensitivity in diagnosing arterial stenoses compared to using AHA post-exercise criteria alone or Exercise-TcPO2 criteria alone.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Health Care Sciences & Services
Nicola Lamberti, Giovanni Piva, Federico Businaro, Lorenzo Caruso, Anna Crepaldi, Pablo Jesus Lopez-Soto, Fabio Manfredini
Summary: This study utilized the banister impulse-response model to evaluate the predictability of a home-based exercise program in patients with peripheral artery disease. The results showed that the model accurately estimated the improvement in walking performance and could be helpful in designing and verifying personalized training programs.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Cindy H. Nguyen, Susan Marzolini, Paul Oh, Scott G. Thomas
Summary: The study demonstrated significant improvements in VO2peak for patients with PAD, CAD, and BOTH following a 6-month CR program. Despite similar prescribed walking distance and duration, improvements in VO2peak were less pronounced in patients with PAD and BOTH compared to those with CAD. Further exploration of alternate exercise strategies for PAD patients is recommended.
CANADIAN JOURNAL OF CARDIOLOGY
(2021)
Review
Cardiac & Cardiovascular Systems
Shireen R. Khoury, Elizabeth Ratchford, Kerry J. Stewart
Summary: Peripheral artery disease (PAD) is a common form of atherosclerosis, particularly in older adults. Supervised exercise therapy (SET) is an effective treatment for improving symptoms and clinical outcomes, but challenges remain in terms of awareness, access, and implementation. Digital health and hybrid approaches may offer solutions to these challenges.
PROGRESS IN CARDIOVASCULAR DISEASES
(2022)
Article
Cardiac & Cardiovascular Systems
Andrew W. Gardner, Polly S. Montgomery, Ming Wang, Menglu Liang
Summary: This randomized controlled trial compared the long-term effects of different exercise programs on symptomatic participants with peripheral artery disease. The study found that a long-term home exercise program (HEP) and transitioning from short-term supervised exercise therapy (SET) to HEP (SET/HEP) were both effective in improving peak walking time and exercise time-to-minimum calf muscle oxygen saturation. These improvements were also correlated with each other.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Medicine, General & Internal
Nicola Lamberti, Sofia Straudi, Roberto Manfredini, Alfredo De Giorgi, Vincenzo Gasbarro, Paolo Zamboni, Fabio Manfredini
Summary: In this study, a structured in-home walking program for PAD patients proved effective in maintaining mobility and controlling risk factors during the COVID-19 pandemic. New-entry subjects showed significant improvements post-lockdown, while previously enrolled patients remained stable. The results suggest that home-based exercise programs guided by phone can be beneficial for PAD patients during pandemic situations.
INTERNAL AND EMERGENCY MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Saman L. Parvar, Linh Ngo, Joseph Dawson, Stephen J. Nicholls, Robert Fitridge, Peter J. Psaltis, Isuru Ranasinghe
Summary: This retrospective cohort study compared the long-term outcomes of endovascular and surgical revascularization in PAD patients and found that although endovascular revascularization can reduce the risk of MALE, it is associated with higher mortality. Surgical revascularization has lower long-term mortality, which contradicts previous studies and highlights the controversy in this field.
EUROPEAN HEART JOURNAL
(2022)
Article
Cardiac & Cardiovascular Systems
John W. Eikelboom, Deepak L. Bhatt, Keith A. A. Fox, Jacqueline Bosch, Stuart J. Connolly, Sonia S. Anand, Alvaro Avezum, Scott D. Berkowitz, Kelley R. H. Branch, Gilles R. Dagenais, Camilo Felix, Tomasz J. Guzik, Robert G. Hart, Aldo P. Maggioni, Eva Muehlhofer, Mukul Sharma, Olga Shestakovska, Salim Yusuf
Summary: The combination of rivaroxaban and aspirin reduces overall cardiovascular mortality and specific cause-specific cardiovascular mortality in patients with chronic CAD or PAD. The mortality benefits increase with higher baseline risk factors.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Poghni A. Peri-Okonny, Sarthak Patel, John A. Spertus, Elizabeth A. Jackson, Ali O. Malik, Jeremy Provance, Carlos Mena-Hurtado, Mehdi H. Shishehbor, Vittal Hijjaji, Kensey L. Gosch, Kim G. Smolderen
Summary: The study found no association between invasive treatment and physical activity levels in patients with claudication, despite the greater improvement in health status in the invasive treatment group. Increased physical activity was associated with better health status gains, suggesting that improving physical activity levels could potentially improve outcomes in peripheral artery disease (PAD).
AMERICAN JOURNAL OF CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Mary M. McDermott, Sudarshan Dayanidhi, Kate Kosmac, Sunil Saini, Joshua Slysz, Christiaan Leeuwenburgh, Lisa Hartnell, Robert Sufit, Luigi Ferrucci
Summary: Aerobic exercise has positive effects on mitochondrial activity and muscle mass in older adults, but its impact on patients with peripheral artery disease remains unclear. Studies show that walking exercise may increase lower extremity ischemia in PAD patients, and more research is needed to clarify the underlying mechanisms.
CIRCULATION RESEARCH
(2021)
Review
Cardiac & Cardiovascular Systems
Vinai C. Bhagirath, David Nash, Darryl Wan, Sonia S. Anand
Summary: Peripheral artery disease (PAD) is associated with high risks of cardiovascular and limb events and death. Preventive therapies, such as antithrombotic therapy, lipid lowering, blood pressure control, diabetes management, smoking cessation, and exercise programs, have been shown to improve symptoms and reduce complications. However, these therapies are underutilised in PAD patients due to barriers including lack of knowledge and access to secondary prevention programs.
CANADIAN JOURNAL OF CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Yifan Gao, Bin Feng, Rong Hu, YingYue Zhang, Yajun Shi, Yong Xu, Jing Ma
Summary: This study aimed to compare the differences in maximum exercise capacity in post-PCI patients measured by CPET and TET, and analyze the factors influencing the differences. The results showed that the maximum exercise capacity measured by TET was significantly higher than that measured by CPET, and it was negatively correlated with waist-hip ratio.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Medicine, General & Internal
Stefano Lanzi, Luca Calanca, Andre Berchtold, Lucia Mazzolai
Summary: This study found that supervised exercise training led to significant improvements in treadmill performance and 6 min walking distance in patients with lower extremity peripheral artery disease. The changes in these measures were associated with improvements in physical and mental health-related quality of life. However, improvements in treadmill performance were not related to changes in health-related quality of life.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Giovanni Piva, Anna Crepaldi, Nicola Lamberti, Lorenzo Caruso, Natascia Rinaldo, Roberto Manfredini, Pablo Jesus Lopez-Soto, Vincenzo Gasbarro, Fabio Manfredini, Alda Storari
Summary: This observational study aimed to monitor the 5-year trends of kidney function in patients with peripheral artery disease (PAD) and concomitant chronic kidney disease (CKD) enrolled or not enrolled into a rehabilitative exercise program. The results showed that patients in the exercise program had improved kidney function and better clinical outcomes compared to those receiving usual care.
Article
Sport Sciences
Natascia Rinaldo, Giovanni Piva, Suzanne Ryder, Anna Crepaldi, Alba Pasini, Lorenzo Caruso, Roberto Manfredini, Sofia Straudi, Fabio Manfredini, Nicola Lamberti
Summary: Despite progress, gender bias still exists in scientific publication authorship. This study examines trends in authorship by gender in the field of exercise sciences and rehabilitation in the last 5 years. The results show that while women are almost equally represented as first authors, bias against women remains in the last authorship position, regardless of geographical area and journal ranking.
JOURNAL OF FUNCTIONAL MORPHOLOGY AND KINESIOLOGY
(2023)
Article
Health Care Sciences & Services
Nicola Lamberti, Luca Traina, Caterina Savrie, Elpiniki Tsolaki, Natascia Rinaldo, Sofia Straudi, Franco Guerzoni, Nicola Napoli, Roberto Manfredini, Vincenzo Gasbarro, Fabio Manfredini
Summary: This study evaluated the sex-specific difference in response to an exercise program among patients with peripheral artery disease and claudication. The results showed that women had a significantly higher 7-year survival rate and lower hospitalization and amputation rates in the exercise group compared to the control group. Therefore, active participation in a home-based pain-free exercise program can reduce the risk of adverse clinical outcomes and improve long-term outcomes, especially for women in PAD patients.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Nursing
Pablo Jesus Lopez-Soto, Francisco Jose Rodriguez-Cortes, Rosa Maria Minarro-Del Moral, Maria Jose Medina-Valverde, Rocio Segura-Ruiz, Pedro Hidalgo-Lopezosa, Roberto Manfredini, Maria Aurora Rodriguez-Borrego
Summary: The study aimed to reduce in-hospital falls by implementing a nurse-led intervention based on the temporal patterns and causes of falls. Through longitudinal prospective and retrospective studies, as well as qualitative analysis, it was found that the implementation of this intervention led to a decrease in the number of falls among hospitalized patients.
Article
Surgery
Fabio Manfredini, Gladiol Zenunaj, Luca Traina, Vincenzo Gasbarro, Nicola Lamberti
Summary: We present a case of a 71-year-old woman with giant cell arteritis and bilateral subclavian and axillary obstruction, who suffered from severe arm claudication that was unresponsive to corticosteroid treatment. Before considering revascularization, she underwent a personalized home-based graded exercise program consisting of walking, hand-bike pedaling, and muscle strength training. Over a period of 9 months, the patient showed significant improvements in radial pressure values, hand temperature values, arm endurance, and forearm muscle oxygenation. Home-based graded exercise proved to be an effective noninvasive option for upper limb claudication.
JOURNAL OF VASCULAR SURGERY CASES INNOVATIONS AND TECHNIQUES
(2023)
Article
Chemistry, Analytical
Antonino Casile, Giulia Fregna, Vittorio Boarini, Chiara Paoluzzi, Fabio Manfredini, Nicola Lamberti, Andrea Baroni, Sofia Straudi
Summary: This study investigated the use of the cost-effective Oculus Quest head-mounted display as a tool for assessing markerless hand motion capabilities in stroke patients, and found that it provided accurate and sensitive measurements comparable to a commercial marker-based system.
Article
Health Care Sciences & Services
Anna Crepaldi, Lorenzo Caruso, Giovanni Piva, Luca Traina, Vincenzo Gasbarro, Roberto Manfredini, Nicola Lamberti, Natascia Rinaldo, Fabio Manfredini, Pablo Jesus Lopez-Soto
Summary: This study aimed to detect foot perfusion changes in PAD patients after a home-based exercise program using infrared thermography. The results showed that after 20 weeks of exercise, foot temperature in both limbs significantly increased, with no significant difference between genders. Additionally, the ankle brachial index and performance also significantly improved over time.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Pharmacology & Pharmacy
F. J. Rodriguez-Cortes, J. E. Jimenez-Hornero, J. F. Alcala-Diaz, R. M. Minarro-del Moral, J. L. Romero-Cabrera, R. Manfredini, M. A. Rodriguez-Borrego, P. J. Lopez-Soto
Summary: The study aimed to determine the impact of the COVID-19 pandemic on hospital admissions for acute myocardial infarction (AMI) and cerebrovascular disease (CVD) in Andalusia, Spain, and analyzed gender and procedural differences. The results showed significant reductions in daily hospital admissions for AMI and CVD during the pandemic. Gender differences were observed, but no significant impact was found in percutaneous coronary interventions.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2023)
Article
Pharmacology & Pharmacy
A. Rizza, A. DE Giorgi, F. Negro, B. Boari, C. Palmieri, S. Berti, R. Manfredini
Summary: The objective of this study was to investigate chronobiological patterns and sex-specific differences among acute myocardial infarction (AMI) patients in Italy. The results showed that factors independently associated with in-hospital death included female sex, age, history of ischemic heart disease, and night-time interventional procedure. The study also found that there was a higher peak of AMI events in summer, while in-hospital mortality rate was higher in winter.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2023)
Article
Respiratory System
Nicola Lamberti, Giovanni Piva, Yuri Battaglia, Michele Franchi, Matteo Pizzolato, Antonio Argentoni, Giorgio Gandolfi, Giulia Gozzi, Margherita Lembo, Pietro Lavisci, Alda Storari, Natascia Rinaldo, Fabio Manfredini, Annalisa Cogo
Summary: This study aimed to investigate the feasibility and effectiveness of low-intensity respiratory muscle training in end-stage kidney disease patients. The results showed that home-based RMT significantly improved respiratory muscle strength in patients.
ADVANCES IN RESPIRATORY MEDICINE
(2023)
Article
Health Care Sciences & Services
Alessandro Borghi, Alfredo De Giorgi, Alberto Monti, Rosaria Cappadona, Roberto Manfredini, Monica Corazza
Summary: This study investigated the chronotype and sleep quality of Italian psoriatic patients and found that sleep disturbance is common in these patients, especially in those with comorbidities, females, and those who live alone.
JOURNAL OF PERSONALIZED MEDICINE
(2023)