期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 25, 期 1, 页码 62-66出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2014.11.014
关键词
Sulforaphane; Cisplatin induced kidney disease; Kidney protection; Reactive oxygen species; Isothiocyanate
资金
- Korea Institute of Science and Technology Institutional Program [2Z04211]
A series of sulforaphane analogues were synthesized with various amines by treatment of carbon disulfide followed by Boc(2)O and DMAP. These synthesized sulforaphane analogues were tested on cisplatin treated cultured LLC-PK1 kidney cell line. Among these analogues, several compounds including SF5 show a potent effect on kidney cell protection assay at the concentration of 2.5 mu M. Further studies with compound SF5 revealed that the kidney cell protection effect was related by inhibiting the apoptosis pathway through JNK-p53-caspase apoptotic cascade. Compound SF5 may be considered as a promising candidate for the development of new kidney protection agent against drug induced acute kidney disease. (C) 2014 Elsevier Ltd. All rights reserved.
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