Article
Pharmacology & Pharmacy
Min Liu, Yulin Peng, Yilin Che, Meirong Zhou, Ying Bai, Wei Tang, Shanshan Huang, Baojing Zhang, Sa Deng, Chao Wang, Zhenlong Yu
Summary: This study revealed the anti-neuroinflammatory mechanism of GBE through the miR-146b-5p/TRAF6 axis and provided a theoretical basis for its rational clinical application.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Immunology
Qiao Zhou, Ding-Xiu He, Yi-Ling Deng, Chun-Li Wang, Lan-Lan Zhang, Fa-Ming Jiang, Laurent Irakoze, Zong-An Liang
Summary: This study found that miR-124-3p has a protective effect on acute lung injury (ALI) by inhibiting the TLR4/NF-kappa B signaling pathway, and miR-124-3p directly targets PDE4B to suppress this signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Wei Gao, Ying Zhang
Summary: Inflammation is crucial in the pathogenesis of acute lung injury, and lncRNA MINCR may exacerbate ALI/ARDS progression by inducing alveolar epithelial cell injury and inflammation through the miR-146b-5p and TRAF6/NF-κB pathways, serving as a potential therapeutic target.
MOLECULAR MEDICINE
(2021)
Article
Plant Sciences
Fei-Ting Hsu, Wei-Lin Liu, Sin-Rong Lee, Long-Bin Jeng, Jiann-Hwa Chen
Summary: Researchers have found that magnolol, a compound derived from Magnolia officinalis, shows potential in the treatment of bladder cancer. Through a series of experiments, it was discovered that magnolol can inhibit the development of bladder cancer by activating apoptosis signaling pathways and inhibiting the NF-kappa B pathway. Importantly, magnolol does not exhibit significant toxicity in normal tissues and holds promise as a safe adjunctive therapy.
Article
Biochemistry & Molecular Biology
Kyung-Hye Roh, Yeojin Lee, Je-Hyun Yoon, Danbi Lee, Eunju Kim, Eunchong Park, In Young Lee, Tae Sung Kim, Hyun Kyu Song, Jaekyoon Shin, Dae-Sik Lim, Eui-Ju Choi
Summary: MST1/STK4 acts as a negative regulator of the TLR4-NF-kappa B signaling pathway, inhibiting TRAF6 autoubiquitination and downstream signaling, thereby limiting inflammation induced by LPS. The research also suggests that MST1/STK4 can regulate the production of proinflammatory cytokines in macrophages.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Medicine, Research & Experimental
Xu Wang, Yunfei Chen, Ke Dong, Yujing Ma, Qizhi Jin, Shujun Yin, Xiaoshi Zhu, Shan Wang
Summary: The study revealed that FER1L4 inhibits the expression of miR-106a-5p/miR-372-5p, activates the E2F1-mediated NF-kappa B pathway, leading to drug resistance in liver cancer.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2021)
Article
Oncology
Taoqiong Li, Li Lin, Qin Liu, Wujiang Gao, Lu Chen, Chunli Sha, Qi Chen, Wenlin Xu, Yuefeng Li, Xiaolan Zhu
Summary: The study revealed that exosomal transfer of miR-429 enhances chemoresistance and proliferation of epithelial ovarian cancer cells. NF-κB promotes miR-429 expression, affecting the calcium-sensing receptor pathway and leading to drug resistance in cells.
AMERICAN JOURNAL OF CANCER RESEARCH
(2021)
Article
Cell Biology
Hua Cao, Xinsheng Han, Yonglin Jia, Baohua Zhang
Summary: The study reveals that HOXA11-AS plays a role in promoting inflammation in Parkinson's disease, leading to neuronal damage and microglia activation. Conversely, miR-124-3p has opposite effects by inhibiting inflammation. By modulating the interactions among these molecules, the neurological damages caused by PD can be alleviated.
Article
Biochemistry & Molecular Biology
Xinying Zhou, Zelin Zhang, Hui Xu, Bo Zhu, Lijie Zhang, Linmiao Lie, Yingqi Huang, Xialin Du, Honglin Liu, Yanfen Li, Yulan Huang, Shengfeng Hu, Chaoying Zhou, Qian Wen, Mailkel P. Pepplenbosch, Li Ma
Summary: Viperin protein is increased in abundance in patients with lymphatic and pulmonary tuberculosis (TB), and its deficiency reduces mycobacterium tuberculosis bacterial loads and enhances macrophage responses. Viperin promotes Mtb infection by inhibiting host innate immune responses in macrophages.
Article
Cell Biology
Ji Young Kim, Ji Hye Shin, Mi-Jeong Kim, Yeeun Kang, Ji Su Lee, Juhee Son, Soo-Kyung Jeong, Daesik Kim, Duk-Hwan Kim, Eunyoung Chun, Ki-Young Lee
Summary: beta-arrestin 2 (ARRB2) is shown to have a negative regulatory role in lung cancer progression by inhibiting TLR3 and TLR4-induced autophagy. The decrease in ARRB2 expression is correlated with enrichment gene sets associated with oncogenic and cancer genes. ARRB2 interacts with TRAF6 and BECN1 to inhibit NF-κB activation and autophagy induced by TLR3 and TLR4. Knockout of ARRB2 enhances cancer migration, invasion, colony formation, and proliferation in response to TLR3 and TLR4 stimulation.
CELL DEATH & DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Shihui Zhang, Zhizhong Shen, Gao Chao, Xiaolong Du, Wentao Zhang, Dan Jin, Yafei Liu
Summary: This study found that circular RNA_0004712 (circ_0004712) is up-regulated in rheumatoid arthritis (RA) and plays a role in RA progression by regulating the miR-633/TRAF6/NF-kappa B signaling pathway. Silencing circ_0004712 suppressed the viability, proliferation, migration, and inflammation of RA fibroblast-like synoviocytes (RA-FLSs) and promoted apoptosis. Circ_0004712 was shown to interact with miR-633 and TRAF6, providing new targets for the treatment of RA.
BIOCHEMICAL GENETICS
(2023)
Article
Medicine, Research & Experimental
Chao Yang, Cheng Yang, Zhi Huang, Jinxin Zhang, Nuoer Chen, Yingfang Guo, Arshad Zahoor, Ganzhen Deng
Summary: This study found that miR-125a-5p can inhibit LPS-induced acute kidney inflammation by targeting the TRAF6/NF-kappa B axis. These findings are significant for the development of molecular therapy in AKI.
Article
Oncology
Julia Busch, Rita Moreno, Laureano de la Vega, Vera Vivian Saul, Susanne Bacher, Felix von Zweydorf, Marius Ueffing, Axel Weber, Christian Johannes Gloeckner, Uwe Linne, Michael Kracht, Michael Lienhard Schmitz
Summary: Phosphorylation of TRAF6 by IKKε plays a crucial role in regulating its degradation, signaling networks and linking metabolic and inflammatory processes, which has implications for cancer research.
Article
Plant Sciences
Tianle Zhan, Baoli Wang, Jiayao Fu, Yanxiong Shao, Lei Ye, Huan Shi, Lingyan Zheng
Summary: The study demonstrated that artesunate (ART) can attenuate BAFF-induced B cell hyperactivation and Sjogren's syndrome (SS)-like symptoms in NOD/Ltj mice. ART inhibited lymphocytic foci formation, B cell infiltration and autoantibody secretion in mice, while also targeting BAFF-activated NF kappa B pathway by regulating TRAF6 degradation to determine B cell survival and proliferation.
Article
Virology
Constanza E. Espada, Corine St Gelais, Serena Bonifati, Victoria V. Maksimova, Michael P. Cahill, Sun Hee Kim, Li Wu
Summary: SAMHD1 restricts HIV-1 replication by limiting the intracellular dNTP pool and suppresses NF-kappa B activation. This suppression is modulated by TRAF6 and TAK1, which play key roles in mediating the negative regulation of the NF-kappa B pathway by SAMHD1.
JOURNAL OF VIROLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Man-Huan Xiao, Yi-Fang Lin, Peng-Peng Xie, Hua-Xing Chen, Jun-Wen Deng, Wei Zhang, Na Zhao, Chen Xie, Yu Meng, Xingguo Liu, Shi-Mei Zhuang, Ying Zhu, Jian-Hong Fang
Summary: This study reveals that downregulation of MPM is associated with increased metastasis potential and recurrence in hepatocellular carcinoma. The restoration of MPM expression inhibits migration and invasion of hepatoma cells, while silencing MPM increases their metastasis ability. MPM interacts with NDUFA7 and regulates mitochondrial complex I activity and the NAD(+)/NADH ratio. miR-17-5p binds to MPM and suppresses its expression.
Article
Oncology
Na Zhao, Jeffrey M. Rosen
Summary: Breast cancer ecosystems are complex, and understanding their heterogeneity through single-cell analysis and spatial pathologies can lead to the development of novel therapies and improved outcomes.
SEMINARS IN CANCER BIOLOGY
(2022)
Article
Oncology
Mahnaz Janghorban, Yuchen Yang, Na Zhao, Clark Hamor, Tuan M. Nguyen, Xiang H-F Zhang, Jeffrey M. Rosen
Summary: Tumor dormancy is a critical phase in cancer research, and inhibition of the Jagged-1/Notch pathway has been shown to delay tumor recurrence, providing a novel therapeutic strategy.
Article
Oncology
Chen Xie, Feng-Yi Wang, Ye Sang, Bin Chen, Jia-Hui Huang, Feng-Jun He, Hui Li, Ying Zhu, Xingguo Liu, Shi-Mei Zhuang, Jian-Hong Fang
Summary: Micropeptides, such as STMP1, have been discovered to play important roles in cellular processes and have been found to be upregulated in various cancer types. STMP1 has been associated with metastasis and recurrence of hepatocellular carcinoma. The study also revealed the interaction between STMP1, DRP1, and MYH9. This study provides a potential therapeutic target for treating metastases.
Article
Biotechnology & Applied Microbiology
Ye Sang, Jin-Yu Liu, Feng-Yi Wang, Xiao-Yu Luo, Zi-Qi Chen, Shi-Mei Zhuang, Ying Zhu
Summary: The roles of micropeptides in cell cycle regulation and cancer development remain largely unknown. In this study, the researchers discovered a micropeptide called STMP1 that was up-regulated in various malignancies, including hepatocellular carcinoma (HCC). They found that high levels of STMP1 were associated with shorter recurrence-free survival in HCC patients. Further experiments showed that STMP1 accelerated cell proliferation and tumor growth by enhancing the activity of mitochondrial complex IV, which led to the promotion of key factors in the cell cycle. The findings suggest that STMP1 may serve as a new regulator of the cell cycle and a potential target for anti-cancer therapy.
Article
Genetics & Heredity
Ming Zhong, Xiaohua Wang, Enyi Zhu, Lian Gong, Lingyan Fei, Liang Zhao, Keping Wu, Chun Tang, Lizhen Zhang, Zhongli Wang, Zhihua Zheng
Summary: This study systematically investigated the role of pyroptosis in clear cell renal cell carcinoma (ccRCC) and identified different subtypes with varied clinical outcomes, immune signatures, and responses to immunotherapy. Activation of pyroptosis was found to promote tumor progression by facilitating immune cell infiltration. A high pyroptosis-score was associated with an unfavorable immune environment and worse prognosis. The study also constructed a prognostic model based on pyroptosis-related long noncoding RNAs (PRlncRNAs) and explored the relationship between high- and low-risk groups with tumor microenvironment, immune infiltration, and drug therapy.
FRONTIERS IN GENETICS
(2022)
Article
Cell Biology
Hongjiang Si, Na Zhao, Andrea Pedroza, Ana-Maria Zaske, Jeffrey M. Rosen, Chad J. Creighton, Kevin Roarty
Summary: Cell-extracellular matrix interactions are important in tumor progression. This study shows that the noncanonical Wnt receptor, Ror2, regulates matrix remodeling and invasion in breast cancer. Loss of Ror2 leads to disruption of E-cadherin, increased tumor cell invasion, and collagen realignment. The up-regulation and redistribution of integrins and fibronectin are also observed downstream of Ror2 loss.
MOLECULAR BIOLOGY OF THE CELL
(2022)
Article
Oncology
Jian-Hong Fang, Jie-Ying Chen, Jia-Lin Zheng, Hui-Xian Zeng, Jun-Guang Chen, Chen-Hui Wu, Jia-Li Cai, Zhi-Yong Wang, Shi-Mei Zhuang
Summary: Angiogenesis plays a crucial role in tumor growth and metastasis, and emerging evidence suggests that metabolic reprogramming in endothelial cells can impact angiogenesis. This study identified multiple regulators in the fructose metabolism pathway that were upregulated in tumor endothelial cells from hepatocellular carcinoma (HCC). It was found that dietary fructose enhanced tumor angiogenesis, growth, and metastasis, which could be attenuated by an inhibitor of fructose transporter SLC2A5. Fructose treatment also promoted endothelial cell proliferation, migration, tube formation, and mitochondrial respiration, while inhibiting fructose metabolism significantly abolished fructose-induced tumor angiogenesis.
Editorial Material
Genetics & Heredity
Yumei Luo, Detu Zhu, Jian-Hong Fang
FRONTIERS IN GENETICS
(2022)
Article
Medicine, Research & Experimental
Enyi Zhu, Xiaorong Shu, Zi Xu, Yanren Peng, Yunxiu Xiang, Yu Liu, Hui Guan, Ming Zhong, Jinhong Li, Li-Zhen Zhang, Ruqiong Nie, Zhihua Zheng
Summary: This study aimed to explore the genes associated with chronic kidney disease (CKD) and calcific aortic valve disease (CAVD) and discover candidate biomarkers for diagnosing CKD with CAVD. Through differential expression analysis and weighted gene co-expression network analysis, CKD-related pathogenic genes in CAVD and potential drugs for CAVD treatment were identified. Machine learning algorithms were used to screen and construct candidate biomarkers and a diagnostic nomogram. Furthermore, immune cell infiltration in CAVD was investigated.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Medicine, Research & Experimental
Hansen Lin, Liangmin Fu, Pengju Li, Jiangquan Zhu, Quanhui Xu, Yinghan Wang, Mukhtar Adan Mumin, Xinwei Zhou, Yuhang Chen, Guannan Shu, Gaosheng Yao, Minyu Chen, Jun Lu, Lizhen Zhang, YuJun Liu, Yiqi Zhao, Jiahao Bao, Wei Chen, Junhang Luo, Xiaofei Li, Zhenhua Chen, Jiazheng Cao
Summary: This study identifies the impact of targeting fatty acid metabolism on the therapeutic effect of PD-1/PD-L1 in the tumor microenvironment, and uncovers the related signal pathways. The model developed can effectively predict the response to different treatment options, highlighting its potential clinical utility.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Oncology
Chong Zhang, Qing Li, Qi Xu, Wei Dong, Chunmei Li, Bin Deng, Jiao Gong, Li-Zhen Zhang, Junfei Jin
Summary: This study reveals the crucial role of IL-1β and SAA3 in the formation of the pre-metastatic niche and pulmonary metastasis of HCC. IL-1β enhances SAA3 expression and recruits myeloid cells to the lung, leading to the promotion of pulmonary metastasis.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2023)