Article
Pediatrics
Shuhao Zhang, Duote Cai, Qingjiang Chen, Yuebin Zhang, Ken Chen, Yi Jin, Wenjuan Luo, Zongwei Huang, Di Hu, Zhigang Gao
Summary: This study aimed to identify predictors of impending or complete spontaneous perforation in choledochal cyst patients and establish the optimal timing for surgery. The results showed that a high level of serum gamma-glutamyl transpeptidase, along with elevated liver enzymes and bilirubin levels, was indicative of the possibility of a perforation. The study suggests that a proactive surgical approach should be considered for patients with a gamma-glutamyl transpeptidase level ≥346.5 U/L.
FRONTIERS IN PEDIATRICS
(2022)
Article
Acoustics
Yue Xin, Xiao Man Wang, Yu Wang, Yan Xiu Hu, Li Qun Jia
Summary: Specific features via ultrasound are effective in diagnosing perforation of congenital choledochal cysts in children. Significant differences were found in clinical characteristics and disease onset age between the perforation group and the control group, but the diagnostic efficacy of both was poor. Interrupted bile duct continuity only occurred in the perforation group with high specificity but poor sensitivity, while the discrimination of combined features showed significantly better diagnostic accuracy.
JOURNAL OF ULTRASOUND IN MEDICINE
(2021)
Article
Pediatrics
In Geol Ho, Kyong Ihn, Ho Jong Jeon, Dong Eun Lee, Seok Joo Han
Summary: This study compared the clinical outcomes of prenatally diagnosed choledochal cysts in infants based on the timing of surgical treatment. The results showed longer hospital stays, increased diet durations, and more surgical complications in early surgery patients. However, there was no significant difference in liver function recovery between the early and late operation groups. Asymptomatic patients should be closely monitored, and it is recommended to postpone definitive surgical intervention until 4 months of age or until weight reaches 7 kg.
FRONTIERS IN PEDIATRICS
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yu Jin Kim, Soo-Hyun Kim, So-Young Yoo, Ji Hye Kim, Soo-Min Jung, Sanghoon Lee, Jeong-Meen Seo, Sung-Hoon Moon, Tae Yeon Jeon
Summary: This study compared the clinical and radiologic findings between perforated and non-perforated choledochal cysts. The results showed that children with perforated choledochal cysts had more severe symptoms, higher levels of inflammatory markers, and a higher incidence of ascites compared to those with non-perforated cysts.
KOREAN JOURNAL OF RADIOLOGY
(2022)
Article
Pediatrics
Adam Kowalski, Grzegorz Kowalewski, Piotr Kalicinski, Katarzyna Pankowska-Wozniak, Marek Szymczak, Hor Ismail, Marek Stefanowicz
Summary: Choledochal cyst is a rare malformation primarily diagnosed in children, and surgical resection followed by Roux-en-Y hepaticojejunostomy remains the most effective therapy. Treating asymptomatic neonates is still a topic of debate.
Review
Genetics & Heredity
Yongqin Ye, Vincent Chi Hang Lui, Paul Kwong Hang Tam
Summary: This review summarizes insights from genomics and transcriptomics studies into the pathogenesis of choledochal cysts (CC), aiming to improve our understanding of its complex pathomechanisms and clinical management of different subtypes of CC.
Article
Gastroenterology & Hepatology
Xisi Guan, Junting Li, Zhe Wang, Jixiao Zeng, Wei Zhong, Jiakang Yu
Summary: This study retrospectively analyzed patients with a prenatal diagnosis of choledochal cyst (CDC) and explored the optimal timing of operative correction and the predictive role of cyst size for symptom development. The results showed a correlation between cyst size and symptom occurrence in the asymptomatic group. In conclusion, surgical treatment in the asymptomatic period is advantageous, and surgery should be performed as soon as possible when the cyst length is greater than 5.2 cm and the width is greater than 4.1 cm, even in the neonatal period.
JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES
(2022)
Article
Pediatrics
Yu-tong Chen, Ming-juan Gao, Ze-bing Zheng, Lu Huang, Qing Du, Dai-wei Zhu, Yuan-mei Liu, Zhu Jin
Summary: This study retrospectively analyzed clinical data of 32 children with hilar cysts and explored information for early diagnosis and treatment of cystic biliary atresia (CBA). The results showed significant differences in biochemical indexes and cyst size between the CBA and infantile choledochal cysts (CC) groups. Cyst width was the most accurate parameter for identifying CBA and CC. For children with early-onset severe jaundice, if the width of the cystic mass was <= 2.5 cm, a diagnosis of CBA was highly likely, and early cholangiography and surgical treatment were necessary.
FRONTIERS IN PEDIATRICS
(2022)
Article
Pediatrics
Yi Jin, Shuhao Zhang, Duote Cai, Yuebin Zhang, Wenjuan Luo, Ken Chen, Qingjiang Chen, Zhigang Gao
Summary: This study retrospectively analyzed the clinical data of 133 patients with choledochal cyst who underwent surgery, including 99 who underwent robot-assisted surgery and 34 who underwent laparoscopic assisted surgery. The results showed that the robot-assisted group had higher detection rate of distal opening, shorter postoperative hospital stay, and higher hospitalization expense compared to the laparoscopic assisted group.
FRONTIERS IN PEDIATRICS
(2023)
Article
Gastroenterology & Hepatology
Camilla Gomes, Patrick Tivnan, David McAneny, Jennifer F. Tseng, Jaroslaw Tkacz, Teviah E. Sachs
Summary: This study reviewed 22 patients aged 18 and older with radiographic diagnosis of choledochal cysts, finding that the management of choledochal cysts in older adults is different from those diagnosed in childhood. Close surveillance of these biliary duct anomalies in older adults may be a better option than resection and reconstruction.
JOURNAL OF GASTROINTESTINAL SURGERY
(2021)
Article
Pediatrics
Tong Yin, Suyun Chen, Long Li, Mei Diao, Ting Huang, Qianqing Li, XiangHui Xie
Summary: The study evaluated the efficacy of one- and two-stage single-incision laparoscopic hepaticojejunostomy for perforated CDCs with good medical conditions. The results showed no significant differences in operative time, postoperative recovery, and hospital stay between the one-stage and two-stage surgeries. The occurrence of bile leakage was higher in the two-stage group, but there were no other serious complications. Liver function normalized within one year postoperatively.
PEDIATRIC SURGERY INTERNATIONAL
(2022)
Article
Pediatrics
Ruyue Gao, Meng Ke, Jie Shi, Yandong Zhang, Jizhen Zou, Mei Diao, Long Li
Summary: This study aimed to evaluate the risk factors of metaplasia and dysplasia in children with choledochal cyst (CDC). Through a retrospective study of 210 CDC children, age, symptoms duration, cyst diameter, recurrent attacks of biliary pancreatitis, and biliary operation history were identified as independent risk factors. A predictive nomogram was successfully constructed to assess the risk of premalignant lesions.
FRONTIERS IN PEDIATRICS
(2023)
Article
Pediatrics
Shan Chen, Yang Lin, Di Xu, Jianli Lin, Yunlong Zeng, Lizhi Li
Summary: This study retrospectively analyzed clinical data from 42 children with choledochal cysts and compared the differences between da Vinci robotic surgery and laparoscopy. The results showed that the robot-assisted group had better postoperative recovery than the laparoscopic group. Therefore, the da Vinci system has advantages in treating pediatric choledochal cysts.
FRONTIERS IN PEDIATRICS
(2022)
Article
Surgery
Haicheng Yuan, Guoqiang Dong, Nan Zhang, Xiangyu Sun, Hongzhi Zhao
Summary: The study indicates that a combination of laparoscopic surgery and intraoperative choledochoscopy is an effective technique for managing type I choledochal cyst in adults, resulting in shorter hospital stay, reduced blood loss, and lower complication rates. This approach may become the preferred treatment for type I choledochal cyst with further development of laparoscopic techniques and instruments.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2021)
Article
Pediatrics
Walter A. Ramsey, Carlos T. Huerta, Shreya M. Ingle, Gareth P. Gilna, Rebecca A. Saberi, Christopher F. O'Neil Jr, Antoine J. Ribieras, Joshua P. Parreco, Eduardo A. Perez, Juan E. Sola, Chad M. Thorson
Summary: Pediatric choledochal cyst can be treated with either open or laparoscopic surgery. Laparoscopic surgery has the advantages of lower costs, shorter hospital stay, and lower risk of complications compared to open surgery.
JOURNAL OF PEDIATRIC SURGERY
(2023)
