Article
Geriatrics & Gerontology
Suriya Prausmueller, Gregor Heitzinger, Noemi Pavo, Georg Spinka, Georg Goliasch, Henrike Arfsten, Cornelia Gabler, Guido Strunk, Christian Hengstenberg, Martin Huelsmann, Philipp E. Bartko
Summary: The paradoxical association between high BMI and better outcome in heart failure patients is examined in this study. The researchers found that malnutrition significantly changes the impact of BMI on prognosis, with obese patients who are also malnourished having a worse outcome compared to well-nourished patients with normal weight.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2022)
Article
Cardiac & Cardiovascular Systems
Shiyang Song, Chih-Liang Tien, Hao Cui, Paul Basil, Ningxia Zhu, Yingyun Gong, Wenbo Li, Hui Li, Qiying Fan, Jong Min Choi, Weijia Luo, Yanfeng Xue, Rui Cao, Wenjun Zhou, Andrea R. Ortiz, Brittany Stork, Vatsala Mundra, Nagireddy Putluri, Brian York, Maoping Chu, Jiang Chang, Sung Yun Jung, Liang Xie, Jiangping Song, Lilei Zhang, Zheng Sun
Summary: This study investigates the function of cardiac Rev-erb in heart diseases and the relationship between cardiac molecular clock dysfunction and the progression of naturally occurring human heart diseases. The researchers found that Rev-erb knockout in mice leads to dilated cardiomyopathy and heart failure. They also discovered the role of cardiac molecular clock in the obesity paradox and found altered temporal patterns of cardiac Rev-erb gene expression in human hearts with dilated cardiomyopathy. The findings suggest that targeting myocardial bioenergetics downstream of Rev-erb may be a potential approach for treating heart failure and dilated cardiomyopathy.
Article
Cardiac & Cardiovascular Systems
Peisen Huang, Zejun Guo, Weihao Liang, Yuzhong Wu, Jingjing Zhao, Xin He, Wengen Zhu, Chen Liu, Yugang Dong, Yuan Yu, Bin Dong
Summary: This study showed that weight loss in patients with HFpEF was independently associated with a higher risk of all-cause mortality, while weight gain was not associated with better survival.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Alexander C. Egbe, William R. Miranda, Jason H. Anderson, Heidi M. Connolly
Summary: This study aimed to determine whether a temporal change in body mass index (BMI) was associated with clinical outcomes independent of baseline BMI in adults with congenital heart disease (CHD). The results showed that weight gain and weight loss were associated with worsening of atherosclerotic cardiovascular disease (ASCVD) risk and an increase in cardiovascular events. These findings support lifestyle interventions aimed at weight maintenance in patients with normal weight and weight loss in overweight or obese patients.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Review
Endocrinology & Metabolism
Stamatia Simati, Alexander Kokkinos, Maria Dalamaga, Georgia Argyrakopoulou
Summary: The obesity paradox refers to the observation that certain chronic diseases show a protective association between body mass index (BMI) and clinical outcomes. However, this association may be influenced by factors such as limitations of BMI, unintended weight loss due to chronic illness, different phenotypes of obesity, and cardiorespiratory fitness levels. Recent evidence suggests that cardioprotective medications, obesity duration, and smoking status also play a role in the obesity paradox.
CURRENT OBESITY REPORTS
(2023)
Article
Cardiac & Cardiovascular Systems
Jennifer J. Rayner, Mark A. Peterzan, William T. Clarke, Christopher T. Rodgers, Stefan Neubauer, Oliver J. Rider
Summary: The study demonstrated that obesity cardiomyopathy and dilated cardiomyopathy have distinct differences in myocardial energy metabolism, with higher ATP demand through CK in obese DCM possibly leading to reduced energy utilization efficiency. Intentional weight loss intervention was associated with significant improvement in myocardial contractility and a decrease in ATP delivery rate, suggesting improved metabolic efficiency.
EUROPEAN HEART JOURNAL
(2022)
Article
Cardiac & Cardiovascular Systems
Linjuan Guo, Xiao Liu, Peng Yu, Wengen Zhu
Summary: The obesity paradox exists in patients with heart failure with preserved ejection fraction (HFpEF) regardless of comorbid atrial fibrillation (AF).
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Cardiac & Cardiovascular Systems
Haibo Gao, Wei Li, Yifei Wang, Xuemei Zhao, Liuxin Li, Hongwei Zheng, Boheng Zhang, Shouling Wu, Qi Zhang
Summary: Weight reduction before and after the diagnosis of heart failure is an independent risk factor for increased all-cause mortality.
CURRENT PROBLEMS IN CARDIOLOGY
(2024)
Article
Endocrinology & Metabolism
Josefina Robertson, Martin Adiels, Lauren Lissner, Kirsten Mehlig, Agnes Af Geijerstam, Martin Lindgren, Magnus Gisslen, Elin Ekblom Bak, Annika Rosengren, Maria Aberg
Summary: This study found that higher BMI in early adulthood was associated with severe COVID-19 many years later. The risk for hospitalization and intensive care unit admission increased with higher BMI values, highlighting the importance of preventing overweight in youth.
Article
Cardiac & Cardiovascular Systems
Gauravpal S. Gill, Phillip H. Lam, Vijaywant Brar, Samir Patel, Cherinne Arundel, Prakash Deedwania, Charles Faselis, Richard M. Allman, Sijian Zhang, Charity J. Morgan, Gregg C. Fonarow, Ali Ahmed
Summary: In-hospital weight loss in patients with acute decompensation of heart failure may be associated with lower risk of mortality and readmission.
JOURNAL OF CARDIAC FAILURE
(2022)
Article
Cardiac & Cardiovascular Systems
Lorraine S. Evangelista, Mini M. Jose, Hanaa Sallam, Hani Serag, George Golovko, Kamil Khanipov, Michele A. Hamilton, Gregg C. Fonarow
Summary: The study compared the effects of two calorie-restricted diets on cardiometabolic risk factors in overweight and obese patients, showing that a high-protein diet can effectively reduce glycosylated hemoglobin levels, cholesterol, and triglycerides, and significantly improve blood pressure.
Article
Geriatrics & Gerontology
Katsuhiko Ohori, Toshiyuki Yano, Satoshi Katano, Hidemichi Kouzu, Suguru Honma, Kanako Shimomura, Takuya Inoue, Yuhei Takamura, Ryohei Nagaoka, Masayuki Koyama, Nobutaka Nagano, Takefumi Fujito, Ryo Nishikawa, Tomoyuki Ishigo, Ayako Watanabe, Akiyoshi Hashimoto, Tetsuji Miura
Summary: The study retrospectively analyzed data from 198 HF patients and found that higher body fat mass was associated with lower short-term cardiac event risk in HF patients, while muscle wasting was not significantly associated with cardiac events.
Review
Nutrition & Dietetics
Simone Perna, Zahra Ilyas, Attilio Giacosa, Clara Gasparri, Gabriella Peroni, Milena Anna Faliva, Chiara Rigon, Maurizio Naso, Antonella Riva, Giovanna Petrangolini, Ali A. Redha, Mariangela Rondanelli
Summary: This meta-analysis study found that probiotic supplementation can significantly reduce BMI, waist circumference, and hip circumference in overweight and obese patients, but the effect on body weight is not significant. Although there is a positive trend, further research is needed before recommending probiotics as a therapeutic strategy for these patients.
Article
Cardiac & Cardiovascular Systems
Tobias Taeger, Jennifer Franke, Norbert Frey, Lutz Frankenstein, Hanna Froehlich
Summary: Obesity is associated with better outcomes in heart failure patients, while cachexia is linked to higher mortality. The prognostic impact of gradual, long-term weight changes in stable heart failure patients is not well understood.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2023)
Review
Cardiac & Cardiovascular Systems
Ebenezer K. Aryee, Bige Ozkan, Chiadi E. Ndumele
Summary: The increase in obesity rates, particularly among socio-economically disadvantaged individuals, has contributed significantly to the prevalence of heart failure. Obesity indirectly affects heart failure through the development of metabolic risk factors and directly affects the myocardium. Multiple mechanisms, including hemodynamic changes and adipose tissue effects, contribute to myocardial dysfunction and increased risk of heart failure. Despite the obesity paradox, intentional weight loss has been shown to improve metabolic risk factors, myocardial dysfunction, and quality of life in patients with heart failure. Ongoing clinical trials are investigating the impact of weight loss on cardiovascular outcomes.
PROGRESS IN CARDIOVASCULAR DISEASES
(2023)
Article
Psychology, Clinical
Samuel J. Westwood, Marion Criaud, Sheut-Ling Lam, Steve Lukito, Sophie Wallace-Hanlon, Olivia S. Kowalczyk, Afroditi Kostara, Joseph Mathew, Deborah Agbedjro, Bruce E. Wexler, Roi Cohen Kadosh, Philip Asherson, Katya Rubia
Summary: This study found no evidence of improved ADHD symptoms or cognitive performance following multi-session anodal tDCS over rIFC combined with CT.
PSYCHOLOGICAL MEDICINE
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Anand Thiyagarajah, Shaun Evans, Dennis H. Lau
TRENDS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Monika Gawalko, Astrid Nl Hermans, Rachel Mj van Der Velden, Konstanze Betz, Dominique Vm Verhaert, Henrike Ak Hillmann, Daniel Scherr, Julia Meier, Arian Sultan, Daniel Steven, Elena Terentieva, Ron Pisters, Martin Hemels, Leonard Voorhout, Piotr Lodzinski, Bartosz Krzowski, Dhiraj Gupta, Nikola Kozhuharov, Laurent Pison, Henri Gruwez, Lien Desteghe, Hein Heidbuchel, Stijn Evens, Emma Svennberg, Tom de Potter, Kevin Vernooy, Nikki Aha Pluymaekers, Martin Manninger, David Duncker, Afzal Sohaib, Dominik Linz, Jeroen M. Hendriks
Summary: In the TeleCheck-AF project, more than one-fourth of patients with atrial fibrillation had optimal motivation and adherence to app-based heart rate/rhythm monitoring. Older age and absence of diabetes were predictors of optimal motivation/adherence.
EUROPEAN JOURNAL OF CARDIOVASCULAR NURSING
(2023)
Article
Cardiac & Cardiovascular Systems
Bao-Oanh Nguyen, Vanessa Weberndorfer, Harry J. G. M. Crijns, Bastiaan Geelhoed, Hugo Ten Cate, Henri Spronk, Abraham Kroon, Ruben De With, Meelad Al-Jazairi, Alexander H. Maass, Yuri Blaauw, Robert G. Tieleman, Martin E. W. Hemels, Justin Luermans, Joris de Groot, Cornelis P. Allaart, Arif Elvan, Mirko De Melis, Coert Scheerder, Anton Jan van Zonneveld, Ulrich Schotten, Dominik Linz, Isabelle Van Gelder, Michiel Rienstra
Summary: This study aims to develop a new atrial fibrillation (AF) progression risk prediction model in patients with paroxysmal AF (PAF) to determine the risk and treatment targets for AF progression. The study found that markers for atrial remodeling, sex, mitral valve regurgitation, waist circumference, and biomarkers associated with coagulation, inflammation, cardiomyocyte stretch, and atherosclerosis were all associated with AF progression.
Article
Cardiac & Cardiovascular Systems
Atul E. Verma, David V. Haines, Lucas Boersma, Nitesh Sood, Andrea E. Natale, Francis Marchlinski, Hugh Calkins, Prashanthan L. Sanders, Douglas Packer, Karl-Heinz Kuck, Gerhard Hindricks, Birce Onal, Jeffrey Cerkvenik, Hiroshi B. Tada, David DeLurgio, PULSED AF Investigators
Summary: Pulsed field ablation is an effective and safe method for treating patients with atrial fibrillation. It has comparable effectiveness to traditional catheter ablation but with a lower rate of complications.
Review
Cardiac & Cardiovascular Systems
Erica S. Ghezzi, Rhianna L. S. Sharman, Joseph B. Selvanayagam, Peter J. Psaltis, Prashanthan Sanders, Jack M. Astley, Sara Knayfati, Vrinda Batra, Hannah A. D. Keage
Summary: This study aimed to synthesize the prevalence and severity of mood disorders in patients with implantable cardioverter defibrillators (ICDs) before and after insertion. The results showed high prevalence of depression and anxiety in ICD patients, particularly in those who experienced shocks. Psychological assessment, monitoring, and therapy should be offered as part of routine care for ICD patients and their partners.
Article
Cardiac & Cardiovascular Systems
Vicente Artola Arita, Martijn E. Van de Lande, Neda Khalilian Ekrami, Bao-Oanh Nguyen, Joost M. Van Melle, Bastiaan Geelhoed, Ruben R. De With, Vanessa Weberndorfer, Omer Erkuner, Hans Hillege, Dominik Linz, Hugo Ten Cate, Henri M. H. Spronk, Tim Koldenhof, Robert G. Tieleman, Ulrich Schotten, Harry J. G. M. Crijns, Isabelle C. Van Gelder, Michiel Rienstra
Summary: This study aimed to assess whether the 4S-AF scheme predicts AF progression in patients with self-terminating AF. The study found that the 4S-AF scheme does not predict AF progression, but the 3S-AF scheme can predict progression. Therefore, the 3S-AF scheme may be more appropriate for predicting AF progression.
Article
Cardiac & Cardiovascular Systems
Roland Richard Tilz, Vanessa Schmidt, Helmut Puererfellner, Philippe Maury, K. R. Julian Chun, Martin Martinek, Christian Sohns, Boris Schmidt, Franck Mandel, Estelle Gandjbakhch, Mikael Laredo, Melanie Anuscha Gunawardene, Stephan Willems, Thomas Beiert, Martin Borlich, Leon Iden, Anna Fueting, Raphael Spittler, Thomas Gaspar, Sergio Richter, Anja Schade, Malte Kuniss, Thomas Neumann, Alexander Francke, Carsten Wunderlich, Dong-In Shin, Dirk Grosse Meininghaus, Mike Foresti, Marc Bonsels, David Reek, Uwe Wiegand, Alexander Bauer, Andreas Metzner, Lars Eckardt, Sorin Tefan Popescu, Olaf Krahnefeld, Christian Sticherling, Michael Kuehne, Dinh Quang Nguyen, Laurent Roten, Ardan M. Saguner, Dominik Linz, Pepijn van der Voort, Bart A. Mulder, Johan Vijgen, Alexandre Almorad, Charles Guenancia, Laurent Fauchier, Serge Boveda, Y. De Greef, Antoine Da Costa, Pierre Jais, Nicolas Derval, Antoine Milhem, Laurence Jesel, Rodrigue Garcia, Herve Poty, Ziad Khoueiry, Julien Seitz, Julien Laborderie, Alexis Mechulan, Francois Brigadeau, Alexandre Zhao, Yannick Saludas, Olivier Piot, Nikhil Ahluwalia, Claire Martin, Jian Chen, Bor Antolic, Georgios Leventopoulos, Emin Evren Ozcan, Hikmet Yorgun, Serkan Cay, Kivanc Yalin, Maichel Sobhy Botros, Ahmed Taher Mahmoud, Ewa Jedrzejczyk-Patej, Osamu Inaba, Ken Okumura, Koichiro Ejima, Houman Khakpour, Noel Boyle, John N. Catanzaro, Vivek Reddy, Sanghamitra Mohanty, Andrea Natale, Hermann Blessberger, Bing Yang, Irene Stevens, Philipp Sommer, Christian Veltmann, Daniel Steven, Julia Vogler, Karl-Heinz Kuck, Jose Luis Merino, Ahmad Keelani, Christian-H. Heeger
Summary: This international multicentre registry investigates the characteristics of oesophageal fistulae after treatment of atrial fibrillation by catheter ablation. The incidence of oesophageal fistula is low and mainly associated with the use of radiofrequency energy. Mortality rate is exceedingly high without surgical or endoscopic intervention.
EUROPEAN HEART JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Jonathan M. Kalman, Ahmed M. Al-Kaisey, Ramanathan Parameswaran, Joshua Hawson, Robert D. Anderson, Michael Lim, David Chieng, Stephen A. Joseph, Alex McLellan, Joseph B. Morton, Paul B. Sparks, Geoffrey Lee, Prashanthan Sanders, Peter M. Kistler
Summary: This study aimed to determine if the timing of catheter ablation for atrial fibrillation (AF) affects arrhythmia outcomes. The results showed that there was no significant difference in the atrial arrhythmia free survival at 12 months post-ablation between patients who underwent early ablation and those who underwent delayed ablation. Other secondary outcomes also showed no significant difference. Therefore, delaying AF ablation by 12 months for antiarrhythmic drug management does not reduce the efficacy of ablation.
EUROPEAN HEART JOURNAL
(2023)
Review
Cardiac & Cardiovascular Systems
Lemma N. Bulto, Jacqueline Roseleur, Sara Noonan, Maria Alejandra Pinero de Plaza, Stephanie Champion, Hila Ariela Dafny, Vincent Pearson, Katie Nesbitt, Lemlem G. Gebremichael, Alline Beleigoli, Aarti Gulyani, Timothy Schultz, Sonia Hines, Robyn A. Clark, Jeroen M. Hendriks
Summary: This review investigated the effectiveness of nurse-led interventions vs. usual care on hypertension management, lifestyle behavior, and patients' knowledge of hypertension. The results showed that nurse-led interventions can reduce systolic and diastolic blood pressure, and have a positive impact on lifestyle behavior. These findings are important in combating the rising burden of hypertension globally.
EUROPEAN JOURNAL OF CARDIOVASCULAR NURSING
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Geraldine Lee, Jeroen M. Hendriks
EUROPEAN JOURNAL OF CARDIOVASCULAR NURSING
(2023)
Article
Cardiac & Cardiovascular Systems
Martin Manninger, Astrid N. L. Hermans, Andrei-Antonio Caracioni, Ursula Rohrer, Anna-Sophie Eberl, Kevin Vernooy, Andreas Zirlik, Dominik Linz, Daniel Scherr
Summary: The study aimed to test the feasibility of postprocedural photoplethysmography (PPG) rhythm telemonitoring during the first week after atrial fibrillation (AF) ablation, and its predictive value for later AF recurrence. The results showed that PPG rhythm telemonitoring during the first week after ablation often triggered clinical interventions, and it could predict late recurrences. This suggests that PPG-based follow-up can bridge the diagnostic and prognostic gap in the blanking period and increase active patient involvement.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Julie Norup Hertel, Kezia Jerltorp, Malthe Emil Hotbjerg Hansen, Jonas L. L. Isaksen, Stefan Michael Sattler, Benedikt Linz, Sevasti-Maria Chaldoupi, Thomas Jespersen, Arnela Saljic, Uffe Gang, Martin Manninger, Dominik Linz
Summary: This study proposes a standardized workflow for 3D-electroanatomical mapping guided pulmonary vein isolation in pigs. The study conducted procedures such as femoral vein puncture, blood pressure measurement, intracardiac ultrasound-guided puncture, and 3D-electroanatomical mapping of the left atrium. The results show that reproducible and safe pulmonary vein isolation can be achieved in pigs using current technologies and a step-by-step approach.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Adrian D. Elliott, Christian V. Verdicchio, Rajiv Mahajan, Melissa E. Middeldorp, Celine Gallagher, Ricardo S. Mishima, Jeroen M. L. Hendriks, Rajeev K. Pathak, Gijo Thomas, Dennis H. Lau, Prashanthan Sanders
Summary: This study aimed to determine the efficacy of exercise interventions on atrial fibrillation (AF) recurrence and symptoms among patients with symptomatic AF. The results showed that patients who participated in an exercise intervention had a higher rate of freedom from AF and lower symptom severity at 12 months. Exercise intervention for 6 months reduced arrhythmia recurrence and improved symptom severity.
JACC-CLINICAL ELECTROPHYSIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Catherine J. O'Shea, Anthony G. Brooks, Melissa E. Middeldorp, Curtis Harper, Jeroen M. Hendriks, Andrea M. Russo, James V. Freeman, Rakesh Gopinathannair, Niraj Varma, Thomas F. Deering, Kevin Campbell, Prashanthan Sanders
Summary: This study aimed to evaluate the impact of a remote monitoring system on anticoagulation treatment in patients with atrial fibrillation (AF) who have cardiac implantable electronic devices. The results showed that despite intensive management through remote monitoring software, a substantial proportion of AF patients remained unanticoagulated. This highlights the need for improved clinical response pathways and an integrated care approach.
JOURNAL OF INTERVENTIONAL CARDIAC ELECTROPHYSIOLOGY
(2023)