期刊
FUTURE ONCOLOGY
卷 15, 期 32, 页码 3693-3699出版社
FUTURE MEDICINE LTD
DOI: 10.2217/fon-2019-0412
关键词
biomarker; cervical cancer; prognosis; survival analysis; web server
类别
资金
- National Natural Science Foundation of China [81602362]
- Yellow River Scholar Program [H2016012]
- Program for Innovative Talents of Science and Technology in Henan Province [18HASTIT048]
- Program for Science and Technology Development in Henan Province [162102310391]
- Program for Young Key Teacher of Henan Province [2016GGJS-214]
- Kaifeng Science and Technology Major Project [18ZD008]
- Bioinformatics Center of Henan University [2018YLJC01]
- Henan University [2015YBZR048, B2015151]
Aim: To establish a web server that can mutually validate prognostic biomarkers of cervical cancer. Methods: Four datasets including expression profiling and relative clinical follow-up data were collected from Gene Expression Omnibus and The Cancer Genome Atlas. The web server was developed by R software. Results: The web server was named OScc including 690 patients and can be accessed at http://bioinfo.henu.edu.cn/CESC/CESCList.jsp. The Kaplan-Meier survival curves with log-rank p-value and hazard ratio will be generated of interested gene in OScc. Compared with previous predictive tools, OScc had the advantages of registration-free, larger sample size and subgroup analysis. Conclusion: The OScc is highly valuable to perform the preliminary assessment and validation of new or interested prognostic biomarkers for cervical cancer.
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