期刊
FOOD AND CHEMICAL TOXICOLOGY
卷 131, 期 -, 页码 -出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.fct.2019.06.005
关键词
Spirulina platensis; Polyunsaturated fatty acids; Hyperlipidaemia; Signal pathway; Gut microbiota
资金
- Project of Fuzhou Municipal Bureau of Science and Technology [2018-G-87]
- Fujian Province Key Laboratory for the Development of Bioactive Material from Marine Algae Grant [2018FZSK01]
- Key Laboratory of Inshore Resources Biotechnology (Quanzhou Normal University) Fujian Province University [2019IRB02]
- 13th Five-year Plan on Fuzhou Marine Economic Innovation and Development Demonstration Project
- Key Laboratory of Marine Biotechnology of Fujian Province
Effects of Spirulina platensis 55% ethanol extract (SPL55) on lipid metabolism in high-fat diet-induced hyperlipidaemic rats were investigated. Ultra performance liquid chromatography-quadrupole time-of-flight mass spectrometry indicated that SPL55 was enriched with polyunsaturated fatty acids. Meanwhile, serum and liver lipid levels, including total triglyceride, total cholesterol, and low-density-lipoprotein cholesterol, were significantly decreased in hyperlipidaemic rats of SPL55. Analysis of tissue sections showed that SPL55 treatment could markedly inhibit hepatic lipid accumulation and steatosis. Moreover, SPL55 regulated the mRNA and protein expression levels of SREBP-1c, HMG-CoA, PEPCK, ACC, and AMPK genes involved in lipid metabolism. Furthermore, SPL55 led to decrease the abundances of Turicibacter, Clostridium_XlVa, and Romboutsia, which were positive correlation with lipid metabolism indicators, and has also enriched Alloprevotella, Prevotella, Porphyromonadaceae, and Barnesiella. These results provided evidence that SPL55 might be developed as a functional food to ameliorate lipid metabolic disorders and hyperlipidaemia.
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