Article
Cardiac & Cardiovascular Systems
Md Jahangir Alam, Shravan Kumar Uppulapu, Vikas Tiwari, Bincy Varghese, Soheb Anwar Mohammed, Ramu Adela, Sudheer Kumar Arava, Sanjay K. Banerjee
Summary: Pregestational diabetes (PGDM) can lead to developmental impairment and alter the cardiac plasticity in the offspring's heart. The abnormal expression of transcription factors due to hyperglycemia during fetal development may be responsible for the molecular defects and phenotypic changes in the heart. We collected 2-day-old hearts from neonatal rats born to diabetic mothers and identified molecular changes associated with heart development, myocardial fibrosis, cardiac conduction, and cell proliferation. The presence of cardiac fibrosis and increased cell proliferation was observed in neonates from diabetic mothers. These findings provide a comprehensive understanding of the cellular events and molecular pathways affected in the neonatal heart during PGDM, contributing to the development of cardiac anomalies in early life.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Obstetrics & Gynecology
Leena Alanne, Amarnath Bhide, Juulia Lantto, Heikki Huhta, Merja Kokki, Mervi Haapsamo, Ganesh Acharya, Juha Rasanen
Summary: In hypoxic fetuses, nifedipine impairs right ventricular function and reduces its cardiac output. However, the detrimental effects of nifedipine are abolished when normal oxygen levels are restored.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2021)
Editorial Material
Multidisciplinary Sciences
Joshua Bloomekatz, Neil C. Chi
Summary: A combination of computational modelling and experimental techniques in live zebrafish embryos reveals the mechanism of how the heart initiates organized and rhythmic beating.
Article
Biology
Jamie C. S. McCoy, John I. Spicer, Simon D. Rundle, Oliver Tills
Summary: Phenomics provides a solution for quantifying developmental responses to elevated temperatures. Using energy proxy traits (EPTs), we assessed the thermal sensitivities of three species of freshwater snail. The results showed marked differences in thermal sensitivities between species, reflecting differences in embryonic physiology and behavior, as well as temperature-induced changes in physiological event timing.
JOURNAL OF EXPERIMENTAL BIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Nimrod Goldshtrom, Angelica M. Vasquez, Diana Vargas Chaves, David A. Bateman, David Kalfa, Stephanie Levasseur, Alejandro J. Torres, Emile Bacha, Ganga Krishnamurthy
Summary: This study aims to evaluate the in-hospital outcomes of patients with different gestational ages in neonatal cardiac surgery and highlight the importance of a dedicated neonatal cardiac program in preventing mortality in preterm infants. The results of the study showed lower in-hospital mortality and morbidity rates for preterm infants undergoing cardiac surgery under the specialized program, particularly for those with isolated congenital heart disease.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2023)
Editorial Material
Multidisciplinary Sciences
Emily Strachan, Irene Miguel-Aliaga
Summary: A fruit-fly organelle can store inorganic phosphate in the form of phospholipids and release it when needed, which is essential for cellular metabolism and signalling.
Article
Cell Biology
Luke R. Perreault, Thanh T. Le, Madeleine J. Oudin, Lauren D. Black
Summary: The study found significant differences in gene expression of cardiac fibroblasts at different developmental ages, mainly driven by developmental age. Increasing age was associated with a significant increase in immune and inflammatory-related functions. These results highlight the phenotypic heterogeneity of cardiac fibroblasts with respect to developmental age.
PHYSIOLOGICAL GENOMICS
(2021)
Article
Medicine, General & Internal
Maria Respondek-Liberska, Oskar Sylwestrzak, Julia Murlewska, Lucja Bialy, Michal Krekora, Monika Tadros-Zins, Ewa Gulczynska, Iwona Strzelecka
Summary: This study analyzed the neonatal outcomes of fetuses with diagnosed functional cardiovascular abnormalities and found a connection with neonatal hyperbilirubinemia. The results showed that good neonatal outcomes can be expected when the fetus has normal heart anatomy and normal heart study. However, when fetal cardiovascular functional abnormalities in normal heart anatomy are detected, a neonatal elevated bilirubin level may be expected, especially with tricuspid valve regurgitation.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Multidisciplinary Sciences
Venkateswaran Ramamoorthi Elangovan, Nadia Saadat, Adel Ghnenis, Vasantha Padmanabhan, Arpita K. Vyas
Summary: Adverse in-utero insults, such as gestational hyperandrogenism, can alter the developmental trajectory of offspring, including the cardiovascular system. This study investigated the transcriptional changes and potential biomarkers of prenatal testosterone excess-induced adverse cardiac programming using genome-wide coding and non-coding RNA expression analysis. The findings suggest sexual dimorphic modulation of cardiac coding and ncRNA with gestational testosterone excess.
SCIENTIFIC REPORTS
(2023)
Review
Medicine, General & Internal
Paul Padovani, Yogen Singh, Robert H. Pass, Corina Maria Vasile, Lynne E. Nield, Alban-Elouen Baruteau
Summary: Technological advancements have greatly impacted the healthcare industry, and the integration of e-health in pediatric cardiology has shown significant potential to improve patient outcomes and reduce healthcare costs. However, there are potential limitations and challenges related to availability, cost-effectiveness, data privacy and security, and ethical, legal, and social implications.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Pediatrics
Vanessa N. Madrigal, Dalia M. Feltman, Steven R. Leuthner, Roxanne Kirsch, Rekha Hamilton, Deborah Dokken, Jennifer Needle, Renee Boss, Efrat Lelkes, Brian Carter, Eduardo Macias, Shazia Bhombal
Summary: This article discusses ethical issues related to neonates with congenital heart disease in clinical practice and emphasizes the importance of clinicians having a basic understanding of bioethics principles and practical applications. The study highlights the need for thorough understanding of individual cases, examination through classic principles of bioethics, and translation into practice.
Article
Computer Science, Artificial Intelligence
Jingyu Wang, Jingying Ma, Shenda Hong, Chi Zhang, Jianliu Wang, Linyan Zhang, Xinran Liu, Rui Bai, Xiaosong Dong, Guoli Liu, Fang Han
Summary: In this study, an easy-to-use Fetal heart rate Signal Quality Index (FSQI) was developed to accurately identify and exclude low-quality signals for assessing fetal health. The FSQI algorithm achieved a high overall accuracy of 99.8842% in signal quality classification and significantly reduced incorrectly detected deceleration events.
EXPERT SYSTEMS WITH APPLICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Thays Maria da Conceicao Silva Carvalho, Silvia Cardarelli, Mauro Giorgi, Andrea Lenzi, Andrea M. Isidori, Fabio Naro
Summary: This study revealed the expression of seven different isoforms of PDEs in developing mouse hearts, with some being modulated from E14.5 to E18.5. PDE4 accounts for the majority of cAMP hydrolyzing ability in the heart, while PDE2A is responsible for cGMP hydrolysis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Hualing Sun, Richard E. Pratt, Victor J. Dzau, Conrad P. Hodgkinson
Summary: Directly reprogramming fibroblasts into cardiomyocytes can improve cardiac function in the infarcted heart, but the low efficacy of this approach limits its clinical applications. We hypothesized that birth imposes fundamental changes in cardiac fibroblasts, thereby affecting their regenerative capabilities. Our study found that fibroblasts derived from neonatal mice showed higher reprogramming efficacy compared to those derived from adult mice, possibly due to the differential expression of pro-angiogenic genes and the transcription factor Epas1. Targeted knockdown of Epas1 improved reprogramming efficacy in adult cardiac fibroblasts, and the addition of an Epas1 targeting siRNA significantly enhanced reprogramming efficacy in vivo.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2023)
Review
Biochemistry & Molecular Biology
Guillaume Coutance, Eva Desire, Jean-Paul Duong Van Huyen
Summary: Despite advances in immunosuppression, allograft rejection remains a significant complication after heart transplantation. The current invasive diagnostic method has limitations, thus innovative strategies are needed to improve the accuracy of diagnosis.
Article
Obstetrics & Gynecology
Christina Y. L. Aye, Adam James Lewandowski, Eric O. Ohuma, Ross Upton, Alice Packham, Yvonne Kenworthy, Fenella Roseman, Tess Norris, Malid Molloholli, Sikolia Wanyonyi, Aris T. Papageorghiou, Paul Leeson
FETAL DIAGNOSIS AND THERAPY
(2018)
Article
Obstetrics & Gynecology
Adam J. Lewandowski
BREASTFEEDING MEDICINE
(2018)
Article
Medicine, General & Internal
Wilby Williamson, Adam J. Lewandowski, Nils D. Forkert, Ludovica Griffanti, Thomas W. Okell, Jill Betts, Henry Boardman, Timo Siepmann, David McKean, Odaro Huckstep, Jane M. Francis, Stefan Neubauer, Renzo Phellan, Mark Jenkinson, Aiden Doherty, Helen Dawes, Eleni Frangou, Christina Malamateniou, Charlie Foster, Paul Leeson
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2018)
Article
Cardiac & Cardiovascular Systems
Betty Raman, Rina Ariga, Marco Spartera, Sanjay Sivalokanathan, Kenneth Chan, Sairia Dass, Steffen E. Petersen, Matthew J. Daniels, Jane Francis, Robert Smittie, Adam J. Lewandowski, Eric O. Ohuma, Christopher Rodgers, Christopher M. Kramer, Masliza Mahmod, Hugh Watkins, Stefan Neubauer
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2019)
Editorial Material
Pediatrics
Adam J. Lewandowski
PEDIATRIC RESEARCH
(2019)
Review
Pediatrics
Afif EL-Khuffash, Amish Jain, Adam J. Lewandowski, Philip T. Levy
PEDIATRIC RESEARCH
(2020)
Article
Multidisciplinary Sciences
Einas Elmahi, Mihir M. Sanghvi, Alexander Jones, Christina Y. L. Aye, Adam J. Lewandowski, Nay Aung, Jackie A. Cooper, Jose Miguel Paiva, Elena Lukaschuk, Stefan K. Piechnik, Stefan Neubauer, Steffen E. Petersen, Paul Leeson
Review
Medicine, General & Internal
Rachael Fox, Jamie Kitt, Paul Leeson, Christina Y. L. Aye, Adam J. Lewandowski
JOURNAL OF CLINICAL MEDICINE
(2019)
Editorial Material
Cardiac & Cardiovascular Systems
Cameron Dockerill, Winok Lapidaire, Adam J. Lewandowski, Paul Leeson
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2020)
Letter
Cardiac & Cardiovascular Systems
Afifah Mohamed, Pablo Lamata, Wilby Williamson, Maryam Alsharqi, Cheryl M. J. Tan, Holger Burchert, Odaro J. Huckstep, Katie Suriano, Jane M. Francis, Joana Leal Pelado, Cristiana Monteiro, Stefan Neubauer, Philip T. Levy, Paul Leeson, Adam J. Lewandowski
JACC-CARDIOVASCULAR IMAGING
(2020)
Article
Cardiac & Cardiovascular Systems
Odaro J. Huckstep, Holger Burchert, Wilby Williamson, Fernando Telles, Cheryl M. J. Tan, Mariane Bertagnolli, Linda Arnold, Afifah Mohamed, Kenny McCormick, Henner Hanssen, Paul Leeson, Adam J. Lewandowski
Summary: The study showed that impaired myocardial functional reserve in young adults born preterm leads to reductions in peak VO2 and heart rate recovery. Peak VO2 and HRR may be useful for risk stratification and treatment monitoring in this population.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2021)
Article
Cardiac & Cardiovascular Systems
Christina Y. L. Aye, Adam J. Lewandowski, Pablo Lamata, Ross Upton, Esther Davis, Eric O. Ohuma, Yvonne Kenworthy, Henry Boardman, Annabelle L. Frost, Satish Adwani, Kenny Mccormick, Paul Leeson
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2020)
Article
Peripheral Vascular Disease
Henry Boardman, Pablo Lamata, Merzaka Lazdam, Ashley Verburg, Timo Siepmann, Ross Upton, Amy Bilderbeck, Rhys Dore, Clare Smedley, Yvonne Kenworthy, Yrsa Sverrisdottir, Christina Y. L. Aye, Wilby Williamson, Odaro Huckstep, Jane M. Francis, Stefan Neubauer, Adam J. Lewandowski, Paul Leeson
Letter
Cardiac & Cardiovascular Systems
Adam J. Lewandowski
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)