Review
Ophthalmology
Adrian T. T. Fung, Yi Yang, Andrew W. W. Kam
Summary: Central serous chorioretinopathy (CSC) is a common non-surgical retinopathy associated with fluid leakage. The exact cause is not fully understood, but changes in the choroid, sclera, and RPE have been observed. CSC can be divided into acute, chronic, and recurrent subtypes, and recent classifications include simple and complex based on RPE changes. Multimodal imaging is useful in the diagnosis and management of CSC and its complications. Treatment options include laser, medications, intravitreal therapy, and surgery, with argon laser and photodynamic therapy having the strongest evidence.
CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2023)
Review
Ophthalmology
Pushpinder Kanda, Arnav Gupta, Chloe Gottlieb, Rustum Karanjia, Stuart G. Coupland, Manpartap Singh Bal
Summary: The pathogenesis of central serous chorioretinopathy (CSCR) remains poorly understood and effective treatments are still lacking. Although various potential mechanisms have been proposed, the literature lacks large-scale, high-quality studies to support any single mechanism. Further exploration is needed to advance our understanding of not only CSCR but also pachychoroid disease as a whole.
Review
Ophthalmology
Sumit Randhir Singh, John Thomas Gote, Jay Chhablani
Summary: Central serous chorioretinopathy (CSCR) is a common chorioretinal disease with various manifestations. Acute CSCR presents with localized neurosensory detachment, while chronic CSCR may show widespread changes in the retinal pigment epithelium (RPE), chronic shallow subretinal fluid, and choroidal neovascularization (CNV). Despite multiple treatment options, there is a lack of standardized treatment protocol or gold standard treatment modality.
Article
Chemistry, Medicinal
Manuel Vilela, Carolina Mengue
Summary: Currently, there is no universally adopted classification system for central serous chorioretinopathy due to unknown aspects related to pathogenesis and clinical spectrum and evolution. The best option may be to aggregate multimodal pieces of information alongside temporal and phenotypic characteristics.
Article
Health Care Sciences & Services
Lars C. Boberg-Ans, Oliver N. Klefter, Marie L. R. Rasmussen, Elon H. C. van Dijk, Yousif Subhi
Summary: This study evaluated the database coverage of randomized clinical trials for central serous chorioretinopathy (CSC) and found that no single database provides full coverage. However, a combination search in the Cochrane Central and PubMed databases can achieve complete coverage while reducing workload.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Ophthalmology
Sumit Randhir Singh, Claudio Iovino, Dinah Zur, Dua Masarwa, Matias Iglicki, Ramkailash Gujar, Marco Lupidi, Dmitrii S. Maltsev, Elodie Bousquet, Mehdi Bencheqroun, Francesca Amoroso, Luiz H. Lima, Srikanta Kumar Padhy, Vishal Govindahari, Khushboo Chandra, Eric H. Souied, Francisco J. Rodriguez, Laura A. Daza, Hernan A. Rios, Carlo Cagini, Enrico Peiretti, Francine Behar-Cohen, Jay Chhablani
Summary: This study aimed to identify the factors predicting the visual and anatomical outcomes in eyes with central serous chorioretinopathy (CSCR). The results showed that factors such as central macular thickness (CMT), subfoveal choroidal thickness (SFCT), linear extent of ellipsoid zone (EZ), and interdigitation zone damage on optical coherence tomography (OCT) were predictive of anatomical and visual outcomes in CSCR eyes.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2022)
Editorial Material
Ophthalmology
Supriya Arora, Baldassarre D. Stea, Russell J. Hamilton, Jay Chhablani
Summary: Low dose radiation can be used in refractory cases of central serous chorioretinopathy (CSCR) to decrease the hyperpermeability of large choroidal vessels.
OPHTHALMOLOGY AND THERAPY
(2022)
Article
Medicine, General & Internal
Takeshi Kimura, Takashi Araki, Yuki Komuku, Hisashi Iwami, Fumi Gomi
Summary: The study found that some CSC patients had lower blood serotonin concentrations, which were associated with increased fluorescein leakage points, recurrence of subretinal fluids, and failure to significantly improve BCVA during follow-up.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Ophthalmology
Zhen Ji Chen, Shi Yao Lu, Shi Song Rong, Mary Ho, Danny Siu-Chun Ng, Haoyu Chen, Bo Gong, Jason C. Yam, Alvin L. Young, Marten Brelen, Clement C. Tham, Chi Pui Pang, Li Jia Chen
Summary: This study identified significant associations between CSCR and six SNPs in ARMS2, CFH, and TNFRSF10A, with TNFRSF10A showing consistent effects across CSCR, nAMD, and PCV, while SNPs in ARMS2 and CFH showed opposite trends. ARMS2, CFH, and TNFRSF10A may impact different phenotypic expressions of CSCR, nAMD, and PCV.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Endocrinology & Metabolism
Shanshan Yu, Kaixuan Cui, Peiqi Wu, Benjuan Wu, Xi Lu, Rong Huang, Xiaoyu Tang, Jianqiang Lin, Boyu Yang, Jinfeng Zhao, Qingjing He, Xiaoling Liang, Yue Xu
Summary: This study suggests that melatonin could be a promising and safe therapeutic strategy for central serous chorioretinopathy (CSC) patients. Melatonin administration inhibited choroidal thickening, vasodilation, and inflammation in an experimental CSC rat model.
JOURNAL OF PINEAL RESEARCH
(2022)
Article
Multidisciplinary Sciences
Joost Brinks, Femke M. van Haalen, Thomas J. van Rijssen, Nienke R. Biermasz, Onno C. Meijer, Alberto M. Pereira, Camiel J. F. Boon, Elon H. C. van Dijk
Summary: The study found that ocular abnormalities resembling (subclinical) central serous chorioretinopathy (CSC) are more common than previously thought in patients with active Cushing's syndrome (CS), and may even exist in patients without visual complaints. Early treatment may be necessary to prevent vision loss in these patients.
SCIENTIFIC REPORTS
(2021)
Editorial Material
Clinical Neurology
Jennifer Ling, Jonathan A. Micieli
Summary: A 37-year-old female presented with painful vision loss in both eyes due to optic neuritis, which was followed by central serous chorioretinopathy after corticosteroid treatment. The CSCR resolved after oral prednisone taper. CSCR can be misdiagnosed as optic neuritis or develop in patients with optic neuritis after corticosteroid treatment, and should be considered in cases of worsening vision after corticosteroid therapy.
Article
Ophthalmology
Amee D. Azad, Maggie Zhou, Armin R. Afshar, Sophie J. Bakri, Suzann Pershing
Summary: This study analyzed the frequency of systemic corticosteroid prescriptions before and after CSC diagnosis and found that many patients continue to be prescribed steroids after CSC diagnosis. The results suggest a need for greater communication and collaboration among providers to ensure that clinical practice reflects evidence-based recommendations.
Article
Multidisciplinary Sciences
Lisa Toto, Rossella D'Aloisio, Chiara De Nicola, Federica Evangelista, Maria Ludovica Ruggeri, Luca Cerino, Maria Beatrice Simonelli, Agbeanda Aharrh-Gnama, Marta Di Nicola, Annamaria Porreca, Rodolfo Mastropasqua
Summary: This study compared anatomical/functional changes after navigated subthreshold pulse laser and oral eplerenone therapy for chronic central serous chorioretinopathy. Both treatments were effective in improving CMT, FSRFT, and BCVA, with a greater absolute variation in the SML group compared to the eplerenone group.
SCIENTIFIC REPORTS
(2022)
Article
Ophthalmology
Maciej Gawecki, Andrzej Grzybowski, Anna Swiech
Summary: Central serous chorioretinopathy (CSCR) is a common disease that can cause visual impairment. This study aimed to identify characteristic biometric parameters for CSCR. The results showed that CSCR patients had increased choroidal thickness, and longer disease duration was associated with decreased retinal thickness.
OPHTHALMOLOGY AND THERAPY
(2023)