Glycoconjugate vaccines: current approaches towards faster vaccine design

Microbe-focused glycan array screening platform

(2019) Andreas Geissner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A platform for glycoengineering a polyvalent pneumococcal bioconjugate vaccine using E. coli as a host

(2019) Christian M. Harding et al.   Nature Communications

An automated platform for the enzyme-mediated assembly of complex oligosaccharides

(2019) Tiehai Li et al.   Nature Chemistry

Glyco-recoded Escherichia coli: Recombineering-based genome editing of native polysaccharide biosynthesis gene clusters

(2019) Laura E. Yates et al.   METABOLIC ENGINEERING

Combined Chemical Synthesis and Tailored Enzymatic Elongation Provide Fully Synthetic and Conjugation-Ready Neisseria meningitidis Serogroup X Vaccine Antigens

(2018) Davide Oldrini et al.   ACS Chemical Biology

The recognition of glycans by protein receptors. Insights from NMR spectroscopy

(2018) Ana Ardá et al.   CHEMICAL COMMUNICATIONS

Automated Chemical Oligosaccharide Synthesis: Novel Approach to Traditional Challenges

(2018) Matteo Panza et al.   CHEMICAL REVIEWS

Toward Automated Enzymatic Synthesis of Oligosaccharides

(2018) Liuqing Wen et al.   CHEMICAL REVIEWS

Sustainable vaccine development: a vaccine manufacturer's perspective

(2018) Rino Rappuoli et al.   CURRENT OPINION IN IMMUNOLOGY

Overexpression of O-polysaccharide chain length regulators in Gram-negative bacteria using the Wzx-/Wzy-dependent pathway enhances production of defined modal length O-polysaccharide polymers for use as haptens in glycoconjugate vaccines

(2018) N. Hegerle et al.   JOURNAL OF APPLIED MICROBIOLOGY

Immunization with outer membrane vesicles displaying conserved surface polysaccharide antigen elicits broadly antimicrobial antibodies

(2018) Taylor C. Stevenson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Applications and perspectives of nanomaterials in novel vaccine development

(2018) Yingbin Shen et al.   MedChemComm

IgG Responses to Porins and Lipopolysaccharide within an Outer Membrane-Based Vaccine against Nontyphoidal Salmonella Develop at Discordant Rates

(2018) Anna E. Schager et al.   mBio

Single-pot glycoprotein biosynthesis using a cell-free transcription-translation system enriched with glycosylation machinery

(2018) Thapakorn Jaroentomeechai et al.   Nature Communications

Changing Priorities in Vaccinology: Antibiotic Resistance Moving to the Top

(2018) Aldo Tagliabue et al.   Frontiers in Immunology

Development of an Efficacious, Semisynthetic Glycoconjugate Vaccine Candidate against Streptococcus pneumoniae Serotype 1

(2018) Benjamin Schumann et al.   ACS Central Science

Comparative immunogenicity and efficacy of equivalent outer membrane vesicle and glycoconjugate vaccines against nontyphoidal Salmonella

(2018) Francesca Micoli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Engineering a Next-Generation Glycoconjugate-Like Streptococcus pneumoniae Vaccine

(2018) Andrew B. Hill et al.   ACS Infectious Diseases

Improving vaccines against Streptococcus pneumoniae using synthetic glycans

(2018) Paulina Kaplonek et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Direct Cloning of Bacterial Surface Polysaccharide Gene Cluster for One-Step Production of Glycoconjugate Vaccine

(2018) Zhongrui Ma et al.   ACS Infectious Diseases

A recombinant conjugated pneumococcal vaccine that protects against murine infections with a similar efficacy to Prevnar-13

(2018) Mark Reglinski et al.   npj Vaccines

Efficient solid-phase synthesis of meningococcal capsular oligosaccharides enables simple and fast chemoenzymatic vaccine production

(2017) Timm Fiebig et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

T cells control the generation of nanomolar-affinity anti-glycan antibodies

(2017) Zinaida Polonskaya et al.   JOURNAL OF CLINICAL INVESTIGATION

Capsule switching of Neisseria meningitidis sequence type 7 serogroup A to serogroup X

(2017) Xuemeng Ji et al.   JOURNAL OF INFECTION

Safety, immunogenicity, and preliminary clinical efficacy of a vaccine against extraintestinal pathogenic Escherichia coli in women with a history of recurrent urinary tract infection: a randomised, single-blind, placebo-controlled phase 1b trial

(2017) Angela Huttner et al.   LANCET INFECTIOUS DISEASES

Preparation and immunogenicity of gold glyco-nanoparticles as antipneumococcal vaccine model

(2017) Maria Vetro et al.   Nanomedicine

Structure of a protective epitope of group BStreptococcustype III capsular polysaccharide

(2017) Filippo Carboni et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Automated glycan assembly using the Glyconeer 2.1 synthesizer

(2017) Heung Sik Hahm et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A semisynthetic Streptococcus pneumoniae serotype 8 glycoconjugate vaccine

(2017) Benjamin Schumann et al.   Science Translational Medicine

The complexity and cost of vaccine manufacturing – An overview

(2017) Stanley Plotkin et al.   VACCINE

Polysaccharide conjugate vaccine protein carriers as a “neglected valency” – Potential and limitations

(2017) Michael Bröker et al.   VACCINE

Characterization of O-antigen delivered by Generalized Modules for Membrane Antigens (GMMA) vaccine candidates against nontyphoidal Salmonella

(2017) G. De Benedetto et al.   VACCINE

Deciphering minimal antigenic epitopes associated with Burkholderia pseudomallei and Burkholderia mallei lipopolysaccharide O-antigens

(2017) Marielle Tamigney Kenfack et al.   Nature Communications

Identification of d-Galactan-III As Part of the Lipopolysaccharide of Klebsiella pneumoniae Serotype O1

(2017) Katarina Stojkovic et al.   Frontiers in Microbiology

A Phase 2a Randomized Study to Evaluate the Safety and Immunogenicity of the 1790GAHB Generalized Modules for Membrane Antigen Vaccine against Shigella sonnei Administered Intramuscularly to Adults from a Shigellosis-Endemic Country

(2017) Christina W. Obiero et al.   Frontiers in Immunology

Comprehensive vaccine design for commensal disease progression

(2017) Charles H. Jones et al.   Science Advances

Safety Profile and Immunologic Responses of a Novel Vaccine Against Shigella sonnei Administered Intramuscularly, Intradermally and Intranasally: Results From Two Parallel Randomized Phase 1 Clinical Studies in Healthy Adult Volunteers in Europe

(2017) Odile Launay et al.   EBioMedicine

The influence of conjugation variables on the design and immunogenicity of a glycoconjugate vaccine against Salmonella Typhi

(2017) M. Arcuri et al.   PLoS One

A Synthetic Carbohydrate Conjugate Vaccine Candidate against Shigellosis: Improved Bioconjugation and Impact of Alum on Immunogenicity

(2016) Robert M. F. van der Put et al.   BIOCONJUGATE CHEMISTRY

Toll-Like Receptor Activation by Generalized Modules for Membrane Antigens from Lipid A Mutants of Salmonella enterica Serovars Typhimurium and Enteritidis

(2016) Omar Rossi et al.   Clinical and Vaccine Immunology

Safety and Immunogenicity of a Candidate Bioconjugate Vaccine against Shigella flexneri 2a Administered to Healthy Adults: a Single-Blind, Randomized Phase I Study

(2016) Mark S. Riddle et al.   Clinical and Vaccine Immunology

The exceptionally broad-based potential of active and passive vaccination targeting the conserved microbial surface polysaccharide PNAG

(2016) David Skurnik et al.   Expert Review of Vaccines

Serum bactericidal assay for the evaluation of typhoid vaccine using a semi-automated colony-counting method

(2016) Mi Seon Jang et al.   MICROBIAL PATHOGENESIS

RecET direct cloning and Redαβ recombineering of biosynthetic gene clusters, large operons or single genes for heterologous expression

(2016) Hailong Wang et al.   Nature Protocols

Outer membrane vesicles displaying engineered glycotopes elicit protective antibodies

(2016) Linxiao Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Directed vaccination against pneumococcal disease

(2016) Yi Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Immunogenicity and safety of a tetravalent E. coli O-antigen bioconjugate vaccine in animal models

(2016) Germie P.J.M. van den Dobbelsteen et al.   VACCINE

Automated assembly of oligosaccharides containing multiple cis-glycosidic linkages

(2016) Heung Sik Hahm et al.   Nature Communications

Multivalent display of minimal Clostridium difficile glycan epitopes mimics antigenic properties of larger glycans

(2016) Felix Broecker et al.   Nature Communications

Food and Drug Administration Approval for Use of Hiberix as a 3-Dose PrimaryHaemophilus influenzaeType b (Hib) Vaccination Series

(2016) Elizabeth C. Briere   MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT

Fully Synthetic Self-Adjuvanting α-2,9-Oligosialic Acid Based Conjugate Vaccines against Group C Meningitis

(2016) Guochao Liao et al.   ACS Central Science

An efficient cell free enzyme-based total synthesis of a meningococcal vaccine candidate

(2016) Timm Fiebig et al.   npj Vaccines

Glycoengineered Outer Membrane Vesicles: A Novel Platform for Bacterial Vaccines

(2016) Nancy L. Price et al.   Scientific Reports

Site-Specific Glycoconjugation of Protein via Bioorthogonal Tetrazine Cycloaddition with a Genetically Encoded trans-Cyclooctene or Bicyclononyne

(2015) Takuya Machida et al.   BIOCONJUGATE CHEMISTRY

Programmed chemo-enzymatic synthesis of the oligosaccharide component of a carbohydrate-based antibacterial vaccine candidate

(2015) Stéphane Salamone et al.   CHEMICAL COMMUNICATIONS

Pneumococcal Capsules and Their Types: Past, Present, and Future

(2015) K. Aaron Geno et al.   CLINICAL MICROBIOLOGY REVIEWS

Simplified low-cost production of O-antigen from Salmonella Typhimurium Generalized Modules for Membrane Antigens (GMMA)

(2015) Eleonora Meloni et al.   JOURNAL OF BIOTECHNOLOGY

Identification of carbohydrate anomers using ion mobility–mass spectrometry

(2015) J. Hofmann et al.   NATURE

Recent advances in the molecular design of synthetic vaccines

(2015) Lyn H. Jones   Nature Chemistry

Automated Solution-Phase Synthesis of β-1,4-Mannuronate and β-1,4-Mannan

(2015) Shu-Lun Tang et al.   ORGANIC LETTERS

Conjugate-like immunogens produced as protein capsular matrix vaccines

(2015) Ann Thanawastien et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Safety and immunogenicity of a candidate bioconjugate vaccine against Shigella dysenteriae type 1 administered to healthy adults: A single blind, partially randomized Phase I study

(2015) Christoph F.R Hatz et al.   VACCINE

Increased efficiency of Campylobacter jejuni N-oligosaccharyltransferase PglB by structure-guided engineering

(2015) J. Ihssen et al.   Open Biology

Production of a Shigella sonnei Vaccine Based on Generalized Modules for Membrane Antigens (GMMA), 1790GAHB

(2015) Christiane Gerke et al.   PLoS One

Chemical Biology Approaches to Designing Defined Carbohydrate Vaccines

(2014) Chakkumkal Anish et al.   CHEMISTRY & BIOLOGY

Dissection of Hexosyl- and Sialyltransferase Domains in the Bifunctional Capsule Polymerases fromNeisseria meningitidisW and Y Defines a New Sialyltransferase Family

(2014) Angela Romanow et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular Cloning and Functional Characterization of Components of the Capsule Biosynthesis Complex ofNeisseria meningitidisSerogroup A

(2014) Timm Fiebig et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Modulation of Endotoxicity ofShigellaGeneralized Modules for Membrane Antigens (GMMA) by Genetic Lipid A Modifications

(2014) Omar Rossi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Synthetic Teichoic Acid Conjugate Vaccine against Nosocomial Gram-Positive Bacteria

(2014) Diana Laverde et al.   PLoS One

Sequential administration of 13-valent pneumococcal conjugate vaccine and 23-valent pneumococcal polysaccharide vaccine in pneumococcal vaccine–naïve adults 60–64 years of age

(2014) Richard N. Greenberg et al.   VACCINE

A peptide-free, liposome-based oligosaccharide vaccine, adjuvanted with a natural killer T cell antigen, generates robust antibody responses in vivo

(2014) S. Deng et al.   Chemical Science

Vaccines against invasive Salmonella disease

(2014) Calman A MacLennan et al.   Human Vaccines & Immunotherapeutics

Production of a recombinant vaccine candidate against Burkholderia pseudomallei exploiting the bacterial N-glycosylation machinery

(2014) Fatima Garcia-Quintanilla et al.   Frontiers in Microbiology

Unnatural amino acid incorporation in E. coli: current and future applications in the design of therapeutic proteins

(2014) Kim Wals et al.   Frontiers in Chemistry

Automated Polysaccharide Synthesis: Assembly of a 30mer Mannoside

(2013) Oliviana Calin et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Functional expression of the capsule polymerase of Neisseria meningitidis serogroup X: A new perspective for vaccine development

(2013) T. Fiebig et al.   GLYCOBIOLOGY

Chemoenzymatic synthesis of immunogenic meningococcal group C polysialic acid-tetanus Hc fragment glycoconjugates

(2013) Pumtiwitt C. McCarthy et al.   GLYCOCONJUGATE JOURNAL

Biochemical and Biophysical Characterization of the Sialyl-/Hexosyltransferase Synthesizing the Meningococcal Serogroup W135 Heteropolysaccharide Capsule

(2013) Angela Romanow et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Prevention of Staphylococcus aureus Infections by Glycoprotein Vaccines Synthesized in Escherichia coli

(2013) Michael Wacker et al.   JOURNAL OF INFECTIOUS DISEASES

Multiple antigen-presenting system (MAPS) to induce comprehensive B- and T-cell immunity

(2013) F. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antibody to a conserved antigenic target is protective against diverse prokaryotic and eukaryotic pathogens

(2013) C. Cywes-Bentley et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Vaccines for low-income countries

(2013) Calman A. MacLennan   SEMINARS IN IMMUNOLOGY

Influence of initial vaccination with 13-valent pneumococcal conjugate vaccine or 23-valent pneumococcal polysaccharide vaccine on anti-pneumococcal responses following subsequent pneumococcal vaccination in adults 50 years and older

(2013) Lisa A. Jackson et al.   VACCINE

Exploitation of bacterial N-linked glycosylation to develop a novel recombinant glycoconjugate vaccine against Francisella tularensis

(2013) J. Cuccui et al.   Open Biology

Vaccine delivery using nanoparticles

(2013) Anthony E. Gregory et al.   Frontiers in Cellular and Infection Microbiology

Automated Solid-Phase Synthesis of β-Mannuronic Acid Alginates

(2012) Marthe T. C. Walvoort et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Glycoconjugate vaccines

(2012) David Pace   EXPERT OPINION ON BIOLOGICAL THERAPY

Engineering, conjugation, and immunogenicity assessment of Escherichia coli O121 O antigen for its potential use as a typhoid vaccine component

(2012) Michael Wetter et al.   GLYCOCONJUGATE JOURNAL

Gold nanoparticles as carriers for a syntheticStreptococcus pneumoniaetype 14 conjugate vaccine

(2012) Dodi Safari et al.   Nanomedicine

HPLC-Assisted Automated Oligosaccharide Synthesis

(2012) N. Vijaya Ganesh et al.   ORGANIC LETTERS

Molecular Characterization of the viaB Locus Encoding the Biosynthetic Machinery for Vi Capsule Formation in Salmonella Typhi

(2012) Michael Wetter et al.   PLoS One

Biochemical and biological characteristics of cross-reacting material 197 (CRM197), a non-toxic mutant of diphtheria toxin: Use as a conjugation protein in vaccines and other potential clinical applications

(2011) Michael Bröker et al.   BIOLOGICALS

Microscale to manufacturing scale-up of cell-free cytokine production-a new approach for shortening protein production development timelines

(2011) James F. Zawada et al.   BIOTECHNOLOGY AND BIOENGINEERING

Automated solid phase synthesis of teichoic acids

(2011) Wouter F. J. Hogendorf et al.   CHEMICAL COMMUNICATIONS

Development of an Automated, High-Throughput Bactericidal Assay That Measures Cellular Respiration as a Survival Readout for Neisseria meningitidis

(2011) Puiying A. Mak et al.   Clinical and Vaccine Immunology

The design of semi-synthetic and synthetic glycoconjugate vaccines

(2011) Paolo Costantino et al.   Expert Opinion on Drug Discovery

Glycoconjugate vaccines and immune interference: A review

(2010) Ron Dagan et al.   VACCINE

New Principles for Glycoside-Bond Formation

(2009) Xiangming Zhu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Chemoenzymatic synthesis of conjugatable oligosialic acids

(2009) Sylvester L. Mosley et al.   BIOCATALYSIS AND BIOTRANSFORMATION

N-linked glycosylation in bacteria: an unexpected application

(2009) Rebecca H Langdon et al.   Future Microbiology

Rational design and immunogenicity of liposome-based diepitope constructs: Application to synthetic oligosaccharides mimicking the Shigella flexneri 2a O-antigen

(2009) Fatouma Said Hassane et al.   VACCINE

Chemistry of a new investigational quadrivalent meningococcal conjugate vaccine that is immunogenic at all ages

(2009) Michael Bröker et al.   VACCINE

Extreme Substrate Promiscuity of theNeisseriaOligosaccharyl Transferase Involved in ProteinO-Glycosylation

(2008) Amirreza Faridmoayer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Physicochemical characterisation of glycoconjugate vaccines for prevention of meningococcal diseases

(2008) Angela Bardotti et al.   VACCINE