Review
Cell & Tissue Engineering
Wen-zhao Liu, Zhan-jun Ma, Jie-ru Li, Xue-wen Kang
Summary: SCI often leads to serious motor and sensory dysfunction of the limbs below the injured segment, causing physical, psychological harm and economic burden. MSC therapy for SCI has shown promise but faces challenges like low survival rate and immune rejection, while exosomes derived from MSCs have great potential in the treatment of SCI.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Engineering, Biomedical
Zhan-Shan Gao, Chuan-Jie Zhang, Nan Xia, He Tian, Dao-Yong Li, Jia-Quan Lin, Xi-Fan Mei, Chao Wu
Summary: This study successfully designed berberine carried by M2-type macrophage-derived exosomes, which efficiently delivered the drug to the injured spinal cord, showing good anti-inflammatory and anti-apoptotic effects. The treatment significantly improved motor function in SCI mice, indicating that Exos-Ber is a potential therapeutic agent for SCI.
ACTA BIOMATERIALIA
(2021)
Article
Biotechnology & Applied Microbiology
Guang Kong, Wu Xiong, Cong Li, Chenyu Xiao, Siming Wang, Wenbo Li, Xiangjun Chen, Juan Wang, Sheng Chen, Yongjie Zhang, Jun Gu, Jin Fan, Zhengshuai Jin
Summary: This study explores the influence of Treg cells on the recovery of BSCB after spinal cord injury (SCI) and its underlying mechanism. The findings suggest that Treg cell-derived exosomes can affect BSCB integrity and motor function by regulating the expression of IRAK1. This provides novel insights for functional repair and inflammation limitation after SCI.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Xiaolie He, Li Yang, Kun Dong, Feng Zhang, Yuchen Liu, Bei Ma, Youwei Chen, Jian Hai, Rongrong Zhu, Liming Cheng
Summary: This study demonstrates the novel function of Gel-Exo in promoting spinal cord injury repair through enhanced neurogenesis and VGF-mediated oligodendrogenesis. Gel-Exo can serve as a biocompatible material for SCI repair.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Wei Peng, Yong Xie, Zixiang Luo, Yudong Liu, Jiaqi Xu, Chengjun Li, Tian Qin, Hongbin Lu, Jianzhong Hu
Summary: Macrophages polarized to the M2 subtype after spinal cord injury (SCI) are beneficial for promoting neurological recovery. The crosstalk between endothelial cells (ECs) and macrophages is crucial for the imbalance between proinflammatory and pro-resolving responses caused by macrophage heterogeneity; however, this crosstalk is strengthened post-SCI, leading to inflammatory cascades and second damage.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Article
Materials Science, Multidisciplinary
Zhuo Li, Yajiang Yuan, Zhongming Zhang, Xiuming Zhang, Hui Yang, Huanan Li, Bao Han, Ziyang Deng, Zipeng Zhou, Xiangyi Fan
Summary: Effectively suppressing hyperactivated inflammatory response is crucial for treating inflammatory diseases. This research designed engineered exosomes derived from M2 macrophages to target inflammation. The modified exosomes demonstrated better uptake by target cells and increased accumulation at the inflammation site. In experiments with spinal cord injury and rheumatoid arthritis models, the engineered exosomes showed enhanced anti-inflammatory effects and improved motor function.
MATERIALS & DESIGN
(2023)
Article
Biotechnology & Applied Microbiology
Wu Xiong, Cong Li, Guang Kong, Qiang Zeng, Siming Wang, Guoyong Yin, Jun Gu, Jin Fan
Summary: This study reveals the mechanism of interaction between Treg cells and microglia, as well as the role of Treg cells in promoting motor function recovery by inhibiting microglia pyroptosis after spinal cord injury.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Engineering, Biomedical
Xingzhi Liu, Lulu Zhang, Zhongjuan Xu, Xuan Xiong, Yanzhen Yu, Hanfei Wu, Hong Qiao, Junjie Zhong, Zhe Zhao, Jianwu Dai, Guangli Suo
Summary: This study aims to develop genetically engineered miR21-loaded exosomes that can be stably tethered to a collagen-I scaffold, promoting the sustained release of miR21 and benefiting spinal cord injury repair.
ACTA BIOMATERIALIA
(2022)
Review
Biochemistry & Molecular Biology
Giovanni Schepici, Serena Silvestro, Emanuela Mazzon
Summary: Spinal cord injury (SCI) is a devastating condition that causes permanent motor and sensory deficits. Researchers have been studying potential therapeutic strategies to mitigate the neuro-inflammatory response following injury. Recent studies have shown that exosomes-derived MSCs (MSC-EXOs) have promising effects as an innovative therapy for SCI patients.
Review
Biotechnology & Applied Microbiology
Xuanxuan Zhang, Wenwei Jiang, Yan Lu, Tiantian Mao, Yu Gu, Dingyue Ju, Chuanming Dong
Summary: Spinal cord injury (SCI) is a serious and disabling disease that often leads to sensory and motor dysfunction, accompanied by various secondary outcomes. The main treatments for SCI include surgery, drugs, and rehabilitation. Cell therapy and exosomes have shown promise in treating SCI, but the therapeutic effect is still controversial. Combining biomaterial scaffolds and exosomes can enhance their delivery to the injury site and improve their viability.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Soo-Eun Sung, Min-Soo Seo, Young-In Kim, Kyung-Ku Kang, Joo-Hee Choi, Sijoon Lee, Minkyoung Sung, Sang-Gu Yim, Ju-Hyeon Lim, Hyun-Gyu Seok, Seung-Yun Yang, Gun-Woo Lee
Summary: This study demonstrated that exosomes isolated from human epidural adipose tissue-derived MSCs can help restore locomotor function in rats with SCI by reducing inflammatory response.
Review
Biotechnology & Applied Microbiology
Mengdie Hu, Zhidong Cao, Dianming Jiang
Summary: MiRNA-modified exosomes have great potential in the treatment of spinal cord injury, and their efficacy is superior to that of exosomes alone. In addition, the SCI model, administration time, and dose have an impact on the treatment effect.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Neurosciences
Yunpeng Shen, Junying Cai
Summary: Spinal cord injury is a severe traumatic disease of the central nervous system, and its pathophysiological process is complex with no clear effective treatment strategy. Recent studies have shown that exosomes combined with miRNA may be a potential therapeutic approach for SCI.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Nanoscience & Nanotechnology
Jiachen Chen, Jiahe Wu, Jiafu Mu, Liming Li, Jingyi Hu, Hangjuan Lin, Jian Cao, Jianqing Gao
Summary: Spinal cord injury (SCI) is a severe traumatic disease that affects multiple organs and causes complications. This study developed a local-implantation system using polydopamine-modified hydrogel encapsulating exosomes derived from Flos Sophorae Immaturus (so-exos) for SCI treatment. The so-exos, acting as natural nanoscale carriers of rutin, effectively improved microenvironment and nerve regeneration. The results demonstrated the potential of the combinational delivery of so-exos for rapid improvement of impaired motor function and alleviation of urination dysfunction in SCI by modulating spinal inflammatory and oxidative conditions.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2023)
Review
Cell Biology
Serena Silvestro, Emanuela Mazzon
Summary: Spinal cord injury is a devastating injury to the central nervous system, and current therapies have not been successful. MiRNA plays a crucial role in CNS development and pathological processes after neural injury, making it a promising candidate for SCI therapy.
Article
Cell Biology
Fengzhi Li, Xue Song, Jiaxin Xu, Yujiao Shi, Ruina Hu, Zhen Ren, Qi Qi, Hezuo Lu, Xiaoxin Cheng, Jianguo Hu
Summary: Morroniside exerts protective effects against hydrogen peroxide-induced OLN-93 cell injury by enhancing antioxidative stress and antiapoptotic activities. The PI3K/Akt signaling pathway is involved in mediating the protective effects of morroniside.
Article
Neurosciences
Meng-Tong Xue, Wen-Jie Sheng, Xue Song, Yu-Jiao Shi, Zhi-Jun Geng, Lin Shen, Rui Wang, He-Zuo Lu, Jian-Guo Hu
Summary: ATL-III improves spinal cord injury by modulating microglial/macrophage polarization, and it possesses anti-inflammatory and neuroprotective effects.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Article
Genetics & Heredity
Yu-Jiao Shi, Wen-Jie Sheng, Meng-Tong Xue, Fei-Xiang Duan, Lin Shen, Shu-Qin Ding, Qi-Yi Wang, Rui Wang, He-Zuo Lue, Jian-Guo Hu
Summary: RNA sequencing was used to evaluate the gene expression changes in injured spinal cords of rats treated with morroniside. The results confirmed the anti-inflammatory and anti-apoptotic effects of morroniside and provided a basis for further research on the protective mechanisms of morroniside in spinal cord injury.