Indole-3-propionic acid inhibits gut dysbiosis and endotoxin leakage to attenuate steatohepatitis in rats

Hepatic CREBZF couples insulin to lipogenesis by inhibiting insig activity and contributes to hepatic steatosis in diet-induced insulin-resistant mice

(2018) Feifei Zhang et al.   HEPATOLOGY

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(2018) Zobair M. Younossi et al.   HEPATOLOGY

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(2018) Yan-Jie Chen et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Gut Microbiota-Derived Tryptophan Metabolites Modulate Inflammatory Response in Hepatocytes and Macrophages

(2018) Smitha Krishnan et al.   Cell Reports

Associations of serum indolepropionic acid, a gut microbiota metabolite, with type 2 diabetes and low-grade inflammation in high-risk individuals

(2018) Marjo Tuomainen et al.   Nutrition & Diabetes

Functional Gut Microbiota Remodeling Contributes to the Caloric Restriction-Induced Metabolic Improvements

(2018) Salvatore Fabbiano et al.   Cell Metabolism

The effect of a multispecies probiotic on microbiota composition in a clinical trial of patients with diarrhea-predominant irritable bowel syndrome

(2018) Keren Hod et al.   NEUROGASTROENTEROLOGY AND MOTILITY

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(2018) Jingjing Cai et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

The diagnosis and management of nonalcoholic fatty liver disease: Practice guidance from the American Association for the Study of Liver Diseases

(2017) Naga Chalasani et al.   HEPATOLOGY

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(2017) Jian-Gao Fan et al.   JOURNAL OF HEPATOLOGY

Sodium butyrate attenuates high-fat diet-induced steatohepatitis in mice by improving gut microbiota and gastrointestinal barrier

(2017) Da Zhou et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Indolepropionic acid and novel lipid metabolites are associated with a lower risk of type 2 diabetes in the Finnish Diabetes Prevention Study

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Hepatic ATF6 Increases Fatty Acid Oxidation to Attenuate Hepatic Steatosis in Mice Through Peroxisome Proliferator–Activated Receptor α

(2016) Xuqing Chen et al.   DIABETES

Loss of Junctional Adhesion Molecule A Promotes Severe Steatohepatitis in Mice on a Diet High in Saturated Fat, Fructose, and Cholesterol

(2016) Khalidur Rahman et al.   GASTROENTEROLOGY

Fibroblast growth factor 21 improves hepatic insulin sensitivity by inhibiting mammalian target of rapamycin complex 1 in mice

(2016) Qi Gong et al.   HEPATOLOGY

Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence, incidence, and outcomes

(2016) Zobair M. Younossi et al.   HEPATOLOGY

Type I interferons and microbial metabolites of tryptophan modulate astrocyte activity and central nervous system inflammation via the aryl hydrocarbon receptor

(2016) Veit Rothhammer et al.   NATURE MEDICINE

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(2016) Christopher Leung et al.   Nature Reviews Gastroenterology & Hepatology

Probiotics modulated gut microbiota suppresses hepatocellular carcinoma growth in mice

(2016) Jun Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

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(2016) Torbjørn Rognes et al.   PeerJ

Fibrosis stage is the strongest predictor for disease-specific mortality in NAFLD after up to 33 years of follow-up

(2015) Mattias Ekstedt et al.   HEPATOLOGY

Dysbiosis gut microbiota associated with inflammation and impaired mucosal immune function in intestine of humans with non-alcoholic fatty liver disease

(2015) Weiwei Jiang et al.   Scientific Reports

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(2014) Anthony M. Bolger et al.   BIOINFORMATICS

The Treatment-Naive Microbiome in New-Onset Crohn’s Disease

(2014) Dirk Gevers et al.   Cell Host & Microbe

Symbiotic Bacterial Metabolites Regulate Gastrointestinal Barrier Function via the Xenobiotic Sensor PXR and Toll-like Receptor 4

(2014) Madhukumar Venkatesh et al.   IMMUNITY

Microbiota Modulate Behavioral and Physiological Abnormalities Associated with Neurodevelopmental Disorders

(2013) Elaine Y. Hsiao et al.   CELL

The pathogenicity of the Streptococcus genus

(2013) W. Krzyściak et al.   EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES

Tryptophan Catabolites from Microbiota Engage Aryl Hydrocarbon Receptor and Balance Mucosal Reactivity via Interleukin-22

(2013) Teresa Zelante et al.   IMMUNITY

Commensal Bacteria-Dependent Indole Production Enhances Epithelial Barrier Function in the Colon

(2013) Yosuke Shimada et al.   PLoS One

Histopathological algorithm and scoring system for evaluation of liver lesions in morbidly obese patients

(2012) Pierre Bedossa et al.   HEPATOLOGY

FLASH assembly of TALENs for high-throughput genome editing

(2012) Deepak Reyon et al.   NATURE BIOTECHNOLOGY

AMPK Phosphorylates and Inhibits SREBP Activity to Attenuate Hepatic Steatosis and Atherosclerosis in Diet-Induced Insulin-Resistant Mice

(2011) Yu Li et al.   Cell Metabolism

Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease

(2011) Zeneng Wang et al.   NATURE

NF-κB in the liver—linking injury, fibrosis and hepatocellular carcinoma

(2011) Tom Luedde et al.   Nature Reviews Gastroenterology & Hepatology

Regulation of Inflammation by Short Chain Fatty Acids

(2011) Marco A.R. Vinolo et al.   Nutrients

From the gut to the peripheral tissues: the multiple effects of butyrate

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Increased Hepatic Myeloperoxidase Activity in Obese Subjects with Nonalcoholic Steatohepatitis

(2009) Sander S. Rensen et al.   AMERICAN JOURNAL OF PATHOLOGY

Metabolomics analysis reveals large effects of gut microflora on mammalian blood metabolites

(2009) W. R. Wikoff et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A core gut microbiome in obese and lean twins

(2008) Peter J. Turnbaugh et al.   NATURE