Article
Chemistry, Multidisciplinary
Yingzheng Zhao, Lanzi Luo, Lantian Huang, Yingying Zhang, Mengqi Tong, Hanxiao Pan, Jianxun Shangguan, Qing Yao, Shihao Xu, Helin Xu
Summary: This study developed a new method, PNO gel, for treating diabetic foot ulcer. The results demonstrated that PNO can accelerate wound healing, reduce inflammation, and promote angiogenesis.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Dermatology
Wangkheirakpam Ramdas Singh, Anshuk Sharma, Hijam Shila Devi, Anjali Bhatia, Madhuribahen Ratishkumar Patel, Dinesh Kumar
Summary: Icariin can reduce inflammation, promote angiogenesis, and improve collagen deposition, enhancing the healing of diabetic wounds.
JOURNAL OF TISSUE VIABILITY
(2022)
Article
Materials Science, Multidisciplinary
Kai Chen, Changci Tong, Jinge Yang, Peifang Cong, Ying Liu, Xiuyun Shi, Xu Liu, Jun Zhang, Rufei Zou, Keshen Xiao, Yuyang Ni, Lei Xu, Mingxiao Hou, Hongxu Jin, Yunen Liu
Summary: The melatonin-loaded hydrogel promotes granulation tissue formation, accelerates wound healing, and reduces inflammation levels.
JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
(2021)
Article
Cell & Tissue Engineering
Yi Yi, Min Wu, Xiaomei Zhou, Mingchen Xiong, Yufang Tan, Honghao Yu, Zeming Liu, Yiping Wu, Qi Zhang
Summary: The study demonstrated that AA2G-treated BMSCs showed enhanced proliferation, angiogenesis and collagen formation abilities. In animal models, the group treated with AA2G exhibited faster wound healing and higher vascularization in the new wound. Moreover, AA2G treatment may enhance the biological functionality of BMSCs through various pathways.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Nanoscience & Nanotechnology
Matthew McGrath, Karolina Zimkowska, Katelyn J. Genoud, Jack Maughan, Javier Gutierrez Gonzalez, Shane Browne, Fergal J. O'Brien
Summary: A biomimetic, bilayered antimicrobial collagen-based scaffold was developed to deal with the etiology of diabetic foot ulcers (DFUs). The scaffold exhibited high structural stability, successfully inhibited the growth and infiltration of Staphylococcus aureus, and supported the proliferation of epidermal cells and vascularization. These results suggest that the bilayered scaffold is a promising candidate for enhancing diabetic wound healing.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Immunology
Rogerio Marchete, Sarah Oliveira, Leonardo Bagne, Jennyffer Ione de Souza Silva, Ana Paula Valverde, Andrea Aparecida de Aro, Mariana Moreira Figueira, Marcio Fronza, Thaina Mikaela Bressam, Vivian Fernandes Furletti de Goes, Fernanda Oliveira de Gaspari de Gaspi, Glaucia Maria Tech dos Santos, Thiago Antonio Moretti Andrade
Summary: The extract of Alternanthera brasiliana exhibits important anti-inflammatory and antioxidant activities, promoting angiogenesis and tissue formation, accelerating wound healing process.
INFLAMMOPHARMACOLOGY
(2021)
Review
Chemistry, Multidisciplinary
Yongping Liang, Jiahui He, Baolin Guo
Summary: Hydrogels have shown promising advantages as wound dressings due to their excellent biochemical and mechanical properties. This review summarizes the advanced functions of hydrogel dressings, such as antimicrobial, adhesion, hemostasis, anti-inflammatory, substance delivery, self-healing, stimulus response, and conductivity, as well as the emerging wound monitoring feature. The potential applications for different types of wounds, including chronic wounds and focus on infected, burn, and diabetic wounds, are discussed, along with proposed future directions for hydrogel wound dressings in wound healing.
Article
Pharmacology & Pharmacy
Juan Yang, Yingjuan He, Sha Nan, Juan Li, Anjuan Pi, Lele Yan, Jinshan Xu, Yuhui Hao
Summary: This study prepared propolis nanoparticles through a pH difference method and characterized their properties. The PNPs showed good stability, antioxidant capacity, and accelerated wound healing in a mouse model. These findings suggest that PNPs could be new candidates for wound healing applications.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Jinpeng Wen, Datao Hu, Ruisi Wang, Kailai Liu, Yunhe Zheng, Jiangchuan He, Xi Chen, Yuchen Zhang, Xinxin Zhao, Yizhuo Bu, Botao Song, Lin Wang, Ke Wang
Summary: Joint wound dressings are limited in their clinical applications due to their mechanical properties and single therapeutic effect. To address this, a novel nanofibrous membrane composed of gelatin and astragalus polysaccharides (GEL/APS NFM) was fabricated using the electrospinning technique. GEL/APS NFM exhibited excellent biocompatibility, stretchability, and wound healing efficiency due to the optimal proportion of GEL and APS. Moreover, released APS in GEL/APS NFM promoted anti-inflammatory, procollagen deposition, and proangiogenic effects, accelerating joint wound healing.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Biotechnology & Applied Microbiology
Fei Fan, Sanjoy Saha, Donny Hanjaya-Putra
Summary: Hydrogels play a crucial role in wound healing by supporting a hydrated environment and promoting better healing outcomes through the incorporation of biomolecules and supporting cells. Various types of hydrogels have been developed and modified to match different stages of wound healing, with challenges related to adoption and future perspectives discussed.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Cell Biology
Liuhanghang Cheng, Xiaoxuan Lei, Zengjun Yang, Yanan Kong, Pengcheng Xu, Shiya Peng, Jue Wang, Cheng Chen, Yunqing Dong, Xiaohong Hu, Xiaorong Zhang, Tymour Forouzanfar, Gang Wu, Xiaobing Fu
Summary: Histatin 1 has been found to accelerate wound healing and improve the mechanical properties of healed skin by promoting the function of fibroblasts. In vitro experiments showed that fibroblasts stimulated by Hst 1 exhibited enhanced migration ability and transformation into myofibroblasts, leading to improved contraction and collagen secretion functions. Additionally, the study identified activation of the mTOR signaling pathway by Hst 1 in fibroblasts.
CELL PROLIFERATION
(2021)
Article
Biochemistry & Molecular Biology
Jia-Hau Yen, Wan-Ting Chio, Chia-Ju Chuang, Hsin-Ling Yang, Sheng-Teng Huang
Summary: This study investigates the wound-healing effectiveness of naringin, a phenolic compound, both in vitro and in vivo. The results show that naringin promotes wound healing by upregulating the expression of growth factors and matrix metalloproteinases. Furthermore, naringin facilitates cell migration and wound healing through the modulation of signaling pathways, such as the VEGF pathway.
Article
Biochemistry & Molecular Biology
M. C. Linju, M. R. Rekha
Summary: The present study developed a L-proline conjugated chitosan scaffold for wound healing. The scaffold was characterized by various tests and showed no cytotoxicity. In vitro experiments demonstrated that the modified scaffold promoted wound closure and collagen deposition. These findings suggest that the L-proline conjugated scaffold has potential as a wound dressing to improve wound healing.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Pharmacology & Pharmacy
Nabil A. Alhakamy, Giuseppe Caruso, Anna Privitera, Osama A. A. Ahmed, Usama A. Fahmy, Shadab Md, Gamal A. Mohamed, Sabrin R. M. Ibrahim, Basma G. Eid, Ashraf B. Abdel-Naim, Filippo Caraci
Summary: Impaired diabetic wound healing is a global concern for healthcare professionals. This study developed a fluoxetine ecofriendly nanoemulsion (FLX-EFNE) and demonstrated its significant efficacy in promoting wound healing in diabetic rats.
Article
Engineering, Biomedical
Jueying Chen, Jiahui He, Yutong Yang, Lipeng Qiao, Juan Hu, Jie Zhang, Baolin Guo
Summary: The development of compressible, stretchable and self-healing hydrogel dressings with good adhesive, antibacterial and angiogenesis properties is needed to promote the regeneration of diabetic wounds in clinical applications.
ACTA BIOMATERIALIA
(2022)
Article
Materials Science, Composites
Dinesh Kumar, Navin Kumar, Prashant Jindal
Summary: MWCNTs-reinforced PU composites were fabricated using solution mixing and compression molding techniques. The study found that the storage modulus of the composites was significantly enhanced at higher frequencies, and even a small amount of MWCNTs could improve the elasticity of the material, attributed to the uniform dispersion of MWCNTs and their adhesion with PU molecules.
JOURNAL OF THERMOPLASTIC COMPOSITE MATERIALS
(2022)
Article
Dermatology
Rajna Ogrin, Mohammod A. Motin, Behzad Aliahmad, Kylie Elder, Jacinta Anderson, Dinesh Kumar
Summary: This study investigated the effectiveness of using thermal imaging to predict venous leg ulcer healing in the homes of participants. The results showed that thermal imaging could not predict the healing progression of ulcers when taken in home settings.
INTERNATIONAL JOURNAL OF LOWER EXTREMITY WOUNDS
(2023)
Review
Cardiac & Cardiovascular Systems
Muhammad Umer, Manish Motwani, John L. Jefferies, Sherif F. Nagueh, Dinesh K. Kalra
Summary: Fabry disease is a rare X-linked disorder that affects glycosphingolipid metabolism. It is caused by alpha-galactosidase A enzyme deficiency, leading to the accumulation of GL3 in lysosomes. Multiple systems are affected, with cardiac involvement being a significant manifestation. Early symptoms include neuropathic pain, skin lesions, anhidrosis, corneal changes, and gastrointestinal symptoms. Later stages may involve strokes, hearing loss, and life-threatening complications. This review focuses on the cardiac manifestations of Fabry disease and the role of multimodality imaging in diagnosis and monitoring.
CURRENT PROBLEMS IN CARDIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Suresh C. C. Tyagi, Sathnur Pushpakumar, Utpal Sen, Sri Prakash L. Mokshagundam, Dinesh K. K. Kalra, Mohamed A. A. Saad, Mahavir Singh
Summary: Although the mechanisms underlying respiratory failure in Duchenne muscular dystrophy (DMD) and long-COVID are unclear, there is evidence of neopterin (NPT) involvement in both conditions. Studies have shown increased levels of NPT and other inflammatory markers in lung tissue, leading to fibrosis of the diaphragm. Understanding the epigenetic regulation and generation of NPT in long-COVID patients is of interest.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cardiac & Cardiovascular Systems
Muhammad Umer, Dinesh K. Kalra
Summary: Fabry disease is a rare genetic disorder caused by a deficiency in the alpha-galactosidase A enzyme, leading to the accumulation of globotriaosylceramide in various organs. Fabry cardiomyopathy is characterized by abnormalities in the heart, including increased ventricular wall thickness, valvular disease, arrhythmias, and heart failure. Early diagnosis and treatment are crucial to prevent complications and improve patient outcomes. This review focuses on the role of cardiovascular magnetic resonance imaging in the diagnosis, decision-making, and monitoring of treatment efficacy.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Aangi J. Shah, Taylor Beckmann, Mounica Vorla, Dinesh K. Kalra
Summary: Pulmonary arterial hypertension (PAH) is a chronic and progressive disorder that affects the pulmonary vasculature and leads to pulmonary and cardiac remodeling. Despite improved life expectancy through targeted therapies, PAH still remains a progressive disease with significant morbidity and mortality. Current vasodilator therapies do not target the underlying pathogenesis of the disease, highlighting the need for the development of new drugs and interventional therapies. This review focuses on newer targets, drugs, and interventional therapies that modify various pathways involved in the pathogenesis of PAH.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Sathnur Pushpakumar, Mahavir Singh, Yuting Zheng, Oluwaseun E. Akinterinwa, Sri Prakash L. Mokshagundam, Utpal Sen, Dinesh K. Kalra, Suresh C. Tyagi
Summary: Renal denervation (RDN) protects against hypertension, hypertrophy, and heart failure (HF) but it is unclear whether RDN preserves ejection fraction (EF) during HFpEF. By creating an aorta-vena cava fistula (AVF) in mice, this study demonstrated that RDN is cardioprotective during HFpEF via preservation of eNOS and endocardial-endothelial function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Chemistry, Medicinal
Muhammad Umer, Dinesh K. K. Kalra
Summary: Fabry disease is a rare genetic disorder that affects the metabolism of glycosphingolipids. It results in the accumulation of globotriaosylceramide in lysosomes due to a deficiency of the alpha-galactosidase A enzyme. This disease affects multiple organs, mainly the kidneys, heart, and cerebrovascular system. Early diagnosis and treatment are crucial in preventing irreversible tissue damage, organ failure, and life-threatening complications that can significantly impact life expectancy. This review focuses on the current and emerging treatment options for Fabry disease.
Article
Cardiac & Cardiovascular Systems
Amit Rout, Sanchit Duhan, Muhammad Umer, Miranda Li, Dinesh Kalra
Review
Cardiac & Cardiovascular Systems
Dinesh K. Kalra, Mounica Vorla, Erin D. Michos, Anandita Agarwala, Salim Virani, Bart Duell, Frederick J. Raal
Summary: With the improvement of antiretroviral therapy, the life expectancy of people living with HIV has increased, but cardiovascular disease has become a major cause of morbidity and mortality in this aging population. Therefore, it is crucial to assess and treat cardiovascular disease risk factors, including dyslipidemia, in this population. However, there is limited evidence regarding the pathogenesis and management of dyslipidemia in people living with HIV.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Editorial Material
Medicine, General & Internal
U. Sagheer, M. K. Shotwell, M. Umer, W. Furtado, J. Joshi, D. K. Kalra
QJM-AN INTERNATIONAL JOURNAL OF MEDICINE
(2023)
Article
Medicine, General & Internal
S. Hammad Jafri, Maya Guglin, Roopa Rao, Onyedika Ilonze, Kareem Ballut, Zulfiqar Qutrio Baloch, Mohammed Qintar, Joel Cohn, Matthew Wilcox, Andrew M. Freeman, Dinesh K. Kalra, Wen-Chih Wu
Summary: This study found that patients with heart failure (HF) were able to achieve similar or even better functional and psychosocial outcomes after intensive cardiac rehabilitation (ICR), despite their lower baseline functional status and psychosocial scores compared to non-HF patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Nachiket Apte, Dinesh K. Kalra
Summary: Ventricular ectopy is a common cardiac arrhythmia that can be managed with antiarrhythmic drugs. However, the use of these drugs should be done cautiously due to potential side effects.
Article
Mechanics
Tejaswini Kumari, Dinesh Kumar, K. N. Rai, S. K. Singh
Summary: This paper presents a mathematical heat transfer model for predicting the temperature profile at the tumor position during hyperthermia treatment in multi-layer skin tissue. It combines the dual-phase-lag model with a Gaussian heat source term and discusses the effects of various parameters and boundary conditions. The study concludes with a discussion on a better approach to treat tumor cells during hyperthermia treatment without harming neighboring healthy tissues.
MECHANICS BASED DESIGN OF STRUCTURES AND MACHINES
(2023)
Article
Mathematics, Applied
D. L. Suthar, Dinesh Kumar, Haile Habenom
Summary: This article discusses the possible solutions of the fractional kinetic equation associated with the generalized multiindex Bessel function using the Laplace transform method. Numerical results and graphical solutions of the main theorems are also provided.
DIFFERENTIAL EQUATIONS AND DYNAMICAL SYSTEMS
(2023)